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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP44
Full Name:
Ubiquitin carboxyl-terminal hydrolase 44
Alias:
Deubiquitinating enzyme 44;Ubiquitin thiolesterase 44;Ubiquitin-specific-processing protease 44
Type:
Mass (Da):
81155
Number AA:
712
UniProt ID:
Q9H0E7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
L
Q
L
A
Q
D
H
S
S
L
N
P
Q
K
W
Site 2
S21
Q
L
A
Q
D
H
S
S
L
N
P
Q
K
W
H
Site 3
S45
I
W
A
C
L
S
C
S
H
V
A
C
G
R
Y
Site 4
S65
L
K
H
F
Q
E
S
S
H
P
V
A
L
E
V
Site 5
T92
Y
V
L
N
D
N
A
T
G
D
L
K
L
L
R
Site 6
T101
D
L
K
L
L
R
R
T
L
S
A
I
K
S
Q
Site 7
S103
K
L
L
R
R
T
L
S
A
I
K
S
Q
N
Y
Site 8
S107
R
T
L
S
A
I
K
S
Q
N
Y
H
C
T
T
Site 9
Y110
S
A
I
K
S
Q
N
Y
H
C
T
T
R
S
G
Site 10
T125
R
F
L
R
S
M
G
T
G
D
D
S
Y
F
L
Site 11
S129
S
M
G
T
G
D
D
S
Y
F
L
H
D
G
A
Site 12
Y130
M
G
T
G
D
D
S
Y
F
L
H
D
G
A
Q
Site 13
S138
F
L
H
D
G
A
Q
S
L
L
Q
S
E
D
Q
Site 14
S142
G
A
Q
S
L
L
Q
S
E
D
Q
L
Y
T
A
Site 15
Y147
L
Q
S
E
D
Q
L
Y
T
A
L
W
H
R
R
Site 16
S169
F
R
T
W
F
E
Q
S
P
I
G
R
K
K
Q
Site 17
Y199
K
R
R
Q
E
L
E
Y
Q
V
K
A
E
L
E
Site 18
S207
Q
V
K
A
E
L
E
S
M
P
P
R
K
S
L
Site 19
S213
E
S
M
P
P
R
K
S
L
R
L
Q
G
L
A
Site 20
T236
S
V
Q
V
P
A
Q
T
P
A
S
P
A
K
D
Site 21
S239
V
P
A
Q
T
P
A
S
P
A
K
D
K
V
L
Site 22
S247
P
A
K
D
K
V
L
S
T
S
E
N
E
I
S
Site 23
S249
K
D
K
V
L
S
T
S
E
N
E
I
S
Q
K
Site 24
S254
S
T
S
E
N
E
I
S
Q
K
V
S
D
S
S
Site 25
S258
N
E
I
S
Q
K
V
S
D
S
S
V
K
R
R
Site 26
S260
I
S
Q
K
V
S
D
S
S
V
K
R
R
P
I
Site 27
S261
S
Q
K
V
S
D
S
S
V
K
R
R
P
I
V
Site 28
T269
V
K
R
R
P
I
V
T
P
G
V
T
G
L
R
Site 29
Y283
R
N
L
G
N
T
C
Y
M
N
S
V
L
Q
V
Site 30
S315
Q
W
L
A
M
T
A
S
E
K
T
R
S
C
K
Site 31
S320
T
A
S
E
K
T
R
S
C
K
H
P
P
V
T
Site 32
T327
S
C
K
H
P
P
V
T
D
T
V
V
Y
Q
M
Site 33
T329
K
H
P
P
V
T
D
T
V
V
Y
Q
M
N
E
Site 34
T342
N
E
C
Q
E
K
D
T
G
F
V
C
S
R
Q
Site 35
S347
K
D
T
G
F
V
C
S
R
Q
S
S
L
S
S
Site 36
S350
G
F
V
C
S
R
Q
S
S
L
S
S
G
L
S
Site 37
S351
F
V
C
S
R
Q
S
S
L
S
S
G
L
S
G
Site 38
S353
C
S
R
Q
S
S
L
S
S
G
L
S
G
G
A
Site 39
S354
S
R
Q
S
S
L
S
S
G
L
S
G
G
A
S
Site 40
S357
S
S
L
S
S
G
L
S
G
G
A
S
K
G
R
Site 41
S361
S
G
L
S
G
G
A
S
K
G
R
K
M
E
L
Site 42
S376
I
Q
P
K
E
P
T
S
Q
Y
I
S
L
C
H
Site 43
Y378
P
K
E
P
T
S
Q
Y
I
S
L
C
H
E
L
Site 44
S380
E
P
T
S
Q
Y
I
S
L
C
H
E
L
H
T
Site 45
Y419
L
I
P
A
F
R
G
Y
A
Q
Q
D
A
Q
E
Site 46
T442
I
Q
R
E
L
E
T
T
G
T
S
L
P
A
L
Site 47
T444
R
E
L
E
T
T
G
T
S
L
P
A
L
I
P
Site 48
T452
S
L
P
A
L
I
P
T
S
Q
R
K
L
I
K
Site 49
S453
L
P
A
L
I
P
T
S
Q
R
K
L
I
K
Q
Site 50
T488
A
C
D
N
K
S
N
T
I
E
P
F
W
D
L
Site 51
S496
I
E
P
F
W
D
L
S
L
E
F
P
E
R
Y
Site 52
Y503
S
L
E
F
P
E
R
Y
Q
C
S
G
K
D
I
Site 53
S512
C
S
G
K
D
I
A
S
Q
P
C
L
V
T
E
Site 54
Y535
E
A
L
E
G
K
I
Y
V
C
D
Q
C
N
S
Site 55
S548
N
S
K
R
R
R
F
S
S
K
P
V
V
L
T
Site 56
S549
S
K
R
R
R
F
S
S
K
P
V
V
L
T
E
Site 57
T555
S
S
K
P
V
V
L
T
E
A
Q
K
Q
L
M
Site 58
S580
H
L
K
R
F
R
W
S
G
R
N
N
R
E
K
Site 59
Y603
E
I
L
N
M
E
P
Y
C
C
R
E
T
L
K
Site 60
T608
E
P
Y
C
C
R
E
T
L
K
S
L
R
P
E
Site 61
Y637
K
G
F
G
S
G
H
Y
T
A
Y
C
Y
N
S
Site 62
Y640
G
S
G
H
Y
T
A
Y
C
Y
N
S
E
G
G
Site 63
T676
Q
A
Y
I
L
F
Y
T
Q
R
V
T
E
N
G
Site 64
T680
L
F
Y
T
Q
R
V
T
E
N
G
H
S
K
L
Site 65
S685
R
V
T
E
N
G
H
S
K
L
L
P
P
E
L
Site 66
S696
P
P
E
L
L
L
G
S
Q
H
P
N
E
D
A
Site 67
T705
H
P
N
E
D
A
D
T
S
S
N
E
I
L
S
Site 68
S706
P
N
E
D
A
D
T
S
S
N
E
I
L
S
_
Site 69
S707
N
E
D
A
D
T
S
S
N
E
I
L
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation