PhosphoNET

           
Protein Info 
   
Short Name:  NKX2-4
Full Name:  Homeobox protein Nkx-2.4
Alias:  NKX2D
Type:  Nucleus protein
Mass (Da):  36179
Number AA:  354
UniProt ID:  Q9H2Z4
International Prot ID:  IPI00737616
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634     Uniprot OncoNet
Molecular Function:  GO:0043565  GO:0003700   PhosphoSite+ KinaseNET
Biological Process:  GO:0007275  GO:0006355   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T8MSLSPKHTTPFSVSD
Site 2T9SLSPKHTTPFSVSDI
Site 3S12PKHTTPFSVSDILSP
Site 4S14HTTPFSVSDILSPIE
Site 5S18FSVSDILSPIEETYK
Site 6Y24LSPIEETYKKFSGAM
Site 7Y48PLGAAAAYRAPPPGP
Site 8S57APPPGPSSQAATVAG
Site 9T61GPSSQAATVAGMQPS
Site 10Y110PHGAMGSYCNGGLGN
Site 11Y124NMGELPAYTDGMRGG
Site 12T134GMRGGAATGWYGANP
Site 13Y137GGAATGWYGANPDPR
Site 14Y145GANPDPRYSSISRFM
Site 15S146ANPDPRYSSISRFMG
Site 16S147NPDPRYSSISRFMGP
Site 17S149DPRYSSISRFMGPSA
Site 18S197RKRRVLFSQAQVYEL
Site 19Y213RRFKQQKYLSAPERE
Site 20S215FKQQKYLSAPEREHL
Site 21S224PEREHLASMIHLTPT
Site 22S271PPPPPPPSPRRVAVP
Site 23S292KPCQNGASTPTPGQA
Site 24T293PCQNGASTPTPGQAG
Site 25T295QNGASTPTPGQAGPQ
Site 26T307GPQPPAPTPAPELEE
Site 27S316APELEELSPSPPALH
Site 28S318ELEELSPSPPALHGP
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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