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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GAN
Full Name:
Gigaxonin
Alias:
FLJ38059; GAN1; Giant axonal neuropathy (gigaxonin); KLHL16
Type:
Cytoskeletal protein
Mass (Da):
67638
Number AA:
597
UniProt ID:
Q9H2C0
International Prot ID:
IPI00022758
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005883
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008219
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
A
R
L
L
R
A
L
S
S
F
R
E
E
S
R
Site 2
S22
R
L
L
R
A
L
S
S
F
R
E
E
S
R
F
Site 3
S27
L
S
S
F
R
E
E
S
R
F
C
D
A
H
L
Site 4
S52
K
N
I
L
A
A
A
S
P
Y
I
R
T
K
L
Site 5
Y61
Y
I
R
T
K
L
N
Y
N
P
P
K
D
D
G
Site 6
S69
N
P
P
K
D
D
G
S
T
Y
K
I
E
L
E
Site 7
T70
P
P
K
D
D
G
S
T
Y
K
I
E
L
E
G
Site 8
Y71
P
K
D
D
G
S
T
Y
K
I
E
L
E
G
I
Site 9
S92
E
I
L
D
Y
I
F
S
G
Q
I
R
L
N
E
Site 10
T101
Q
I
R
L
N
E
D
T
I
Q
D
V
V
Q
A
Site 11
Y151
Y
C
L
H
H
V
H
Y
L
A
T
E
Y
L
E
Site 12
Y156
V
H
Y
L
A
T
E
Y
L
E
T
H
F
R
D
Site 13
T159
L
A
T
E
Y
L
E
T
H
F
R
D
V
S
S
Site 14
S165
E
T
H
F
R
D
V
S
S
T
E
E
F
L
E
Site 15
S166
T
H
F
R
D
V
S
S
T
E
E
F
L
E
L
Site 16
T167
H
F
R
D
V
S
S
T
E
E
F
L
E
L
S
Site 17
S174
T
E
E
F
L
E
L
S
P
Q
K
L
K
E
V
Site 18
S183
Q
K
L
K
E
V
I
S
L
E
K
L
N
V
G
Site 19
S228
L
W
V
S
G
L
D
S
S
Y
L
R
E
Q
M
Site 20
S229
W
V
S
G
L
D
S
S
Y
L
R
E
Q
M
L
Site 21
Y230
V
S
G
L
D
S
S
Y
L
R
E
Q
M
L
N
Site 22
S249
R
E
I
V
K
E
C
S
N
I
P
L
S
Q
P
Site 23
S254
E
C
S
N
I
P
L
S
Q
P
Q
Q
G
E
A
Site 24
Y271
A
N
F
K
P
R
G
Y
S
E
C
I
V
T
V
Site 25
S272
N
F
K
P
R
G
Y
S
E
C
I
V
T
V
G
Site 26
T277
G
Y
S
E
C
I
V
T
V
G
G
E
E
R
V
Site 27
S285
V
G
G
E
E
R
V
S
R
K
P
T
A
A
M
Site 28
T289
E
R
V
S
R
K
P
T
A
A
M
R
C
M
C
Site 29
S313
W
I
E
L
A
P
L
S
M
P
R
I
N
H
G
Site 30
T340
G
Q
D
E
N
K
Q
T
L
S
S
G
E
K
Y
Site 31
Y347
T
L
S
S
G
E
K
Y
D
P
D
A
N
T
W
Site 32
T353
K
Y
D
P
D
A
N
T
W
T
A
L
P
P
M
Site 33
Y394
E
L
I
S
M
E
C
Y
D
I
Y
S
K
T
W
Site 34
Y397
S
M
E
C
Y
D
I
Y
S
K
T
W
T
K
Q
Site 35
T402
D
I
Y
S
K
T
W
T
K
Q
P
D
L
T
M
Site 36
T408
W
T
K
Q
P
D
L
T
M
V
R
K
I
G
C
Site 37
Y424
A
A
M
K
K
K
I
Y
A
M
G
G
G
S
Y
Site 38
S437
S
Y
G
K
L
F
E
S
V
E
C
Y
D
P
R
Site 39
Y441
L
F
E
S
V
E
C
Y
D
P
R
T
Q
Q
W
Site 40
Y471
C
G
V
A
M
E
L
Y
V
F
G
G
V
R
S
Site 41
T489
A
Q
G
S
E
M
V
T
C
K
S
E
F
Y
H
Site 42
Y504
D
E
F
K
R
W
I
Y
L
N
D
Q
N
L
C
Site 43
T537
Y
V
I
G
D
L
D
T
G
T
N
Y
D
Y
V
Site 44
T539
I
G
D
L
D
T
G
T
N
Y
D
Y
V
R
E
Site 45
Y541
D
L
D
T
G
T
N
Y
D
Y
V
R
E
F
K
Site 46
Y543
D
T
G
T
N
Y
D
Y
V
R
E
F
K
R
S
Site 47
T551
V
R
E
F
K
R
S
T
G
T
W
H
H
T
K
Site 48
T557
S
T
G
T
W
H
H
T
K
P
L
L
P
S
D
Site 49
S563
H
T
K
P
L
L
P
S
D
L
R
R
T
G
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation