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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TTYH1
Full Name:
Protein tweety homolog 1
Alias:
TTY1; Tweety
Type:
Mass (Da):
49051
Number AA:
450
UniProt ID:
Q9H313
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034707
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005254
GO:0031404
GO:0005381
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0006826
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
P
P
G
Y
R
P
S
A
W
V
H
L
L
H
Site 2
S31
F
Q
L
R
P
V
P
S
V
F
A
P
Q
E
Q
Site 3
S80
R
P
P
E
P
P
G
S
K
I
P
S
P
G
G
Site 4
S84
P
P
G
S
K
I
P
S
P
G
G
G
C
V
T
Site 5
Y110
T
G
I
G
I
G
F
Y
G
N
S
E
T
S
D
Site 6
S113
G
I
G
F
Y
G
N
S
E
T
S
D
G
V
S
Site 7
S116
F
Y
G
N
S
E
T
S
D
G
V
S
Q
L
S
Site 8
S120
S
E
T
S
D
G
V
S
Q
L
S
S
A
L
L
Site 9
S123
S
D
G
V
S
Q
L
S
S
A
L
L
H
A
N
Site 10
S124
D
G
V
S
Q
L
S
S
A
L
L
H
A
N
H
Site 11
T153
R
L
G
E
A
V
R
T
E
L
T
T
L
E
E
Site 12
T157
A
V
R
T
E
L
T
T
L
E
E
V
L
E
P
Site 13
S198
F
W
Q
G
V
P
L
S
P
L
Q
V
A
E
N
Site 14
S207
L
Q
V
A
E
N
V
S
F
V
E
E
Y
R
W
Site 15
Y281
F
C
S
N
P
D
P
Y
V
L
N
L
T
Q
E
Site 16
T286
D
P
Y
V
L
N
L
T
Q
E
E
T
G
L
S
Site 17
S293
T
Q
E
E
T
G
L
S
S
D
I
L
S
Y
Y
Site 18
S294
Q
E
E
T
G
L
S
S
D
I
L
S
Y
Y
L
Site 19
S308
L
L
C
N
R
A
V
S
N
P
F
Q
Q
R
L
Site 20
T316
N
P
F
Q
Q
R
L
T
L
S
Q
R
A
L
A
Site 21
S318
F
Q
Q
R
L
T
L
S
Q
R
A
L
A
N
I
Site 22
S327
R
A
L
A
N
I
H
S
Q
L
L
G
L
E
R
Site 23
S342
E
A
V
P
Q
F
P
S
A
Q
K
P
L
L
S
Site 24
S349
S
A
Q
K
P
L
L
S
L
E
E
T
L
N
V
Site 25
T353
P
L
L
S
L
E
E
T
L
N
V
T
E
G
N
Site 26
S372
V
A
L
L
H
C
R
S
L
H
K
D
Y
G
A
Site 27
Y377
C
R
S
L
H
K
D
Y
G
A
A
L
R
G
L
Site 28
S423
A
W
A
L
F
P
P
S
D
D
Y
D
D
T
D
Site 29
Y426
L
F
P
P
S
D
D
Y
D
D
T
D
D
D
D
Site 30
T429
P
S
D
D
Y
D
D
T
D
D
D
D
P
F
N
Site 31
S440
D
P
F
N
P
Q
E
S
K
R
F
V
Q
W
Q
Site 32
S448
K
R
F
V
Q
W
Q
S
S
I
_
_
_
_
_
Site 33
S449
R
F
V
Q
W
Q
S
S
I
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation