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Updated November 2019
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Protein Info
Short Name:
C5orf42
Full Name:
Uncharacterized protein C5orf42
Alias:
Type:
Mass (Da):
236517
Number AA:
2095
UniProt ID:
Q9H799
International Prot ID:
IPI00395010
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
T
F
Q
L
L
I
D
S
A
K
D
F
S
K
R
Site 2
S22
I
D
S
A
K
D
F
S
K
R
L
W
G
L
V
Site 3
S111
Q
K
I
R
M
K
G
S
L
P
S
L
S
P
F
Site 4
S114
R
M
K
G
S
L
P
S
L
S
P
F
P
Q
S
Site 5
S116
K
G
S
L
P
S
L
S
P
F
P
Q
S
L
L
Site 6
S121
S
L
S
P
F
P
Q
S
L
L
N
Y
C
K
G
Site 7
S171
L
H
V
R
D
K
L
S
Y
S
C
R
Q
Y
Q
Site 8
Y172
H
V
R
D
K
L
S
Y
S
C
R
Q
Y
Q
K
Site 9
S173
V
R
D
K
L
S
Y
S
C
R
Q
Y
Q
K
A
Site 10
Y177
L
S
Y
S
C
R
Q
Y
Q
K
A
R
E
N
V
Site 11
Y264
R
V
P
L
R
D
K
Y
H
S
L
H
Q
R
L
Site 12
S266
P
L
R
D
K
Y
H
S
L
H
Q
R
L
R
H
Site 13
S309
R
V
R
R
N
I
G
S
F
E
V
N
I
W
E
Site 14
Y332
E
A
P
G
V
D
R
Y
S
L
G
T
S
L
S
Site 15
S333
A
P
G
V
D
R
Y
S
L
G
T
S
L
S
R
Site 16
T336
V
D
R
Y
S
L
G
T
S
L
S
R
S
T
L
Site 17
S337
D
R
Y
S
L
G
T
S
L
S
R
S
T
L
T
Site 18
S339
Y
S
L
G
T
S
L
S
R
S
T
L
T
E
L
Site 19
S341
L
G
T
S
L
S
R
S
T
L
T
E
L
G
D
Site 20
T342
G
T
S
L
S
R
S
T
L
T
E
L
G
D
S
Site 21
S349
T
L
T
E
L
G
D
S
V
V
H
S
D
A
D
Site 22
S353
L
G
D
S
V
V
H
S
D
A
D
T
F
S
E
Site 23
S359
H
S
D
A
D
T
F
S
E
A
L
S
V
E
E
Site 24
S363
D
T
F
S
E
A
L
S
V
E
E
K
S
R
I
Site 25
Y373
E
K
S
R
I
N
I
Y
Q
R
N
A
P
N
H
Site 26
S412
K
E
D
H
E
K
L
S
Q
N
T
L
P
V
I
Site 27
Y431
F
E
R
D
D
D
E
Y
I
K
F
L
D
L
F
Site 28
Y441
F
L
D
L
F
L
S
Y
I
L
E
R
D
L
P
Site 29
Y449
I
L
E
R
D
L
P
Y
S
R
D
A
D
I
P
Site 30
S450
L
E
R
D
L
P
Y
S
R
D
A
D
I
P
F
Site 31
S460
A
D
I
P
F
L
T
S
F
S
G
K
L
R
E
Site 32
T479
S
L
L
F
D
V
H
T
T
L
K
R
H
Q
S
Site 33
S486
T
T
L
K
R
H
Q
S
K
T
K
S
Q
N
V
Site 34
T488
L
K
R
H
Q
S
K
T
K
S
Q
N
V
F
R
Site 35
S490
R
H
Q
S
K
T
K
S
Q
N
V
F
R
A
G
Site 36
S506
C
F
V
V
A
P
E
S
Y
E
S
E
K
S
S
Site 37
S509
V
A
P
E
S
Y
E
S
E
K
S
S
S
L
N
Site 38
S512
E
S
Y
E
S
E
K
S
S
S
L
N
D
E
Y
Site 39
S513
S
Y
E
S
E
K
S
S
S
L
N
D
E
Y
G
Site 40
S514
Y
E
S
E
K
S
S
S
L
N
D
E
Y
G
M
Site 41
Y519
S
S
S
L
N
D
E
Y
G
M
H
L
E
N
Q
Site 42
S529
H
L
E
N
Q
K
L
S
S
S
V
L
V
N
Q
Site 43
S531
E
N
Q
K
L
S
S
S
V
L
V
N
Q
G
I
Site 44
Y544
G
I
K
P
F
L
Q
Y
P
S
N
E
V
N
K
Site 45
S565
L
F
G
L
K
Q
R
S
I
Y
K
I
Q
D
D
Site 46
Y567
G
L
K
Q
R
S
I
Y
K
I
Q
D
D
T
R
Site 47
T573
I
Y
K
I
Q
D
D
T
R
E
K
C
L
I
Q
Site 48
T589
S
S
N
H
I
F
W
T
P
K
S
I
K
T
R
Site 49
T595
W
T
P
K
S
I
K
T
R
R
C
I
F
K
A
Site 50
S643
N
R
R
L
L
C
D
S
G
I
T
E
S
S
S
Site 51
T646
L
L
C
D
S
G
I
T
E
S
S
S
E
Y
S
Site 52
S648
C
D
S
G
I
T
E
S
S
S
E
Y
S
P
V
Site 53
S649
D
S
G
I
T
E
S
S
S
E
Y
S
P
V
I
Site 54
S650
S
G
I
T
E
S
S
S
E
Y
S
P
V
I
R
Site 55
Y652
I
T
E
S
S
S
E
Y
S
P
V
I
R
V
K
Site 56
S653
T
E
S
S
S
E
Y
S
P
V
I
R
V
K
T
Site 57
Y676
L
W
L
L
E
Q
P
Y
F
A
T
Y
K
A
K
Site 58
T695
K
M
V
E
N
R
D
T
G
C
Q
I
G
P
N
Site 59
S707
G
P
N
I
E
R
E
S
K
S
D
A
G
G
S
Site 60
S709
N
I
E
R
E
S
K
S
D
A
G
G
S
V
A
Site 61
S714
S
K
S
D
A
G
G
S
V
A
V
A
T
P
G
Site 62
T719
G
G
S
V
A
V
A
T
P
G
G
T
E
E
R
Site 63
S789
E
E
M
D
M
H
I
S
D
Y
E
E
D
I
E
Site 64
Y791
M
D
M
H
I
S
D
Y
E
E
D
I
E
E
S
Site 65
S798
Y
E
E
D
I
E
E
S
V
G
G
F
R
S
P
Site 66
T823
Q
Q
L
E
E
E
F
T
E
E
V
Q
C
Q
R
Site 67
T836
Q
R
E
E
P
L
E
T
I
M
E
E
K
S
T
Site 68
S842
E
T
I
M
E
E
K
S
T
E
Q
K
G
M
I
Site 69
T843
T
I
M
E
E
K
S
T
E
Q
K
G
M
I
E
Site 70
S853
K
G
M
I
E
A
F
S
H
P
G
H
T
T
P
Site 71
T859
F
S
H
P
G
H
T
T
P
Q
S
M
Q
V
D
Site 72
S862
P
G
H
T
T
P
Q
S
M
Q
V
D
T
S
S
Site 73
T867
P
Q
S
M
Q
V
D
T
S
S
E
I
S
S
A
Site 74
S868
Q
S
M
Q
V
D
T
S
S
E
I
S
S
A
Q
Site 75
S869
S
M
Q
V
D
T
S
S
E
I
S
S
A
Q
I
Site 76
S872
V
D
T
S
S
E
I
S
S
A
Q
I
S
T
Y
Site 77
S873
D
T
S
S
E
I
S
S
A
Q
I
S
T
Y
K
Site 78
S877
E
I
S
S
A
Q
I
S
T
Y
K
E
K
S
S
Site 79
Y879
S
S
A
Q
I
S
T
Y
K
E
K
S
S
S
V
Site 80
S883
I
S
T
Y
K
E
K
S
S
S
V
P
L
L
I
Site 81
S884
S
T
Y
K
E
K
S
S
S
V
P
L
L
I
S
Site 82
S885
T
Y
K
E
K
S
S
S
V
P
L
L
I
S
N
Site 83
S898
S
N
G
V
N
V
A
S
Q
P
P
A
P
T
P
Site 84
T904
A
S
Q
P
P
A
P
T
P
Q
K
T
Q
R
N
Site 85
T908
P
A
P
T
P
Q
K
T
Q
R
N
E
F
T
A
Site 86
S923
Q
L
P
D
C
S
E
S
V
R
Q
M
L
Q
D
Site 87
T960
S
F
A
N
L
P
D
T
Q
Q
L
V
Q
Q
S
Site 88
S967
T
Q
Q
L
V
Q
Q
S
Q
S
V
H
L
G
E
Site 89
S969
Q
L
V
Q
Q
S
Q
S
V
H
L
G
E
S
Q
Site 90
S975
Q
S
V
H
L
G
E
S
Q
E
S
N
L
R
G
Site 91
S978
H
L
G
E
S
Q
E
S
N
L
R
G
C
G
D
Site 92
S1003
R
F
F
I
K
P
Q
S
M
G
E
N
A
R
E
Site 93
S1015
A
R
E
P
R
K
N
S
P
H
C
H
E
G
T
Site 94
T1022
S
P
H
C
H
E
G
T
I
P
S
G
Q
N
S
Site 95
S1025
C
H
E
G
T
I
P
S
G
Q
N
S
T
G
N
Site 96
S1029
T
I
P
S
G
Q
N
S
T
G
N
V
Q
N
V
Site 97
S1058
R
K
K
G
P
I
P
S
S
Q
N
L
P
S
T
Site 98
S1059
K
K
G
P
I
P
S
S
Q
N
L
P
S
T
S
Site 99
S1064
P
S
S
Q
N
L
P
S
T
S
F
Y
P
A
P
Site 100
S1066
S
Q
N
L
P
S
T
S
F
Y
P
A
P
A
G
Site 101
Y1068
N
L
P
S
T
S
F
Y
P
A
P
A
G
N
T
Site 102
S1081
N
T
H
L
Y
L
L
S
T
P
S
V
V
Q
K
Site 103
T1098
R
L
I
P
H
A
K
T
F
S
P
G
D
G
F
Site 104
S1100
I
P
H
A
K
T
F
S
P
G
D
G
F
P
L
Site 105
S1112
F
P
L
L
Q
F
K
S
K
Q
E
F
Q
P
L
Site 106
S1144
P
R
E
A
W
G
L
S
D
S
F
Q
P
A
L
Site 107
S1146
E
A
W
G
L
S
D
S
F
Q
P
A
L
P
Q
Site 108
T1159
P
Q
R
A
A
Q
T
T
P
A
S
H
L
N
V
Site 109
S1162
A
A
Q
T
T
P
A
S
H
L
N
V
S
Q
Y
Site 110
S1167
P
A
S
H
L
N
V
S
Q
Y
N
T
E
A
R
Site 111
Y1169
S
H
L
N
V
S
Q
Y
N
T
E
A
R
K
K
Site 112
T1171
L
N
V
S
Q
Y
N
T
E
A
R
K
K
E
V
Site 113
Y1200
N
H
V
N
L
D
Q
Y
V
G
Q
E
N
L
T
Site 114
T1207
Y
V
G
Q
E
N
L
T
P
Q
Q
D
S
S
V
Site 115
S1213
L
T
P
Q
Q
D
S
S
V
F
I
K
P
E
K
Site 116
T1228
L
F
D
V
K
P
G
T
L
E
I
S
P
H
H
Site 117
S1232
K
P
G
T
L
E
I
S
P
H
H
S
F
G
L
Site 118
S1254
K
P
P
N
M
F
P
S
T
S
R
A
S
I
T
Site 119
T1255
P
P
N
M
F
P
S
T
S
R
A
S
I
T
V
Site 120
S1256
P
N
M
F
P
S
T
S
R
A
S
I
T
V
P
Site 121
S1259
F
P
S
T
S
R
A
S
I
T
V
P
S
T
P
Site 122
T1261
S
T
S
R
A
S
I
T
V
P
S
T
P
I
Q
Site 123
Y1276
P
I
A
E
E
R
K
Y
P
R
L
S
L
L
H
Site 124
S1280
E
R
K
Y
P
R
L
S
L
L
H
S
H
L
S
Site 125
S1284
P
R
L
S
L
L
H
S
H
L
S
P
E
N
R
Site 126
S1287
S
L
L
H
S
H
L
S
P
E
N
R
C
K
K
Site 127
T1295
P
E
N
R
C
K
K
T
Q
L
I
P
L
E
N
Site 128
S1309
N
L
I
A
F
K
Q
S
Q
Q
K
L
T
H
N
Site 129
S1344
E
V
R
Q
G
K
D
S
K
K
R
Q
R
R
R
Site 130
T1371
L
R
R
K
P
N
V
T
F
R
P
E
N
S
I
Site 131
S1384
S
I
I
N
N
D
D
S
E
I
I
K
K
P
K
Site 132
S1399
E
Q
Q
E
H
C
G
S
H
P
L
D
D
F
D
Site 133
T1417
E
M
L
Q
D
D
N
T
S
A
G
L
H
F
M
Site 134
S1434
V
K
K
K
A
I
G
S
Q
D
A
S
T
N
T
Site 135
S1438
A
I
G
S
Q
D
A
S
T
N
T
D
P
E
H
Site 136
T1439
I
G
S
Q
D
A
S
T
N
T
D
P
E
H
E
Site 137
T1449
D
P
E
H
E
P
L
T
A
P
Q
L
L
V
P
Site 138
S1465
V
Y
L
N
L
K
L
S
S
E
M
S
E
K
P
Site 139
S1469
L
K
L
S
S
E
M
S
E
K
P
W
S
P
S
Site 140
S1474
E
M
S
E
K
P
W
S
P
S
I
P
H
T
V
Site 141
S1476
S
E
K
P
W
S
P
S
I
P
H
T
V
T
N
Site 142
T1480
W
S
P
S
I
P
H
T
V
T
N
L
V
G
H
Site 143
T1482
P
S
I
P
H
T
V
T
N
L
V
G
H
T
Y
Site 144
S1527
S
D
H
L
A
V
P
S
S
A
E
L
H
Y
M
Site 145
S1528
D
H
L
A
V
P
S
S
A
E
L
H
Y
M
A
Site 146
Y1533
P
S
S
A
E
L
H
Y
M
A
A
S
V
T
N
Site 147
T1539
H
Y
M
A
A
S
V
T
N
A
V
P
P
H
N
Site 148
S1549
V
P
P
H
N
F
K
S
Q
G
L
P
K
P
E
Site 149
S1563
E
F
R
F
K
G
Q
S
T
K
S
D
S
A
E
Site 150
T1564
F
R
F
K
G
Q
S
T
K
S
D
S
A
E
D
Site 151
S1566
F
K
G
Q
S
T
K
S
D
S
A
E
D
Y
L
Site 152
S1568
G
Q
S
T
K
S
D
S
A
E
D
Y
L
L
W
Site 153
Y1572
K
S
D
S
A
E
D
Y
L
L
W
K
R
L
Q
Site 154
S1582
W
K
R
L
Q
G
V
S
A
A
C
P
A
P
S
Site 155
S1590
A
A
C
P
A
P
S
S
A
A
H
Q
L
E
H
Site 156
T1653
S
G
P
E
F
K
K
T
L
A
S
K
T
I
S
Site 157
S1656
E
F
K
K
T
L
A
S
K
T
I
S
I
S
E
Site 158
T1658
K
K
T
L
A
S
K
T
I
S
I
S
E
E
V
Site 159
S1660
T
L
A
S
K
T
I
S
I
S
E
E
V
R
F
Site 160
S1662
A
S
K
T
I
S
I
S
E
E
V
R
F
L
T
Site 161
T1669
S
E
E
V
R
F
L
T
H
M
D
E
E
D
Q
Site 162
S1677
H
M
D
E
E
D
Q
S
D
K
K
E
T
S
E
Site 163
S1683
Q
S
D
K
K
E
T
S
E
P
E
F
S
I
T
Site 164
S1688
E
T
S
E
P
E
F
S
I
T
E
N
Y
S
G
Site 165
T1690
S
E
P
E
F
S
I
T
E
N
Y
S
G
Q
K
Site 166
T1698
E
N
Y
S
G
Q
K
T
C
V
F
P
T
A
D
Site 167
S1709
P
T
A
D
S
A
V
S
L
S
S
S
S
D
Q
Site 168
S1711
A
D
S
A
V
S
L
S
S
S
S
D
Q
N
T
Site 169
S1713
S
A
V
S
L
S
S
S
S
D
Q
N
T
T
S
Site 170
S1714
A
V
S
L
S
S
S
S
D
Q
N
T
T
S
P
Site 171
T1718
S
S
S
S
D
Q
N
T
T
S
P
G
M
N
S
Site 172
S1720
S
S
D
Q
N
T
T
S
P
G
M
N
S
S
D
Site 173
S1726
T
S
P
G
M
N
S
S
D
E
L
C
E
S
V
Site 174
S1732
S
S
D
E
L
C
E
S
V
S
V
H
P
L
Q
Site 175
S1734
D
E
L
C
E
S
V
S
V
H
P
L
Q
M
T
Site 176
S1761
I
I
K
D
G
V
S
S
E
E
L
G
L
T
E
Site 177
T1767
S
S
E
E
L
G
L
T
E
Q
A
M
G
T
S
Site 178
Y1779
G
T
S
R
I
Q
H
Y
S
G
R
H
S
Q
R
Site 179
S1780
T
S
R
I
Q
H
Y
S
G
R
H
S
Q
R
T
Site 180
S1784
Q
H
Y
S
G
R
H
S
Q
R
T
D
K
E
R
Site 181
T1787
S
G
R
H
S
Q
R
T
D
K
E
R
R
E
I
Site 182
Y1809
R
K
E
R
M
A
K
Y
L
N
E
L
A
E
K
Site 183
Y1832
C
P
R
S
N
P
L
Y
M
T
S
R
E
I
R
Site 184
T1834
R
S
N
P
L
Y
M
T
S
R
E
I
R
L
R
Site 185
S1854
E
K
D
R
L
L
L
S
E
H
Y
S
R
R
I
Site 186
Y1857
R
L
L
L
S
E
H
Y
S
R
R
I
S
Q
A
Site 187
S1858
L
L
L
S
E
H
Y
S
R
R
I
S
Q
A
Y
Site 188
S1862
E
H
Y
S
R
R
I
S
Q
A
Y
G
L
M
N
Site 189
Y1865
S
R
R
I
S
Q
A
Y
G
L
M
N
E
L
L
Site 190
S1875
M
N
E
L
L
S
E
S
V
Q
L
P
T
L
P
Site 191
T1880
S
E
S
V
Q
L
P
T
L
P
Q
K
P
L
P
Site 192
S1891
K
P
L
P
N
K
P
S
P
T
Q
S
S
S
C
Site 193
T1893
L
P
N
K
P
S
P
T
Q
S
S
S
C
Q
H
Site 194
S1895
N
K
P
S
P
T
Q
S
S
S
C
Q
H
C
P
Site 195
S1896
K
P
S
P
T
Q
S
S
S
C
Q
H
C
P
S
Site 196
S1897
P
S
P
T
Q
S
S
S
C
Q
H
C
P
S
P
Site 197
S1903
S
S
C
Q
H
C
P
S
P
R
G
E
N
Q
H
Site 198
S1913
G
E
N
Q
H
G
H
S
F
L
I
N
R
P
G
Site 199
Y1924
N
R
P
G
K
V
K
Y
M
S
K
P
S
Y
I
Site 200
S1926
P
G
K
V
K
Y
M
S
K
P
S
Y
I
H
K
Site 201
S1929
V
K
Y
M
S
K
P
S
Y
I
H
K
R
K
S
Site 202
Y1930
K
Y
M
S
K
P
S
Y
I
H
K
R
K
S
F
Site 203
S1936
S
Y
I
H
K
R
K
S
F
G
Q
P
Q
G
S
Site 204
S1943
S
F
G
Q
P
Q
G
S
P
W
P
H
G
T
A
Site 205
T1951
P
W
P
H
G
T
A
T
F
T
I
Q
K
K
A
Site 206
T1969
K
A
A
V
R
K
A
T
Q
S
P
V
T
F
Q
Site 207
S1971
A
V
R
K
A
T
Q
S
P
V
T
F
Q
K
G
Site 208
T1974
K
A
T
Q
S
P
V
T
F
Q
K
G
S
N
A
Site 209
S1979
P
V
T
F
Q
K
G
S
N
A
P
C
H
S
L
Site 210
S1985
G
S
N
A
P
C
H
S
L
Q
H
T
K
K
H
Site 211
T1989
P
C
H
S
L
Q
H
T
K
K
H
G
S
A
G
Site 212
T2001
S
A
G
L
A
P
Q
T
K
Q
V
C
V
E
Y
Site 213
Y2008
T
K
Q
V
C
V
E
Y
E
R
E
E
T
V
V
Site 214
T2013
V
E
Y
E
R
E
E
T
V
V
S
P
W
T
I
Site 215
S2016
E
R
E
E
T
V
V
S
P
W
T
I
P
S
E
Site 216
T2019
E
T
V
V
S
P
W
T
I
P
S
E
I
H
K
Site 217
S2031
I
H
K
I
L
H
E
S
H
N
S
L
L
Q
D
Site 218
S2034
I
L
H
E
S
H
N
S
L
L
Q
D
L
S
P
Site 219
S2040
N
S
L
L
Q
D
L
S
P
T
E
E
E
E
P
Site 220
S2058
F
G
V
G
G
V
D
S
V
S
E
S
T
G
S
Site 221
S2062
G
V
D
S
V
S
E
S
T
G
S
I
L
S
K
Site 222
S2065
S
V
S
E
S
T
G
S
I
L
S
K
L
D
W
Site 223
S2068
E
S
T
G
S
I
L
S
K
L
D
W
N
A
I
Site 224
S2088
S
V
E
D
Q
G
L
S
V
H
W
A
L
D
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation