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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RPAP3
Full Name:
RNA polymerase II-associated protein 3
Alias:
FLJ21908; RNA polymerase II associated protein 3; RNA polymerase II-associated protein 3: RNA polymerase II-associated protein 3; Spag
Type:
Unknown function
Mass (Da):
75719
Number AA:
665
UniProt ID:
Q9H6T3
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S73
K
G
K
A
K
E
S
S
K
K
T
R
E
E
N
Site 2
T76
A
K
E
S
S
K
K
T
R
E
E
N
T
K
N
Site 3
T81
K
K
T
R
E
E
N
T
K
N
R
I
K
S
Y
Site 4
S87
N
T
K
N
R
I
K
S
Y
D
Y
E
A
W
A
Site 5
Y88
T
K
N
R
I
K
S
Y
D
Y
E
A
W
A
K
Site 6
Y90
N
R
I
K
S
Y
D
Y
E
A
W
A
K
L
D
Site 7
S110
D
E
L
D
K
D
D
S
T
H
E
S
L
S
Q
Site 8
T111
E
L
D
K
D
D
S
T
H
E
S
L
S
Q
E
Site 9
S114
K
D
D
S
T
H
E
S
L
S
Q
E
S
E
S
Site 10
S116
D
S
T
H
E
S
L
S
Q
E
S
E
S
E
E
Site 11
S119
H
E
S
L
S
Q
E
S
E
S
E
E
D
G
I
Site 12
S121
S
L
S
Q
E
S
E
S
E
E
D
G
I
H
V
Site 13
S130
E
D
G
I
H
V
D
S
Q
K
A
L
V
L
K
Site 14
Y143
L
K
E
K
G
N
K
Y
F
K
Q
G
K
Y
D
Site 15
Y149
K
Y
F
K
Q
G
K
Y
D
E
A
I
D
C
Y
Site 16
Y156
Y
D
E
A
I
D
C
Y
T
K
G
M
D
A
D
Site 17
Y165
K
G
M
D
A
D
P
Y
N
P
V
L
P
T
N
Site 18
T171
P
Y
N
P
V
L
P
T
N
R
A
S
A
Y
F
Site 19
S175
V
L
P
T
N
R
A
S
A
Y
F
R
L
K
K
Site 20
Y177
P
T
N
R
A
S
A
Y
F
R
L
K
K
F
A
Site 21
Y200
A
V
A
L
N
R
S
Y
T
K
A
Y
S
R
R
Site 22
T201
V
A
L
N
R
S
Y
T
K
A
Y
S
R
R
G
Site 23
Y204
N
R
S
Y
T
K
A
Y
S
R
R
G
A
A
R
Site 24
S205
R
S
Y
T
K
A
Y
S
R
R
G
A
A
R
F
Site 25
Y224
L
E
E
A
K
K
D
Y
E
R
V
L
E
L
E
Site 26
S245
T
N
E
L
R
K
I
S
Q
A
L
A
S
K
E
Site 27
S250
K
I
S
Q
A
L
A
S
K
E
N
S
Y
P
K
Site 28
S254
A
L
A
S
K
E
N
S
Y
P
K
E
A
D
I
Site 29
Y255
L
A
S
K
E
N
S
Y
P
K
E
A
D
I
V
Site 30
S265
E
A
D
I
V
I
K
S
T
E
G
E
R
K
Q
Site 31
S284
Q
N
K
Q
Q
A
I
S
E
K
D
R
G
N
G
Site 32
Y298
G
F
F
K
E
G
K
Y
E
R
A
I
E
C
Y
Site 33
Y305
Y
E
R
A
I
E
C
Y
T
R
G
I
A
A
D
Site 34
Y326
P
A
N
R
A
M
A
Y
L
K
I
Q
K
Y
E
Site 35
Y332
A
Y
L
K
I
Q
K
Y
E
E
A
E
K
D
C
Site 36
T340
E
E
A
E
K
D
C
T
Q
A
I
L
L
D
G
Site 37
S348
Q
A
I
L
L
D
G
S
Y
S
K
A
F
A
R
Site 38
Y349
A
I
L
L
D
G
S
Y
S
K
A
F
A
R
R
Site 39
S350
I
L
L
D
G
S
Y
S
K
A
F
A
R
R
G
Site 40
T358
K
A
F
A
R
R
G
T
A
R
T
F
L
G
K
Site 41
T361
A
R
R
G
T
A
R
T
F
L
G
K
L
N
E
Site 42
T375
E
A
K
Q
D
F
E
T
V
L
L
L
E
P
G
Site 43
S391
K
Q
A
V
T
E
L
S
K
I
K
K
E
L
I
Site 44
T411
D
D
V
F
L
D
S
T
Q
R
Q
N
V
V
K
Site 45
S428
D
N
P
P
H
P
G
S
T
K
P
L
K
K
V
Site 46
S452
Q
T
I
D
V
P
D
S
T
T
A
A
A
P
E
Site 47
S476
I
A
A
T
G
T
T
S
K
K
N
S
S
Q
D
Site 48
S480
G
T
T
S
K
K
N
S
S
Q
D
D
L
F
P
Site 49
S481
T
T
S
K
K
N
S
S
Q
D
D
L
F
P
T
Site 50
S489
Q
D
D
L
F
P
T
S
D
T
P
R
A
K
V
Site 51
T491
D
L
F
P
T
S
D
T
P
R
A
K
V
L
K
Site 52
S503
V
L
K
I
E
E
V
S
D
T
S
S
L
Q
P
Site 53
T505
K
I
E
E
V
S
D
T
S
S
L
Q
P
Q
A
Site 54
S507
E
E
V
S
D
T
S
S
L
Q
P
Q
A
S
L
Site 55
S513
S
S
L
Q
P
Q
A
S
L
K
Q
D
V
C
Q
Site 56
S521
L
K
Q
D
V
C
Q
S
Y
S
E
K
M
P
I
Site 57
S549
L
P
P
I
P
A
N
S
F
Q
L
E
S
D
F
Site 58
S554
A
N
S
F
Q
L
E
S
D
F
R
Q
L
K
S
Site 59
S561
S
D
F
R
Q
L
K
S
S
P
D
M
L
Y
Q
Site 60
S562
D
F
R
Q
L
K
S
S
P
D
M
L
Y
Q
Y
Site 61
Y567
K
S
S
P
D
M
L
Y
Q
Y
L
K
Q
I
E
Site 62
Y569
S
P
D
M
L
Y
Q
Y
L
K
Q
I
E
P
S
Site 63
S576
Y
L
K
Q
I
E
P
S
L
Y
P
K
L
F
Q
Site 64
Y578
K
Q
I
E
P
S
L
Y
P
K
L
F
Q
K
N
Site 65
Y602
V
K
I
L
H
D
F
Y
I
E
K
E
K
P
L
Site 66
S619
F
E
I
L
Q
R
L
S
E
L
K
R
F
D
M
Site 67
S649
L
F
N
H
I
D
K
S
G
L
K
D
S
S
V
Site 68
S654
D
K
S
G
L
K
D
S
S
V
E
E
L
K
K
Site 69
S655
K
S
G
L
K
D
S
S
V
E
E
L
K
K
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation