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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DEF6
Full Name:
Differentially expressed in FDCP 6 homolog
Alias:
DEFI6; Differentially expressed in FDCP 6; IBP; IRF4-binding protein; SLAT
Type:
Plasma membrane, Cytoplasm, Nucleus protein
Mass (Da):
73910
Number AA:
631
UniProt ID:
Q9H4E7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0005886
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
T
A
L
D
V
E
K
S
G
K
V
S
K
S
Q
Site 2
S27
V
E
K
S
G
K
V
S
K
S
Q
L
K
V
L
Site 3
S29
K
S
G
K
V
S
K
S
Q
L
K
V
L
S
H
Site 4
S35
K
S
Q
L
K
V
L
S
H
N
L
Y
T
V
L
Site 5
S64
D
D
D
D
G
P
V
S
S
Q
G
Y
M
P
Y
Site 6
S65
D
D
D
G
P
V
S
S
Q
G
Y
M
P
Y
L
Site 7
Y68
G
P
V
S
S
Q
G
Y
M
P
Y
L
N
K
Y
Site 8
Y71
S
S
Q
G
Y
M
P
Y
L
N
K
Y
I
L
D
Site 9
Y75
Y
M
P
Y
L
N
K
Y
I
L
D
K
V
E
E
Site 10
T98
D
E
L
C
W
T
L
T
A
K
K
N
Y
R
A
Site 11
S107
K
K
N
Y
R
A
D
S
N
G
N
S
M
L
S
Site 12
S111
R
A
D
S
N
G
N
S
M
L
S
N
Q
D
A
Site 13
S114
S
N
G
N
S
M
L
S
N
Q
D
A
F
R
L
Site 14
Y133
N
F
L
S
E
D
K
Y
P
L
I
M
V
P
D
Site 15
Y144
M
V
P
D
E
V
E
Y
L
L
K
K
V
L
S
Site 16
S154
K
K
V
L
S
S
M
S
L
E
V
S
L
G
E
Site 17
S158
S
S
M
S
L
E
V
S
L
G
E
L
E
E
L
Site 18
T201
L
R
G
V
G
R
D
T
L
S
M
A
I
H
E
Site 19
Y210
S
M
A
I
H
E
V
Y
Q
E
L
I
Q
D
V
Site 20
Y222
Q
D
V
L
K
Q
G
Y
L
W
K
R
G
H
L
Site 21
Y247
L
Q
P
S
C
L
C
Y
F
G
S
E
E
C
K
Site 22
Y290
V
K
T
A
N
R
T
Y
E
M
S
A
S
D
T
Site 23
S293
A
N
R
T
Y
E
M
S
A
S
D
T
R
Q
R
Site 24
S295
R
T
Y
E
M
S
A
S
D
T
R
Q
R
Q
E
Site 25
T297
Y
E
M
S
A
S
D
T
R
Q
R
Q
E
W
T
Site 26
S320
L
Q
A
E
G
K
T
S
L
H
K
D
L
K
Q
Site 27
S387
E
E
E
E
R
R
R
S
Q
H
R
E
L
Q
Q
Site 28
S409
E
A
E
Q
A
R
A
S
M
Q
A
E
M
E
L
Site 29
S454
K
A
R
R
D
E
E
S
V
R
I
A
Q
T
R
Site 30
Y483
L
K
E
E
Q
E
R
Y
I
E
R
A
Q
Q
E
Site 31
S537
Q
R
K
L
R
Q
A
S
T
N
V
K
H
W
N
Site 32
T538
R
K
L
R
Q
A
S
T
N
V
K
H
W
N
V
Site 33
T563
P
G
D
K
R
P
V
T
S
S
S
F
S
G
F
Site 34
S564
G
D
K
R
P
V
T
S
S
S
F
S
G
F
Q
Site 35
S565
D
K
R
P
V
T
S
S
S
F
S
G
F
Q
P
Site 36
S566
K
R
P
V
T
S
S
S
F
S
G
F
Q
P
P
Site 37
S580
P
L
L
A
H
R
D
S
S
L
K
R
L
T
R
Site 38
S581
L
L
A
H
R
D
S
S
L
K
R
L
T
R
W
Site 39
T586
D
S
S
L
K
R
L
T
R
W
G
S
Q
G
N
Site 40
S590
K
R
L
T
R
W
G
S
Q
G
N
R
T
P
S
Site 41
T595
W
G
S
Q
G
N
R
T
P
S
P
N
S
N
E
Site 42
S597
S
Q
G
N
R
T
P
S
P
N
S
N
E
Q
Q
Site 43
S600
N
R
T
P
S
P
N
S
N
E
Q
Q
K
S
L
Site 44
S606
N
S
N
E
Q
Q
K
S
L
N
G
G
D
E
A
Site 45
S618
D
E
A
P
A
P
A
S
T
P
Q
E
D
K
L
Site 46
T619
E
A
P
A
P
A
S
T
P
Q
E
D
K
L
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation