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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCG8
Full Name:
ATP-binding cassette sub-family G member 8
Alias:
Sterolin-2
Type:
Mass (Da):
75679
Number AA:
673
UniProt ID:
Q9H221
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
R
G
L
P
K
G
A
T
P
Q
D
T
S
G
L
Site 2
S29
G
L
Q
D
R
L
F
S
S
E
S
D
N
S
L
Site 3
S30
L
Q
D
R
L
F
S
S
E
S
D
N
S
L
Y
Site 4
S32
D
R
L
F
S
S
E
S
D
N
S
L
Y
F
T
Site 5
S35
F
S
S
E
S
D
N
S
L
Y
F
T
Y
S
G
Site 6
Y37
S
E
S
D
N
S
L
Y
F
T
Y
S
G
Q
P
Site 7
T39
S
D
N
S
L
Y
F
T
Y
S
G
Q
P
N
T
Site 8
S41
N
S
L
Y
F
T
Y
S
G
Q
P
N
T
L
E
Site 9
T46
T
Y
S
G
Q
P
N
T
L
E
V
R
D
L
N
Site 10
Y54
L
E
V
R
D
L
N
Y
Q
V
D
L
A
S
Q
Site 11
T76
A
Q
F
K
M
P
W
T
S
P
S
C
Q
N
S
Site 12
S83
T
S
P
S
C
Q
N
S
C
E
L
G
I
Q
N
Site 13
S92
E
L
G
I
Q
N
L
S
F
K
V
R
S
G
Q
Site 14
T119
A
S
L
L
D
V
I
T
G
R
G
H
G
G
K
Site 15
S140
W
I
N
G
Q
P
S
S
P
Q
L
V
R
K
C
Site 16
T178
A
Q
M
R
L
P
R
T
F
S
Q
A
Q
R
D
Site 17
S180
M
R
L
P
R
T
F
S
Q
A
Q
R
D
K
R
Site 18
T203
R
L
R
Q
C
A
D
T
R
V
G
N
M
Y
V
Site 19
Y209
D
T
R
V
G
N
M
Y
V
R
G
L
S
G
G
Site 20
S214
N
M
Y
V
R
G
L
S
G
G
E
R
R
R
V
Site 21
S222
G
G
E
R
R
R
V
S
I
G
V
Q
L
L
W
Site 22
S245
E
P
T
S
G
L
D
S
F
T
A
H
N
L
V
Site 23
T254
T
A
H
N
L
V
K
T
L
S
R
L
A
K
G
Site 24
S256
H
N
L
V
K
T
L
S
R
L
A
K
G
N
R
Site 25
S268
G
N
R
L
V
L
I
S
L
H
Q
P
R
S
D
Site 26
S274
I
S
L
H
Q
P
R
S
D
I
F
R
L
F
D
Site 27
Y309
Q
Y
F
T
A
I
G
Y
P
C
P
R
Y
S
N
Site 28
Y314
I
G
Y
P
C
P
R
Y
S
N
P
A
D
F
Y
Site 29
S315
G
Y
P
C
P
R
Y
S
N
P
A
D
F
Y
V
Site 30
Y321
Y
S
N
P
A
D
F
Y
V
D
L
T
S
I
D
Site 31
T325
A
D
F
Y
V
D
L
T
S
I
D
R
R
S
R
Site 32
S326
D
F
Y
V
D
L
T
S
I
D
R
R
S
R
E
Site 33
S331
L
T
S
I
D
R
R
S
R
E
Q
E
L
A
T
Site 34
S344
A
T
R
E
K
A
Q
S
L
A
A
L
F
L
E
Site 35
T372
T
K
D
L
D
E
D
T
C
V
E
S
S
V
T
Site 36
S377
E
D
T
C
V
E
S
S
V
T
P
L
D
T
N
Site 37
T383
S
S
V
T
P
L
D
T
N
C
L
P
S
P
T
Site 38
S388
L
D
T
N
C
L
P
S
P
T
K
M
P
G
A
Site 39
T401
G
A
V
Q
Q
F
T
T
L
I
R
R
Q
I
S
Site 40
S408
T
L
I
R
R
Q
I
S
N
D
F
R
D
L
P
Site 41
T416
N
D
F
R
D
L
P
T
L
L
I
H
G
A
E
Site 42
Y479
Y
S
E
R
A
M
L
Y
Y
E
L
E
D
G
L
Site 43
Y480
S
E
R
A
M
L
Y
Y
E
L
E
D
G
L
Y
Site 44
Y487
Y
E
L
E
D
G
L
Y
T
T
G
P
Y
F
F
Site 45
T612
K
I
Q
F
S
R
R
T
Y
K
M
P
L
G
N
Site 46
Y613
I
Q
F
S
R
R
T
Y
K
M
P
L
G
N
L
Site 47
T621
K
M
P
L
G
N
L
T
I
A
V
S
G
D
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation