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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
REXO4
Full Name:
RNA exonuclease 4
Alias:
EC 3.1.-.-; Exonuclease XPMC2; PMC2; Prevents mitotic catastrophe 2; REX4; REX4, RNA exonuclease 4; XPMC2; XPMC2H
Type:
Mass (Da):
46672
Number AA:
422
UniProt ID:
Q9GZR2
International Prot ID:
Isoform1 - IPI00010653
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005634
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0004527
GO:0003700
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0010468
GO:0019219
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
G
K
A
K
V
P
A
S
K
R
A
P
S
S
P
Site 2
S14
P
A
S
K
R
A
P
S
S
P
V
A
K
P
G
Site 3
S15
A
S
K
R
A
P
S
S
P
V
A
K
P
G
P
Site 4
T25
A
K
P
G
P
V
K
T
L
T
R
K
K
N
K
Site 5
T27
P
G
P
V
K
T
L
T
R
K
K
N
K
K
K
Site 6
S40
K
K
K
R
F
W
K
S
K
A
R
E
V
S
K
Site 7
S46
K
S
K
A
R
E
V
S
K
K
P
A
S
G
P
Site 8
S51
E
V
S
K
K
P
A
S
G
P
G
A
V
V
R
Site 9
S67
P
K
A
P
E
D
F
S
Q
N
W
K
A
L
Q
Site 10
S82
E
W
L
L
K
Q
K
S
Q
A
P
E
K
P
L
Site 11
S92
P
E
K
P
L
V
I
S
Q
M
G
S
K
K
K
Site 12
S96
L
V
I
S
Q
M
G
S
K
K
K
P
K
I
I
Site 13
T110
I
Q
Q
N
K
K
E
T
S
P
Q
V
K
G
E
Site 14
S111
Q
Q
N
K
K
E
T
S
P
Q
V
K
G
E
E
Site 15
S128
A
G
K
D
Q
E
A
S
R
G
S
V
P
S
G
Site 16
S131
D
Q
E
A
S
R
G
S
V
P
S
G
S
K
M
Site 17
S134
A
S
R
G
S
V
P
S
G
S
K
M
D
R
R
Site 18
S136
R
G
S
V
P
S
G
S
K
M
D
R
R
A
P
Site 19
T147
R
R
A
P
V
P
R
T
K
A
S
G
T
E
H
Site 20
S150
P
V
P
R
T
K
A
S
G
T
E
H
N
K
K
Site 21
T163
K
K
G
T
K
E
R
T
N
G
D
I
V
P
E
Site 22
T190
E
A
A
P
A
P
P
T
E
E
D
I
W
F
D
Site 23
S223
A
R
K
Q
L
G
Q
S
E
G
S
V
S
L
S
Site 24
S226
Q
L
G
Q
S
E
G
S
V
S
L
S
L
V
K
Site 25
S228
G
Q
S
E
G
S
V
S
L
S
L
V
K
E
Q
Site 26
S230
S
E
G
S
V
S
L
S
L
V
K
E
Q
A
F
Site 27
S260
V
G
P
K
G
E
E
S
M
A
A
R
V
S
I
Site 28
S266
E
S
M
A
A
R
V
S
I
V
N
Q
Y
G
K
Site 29
Y279
G
K
C
V
Y
D
K
Y
V
K
P
T
E
P
V
Site 30
T287
V
K
P
T
E
P
V
T
D
Y
R
T
A
V
S
Site 31
Y289
P
T
E
P
V
T
D
Y
R
T
A
V
S
G
I
Site 32
T291
E
P
V
T
D
Y
R
T
A
V
S
G
I
R
P
Site 33
T347
P
K
K
K
I
R
D
T
Q
K
Y
K
P
F
K
Site 34
Y350
K
I
R
D
T
Q
K
Y
K
P
F
K
S
Q
V
Site 35
S355
Q
K
Y
K
P
F
K
S
Q
V
K
S
G
R
P
Site 36
S359
P
F
K
S
Q
V
K
S
G
R
P
S
L
R
L
Site 37
S363
Q
V
K
S
G
R
P
S
L
R
L
L
S
E
K
Site 38
S368
R
P
S
L
R
L
L
S
E
K
I
L
G
L
Q
Site 39
Y394
A
Q
A
A
M
R
L
Y
V
M
V
K
K
E
W
Site 40
T413
R
D
R
R
P
L
L
T
A
P
D
H
C
S
D
Site 41
S419
L
T
A
P
D
H
C
S
D
D
A
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation