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Updated November 2019
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Protein Info
Short Name:
PEG3
Full Name:
Paternally-expressed gene 3 protein
Alias:
Zinc finger and SCAN domain-containing protein 24
Type:
Mass (Da):
180827
Number AA:
1588
UniProt ID:
Q9GZU2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
L
P
P
K
H
L
S
A
T
K
P
K
K
S
Site 2
T10
P
P
K
H
L
S
A
T
K
P
K
K
S
W
A
Site 3
S15
S
A
T
K
P
K
K
S
W
A
P
N
L
Y
E
Site 4
Y21
K
S
W
A
P
N
L
Y
E
L
D
S
D
L
T
Site 5
S25
P
N
L
Y
E
L
D
S
D
L
T
K
E
P
D
Site 6
T28
Y
E
L
D
S
D
L
T
K
E
P
D
V
I
I
Site 7
S42
I
G
E
G
P
T
D
S
E
F
F
H
Q
R
F
Site 8
Y54
Q
R
F
R
N
L
I
Y
V
E
F
V
G
P
R
Site 9
T63
E
F
V
G
P
R
K
T
L
I
K
L
R
N
L
Site 10
T119
E
N
C
E
K
L
V
T
L
L
E
N
Y
K
E
Site 11
Y128
L
E
N
Y
K
E
M
Y
Q
P
E
D
D
N
N
Site 12
S136
Q
P
E
D
D
N
N
S
D
V
T
S
D
D
D
Site 13
T139
D
D
N
N
S
D
V
T
S
D
D
D
M
T
R
Site 14
S140
D
N
N
S
D
V
T
S
D
D
D
M
T
R
N
Site 15
T145
V
T
S
D
D
D
M
T
R
N
R
R
E
S
S
Site 16
S151
M
T
R
N
R
R
E
S
S
P
P
H
S
V
H
Site 17
S152
T
R
N
R
R
E
S
S
P
P
H
S
V
H
S
Site 18
S156
R
E
S
S
P
P
H
S
V
H
S
F
S
D
R
Site 19
S159
S
P
P
H
S
V
H
S
F
S
D
R
D
W
D
Site 20
S161
P
H
S
V
H
S
F
S
D
R
D
W
D
R
R
Site 21
S171
D
W
D
R
R
G
R
S
R
D
M
E
P
R
D
Site 22
S181
M
E
P
R
D
R
W
S
H
T
R
N
P
R
S
Site 23
T183
P
R
D
R
W
S
H
T
R
N
P
R
S
R
M
Site 24
S188
S
H
T
R
N
P
R
S
R
M
P
P
R
D
L
Site 25
S196
R
M
P
P
R
D
L
S
L
P
V
V
A
K
T
Site 26
S204
L
P
V
V
A
K
T
S
F
E
M
D
R
E
D
Site 27
S215
D
R
E
D
D
R
D
S
R
A
Y
E
S
R
S
Site 28
Y218
D
D
R
D
S
R
A
Y
E
S
R
S
Q
D
A
Site 29
S222
S
R
A
Y
E
S
R
S
Q
D
A
E
S
Y
Q
Site 30
T243
E
D
R
K
P
H
N
T
I
Q
D
N
M
E
N
Site 31
S256
E
N
Y
R
K
L
L
S
L
V
Q
L
A
E
D
Site 32
S267
L
A
E
D
D
G
H
S
H
M
T
Q
G
H
S
Site 33
T270
D
D
G
H
S
H
M
T
Q
G
H
S
S
R
S
Site 34
S274
S
H
M
T
Q
G
H
S
S
R
S
K
R
S
A
Site 35
S275
H
M
T
Q
G
H
S
S
R
S
K
R
S
A
Y
Site 36
S277
T
Q
G
H
S
S
R
S
K
R
S
A
Y
P
S
Site 37
S280
H
S
S
R
S
K
R
S
A
Y
P
S
T
S
R
Site 38
Y282
S
R
S
K
R
S
A
Y
P
S
T
S
R
G
L
Site 39
S284
S
K
R
S
A
Y
P
S
T
S
R
G
L
K
T
Site 40
T285
K
R
S
A
Y
P
S
T
S
R
G
L
K
T
M
Site 41
S286
R
S
A
Y
P
S
T
S
R
G
L
K
T
M
P
Site 42
T291
S
T
S
R
G
L
K
T
M
P
E
A
K
K
S
Site 43
S298
T
M
P
E
A
K
K
S
T
H
R
R
G
I
C
Site 44
T299
M
P
E
A
K
K
S
T
H
R
R
G
I
C
E
Site 45
S309
R
G
I
C
E
D
E
S
S
H
G
V
I
M
E
Site 46
S310
G
I
C
E
D
E
S
S
H
G
V
I
M
E
K
Site 47
S323
E
K
F
I
K
D
V
S
R
S
S
K
S
G
R
Site 48
S326
I
K
D
V
S
R
S
S
K
S
G
R
A
R
E
Site 49
S328
D
V
S
R
S
S
K
S
G
R
A
R
E
S
S
Site 50
S334
K
S
G
R
A
R
E
S
S
D
R
S
Q
R
F
Site 51
S335
S
G
R
A
R
E
S
S
D
R
S
Q
R
F
P
Site 52
S338
A
R
E
S
S
D
R
S
Q
R
F
P
R
M
S
Site 53
S345
S
Q
R
F
P
R
M
S
D
D
N
W
K
D
I
Site 54
S353
D
D
N
W
K
D
I
S
L
N
K
R
E
S
V
Site 55
S359
I
S
L
N
K
R
E
S
V
I
Q
Q
R
V
Y
Site 56
Y366
S
V
I
Q
Q
R
V
Y
E
G
N
A
F
R
G
Site 57
S379
R
G
G
F
R
F
N
S
T
L
V
S
R
K
R
Site 58
T380
G
G
F
R
F
N
S
T
L
V
S
R
K
R
V
Site 59
S383
R
F
N
S
T
L
V
S
R
K
R
V
L
E
R
Site 60
Y394
V
L
E
R
K
R
R
Y
H
F
D
T
D
G
K
Site 61
T398
K
R
R
Y
H
F
D
T
D
G
K
G
S
I
H
Site 62
S420
K
K
P
F
E
C
G
S
E
M
R
K
A
M
S
Site 63
S427
S
E
M
R
K
A
M
S
V
S
S
L
S
S
L
Site 64
S429
M
R
K
A
M
S
V
S
S
L
S
S
L
S
S
Site 65
S430
R
K
A
M
S
V
S
S
L
S
S
L
S
S
P
Site 66
S435
V
S
S
L
S
S
L
S
S
P
S
F
T
E
S
Site 67
S436
S
S
L
S
S
L
S
S
P
S
F
T
E
S
Q
Site 68
S438
L
S
S
L
S
S
P
S
F
T
E
S
Q
P
I
Site 69
T440
S
L
S
S
P
S
F
T
E
S
Q
P
I
D
F
Site 70
S442
S
S
P
S
F
T
E
S
Q
P
I
D
F
G
A
Site 71
S462
D
E
C
G
R
S
F
S
V
I
S
E
F
V
E
Site 72
Y480
M
H
T
R
E
N
L
Y
E
Y
G
E
S
F
I
Site 73
Y482
T
R
E
N
L
Y
E
Y
G
E
S
F
I
H
S
Site 74
S498
A
V
S
E
V
Q
K
S
Q
V
G
G
K
R
F
Site 75
T513
E
C
K
D
C
G
E
T
F
N
K
S
A
A
L
Site 76
S517
C
G
E
T
F
N
K
S
A
A
L
A
E
H
R
Site 77
Y531
R
K
I
H
A
R
G
Y
L
V
E
C
K
N
Q
Site 78
S547
C
E
E
A
F
M
P
S
P
T
F
S
E
L
Q
Site 79
T549
E
A
F
M
P
S
P
T
F
S
E
L
Q
K
I
Site 80
S551
F
M
P
S
P
T
F
S
E
L
Q
K
I
Y
G
Site 81
Y563
I
Y
G
K
D
K
F
Y
E
C
R
V
C
K
E
Site 82
T571
E
C
R
V
C
K
E
T
F
L
H
S
S
A
L
Site 83
T607
R
E
R
E
R
G
E
T
F
R
P
S
P
A
L
Site 84
S611
R
G
E
T
F
R
P
S
P
A
L
N
E
F
Q
Site 85
Y627
M
Y
G
K
E
K
M
Y
E
C
K
V
C
G
E
Site 86
T635
E
C
K
V
C
G
E
T
F
L
H
S
S
S
L
Site 87
S639
C
G
E
T
F
L
H
S
S
S
L
K
E
H
Q
Site 88
S641
E
T
F
L
H
S
S
S
L
K
E
H
Q
K
I
Site 89
T665
K
G
K
V
C
E
E
T
F
I
P
G
Q
S
L
Site 90
S671
E
T
F
I
P
G
Q
S
L
K
R
R
Q
K
T
Site 91
T678
S
L
K
R
R
Q
K
T
Y
N
K
E
K
L
C
Site 92
Y679
L
K
R
R
Q
K
T
Y
N
K
E
K
L
C
D
Site 93
S697
G
R
D
A
F
M
Q
S
S
E
L
S
E
H
Q
Site 94
S698
R
D
A
F
M
Q
S
S
E
L
S
E
H
Q
K
Site 95
S701
F
M
Q
S
S
E
L
S
E
H
Q
K
I
H
S
Site 96
Y718
N
L
F
E
G
R
G
Y
E
K
S
V
I
H
S
Site 97
S721
E
G
R
G
Y
E
K
S
V
I
H
S
G
P
F
Site 98
S725
Y
E
K
S
V
I
H
S
G
P
F
T
E
S
Q
Site 99
T729
V
I
H
S
G
P
F
T
E
S
Q
K
S
H
T
Site 100
S731
H
S
G
P
F
T
E
S
Q
K
S
H
T
I
T
Site 101
S734
P
F
T
E
S
Q
K
S
H
T
I
T
R
P
L
Site 102
T738
S
Q
K
S
H
T
I
T
R
P
L
E
S
D
E
Site 103
S743
T
I
T
R
P
L
E
S
D
E
D
E
K
A
F
Site 104
T751
D
E
D
E
K
A
F
T
I
S
S
N
P
Y
E
Site 105
S754
E
K
A
F
T
I
S
S
N
P
Y
E
N
Q
K
Site 106
Y757
F
T
I
S
S
N
P
Y
E
N
Q
K
I
P
T
Site 107
Y769
I
P
T
K
E
N
V
Y
E
A
K
S
Y
E
R
Site 108
S773
E
N
V
Y
E
A
K
S
Y
E
R
S
V
I
H
Site 109
Y774
N
V
Y
E
A
K
S
Y
E
R
S
V
I
H
S
Site 110
S777
E
A
K
S
Y
E
R
S
V
I
H
S
L
A
S
Site 111
S781
Y
E
R
S
V
I
H
S
L
A
S
V
E
A
Q
Site 112
S784
S
V
I
H
S
L
A
S
V
E
A
Q
K
S
H
Site 113
S790
A
S
V
E
A
Q
K
S
H
S
V
A
G
P
S
Site 114
S792
V
E
A
Q
K
S
H
S
V
A
G
P
S
K
P
Site 115
S797
S
H
S
V
A
G
P
S
K
P
K
V
M
A
E
Site 116
S809
M
A
E
S
T
I
Q
S
F
D
A
I
N
H
Q
Site 117
T824
R
V
R
A
G
G
N
T
S
E
G
R
E
Y
S
Site 118
S825
V
R
A
G
G
N
T
S
E
G
R
E
Y
S
R
Site 119
Y830
N
T
S
E
G
R
E
Y
S
R
S
V
I
H
S
Site 120
S831
T
S
E
G
R
E
Y
S
R
S
V
I
H
S
L
Site 121
S833
E
G
R
E
Y
S
R
S
V
I
H
S
L
V
A
Site 122
S837
Y
S
R
S
V
I
H
S
L
V
A
S
K
P
P
Site 123
S841
V
I
H
S
L
V
A
S
K
P
P
R
S
H
N
Site 124
S846
V
A
S
K
P
P
R
S
H
N
G
N
E
L
V
Site 125
S855
N
G
N
E
L
V
E
S
N
E
K
G
E
S
S
Site 126
S861
E
S
N
E
K
G
E
S
S
I
Y
I
S
D
L
Site 127
S862
S
N
E
K
G
E
S
S
I
Y
I
S
D
L
N
Site 128
Y864
E
K
G
E
S
S
I
Y
I
S
D
L
N
D
K
Site 129
S866
G
E
S
S
I
Y
I
S
D
L
N
D
K
R
Q
Site 130
Y891
G
G
S
K
N
R
N
Y
E
D
S
V
I
Q
S
Site 131
S894
K
N
R
N
Y
E
D
S
V
I
Q
S
V
F
R
Site 132
S898
Y
E
D
S
V
I
Q
S
V
F
R
A
K
P
Q
Site 133
S907
F
R
A
K
P
Q
K
S
V
P
G
E
G
S
G
Site 134
S923
F
K
K
D
G
E
F
S
V
P
S
S
N
V
R
Site 135
S927
G
E
F
S
V
P
S
S
N
V
R
E
Y
Q
K
Site 136
Y932
P
S
S
N
V
R
E
Y
Q
K
A
R
A
K
K
Site 137
Y941
K
A
R
A
K
K
K
Y
I
E
H
R
S
N
E
Site 138
S946
K
K
Y
I
E
H
R
S
N
E
T
S
V
I
H
Site 139
S950
E
H
R
S
N
E
T
S
V
I
H
S
L
P
F
Site 140
S954
N
E
T
S
V
I
H
S
L
P
F
G
E
Q
T
Site 141
T961
S
L
P
F
G
E
Q
T
F
R
P
R
G
M
L
Site 142
Y969
F
R
P
R
G
M
L
Y
E
C
Q
E
C
G
E
Site 143
S982
G
E
C
F
A
H
S
S
D
L
T
E
H
Q
K
Site 144
T985
F
A
H
S
S
D
L
T
E
H
Q
K
I
H
D
Site 145
S997
I
H
D
R
E
K
P
S
G
S
R
N
Y
E
W
Site 146
Y1002
K
P
S
G
S
R
N
Y
E
W
S
V
I
R
S
Site 147
S1005
G
S
R
N
Y
E
W
S
V
I
R
S
L
A
P
Site 148
S1009
Y
E
W
S
V
I
R
S
L
A
P
T
D
P
Q
Site 149
T1013
V
I
R
S
L
A
P
T
D
P
Q
T
S
Y
A
Site 150
T1017
L
A
P
T
D
P
Q
T
S
Y
A
Q
E
Q
Y
Site 151
T1042
D
F
R
Q
F
F
A
T
S
E
D
L
N
T
N
Site 152
T1048
A
T
S
E
D
L
N
T
N
Q
K
I
Y
D
Q
Site 153
Y1053
L
N
T
N
Q
K
I
Y
D
Q
E
K
S
H
G
Site 154
S1058
K
I
Y
D
Q
E
K
S
H
G
E
E
S
Q
G
Site 155
S1063
E
K
S
H
G
E
E
S
Q
G
E
N
T
D
G
Site 156
S1075
T
D
G
E
E
T
H
S
E
E
T
H
G
Q
E
Site 157
S1092
E
D
P
V
I
Q
G
S
D
M
E
D
P
Q
K
Site 158
Y1107
D
D
P
D
D
K
I
Y
E
C
E
D
C
G
L
Site 159
T1120
G
L
G
F
V
D
L
T
D
L
T
D
H
Q
K
Site 160
T1123
F
V
D
L
T
D
L
T
D
H
Q
K
V
H
S
Site 161
S1137
S
R
K
C
L
V
D
S
R
E
Y
T
H
S
V
Site 162
Y1140
C
L
V
D
S
R
E
Y
T
H
S
V
I
H
T
Site 163
T1141
L
V
D
S
R
E
Y
T
H
S
V
I
H
T
H
Site 164
S1143
D
S
R
E
Y
T
H
S
V
I
H
T
H
S
I
Site 165
T1147
Y
T
H
S
V
I
H
T
H
S
I
S
E
Y
Q
Site 166
Y1153
H
T
H
S
I
S
E
Y
Q
R
D
Y
T
G
E
Site 167
Y1157
I
S
E
Y
Q
R
D
Y
T
G
E
Q
L
Y
E
Site 168
T1158
S
E
Y
Q
R
D
Y
T
G
E
Q
L
Y
E
C
Site 169
Y1163
D
Y
T
G
E
Q
L
Y
E
C
P
K
C
G
E
Site 170
S1171
E
C
P
K
C
G
E
S
F
I
H
S
S
F
L
Site 171
S1176
G
E
S
F
I
H
S
S
F
L
F
E
H
Q
R
Site 172
Y1191
I
H
E
Q
D
Q
L
Y
S
M
K
G
C
D
D
Site 173
S1238
G
Q
G
F
I
H
S
S
A
L
N
E
H
M
R
Site 174
S1256
E
D
D
L
L
E
Q
S
Q
M
A
E
E
A
I
Site 175
S1275
A
L
T
E
F
Q
R
S
Q
T
E
E
R
L
F
Site 176
T1277
T
E
F
Q
R
S
Q
T
E
E
R
L
F
E
C
Site 177
T1302
A
E
L
A
D
H
V
T
V
H
K
N
E
P
Y
Site 178
Y1309
T
V
H
K
N
E
P
Y
E
Y
G
S
S
Y
T
Site 179
Y1311
H
K
N
E
P
Y
E
Y
G
S
S
Y
T
H
T
Site 180
S1314
E
P
Y
E
Y
G
S
S
Y
T
H
T
S
F
L
Site 181
Y1315
P
Y
E
Y
G
S
S
Y
T
H
T
S
F
L
T
Site 182
T1318
Y
G
S
S
Y
T
H
T
S
F
L
T
E
P
L
Site 183
S1319
G
S
S
Y
T
H
T
S
F
L
T
E
P
L
K
Site 184
Y1332
L
K
G
A
I
P
F
Y
E
C
K
D
C
G
K
Site 185
S1344
C
G
K
S
F
I
H
S
T
V
L
T
K
H
K
Site 186
T1345
G
K
S
F
I
H
S
T
V
L
T
K
H
K
E
Site 187
T1348
F
I
H
S
T
V
L
T
K
H
K
E
L
H
L
Site 188
Y1504
E
I
Q
V
E
E
P
Y
Y
D
C
H
E
C
T
Site 189
Y1505
I
Q
V
E
E
P
Y
Y
D
C
H
E
C
T
E
Site 190
T1513
D
C
H
E
C
T
E
T
F
T
S
S
T
A
F
Site 191
S1516
E
C
T
E
T
F
T
S
S
T
A
F
S
E
H
Site 192
S1517
C
T
E
T
F
T
S
S
T
A
F
S
E
H
L
Site 193
S1521
F
T
S
S
T
A
F
S
E
H
L
K
T
H
A
Site 194
S1529
E
H
L
K
T
H
A
S
M
I
I
F
E
P
A
Site 195
Y1545
A
F
G
E
C
S
G
Y
I
E
R
A
S
T
S
Site 196
S1550
S
G
Y
I
E
R
A
S
T
S
T
G
G
A
N
Site 197
T1551
G
Y
I
E
R
A
S
T
S
T
G
G
A
N
Q
Site 198
Y1563
A
N
Q
A
D
E
K
Y
F
K
C
D
V
C
G
Site 199
S1578
Q
L
F
N
D
R
L
S
L
A
R
H
Q
N
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation