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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRIP2
Full Name:
Glutamate receptor-interacting protein 2
Alias:
Glutamate receptor interacting protein 2
Type:
Membrane, Cytoplasm protein
Mass (Da):
112501
Number AA:
1043
UniProt ID:
Q9C0E4
International Prot ID:
IPI00180230
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0019898
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
L
C
G
L
S
R
E
T
P
G
E
A
D
D
G
Site 2
Y18
G
E
A
D
D
G
P
Y
S
K
G
G
K
D
A
Site 3
S19
E
A
D
D
G
P
Y
S
K
G
G
K
D
A
G
Site 4
S31
D
A
G
G
A
D
V
S
L
A
C
R
R
Q
S
Site 5
S38
S
L
A
C
R
R
Q
S
I
P
E
E
F
R
G
Site 6
T47
P
E
E
F
R
G
I
T
V
V
E
L
I
K
K
Site 7
S57
E
L
I
K
K
E
G
S
T
L
G
L
T
I
S
Site 8
T62
E
G
S
T
L
G
L
T
I
S
G
G
T
D
K
Site 9
S64
S
T
L
G
L
T
I
S
G
G
T
D
K
D
G
Site 10
T67
G
L
T
I
S
G
G
T
D
K
D
G
K
P
R
Site 11
S76
K
D
G
K
P
R
V
S
N
L
R
P
G
G
L
Site 12
S87
P
G
G
L
A
A
R
S
D
L
L
N
I
G
D
Site 13
Y129
R
V
V
L
E
V
E
Y
E
L
P
P
P
A
P
Site 14
S144
E
N
N
P
R
I
I
S
K
T
V
D
V
S
L
Site 15
T146
N
P
R
I
I
S
K
T
V
D
V
S
L
Y
K
Site 16
S150
I
S
K
T
V
D
V
S
L
Y
K
E
G
N
S
Site 17
Y152
K
T
V
D
V
S
L
Y
K
E
G
N
S
F
G
Site 18
S157
S
L
Y
K
E
G
N
S
F
G
F
V
L
R
G
Site 19
S173
A
H
E
D
G
H
K
S
R
P
L
V
L
T
Y
Site 20
T179
K
S
R
P
L
V
L
T
Y
V
R
P
G
G
P
Site 21
Y180
S
R
P
L
V
L
T
Y
V
R
P
G
G
P
A
Site 22
S192
G
P
A
D
R
E
G
S
L
K
V
G
D
R
L
Site 23
T218
S
H
A
T
A
L
A
T
L
R
Q
C
S
H
E
Site 24
Y232
E
A
L
F
Q
V
E
Y
D
V
A
T
P
D
T
Site 25
T236
Q
V
E
Y
D
V
A
T
P
D
T
V
A
N
A
Site 26
T239
Y
D
V
A
T
P
D
T
V
A
N
A
S
G
P
Site 27
T264
S
A
L
G
I
S
L
T
T
T
S
L
R
N
K
Site 28
S272
T
T
S
L
R
N
K
S
V
I
T
I
D
R
I
Site 29
S283
I
D
R
I
K
P
A
S
V
V
D
R
S
G
A
Site 30
S288
P
A
S
V
V
D
R
S
G
A
L
H
P
G
D
Site 31
S299
H
P
G
D
H
I
L
S
I
D
G
T
S
M
E
Site 32
S319
E
A
T
K
L
L
A
S
I
S
E
K
V
R
L
Site 33
S334
E
I
L
P
V
P
Q
S
Q
R
P
L
R
P
S
Site 34
S341
S
Q
R
P
L
R
P
S
E
A
V
K
V
Q
R
Site 35
S364
P
C
V
P
S
C
H
S
P
R
P
G
H
C
R
Site 36
T374
P
G
H
C
R
M
P
T
W
A
T
P
A
G
Q
Site 37
T377
C
R
M
P
T
W
A
T
P
A
G
Q
D
Q
S
Site 38
S384
T
P
A
G
Q
D
Q
S
R
S
L
S
S
T
P
Site 39
S386
A
G
Q
D
Q
S
R
S
L
S
S
T
P
F
S
Site 40
S388
Q
D
Q
S
R
S
L
S
S
T
P
F
S
S
P
Site 41
S389
D
Q
S
R
S
L
S
S
T
P
F
S
S
P
T
Site 42
T390
Q
S
R
S
L
S
S
T
P
F
S
S
P
T
L
Site 43
S393
S
L
S
S
T
P
F
S
S
P
T
L
N
H
A
Site 44
S394
L
S
S
T
P
F
S
S
P
T
L
N
H
A
F
Site 45
T396
S
T
P
F
S
S
P
T
L
N
H
A
F
S
C
Site 46
S402
P
T
L
N
H
A
F
S
C
N
N
P
S
T
L
Site 47
S407
A
F
S
C
N
N
P
S
T
L
P
R
G
S
Q
Site 48
T408
F
S
C
N
N
P
S
T
L
P
R
G
S
Q
P
Site 49
S413
P
S
T
L
P
R
G
S
Q
P
M
S
P
R
T
Site 50
S417
P
R
G
S
Q
P
M
S
P
R
T
T
M
G
R
Site 51
T420
S
Q
P
M
S
P
R
T
T
M
G
R
R
R
Q
Site 52
T421
Q
P
M
S
P
R
T
T
M
G
R
R
R
Q
R
Site 53
S434
Q
R
R
R
E
H
K
S
S
L
S
L
A
S
S
Site 54
S435
R
R
R
E
H
K
S
S
L
S
L
A
S
S
T
Site 55
S437
R
E
H
K
S
S
L
S
L
A
S
S
T
V
G
Site 56
S440
K
S
S
L
S
L
A
S
S
T
V
G
P
G
G
Site 57
S441
S
S
L
S
L
A
S
S
T
V
G
P
G
G
Q
Site 58
T555
S
V
I
P
S
S
G
T
F
H
V
K
L
P
K
Site 59
T571
R
S
V
E
L
G
I
T
I
S
S
A
S
R
K
Site 60
S573
V
E
L
G
I
T
I
S
S
A
S
R
K
R
G
Site 61
S586
R
G
E
P
L
I
I
S
D
I
K
K
G
S
V
Site 62
T597
K
G
S
V
A
H
R
T
G
T
L
E
P
G
D
Site 63
T599
S
V
A
H
R
T
G
T
L
E
P
G
D
K
L
Site 64
S644
I
R
K
D
E
D
N
S
D
E
L
E
T
T
G
Site 65
T650
N
S
D
E
L
E
T
T
G
A
V
S
Y
T
V
Site 66
T656
T
T
G
A
V
S
Y
T
V
E
L
K
R
Y
G
Site 67
Y662
Y
T
V
E
L
K
R
Y
G
G
P
L
G
I
T
Site 68
T669
Y
G
G
P
L
G
I
T
I
S
G
T
E
E
P
Site 69
S671
G
P
L
G
I
T
I
S
G
T
E
E
P
F
D
Site 70
S717
S
L
K
G
R
P
L
S
E
A
I
H
L
L
Q
Site 71
S747
R
P
L
L
P
R
K
S
G
S
L
S
E
T
S
Site 72
S749
L
L
P
R
K
S
G
S
L
S
E
T
S
D
A
Site 73
S751
P
R
K
S
G
S
L
S
E
T
S
D
A
D
E
Site 74
T753
K
S
G
S
L
S
E
T
S
D
A
D
E
D
P
Site 75
S754
S
G
S
L
S
E
T
S
D
A
D
E
D
P
A
Site 76
S779
R
F
S
P
A
V
P
S
V
D
S
A
V
E
S
Site 77
S782
P
A
V
P
S
V
D
S
A
V
E
S
W
D
S
Site 78
S786
S
V
D
S
A
V
E
S
W
D
S
S
A
T
E
Site 79
S789
S
A
V
E
S
W
D
S
S
A
T
E
G
G
F
Site 80
S790
A
V
E
S
W
D
S
S
A
T
E
G
G
F
G
Site 81
S801
G
G
F
G
G
P
G
S
Y
T
P
Q
A
A
A
Site 82
T803
F
G
G
P
G
S
Y
T
P
Q
A
A
A
R
G
Site 83
T811
P
Q
A
A
A
R
G
T
T
P
Q
E
R
R
P
Site 84
T812
Q
A
A
A
R
G
T
T
P
Q
E
R
R
P
G
Site 85
S824
R
P
G
W
L
R
G
S
P
P
P
T
E
P
R
Site 86
T828
L
R
G
S
P
P
P
T
E
P
R
R
T
S
Y
Site 87
T833
P
P
T
E
P
R
R
T
S
Y
T
P
T
P
A
Site 88
S834
P
T
E
P
R
R
T
S
Y
T
P
T
P
A
D
Site 89
Y835
T
E
P
R
R
T
S
Y
T
P
T
P
A
D
E
Site 90
T836
E
P
R
R
T
S
Y
T
P
T
P
A
D
E
S
Site 91
T838
R
R
T
S
Y
T
P
T
P
A
D
E
S
F
P
Site 92
S843
T
P
T
P
A
D
E
S
F
P
E
E
E
E
G
Site 93
S858
D
D
W
E
P
P
T
S
P
A
P
G
P
A
R
Site 94
S882
E
A
L
E
D
L
E
S
C
G
Q
S
E
L
L
Site 95
S886
D
L
E
S
C
G
Q
S
E
L
L
R
E
L
E
Site 96
T900
E
A
S
I
M
T
G
T
V
Q
R
V
A
L
E
Site 97
S924
R
G
R
E
V
R
A
S
P
A
E
M
E
E
L
Site 98
S956
M
R
H
D
F
G
F
S
V
S
D
G
L
L
E
Site 99
Y967
G
L
L
E
K
G
V
Y
V
H
T
V
R
P
D
Site 100
T970
E
K
G
V
Y
V
H
T
V
R
P
D
G
P
A
Site 101
S1020
D
V
L
E
L
I
I
S
R
K
P
H
T
A
H
Site 102
T1025
I
I
S
R
K
P
H
T
A
H
S
S
R
A
P
Site 103
S1028
R
K
P
H
T
A
H
S
S
R
A
P
R
S
P
Site 104
S1029
K
P
H
T
A
H
S
S
R
A
P
R
S
P
G
Site 105
S1034
H
S
S
R
A
P
R
S
P
G
P
S
S
P
R
Site 106
S1038
A
P
R
S
P
G
P
S
S
P
R
M
L
_
_
Site 107
S1039
P
R
S
P
G
P
S
S
P
R
M
L
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation