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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL25
Full Name:
Ectoderm-neural cortex protein 2
Alias:
BTB/POZ KELCH domain protein; Ectodermal-neural cortex 2; ENC2; ENC-2; FLJ12587; Kelch-like 25; Kelch-like 25 (Drosophila)
Type:
Unknown function
Mass (Da):
65920
Number AA:
UniProt ID:
Q9H0H3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
S
V
S
V
H
E
T
R
K
S
R
S
S
T
Site 2
S11
S
V
H
E
T
R
K
S
R
S
S
T
G
S
M
Site 3
S13
H
E
T
R
K
S
R
S
S
T
G
S
M
N
V
Site 4
S14
E
T
R
K
S
R
S
S
T
G
S
M
N
V
T
Site 5
T15
T
R
K
S
R
S
S
T
G
S
M
N
V
T
L
Site 6
S17
K
S
R
S
S
T
G
S
M
N
V
T
L
F
H
Site 7
T21
S
T
G
S
M
N
V
T
L
F
H
K
A
S
H
Site 8
S67
H
R
A
V
L
A
A
S
S
R
Y
F
E
A
M
Site 9
Y70
V
L
A
A
S
S
R
Y
F
E
A
M
F
S
H
Site 10
S76
R
Y
F
E
A
M
F
S
H
G
L
R
E
S
R
Site 11
S82
F
S
H
G
L
R
E
S
R
D
D
T
V
N
F
Site 12
T86
L
R
E
S
R
D
D
T
V
N
F
Q
D
N
L
Site 13
S119
I
N
E
E
N
A
E
S
L
L
E
A
G
D
M
Site 14
T178
M
C
L
V
H
F
E
T
V
R
Q
S
E
D
F
Site 15
S182
H
F
E
T
V
R
Q
S
E
D
F
N
S
L
S
Site 16
S187
R
Q
S
E
D
F
N
S
L
S
K
D
T
L
L
Site 17
S189
S
E
D
F
N
S
L
S
K
D
T
L
L
D
L
Site 18
S198
D
T
L
L
D
L
I
S
S
D
E
L
E
T
E
Site 19
S199
T
L
L
D
L
I
S
S
D
E
L
E
T
E
D
Site 20
T274
D
E
A
L
R
C
K
T
R
I
L
Q
N
D
G
Site 21
S285
Q
N
D
G
V
V
T
S
P
C
A
R
P
R
K
Site 22
T296
R
P
R
K
A
G
H
T
L
L
I
L
G
G
Q
Site 23
Y311
T
F
M
C
D
K
I
Y
Q
V
D
H
K
A
K
Site 24
S328
I
P
K
A
D
L
P
S
P
R
K
E
F
S
A
Site 25
S334
P
S
P
R
K
E
F
S
A
S
A
I
G
C
K
Site 26
S336
P
R
K
E
F
S
A
S
A
I
G
C
K
V
Y
Site 27
T345
I
G
C
K
V
Y
V
T
G
G
R
G
S
E
N
Site 28
S350
Y
V
T
G
G
R
G
S
E
N
G
V
S
K
D
Site 29
S355
R
G
S
E
N
G
V
S
K
D
V
W
V
Y
D
Site 30
Y361
V
S
K
D
V
W
V
Y
D
T
V
H
E
E
W
Site 31
S383
I
A
R
F
G
H
G
S
A
E
L
E
N
C
L
Site 32
S406
L
A
G
V
F
P
A
S
P
S
V
S
L
K
Q
Site 33
S410
F
P
A
S
P
S
V
S
L
K
Q
V
E
K
Y
Site 34
Y417
S
L
K
Q
V
E
K
Y
D
P
G
A
N
K
W
Site 35
T473
D
P
S
E
N
R
W
T
I
K
A
E
C
P
Q
Site 36
T485
C
P
Q
P
W
R
Y
T
A
A
A
V
L
G
S
Site 37
S507
D
T
E
F
T
A
A
S
A
Y
R
F
D
C
E
Site 38
S530
D
M
T
A
K
R
M
S
C
H
A
L
A
S
G
Site 39
Y546
K
L
Y
V
V
G
G
Y
F
G
T
Q
R
C
K
Site 40
T549
V
V
G
G
Y
F
G
T
Q
R
C
K
T
L
D
Site 41
T554
F
G
T
Q
R
C
K
T
L
D
C
Y
D
P
T
Site 42
Y558
R
C
K
T
L
D
C
Y
D
P
T
S
D
T
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation