KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HEATR1
Full Name:
HEAT repeat-containing protein 1
Alias:
BAP28; FLJ10359; HEAT repeat containing 1; HEAT repeat containing protein 1; HEAT1; HEATR; Protein BAP28
Type:
Uncharacterized protein
Mass (Da):
242370
Number AA:
2144
UniProt ID:
Q9H583
International Prot ID:
IPI00024279
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0030529
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006364
GO:0006364
GO:0006396
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T2
_
_
_
_
_
_
M
T
S
L
A
Q
Q
L
Q
Site 2
S16
Q
R
L
A
L
P
Q
S
D
A
S
L
L
S
R
Site 3
S19
A
L
P
Q
S
D
A
S
L
L
S
R
D
E
V
Site 4
S22
Q
S
D
A
S
L
L
S
R
D
E
V
A
S
L
Site 5
S28
L
S
R
D
E
V
A
S
L
L
F
D
P
K
E
Site 6
S61
E
L
L
G
I
D
P
S
F
E
Q
F
E
A
P
Site 7
T76
L
F
S
Q
L
A
K
T
L
E
R
S
V
Q
T
Site 8
Y126
H
R
F
H
I
H
L
Y
N
Q
D
S
L
I
A
Site 9
Y206
S
V
K
V
F
A
E
Y
P
G
S
S
A
Q
L
Site 10
S252
Y
I
Q
K
G
L
K
S
S
L
P
D
Y
R
A
Site 11
S253
I
Q
K
G
L
K
S
S
L
P
D
Y
R
A
A
Site 12
Y257
L
K
S
S
L
P
D
Y
R
A
A
T
Y
M
I
Site 13
S295
K
T
L
T
K
I
P
S
L
I
K
D
G
L
S
Site 14
S315
L
Q
R
Q
K
P
E
S
L
G
K
K
P
F
P
Site 15
Y341
L
H
G
I
S
E
T
Y
D
V
S
P
L
L
H
Site 16
Y375
E
G
M
D
G
Q
I
Y
K
R
H
L
E
A
I
Site 17
T384
R
H
L
E
A
I
L
T
K
I
S
L
K
N
N
Site 18
Y404
A
S
L
L
F
E
E
Y
I
S
Y
S
S
Q
E
Site 19
S406
L
L
F
E
E
Y
I
S
Y
S
S
Q
E
E
M
Site 20
Y407
L
F
E
E
Y
I
S
Y
S
S
Q
E
E
M
D
Site 21
S409
E
E
Y
I
S
Y
S
S
Q
E
E
M
D
S
N
Site 22
S415
S
S
Q
E
E
M
D
S
N
K
V
S
L
L
N
Site 23
S419
E
M
D
S
N
K
V
S
L
L
N
E
Q
F
L
Site 24
S434
P
L
I
R
L
L
E
S
K
Y
P
R
T
L
D
Site 25
Y436
I
R
L
L
E
S
K
Y
P
R
T
L
D
V
V
Site 26
T439
L
E
S
K
Y
P
R
T
L
D
V
V
L
E
E
Site 27
S465
E
L
F
H
Q
F
V
S
L
S
T
S
G
G
K
Site 28
S467
F
H
Q
F
V
S
L
S
T
S
G
G
K
Y
Q
Site 29
S469
Q
F
V
S
L
S
T
S
G
G
K
Y
Q
F
L
Site 30
Y473
L
S
T
S
G
G
K
Y
Q
F
L
A
D
S
D
Site 31
S479
K
Y
Q
F
L
A
D
S
D
T
S
L
M
L
S
Site 32
S486
S
D
T
S
L
M
L
S
L
N
H
P
L
A
P
Site 33
S509
L
K
K
I
M
K
T
S
K
E
G
V
D
E
S
Site 34
S516
S
K
E
G
V
D
E
S
F
I
K
E
A
V
L
Site 35
S550
I
F
K
E
H
F
S
S
E
V
T
I
S
N
L
Site 36
T553
E
H
F
S
S
E
V
T
I
S
N
L
L
N
L
Site 37
S590
L
I
K
E
E
I
L
S
E
N
D
Q
L
S
N
Site 38
T614
M
V
I
N
N
D
D
T
E
S
A
E
M
K
I
Site 39
S616
I
N
N
D
D
T
E
S
A
E
M
K
I
A
I
Site 40
S650
A
L
E
N
V
I
K
S
T
K
P
G
K
L
I
Site 41
S678
N
I
N
L
G
D
P
S
S
M
L
K
M
V
E
Site 42
S679
I
N
L
G
D
P
S
S
M
L
K
M
V
E
D
Site 43
S689
K
M
V
E
D
L
I
S
V
G
E
E
E
S
F
Site 44
S695
I
S
V
G
E
E
E
S
F
N
L
K
Q
K
V
Site 45
S709
V
T
F
H
V
I
L
S
V
L
V
S
C
C
S
Site 46
T721
C
C
S
S
L
K
E
T
H
F
P
F
A
I
R
Site 47
T745
K
K
L
E
S
V
I
T
A
V
E
I
P
S
E
Site 48
Y771
P
V
E
L
W
A
H
Y
V
E
E
L
N
S
T
Site 49
T778
Y
V
E
E
L
N
S
T
Q
R
V
A
V
E
D
Site 50
Y798
F
S
L
K
K
F
I
Y
A
L
K
A
P
K
S
Site 51
S805
Y
A
L
K
A
P
K
S
F
P
K
G
D
I
W
Site 52
Y825
L
K
E
D
S
R
D
Y
L
H
L
L
I
G
L
Site 53
T872
K
F
C
S
V
L
W
T
Y
G
S
S
L
S
N
Site 54
S875
S
V
L
W
T
Y
G
S
S
L
S
N
P
L
N
Site 55
S878
W
T
Y
G
S
S
L
S
N
P
L
N
C
S
V
Site 56
T906
A
M
L
S
S
Q
K
T
Q
C
K
H
Q
L
A
Site 57
S914
Q
C
K
H
Q
L
A
S
I
S
S
P
V
V
T
Site 58
S929
S
L
L
I
N
L
G
S
P
V
K
E
V
R
R
Site 59
S968
S
K
A
E
E
I
T
S
D
A
A
Y
V
I
Q
Site 60
S992
Q
R
E
K
K
L
K
S
H
Q
K
L
S
E
T
Site 61
S997
L
K
S
H
Q
K
L
S
E
T
L
K
N
L
L
Site 62
T999
S
H
Q
K
L
S
E
T
L
K
N
L
L
S
C
Site 63
Y1067
L
H
L
T
L
G
K
Y
N
E
F
S
V
S
L
Site 64
S1071
L
G
K
Y
N
E
F
S
V
S
L
L
N
E
D
Site 65
S1073
K
Y
N
E
F
S
V
S
L
L
N
E
D
P
K
Site 66
S1081
L
L
N
E
D
P
K
S
L
D
I
F
I
K
A
Site 67
S1119
K
P
F
F
A
A
I
S
D
E
K
V
Q
Q
K
Site 68
T1146
K
N
S
H
C
A
Q
T
V
S
S
V
F
K
G
Site 69
S1190
Q
K
M
Q
Q
K
K
S
Q
D
L
E
S
V
Q
Site 70
S1195
K
K
S
Q
D
L
E
S
V
Q
E
V
G
G
S
Site 71
S1202
S
V
Q
E
V
G
G
S
Y
W
Q
R
V
T
L
Site 72
S1222
Q
H
K
K
K
L
R
S
P
Q
I
L
V
P
T
Site 73
S1267
L
N
I
C
Q
K
L
S
P
D
G
G
K
I
P
Site 74
T1300
R
L
S
E
M
P
Q
T
H
H
H
A
L
L
L
Site 75
Y1341
V
M
R
L
D
D
T
Y
S
F
Q
V
I
N
K
Site 76
S1342
M
R
L
D
D
T
Y
S
F
Q
V
I
N
K
T
Site 77
S1360
V
I
P
A
L
I
Q
S
D
S
G
D
S
I
E
Site 78
S1362
P
A
L
I
Q
S
D
S
G
D
S
I
E
V
S
Site 79
S1365
I
Q
S
D
S
G
D
S
I
E
V
S
R
N
V
Site 80
S1369
S
G
D
S
I
E
V
S
R
N
V
E
E
I
V
Site 81
T1480
L
P
E
E
K
E
E
T
I
P
K
A
V
S
F
Site 82
S1486
E
T
I
P
K
A
V
S
F
N
K
S
E
S
Q
Site 83
S1490
K
A
V
S
F
N
K
S
E
S
Q
E
E
M
L
Site 84
S1492
V
S
F
N
K
S
E
S
Q
E
E
M
L
Q
V
Site 85
S1517
L
R
H
F
K
F
L
S
V
S
F
M
S
Q
L
Site 86
S1519
H
F
K
F
L
S
V
S
F
M
S
Q
L
L
S
Site 87
S1526
S
F
M
S
Q
L
L
S
S
N
N
F
L
K
K
Site 88
S1527
F
M
S
Q
L
L
S
S
N
N
F
L
K
K
V
Site 89
S1537
F
L
K
K
V
V
E
S
G
G
P
E
I
L
K
Site 90
T1573
E
R
N
A
D
K
L
T
V
K
F
W
R
A
L
Site 91
S1582
K
F
W
R
A
L
L
S
K
A
Y
D
L
L
D
Site 92
T1597
K
V
N
A
L
L
P
T
E
T
F
I
P
V
I
Site 93
T1599
N
A
L
L
P
T
E
T
F
I
P
V
I
R
G
Site 94
S1614
L
V
G
N
P
L
P
S
V
R
R
K
A
L
D
Site 95
T1636
Q
N
I
S
W
K
K
T
I
V
T
R
F
L
K
Site 96
T1669
E
Q
A
I
N
R
Q
T
A
L
Y
T
L
K
L
Site 97
S1739
Q
L
P
S
L
M
P
S
L
L
T
T
M
K
N
Site 98
S1748
L
T
T
M
K
N
T
S
E
L
V
S
S
E
V
Site 99
S1752
K
N
T
S
E
L
V
S
S
E
V
Y
L
L
S
Site 100
S1794
I
H
L
E
K
I
T
S
E
M
G
S
A
S
Q
Site 101
S1798
K
I
T
S
E
M
G
S
A
S
Q
A
N
I
R
Site 102
S1800
T
S
E
M
G
S
A
S
Q
A
N
I
R
L
T
Site 103
T1807
S
Q
A
N
I
R
L
T
S
L
K
K
T
L
A
Site 104
S1808
Q
A
N
I
R
L
T
S
L
K
K
T
L
A
T
Site 105
T1812
R
L
T
S
L
K
K
T
L
A
T
T
L
A
P
Site 106
S1862
M
K
K
E
E
L
T
S
H
Q
S
Q
L
T
A
Site 107
S1865
E
E
L
T
S
H
Q
S
Q
L
T
A
F
F
L
Site 108
S1882
L
D
F
R
A
Q
H
S
E
N
D
L
E
E
V
Site 109
T1892
D
L
E
E
V
G
K
T
E
N
C
I
I
D
C
Site 110
T1935
A
P
K
D
R
L
L
T
F
Y
N
L
A
D
C
Site 111
T1974
N
Q
V
N
I
S
K
T
D
E
A
F
F
D
S
Site 112
S1981
T
D
E
A
F
F
D
S
E
N
D
P
E
K
C
Site 113
T2007
Y
K
I
F
L
F
D
T
Q
H
F
I
S
K
E
Site 114
S2012
F
D
T
Q
H
F
I
S
K
E
R
A
E
A
L
Site 115
T2042
E
K
F
Q
E
R
V
T
K
H
L
I
P
C
I
Site 116
S2060
S
V
A
M
A
D
D
S
L
W
K
P
L
N
Y
Site 117
T2073
N
Y
Q
I
L
L
K
T
R
D
S
S
P
K
V
Site 118
S2076
I
L
L
K
T
R
D
S
S
P
K
V
R
F
A
Site 119
S2077
L
L
K
T
R
D
S
S
P
K
V
R
F
A
A
Site 120
T2087
V
R
F
A
A
L
I
T
V
L
A
L
A
E
K
Site 121
T2134
K
T
I
Q
Q
L
E
T
V
L
G
E
P
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation