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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SENP6
Full Name:
Sentrin-specific protease 6
Alias:
FKSG6; KIAA0797; Protease FKSG6; SEN6; Sentrin/sumo-specific protease SENP6; SSP1; Sumo-1 specific protease 1; SUMO1/sentrin specific peptidase 6; SUSP1
Type:
Protease; EC 3.4.22.-
Mass (Da):
126146
Number AA:
1112
UniProt ID:
Q9GZR1
International Prot ID:
IPI00023586
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008234
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
A
G
K
S
G
G
S
A
G
E
I
Site 2
S9
A
A
G
K
S
G
G
S
A
G
E
I
T
F
L
Site 3
S22
F
L
E
A
L
A
R
S
E
S
K
R
D
G
G
Site 4
S24
E
A
L
A
R
S
E
S
K
R
D
G
G
F
K
Site 5
S35
G
G
F
K
N
N
W
S
F
D
H
E
E
E
S
Site 6
S42
S
F
D
H
E
E
E
S
E
G
D
T
D
K
D
Site 7
T46
E
E
E
S
E
G
D
T
D
K
D
G
T
N
L
Site 8
T51
G
D
T
D
K
D
G
T
N
L
L
S
V
D
E
Site 9
S55
K
D
G
T
N
L
L
S
V
D
E
D
E
D
S
Site 10
S62
S
V
D
E
D
E
D
S
E
T
S
K
G
K
K
Site 11
T64
D
E
D
E
D
S
E
T
S
K
G
K
K
L
N
Site 12
S74
G
K
K
L
N
R
R
S
E
I
V
A
N
S
S
Site 13
T88
S
G
E
F
I
L
K
T
Y
V
R
R
N
K
S
Site 14
Y89
G
E
F
I
L
K
T
Y
V
R
R
N
K
S
E
Site 15
S95
T
Y
V
R
R
N
K
S
E
S
F
K
T
L
K
Site 16
S97
V
R
R
N
K
S
E
S
F
K
T
L
K
G
N
Site 17
T100
N
K
S
E
S
F
K
T
L
K
G
N
P
I
G
Site 18
S112
P
I
G
L
N
M
L
S
N
N
K
K
L
S
E
Site 19
S118
L
S
N
N
K
K
L
S
E
N
T
Q
N
T
S
Site 20
T121
N
K
K
L
S
E
N
T
Q
N
T
S
L
C
S
Site 21
S125
S
E
N
T
Q
N
T
S
L
C
S
G
T
V
V
Site 22
T130
N
T
S
L
C
S
G
T
V
V
H
G
R
R
F
Site 23
S154
V
K
T
A
A
Q
S
S
L
D
R
K
E
R
K
Site 24
Y163
D
R
K
E
R
K
E
Y
P
P
H
V
Q
K
V
Site 25
S178
E
I
N
P
V
R
L
S
R
L
Q
G
V
E
R
Site 26
T190
V
E
R
I
M
K
K
T
E
E
S
E
S
Q
V
Site 27
S195
K
K
T
E
E
S
E
S
Q
V
E
P
E
I
K
Site 28
S212
V
Q
Q
K
R
H
C
S
T
Y
Q
P
T
P
P
Site 29
T213
Q
Q
K
R
H
C
S
T
Y
Q
P
T
P
P
L
Site 30
Y214
Q
K
R
H
C
S
T
Y
Q
P
T
P
P
L
S
Site 31
T217
H
C
S
T
Y
Q
P
T
P
P
L
S
P
A
S
Site 32
S221
Y
Q
P
T
P
P
L
S
P
A
S
K
K
C
L
Site 33
S224
T
P
P
L
S
P
A
S
K
K
C
L
T
H
L
Site 34
T243
R
N
C
R
Q
A
I
T
L
N
E
S
T
G
P
Site 35
S255
T
G
P
L
L
R
T
S
I
H
Q
N
S
G
G
Site 36
S265
Q
N
S
G
G
Q
K
S
Q
N
T
G
L
T
T
Site 37
Y298
C
D
D
S
K
H
T
Y
L
Q
T
N
G
K
V
Site 38
T323
T
N
L
K
E
R
K
T
S
L
S
D
L
N
D
Site 39
S324
N
L
K
E
R
K
T
S
L
S
D
L
N
D
P
Site 40
S326
K
E
R
K
T
S
L
S
D
L
N
D
P
I
I
Site 41
S335
L
N
D
P
I
I
L
S
S
D
D
D
D
D
N
Site 42
S336
N
D
P
I
I
L
S
S
D
D
D
D
D
N
D
Site 43
T345
D
D
D
D
N
D
R
T
N
R
R
E
S
I
S
Site 44
S350
D
R
T
N
R
R
E
S
I
S
P
Q
P
A
D
Site 45
S352
T
N
R
R
E
S
I
S
P
Q
P
A
D
S
A
Site 46
S358
I
S
P
Q
P
A
D
S
A
C
S
S
P
A
P
Site 47
S361
Q
P
A
D
S
A
C
S
S
P
A
P
S
T
G
Site 48
S362
P
A
D
S
A
C
S
S
P
A
P
S
T
G
K
Site 49
S366
A
C
S
S
P
A
P
S
T
G
K
V
E
A
A
Site 50
S387
R
A
E
R
E
L
R
S
I
P
E
D
S
E
L
Site 51
T396
P
E
D
S
E
L
N
T
V
T
L
P
R
K
A
Site 52
T398
D
S
E
L
N
T
V
T
L
P
R
K
A
R
M
Site 53
T416
F
G
N
S
I
I
N
T
P
L
K
R
R
K
V
Site 54
S425
L
K
R
R
K
V
F
S
Q
E
P
P
D
A
L
Site 55
S435
P
P
D
A
L
A
L
S
C
Q
S
S
F
D
S
Site 56
S442
S
C
Q
S
S
F
D
S
V
I
L
N
C
R
S
Site 57
T596
N
G
R
L
V
A
C
T
R
T
Y
E
E
S
I
Site 58
T598
R
L
V
A
C
T
R
T
Y
E
E
S
I
K
G
Site 59
Y599
L
V
A
C
T
R
T
Y
E
E
S
I
K
G
S
Site 60
S602
C
T
R
T
Y
E
E
S
I
K
G
S
C
G
Q
Site 61
S606
Y
E
E
S
I
K
G
S
C
G
Q
K
E
N
K
Site 62
T616
Q
K
E
N
K
I
K
T
V
S
F
E
S
K
I
Site 63
S618
E
N
K
I
K
T
V
S
F
E
S
K
I
Q
L
Site 64
S627
E
S
K
I
Q
L
R
S
K
Q
E
F
Q
F
F
Site 65
T640
F
F
D
E
E
E
E
T
G
E
N
H
T
I
F
Site 66
Y657
P
V
E
K
L
I
V
Y
P
P
P
P
A
K
G
Site 67
S667
P
P
A
K
G
G
I
S
V
T
N
E
D
L
H
Site 68
S711
A
D
R
I
H
I
F
S
S
F
F
Y
K
R
L
Site 69
Y715
H
I
F
S
S
F
F
Y
K
R
L
N
Q
R
E
Site 70
T728
R
E
R
R
N
H
E
T
T
N
L
S
I
Q
Q
Site 71
T729
E
R
R
N
H
E
T
T
N
L
S
I
Q
Q
K
Site 72
S732
N
H
E
T
T
N
L
S
I
Q
Q
K
R
H
G
Site 73
T743
K
R
H
G
R
V
K
T
W
T
R
H
V
D
I
Site 74
Y781
P
G
L
E
K
P
K
Y
E
P
N
P
H
Y
H
Site 75
Y787
K
Y
E
P
N
P
H
Y
H
E
N
A
V
I
Q
Site 76
S802
K
C
S
T
V
E
D
S
C
I
S
S
S
A
S
Site 77
S805
T
V
E
D
S
C
I
S
S
S
A
S
E
M
E
Site 78
S806
V
E
D
S
C
I
S
S
S
A
S
E
M
E
S
Site 79
S807
E
D
S
C
I
S
S
S
A
S
E
M
E
S
C
Site 80
S809
S
C
I
S
S
S
A
S
E
M
E
S
C
S
Q
Site 81
S813
S
S
A
S
E
M
E
S
C
S
Q
N
S
S
A
Site 82
S815
A
S
E
M
E
S
C
S
Q
N
S
S
A
K
P
Site 83
S819
E
S
C
S
Q
N
S
S
A
K
P
V
I
K
K
Site 84
S839
H
C
I
A
V
I
D
S
N
P
G
Q
E
E
S
Site 85
S846
S
N
P
G
Q
E
E
S
D
P
R
Y
K
R
N
Site 86
Y850
Q
E
E
S
D
P
R
Y
K
R
N
I
C
S
V
Site 87
S856
R
Y
K
R
N
I
C
S
V
K
Y
S
V
K
K
Site 88
Y859
R
N
I
C
S
V
K
Y
S
V
K
K
I
N
H
Site 89
S869
K
K
I
N
H
T
A
S
E
N
E
E
F
N
K
Site 90
T888
S
Q
K
V
A
D
R
T
K
S
E
N
G
L
Q
Site 91
S890
K
V
A
D
R
T
K
S
E
N
G
L
Q
N
E
Site 92
S898
E
N
G
L
Q
N
E
S
L
S
S
T
H
H
T
Site 93
S900
G
L
Q
N
E
S
L
S
S
T
H
H
T
D
G
Site 94
S901
L
Q
N
E
S
L
S
S
T
H
H
T
D
G
L
Site 95
T902
Q
N
E
S
L
S
S
T
H
H
T
D
G
L
S
Site 96
T905
S
L
S
S
T
H
H
T
D
G
L
S
K
I
R
Site 97
S909
T
H
H
T
D
G
L
S
K
I
R
L
N
Y
S
Site 98
Y915
L
S
K
I
R
L
N
Y
S
D
E
S
P
E
A
Site 99
S916
S
K
I
R
L
N
Y
S
D
E
S
P
E
A
G
Site 100
S919
R
L
N
Y
S
D
E
S
P
E
A
G
K
M
L
Site 101
S943
D
Q
D
N
Q
D
D
S
S
D
D
G
F
L
A
Site 102
S944
Q
D
N
Q
D
D
S
S
D
D
G
F
L
A
D
Site 103
S978
P
C
I
L
L
M
D
S
L
R
G
P
S
R
S
Site 104
S983
M
D
S
L
R
G
P
S
R
S
N
V
V
K
I
Site 105
S985
S
L
R
G
P
S
R
S
N
V
V
K
I
L
R
Site 106
S1005
E
W
E
V
K
K
G
S
K
R
S
F
S
K
D
Site 107
S1008
V
K
K
G
S
K
R
S
F
S
K
D
V
M
K
Site 108
S1010
K
G
S
K
R
S
F
S
K
D
V
M
K
G
S
Site 109
S1017
S
K
D
V
M
K
G
S
N
P
K
V
P
Q
Q
Site 110
T1066
F
P
P
P
R
M
R
T
K
R
E
E
I
R
N
Site 111
S1083
L
K
L
Q
E
D
Q
S
K
E
K
R
K
H
K
Site 112
T1092
E
K
R
K
H
K
D
T
Y
S
T
E
A
P
L
Site 113
Y1093
K
R
K
H
K
D
T
Y
S
T
E
A
P
L
G
Site 114
S1094
R
K
H
K
D
T
Y
S
T
E
A
P
L
G
E
Site 115
T1095
K
H
K
D
T
Y
S
T
E
A
P
L
G
E
G
Site 116
Y1106
L
G
E
G
T
E
Q
Y
V
N
S
I
S
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation