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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAMTS10
Full Name:
A disintegrin and metalloproteinase with thrombospondin motifs 10
Alias:
a disintegrin and metalloproteinase with thrombospondin motifs 10; ADAM metallopeptidase with thrombospondin type 1 motif, 10; ADAM-TS 10; ADAM-TS10; ADAMTS-10; ATS10; WMS
Type:
EC 3.4.24.-; Protease
Mass (Da):
120870
Number AA:
UniProt ID:
Q9H324
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
L
G
L
M
F
E
V
T
H
A
F
R
S
Q
D
Site 2
S28
E
V
T
H
A
F
R
S
Q
D
E
F
L
S
S
Site 3
S34
R
S
Q
D
E
F
L
S
S
L
E
S
Y
E
I
Site 4
S35
S
Q
D
E
F
L
S
S
L
E
S
Y
E
I
A
Site 5
Y39
F
L
S
S
L
E
S
Y
E
I
A
F
P
T
R
Site 6
S57
N
G
A
L
L
A
F
S
P
P
P
P
R
R
Q
Site 7
T68
P
R
R
Q
R
R
G
T
G
A
T
A
E
S
R
Site 8
T71
Q
R
R
G
T
G
A
T
A
E
S
R
L
F
Y
Site 9
S74
G
T
G
A
T
A
E
S
R
L
F
Y
K
V
A
Site 10
Y78
T
A
E
S
R
L
F
Y
K
V
A
S
P
S
T
Site 11
S103
R
L
L
A
G
H
V
S
V
E
Y
W
T
R
E
Site 12
Y106
A
G
H
V
S
V
E
Y
W
T
R
E
G
L
A
Site 13
Y124
A
A
R
P
H
C
L
Y
A
G
H
L
Q
G
Q
Site 14
S133
G
H
L
Q
G
Q
A
S
T
S
H
V
A
I
S
Site 15
Y156
I
V
A
D
E
E
E
Y
L
I
E
P
L
H
G
Site 16
S168
L
H
G
G
P
K
G
S
R
S
P
E
E
S
G
Site 17
S170
G
G
P
K
G
S
R
S
P
E
E
S
G
P
H
Site 18
S174
G
S
R
S
P
E
E
S
G
P
H
V
V
Y
K
Site 19
Y180
E
S
G
P
H
V
V
Y
K
R
S
S
L
R
H
Site 20
S183
P
H
V
V
Y
K
R
S
S
L
R
H
P
H
L
Site 21
S184
H
V
V
Y
K
R
S
S
L
R
H
P
H
L
D
Site 22
T192
L
R
H
P
H
L
D
T
A
C
G
V
R
D
E
Site 23
T211
G
R
P
W
W
L
R
T
L
K
P
P
P
A
R
Site 24
T224
A
R
P
L
G
N
E
T
E
R
G
Q
P
G
L
Site 25
S234
G
Q
P
G
L
K
R
S
V
S
R
E
R
Y
V
Site 26
S236
P
G
L
K
R
S
V
S
R
E
R
Y
V
E
T
Site 27
Y240
R
S
V
S
R
E
R
Y
V
E
T
L
V
V
A
Site 28
Y254
A
D
K
M
M
V
A
Y
H
G
R
R
D
V
E
Site 29
Y263
G
R
R
D
V
E
Q
Y
V
L
A
I
M
N
I
Site 30
S278
V
A
K
L
F
Q
D
S
S
L
G
S
T
V
N
Site 31
T283
Q
D
S
S
L
G
S
T
V
N
I
L
V
T
R
Site 32
T300
L
L
T
E
D
Q
P
T
L
E
I
T
H
H
A
Site 33
S313
H
A
G
K
S
L
D
S
F
C
K
W
Q
K
S
Site 34
T341
N
G
V
A
N
H
D
T
A
V
L
I
T
R
Y
Site 35
Y353
T
R
Y
D
I
C
I
Y
K
N
K
P
C
G
T
Site 36
S375
G
M
C
E
R
E
R
S
C
S
V
N
E
D
I
Site 37
S377
C
E
R
E
R
S
C
S
V
N
E
D
I
G
L
Site 38
T397
I
A
H
E
I
G
H
T
F
G
M
N
H
D
G
Site 39
S408
N
H
D
G
V
G
N
S
C
G
A
R
G
Q
D
Site 40
T428
A
A
H
I
T
M
K
T
N
P
F
V
W
S
S
Site 41
Y440
W
S
S
C
S
R
D
Y
I
T
S
F
L
D
S
Site 42
T442
S
C
S
R
D
Y
I
T
S
F
L
D
S
G
L
Site 43
S443
C
S
R
D
Y
I
T
S
F
L
D
S
G
L
G
Site 44
Y464
P
P
R
Q
D
F
V
Y
P
T
V
A
P
G
Q
Site 45
T466
R
Q
D
F
V
Y
P
T
V
A
P
G
Q
A
Y
Site 46
Y473
T
V
A
P
G
Q
A
Y
D
A
D
E
Q
C
R
Site 47
Y492
V
K
S
R
Q
C
K
Y
G
E
V
C
S
E
L
Site 48
T510
S
K
S
N
R
C
I
T
N
S
I
P
A
A
E
Site 49
S512
S
N
R
C
I
T
N
S
I
P
A
A
E
G
T
Site 50
S541
R
V
C
V
P
F
G
S
R
P
E
G
V
D
G
Site 51
T562
P
W
G
D
C
S
R
T
C
G
G
G
V
S
S
Site 52
S568
R
T
C
G
G
G
V
S
S
S
S
R
H
C
D
Site 53
S569
T
C
G
G
G
V
S
S
S
S
R
H
C
D
S
Site 54
S570
C
G
G
G
V
S
S
S
S
R
H
C
D
S
P
Site 55
S571
G
G
G
V
S
S
S
S
R
H
C
D
S
P
R
Site 56
S576
S
S
S
R
H
C
D
S
P
R
P
T
I
G
G
Site 57
T580
H
C
D
S
P
R
P
T
I
G
G
K
Y
C
L
Site 58
Y585
R
P
T
I
G
G
K
Y
C
L
G
E
R
R
R
Site 59
S595
G
E
R
R
R
H
R
S
C
N
T
D
D
C
P
Site 60
T598
R
R
H
R
S
C
N
T
D
D
C
P
P
G
S
Site 61
S605
T
D
D
C
P
P
G
S
Q
D
F
R
E
V
Q
Site 62
S614
D
F
R
E
V
Q
C
S
E
F
D
S
I
P
F
Site 63
S618
V
Q
C
S
E
F
D
S
I
P
F
R
G
K
F
Site 64
T630
G
K
F
Y
K
W
K
T
Y
R
G
G
G
V
K
Site 65
T668
G
T
P
C
R
P
D
T
V
D
I
C
V
S
G
Site 66
S688
G
C
D
R
V
L
G
S
D
L
R
E
D
K
C
Site 67
S703
R
V
C
G
G
D
G
S
A
C
E
T
I
E
G
Site 68
T707
G
D
G
S
A
C
E
T
I
E
G
V
F
S
P
Site 69
S713
E
T
I
E
G
V
F
S
P
A
S
P
G
A
G
Site 70
S716
E
G
V
F
S
P
A
S
P
G
A
G
Y
E
D
Site 71
Y721
P
A
S
P
G
A
G
Y
E
D
V
V
W
I
P
Site 72
S744
Q
D
L
N
L
S
L
S
H
L
A
L
K
G
D
Site 73
S754
A
L
K
G
D
Q
E
S
L
L
L
E
G
L
P
Site 74
T763
L
L
E
G
L
P
G
T
P
Q
P
H
R
L
P
Site 75
T775
R
L
P
L
A
G
T
T
F
Q
L
R
Q
G
P
Site 76
S787
Q
G
P
D
Q
V
Q
S
L
E
A
L
G
P
I
Site 77
S823
N
A
P
I
A
R
D
S
L
P
P
Y
S
W
H
Site 78
Y827
A
R
D
S
L
P
P
Y
S
W
H
Y
A
P
W
Site 79
S858
E
C
R
N
Q
L
D
S
S
A
V
A
P
H
Y
Site 80
Y865
S
S
A
V
A
P
H
Y
C
S
A
H
S
K
L
Site 81
T881
K
R
Q
R
A
C
N
T
E
P
C
P
P
D
W
Site 82
S899
N
W
S
L
C
S
R
S
C
D
A
G
V
R
S
Site 83
S906
S
C
D
A
G
V
R
S
R
S
V
V
C
Q
R
Site 84
S908
D
A
G
V
R
S
R
S
V
V
C
Q
R
R
V
Site 85
S916
V
V
C
Q
R
R
V
S
A
A
E
E
K
A
L
Site 86
S926
E
E
K
A
L
D
D
S
A
C
P
Q
P
R
P
Site 87
T943
L
E
A
C
H
G
P
T
C
P
P
E
W
A
A
Site 88
T957
A
L
D
W
S
E
C
T
P
S
C
G
P
G
L
Site 89
S973
H
R
V
V
L
C
K
S
A
D
H
R
A
T
L
Site 90
T979
K
S
A
D
H
R
A
T
L
P
P
A
H
C
S
Site 91
S986
T
L
P
P
A
H
C
S
P
A
A
K
P
P
A
Site 92
T994
P
A
A
K
P
P
A
T
M
R
C
N
L
R
R
Site 93
S1027
G
V
G
Q
R
Q
R
S
V
R
C
T
S
H
T
Site 94
T1031
R
Q
R
S
V
R
C
T
S
H
T
G
Q
A
S
Site 95
S1032
Q
R
S
V
R
C
T
S
H
T
G
Q
A
S
H
Site 96
T1034
S
V
R
C
T
S
H
T
G
Q
A
S
H
E
C
Site 97
S1038
T
S
H
T
G
Q
A
S
H
E
C
T
E
A
L
Site 98
T1042
G
Q
A
S
H
E
C
T
E
A
L
R
P
P
T
Site 99
T1049
T
E
A
L
R
P
P
T
T
Q
Q
C
E
A
K
Site 100
T1050
E
A
L
R
P
P
T
T
Q
Q
C
E
A
K
C
Site 101
S1059
Q
C
E
A
K
C
D
S
P
T
P
G
D
G
P
Site 102
T1061
E
A
K
C
D
S
P
T
P
G
D
G
P
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation