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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ASCC2
Full Name:
Activating signal cointegrator 1 complex subunit 2
Alias:
ASC-1 complex subunit p100; ASC1p100; Trip4 complex subunit p100
Type:
Mass (Da):
86360
Number AA:
757
UniProt ID:
Q9H1I8
International Prot ID:
IPI00452803
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
I
T
H
K
D
P
K
T
G
K
L
R
T
S
P
Site 2
S24
K
T
G
K
L
R
T
S
P
A
L
H
P
E
Q
Site 3
Y36
P
E
Q
K
A
D
R
Y
F
V
L
Y
K
P
P
Site 4
Y40
A
D
R
Y
F
V
L
Y
K
P
P
P
K
D
N
Site 5
T60
E
E
Y
L
E
R
A
T
F
V
A
N
D
L
D
Site 6
T86
C
Q
V
I
F
D
E
T
L
Q
K
C
L
D
S
Site 7
S93
T
L
Q
K
C
L
D
S
Y
L
R
Y
V
P
R
Site 8
Y94
L
Q
K
C
L
D
S
Y
L
R
Y
V
P
R
K
Site 9
Y97
C
L
D
S
Y
L
R
Y
V
P
R
K
F
D
E
Site 10
S108
K
F
D
E
G
V
A
S
A
P
E
V
V
D
M
Site 11
S131
F
L
T
F
L
R
M
S
T
H
K
E
S
K
D
Site 12
T132
L
T
F
L
R
M
S
T
H
K
E
S
K
D
H
Site 13
S136
R
M
S
T
H
K
E
S
K
D
H
F
I
S
P
Site 14
S142
E
S
K
D
H
F
I
S
P
S
A
F
G
E
I
Site 15
S144
K
D
H
F
I
S
P
S
A
F
G
E
I
L
Y
Site 16
T185
K
M
I
G
N
I
F
T
Q
Q
P
S
Y
Y
S
Site 17
Y190
I
F
T
Q
Q
P
S
Y
Y
S
D
L
D
E
T
Site 18
T197
Y
Y
S
D
L
D
E
T
L
P
T
I
L
Q
V
Site 19
T222
Q
G
D
G
A
N
T
T
P
Q
K
L
E
E
R
Site 20
T233
L
E
E
R
G
R
L
T
P
S
D
M
P
L
L
Site 21
S235
E
R
G
R
L
T
P
S
D
M
P
L
L
E
L
Site 22
Y277
F
Q
K
H
D
F
C
Y
R
L
A
S
F
Y
E
Site 23
S302
K
K
R
R
L
E
D
S
K
L
L
G
D
L
W
Site 24
S313
G
D
L
W
Q
R
L
S
H
S
R
K
K
L
M
Site 25
S315
L
W
Q
R
L
S
H
S
R
K
K
L
M
E
I
Site 26
S356
E
F
L
Q
I
F
S
S
L
L
Q
E
K
R
F
Site 27
Y367
E
K
R
F
L
R
D
Y
D
A
L
F
P
V
A
Site 28
S384
I
S
L
L
Q
Q
A
S
S
V
L
D
E
T
R
Site 29
S385
S
L
L
Q
Q
A
S
S
V
L
D
E
T
R
T
Site 30
Y394
L
D
E
T
R
T
A
Y
I
L
Q
A
V
E
S
Site 31
T412
G
V
D
R
R
K
A
T
D
A
K
D
P
S
V
Site 32
S418
A
T
D
A
K
D
P
S
V
I
E
E
P
N
G
Site 33
T431
N
G
E
P
N
G
V
T
V
T
A
E
A
V
S
Site 34
S438
T
V
T
A
E
A
V
S
Q
A
S
S
H
P
E
Site 35
S442
E
A
V
S
Q
A
S
S
H
P
E
N
S
E
E
Site 36
S447
A
S
S
H
P
E
N
S
E
E
E
E
C
M
G
Site 37
Y493
F
I
L
A
C
L
E
Y
Y
H
Y
D
P
E
Q
Site 38
Y496
A
C
L
E
Y
Y
H
Y
D
P
E
Q
V
I
N
Site 39
S515
E
R
L
A
P
T
L
S
Q
L
D
R
N
L
D
Site 40
T530
R
E
M
K
P
D
P
T
P
L
L
T
S
R
H
Site 41
T534
P
D
P
T
P
L
L
T
S
R
H
N
V
F
Q
Site 42
S549
N
D
E
F
D
V
F
S
R
D
S
V
D
L
S
Site 43
S552
F
D
V
F
S
R
D
S
V
D
L
S
R
V
H
Site 44
S556
S
R
D
S
V
D
L
S
R
V
H
K
G
K
S
Site 45
S563
S
R
V
H
K
G
K
S
T
R
K
E
E
N
T
Site 46
T564
R
V
H
K
G
K
S
T
R
K
E
E
N
T
R
Site 47
T570
S
T
R
K
E
E
N
T
R
S
L
L
N
D
K
Site 48
S572
R
K
E
E
N
T
R
S
L
L
N
D
K
R
A
Site 49
Y587
V
A
A
Q
R
Q
R
Y
E
Q
Y
S
V
V
V
Site 50
S591
R
Q
R
Y
E
Q
Y
S
V
V
V
E
E
V
P
Site 51
S604
V
P
L
Q
P
G
E
S
L
P
Y
H
S
V
Y
Site 52
Y607
Q
P
G
E
S
L
P
Y
H
S
V
Y
Y
E
D
Site 53
S609
G
E
S
L
P
Y
H
S
V
Y
Y
E
D
E
Y
Site 54
Y611
S
L
P
Y
H
S
V
Y
Y
E
D
E
Y
D
D
Site 55
Y616
S
V
Y
Y
E
D
E
Y
D
D
T
Y
D
G
N
Site 56
Y620
E
D
E
Y
D
D
T
Y
D
G
N
Q
V
G
A
Site 57
S632
V
G
A
N
D
A
D
S
D
D
E
L
I
S
R
Site 58
S638
D
S
D
D
E
L
I
S
R
R
P
F
T
I
P
Site 59
T643
L
I
S
R
R
P
F
T
I
P
Q
V
L
R
T
Site 60
T650
T
I
P
Q
V
L
R
T
K
V
P
R
E
G
Q
Site 61
Y702
A
F
L
A
K
K
G
Y
R
H
D
S
S
T
A
Site 62
S706
K
K
G
Y
R
H
D
S
S
T
A
V
A
G
S
Site 63
S707
K
G
Y
R
H
D
S
S
T
A
V
A
G
S
P
Site 64
T708
G
Y
R
H
D
S
S
T
A
V
A
G
S
P
R
Site 65
S713
S
S
T
A
V
A
G
S
P
R
G
H
G
Q
S
Site 66
S720
S
P
R
G
H
G
Q
S
R
E
T
T
Q
E
R
Site 67
T723
G
H
G
Q
S
R
E
T
T
Q
E
R
R
K
K
Site 68
T724
H
G
Q
S
R
E
T
T
Q
E
R
R
K
K
E
Site 69
T744
R
A
N
H
N
R
R
T
M
A
D
R
K
R
S
Site 70
S751
T
M
A
D
R
K
R
S
K
G
M
I
P
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation