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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EPS8L2
Full Name:
Epidermal growth factor receptor kinase substrate 8-like protein 2
Alias:
Epidermal growth factor receptor pathway substrate 8-like protein 2; Epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8-like 2; EPS8R2; EPS8-related protein 2; ES8L2; FLJ21935; FLJ22171; MGC3088
Type:
Actin binding protein; Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
80621
Number AA:
715
UniProt ID:
Q9H6S3
International Prot ID:
IPI00414315
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
Q
S
G
A
V
S
C
C
P
G
A
T
N
Site 2
S17
C
P
G
A
T
N
G
S
L
G
R
S
D
G
V
Site 3
S21
T
N
G
S
L
G
R
S
D
G
V
A
K
M
S
Site 4
S28
S
D
G
V
A
K
M
S
P
K
D
L
F
E
Q
Site 5
Y39
L
F
E
Q
R
K
K
Y
S
N
S
N
V
I
M
Site 6
S42
Q
R
K
K
Y
S
N
S
N
V
I
M
H
E
T
Site 7
Y52
I
M
H
E
T
S
Q
Y
H
V
Q
H
L
A
T
Site 8
T59
Y
H
V
Q
H
L
A
T
F
I
M
D
K
S
E
Site 9
S70
D
K
S
E
A
I
T
S
V
D
D
A
I
R
K
Site 10
S83
R
K
L
V
Q
L
S
S
K
E
K
I
W
T
Q
Site 11
T89
S
S
K
E
K
I
W
T
Q
E
M
L
L
Q
V
Site 12
S108
L
R
L
L
D
I
E
S
Q
E
E
L
E
D
F
Site 13
T119
L
E
D
F
P
L
P
T
V
Q
R
S
Q
T
V
Site 14
S123
P
L
P
T
V
Q
R
S
Q
T
V
L
N
Q
L
Site 15
T125
P
T
V
Q
R
S
Q
T
V
L
N
Q
L
R
Y
Site 16
S143
L
L
L
V
C
Q
D
S
E
Q
S
K
P
D
V
Site 17
T184
G
K
K
M
R
P
Q
T
L
K
G
H
Q
E
K
Site 18
S197
E
K
I
R
Q
R
Q
S
I
L
P
P
P
Q
G
Site 19
S217
F
Q
H
R
G
G
D
S
P
E
A
K
N
R
V
Site 20
S231
V
G
P
Q
V
P
L
S
E
P
G
F
R
R
R
Site 21
S240
P
G
F
R
R
R
E
S
Q
E
E
P
R
A
V
Site 22
T303
A
P
A
E
G
V
L
T
L
R
A
R
P
P
S
Site 23
S310
T
L
R
A
R
P
P
S
E
G
E
F
I
D
C
Site 24
S339
Q
K
H
I
Q
N
P
S
A
A
E
L
V
H
F
Site 25
S368
P
D
I
A
R
S
V
S
C
P
L
L
S
R
D
Site 26
S390
H
L
V
P
K
E
M
S
L
W
E
S
L
G
E
Site 27
S394
K
E
M
S
L
W
E
S
L
G
E
S
W
M
R
Site 28
S398
L
W
E
S
L
G
E
S
W
M
R
P
R
S
E
Site 29
S404
E
S
W
M
R
P
R
S
E
W
P
R
E
P
Q
Site 30
Y415
R
E
P
Q
V
P
L
Y
V
P
K
F
H
S
G
Site 31
S442
W
E
V
E
G
L
A
S
A
P
I
E
E
V
S
Site 32
S449
S
A
P
I
E
E
V
S
P
V
S
R
Q
S
I
Site 33
S455
V
S
P
V
S
R
Q
S
I
R
N
S
Q
K
H
Site 34
S459
S
R
Q
S
I
R
N
S
Q
K
H
S
P
T
S
Site 35
S463
I
R
N
S
Q
K
H
S
P
T
S
E
P
T
P
Site 36
T465
N
S
Q
K
H
S
P
T
S
E
P
T
P
P
G
Site 37
S466
S
Q
K
H
S
P
T
S
E
P
T
P
P
G
D
Site 38
T469
H
S
P
T
S
E
P
T
P
P
G
D
A
L
P
Site 39
S479
G
D
A
L
P
P
V
S
S
P
H
T
H
R
G
Site 40
S480
D
A
L
P
P
V
S
S
P
H
T
H
R
G
Y
Site 41
T483
P
P
V
S
S
P
H
T
H
R
G
Y
Q
P
T
Site 42
Y487
S
P
H
T
H
R
G
Y
Q
P
T
P
A
M
A
Site 43
T490
T
H
R
G
Y
Q
P
T
P
A
M
A
K
Y
V
Site 44
Y501
A
K
Y
V
K
I
L
Y
D
F
T
A
R
N
A
Site 45
T504
V
K
I
L
Y
D
F
T
A
R
N
A
N
E
L
Site 46
S512
A
R
N
A
N
E
L
S
V
L
K
D
E
V
L
Site 47
S533
R
Q
W
W
K
L
R
S
R
S
G
Q
A
G
Y
Site 48
S535
W
W
K
L
R
S
R
S
G
Q
A
G
Y
V
P
Site 49
Y540
S
R
S
G
Q
A
G
Y
V
P
C
N
I
L
G
Site 50
Y565
F
E
Q
A
G
Q
K
Y
W
G
P
A
S
P
T
Site 51
S570
Q
K
Y
W
G
P
A
S
P
T
H
K
L
P
P
Site 52
T572
Y
W
G
P
A
S
P
T
H
K
L
P
P
S
F
Site 53
S578
P
T
H
K
L
P
P
S
F
P
G
N
K
D
E
Site 54
S602
D
E
L
I
R
K
I
S
N
I
R
A
Q
P
Q
Site 55
S617
R
H
F
R
V
E
R
S
Q
P
V
S
Q
P
L
Site 56
S621
V
E
R
S
Q
P
V
S
Q
P
L
T
Y
E
S
Site 57
T625
Q
P
V
S
Q
P
L
T
Y
E
S
G
P
D
E
Site 58
S643
W
L
E
A
K
A
F
S
P
R
I
V
E
N
L
Site 59
S660
L
T
G
P
Q
L
F
S
L
N
K
E
E
L
K
Site 60
Y678
G
E
E
G
V
R
V
Y
S
Q
L
T
M
Q
K
Site 61
S679
E
E
G
V
R
V
Y
S
Q
L
T
M
Q
K
A
Site 62
S693
A
F
L
E
K
Q
Q
S
G
S
E
L
E
E
L
Site 63
S695
L
E
K
Q
Q
S
G
S
E
L
E
E
L
M
N
Site 64
S715
N
Q
R
R
G
E
D
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation