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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NT5C3
Full Name:
Cytosolic 5'-nucleotidase 3
Alias:
5NT3; CN-III; Cytosolic 5'-nucleotidase III; Cytosolic ''nucleotidase 3; Cytosolic ''nucleotidase III; ''nucleotidase, cytosolic III; P''-1; P36; P5N1; P5N-1; PN-I; PSN1; Pyrimidine 5'-nucleotidase 1; Pyrimidine ''nucleotidase 1; UMPH; UMPH1; Uridine 5'-monophosphate hydrolase 1; Uridine ''monophosphate hydrolase 1
Type:
Transferase; Endoplasmic reticulum; Nucleotide Metabolism - purine; EC 3.1.3.5; Nucleotide Metabolism - pyrimidine; Phosphatase (non-protein); Cofactor and Vitamin Metabolism - nicotinate and nicotinamide
Mass (Da):
37930
Number AA:
336
UniProt ID:
Q9H0P0
International Prot ID:
IPI00100192
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0008665
GO:0008253
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0009117
GO:0006213
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T42
I
F
T
L
K
R
K
T
G
R
K
T
K
I
I
Site 2
T46
K
R
K
T
G
R
K
T
K
I
I
E
M
M
P
Site 3
S58
M
M
P
E
F
Q
K
S
S
V
R
I
K
N
P
Site 4
S59
M
P
E
F
Q
K
S
S
V
R
I
K
N
P
T
Site 5
T66
S
V
R
I
K
N
P
T
R
V
E
E
I
I
C
Site 6
T92
I
I
T
D
F
D
M
T
L
S
R
F
S
Y
K
Site 7
S94
T
D
F
D
M
T
L
S
R
F
S
Y
K
G
K
Site 8
S97
D
M
T
L
S
R
F
S
Y
K
G
K
R
C
P
Site 9
Y98
M
T
L
S
R
F
S
Y
K
G
K
R
C
P
T
Site 10
T105
Y
K
G
K
R
C
P
T
C
H
N
I
I
D
N
Site 11
Y131
L
L
Q
L
K
E
K
Y
Y
A
I
E
V
D
P
Site 12
T141
I
E
V
D
P
V
L
T
V
E
E
K
Y
P
Y
Site 13
Y146
V
L
T
V
E
E
K
Y
P
Y
M
V
E
W
Y
Site 14
Y148
T
V
E
E
K
Y
P
Y
M
V
E
W
Y
T
K
Site 15
S177
L
K
E
I
V
A
E
S
D
V
M
L
K
E
G
Site 16
Y185
D
V
M
L
K
E
G
Y
E
N
F
F
D
K
L
Site 17
S228
H
P
N
V
K
V
V
S
N
F
M
D
F
D
E
Site 18
T236
N
F
M
D
F
D
E
T
G
V
L
K
G
F
K
Site 19
T260
H
D
G
A
L
R
N
T
E
Y
F
N
Q
L
K
Site 20
Y262
G
A
L
R
N
T
E
Y
F
N
Q
L
K
D
N
Site 21
S270
F
N
Q
L
K
D
N
S
N
I
I
L
L
G
D
Site 22
S278
N
I
I
L
L
G
D
S
Q
G
D
L
R
M
A
Site 23
Y311
V
D
E
L
L
E
K
Y
M
D
S
Y
D
I
V
Site 24
Y315
L
E
K
Y
M
D
S
Y
D
I
V
L
V
Q
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation