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Updated November 2019
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Protein Info
Short Name:
ZC3H12C
Full Name:
Probable ribonuclease ZC3H12C
Alias:
MCP-induced protein 3;Zinc finger CCCH domain-containing protein 12C
Type:
Uncharacterized protein
Mass (Da):
99340
Number AA:
883
UniProt ID:
Q9C0D7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004519
GO:0000287
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
P
G
G
G
S
Q
E
Y
G
V
L
C
I
Q
E
Site 2
Y17
G
V
L
C
I
Q
E
Y
R
K
N
S
K
V
E
Site 3
S21
I
Q
E
Y
R
K
N
S
K
V
E
S
S
T
R
Site 4
S25
R
K
N
S
K
V
E
S
S
T
R
N
N
F
M
Site 5
S26
K
N
S
K
V
E
S
S
T
R
N
N
F
M
G
Site 6
Y46
G
H
D
L
G
H
L
Y
V
E
S
T
D
P
Q
Site 7
S49
L
G
H
L
Y
V
E
S
T
D
P
Q
L
S
P
Site 8
T50
G
H
L
Y
V
E
S
T
D
P
Q
L
S
P
A
Site 9
S55
E
S
T
D
P
Q
L
S
P
A
V
P
W
S
T
Site 10
S61
L
S
P
A
V
P
W
S
T
V
E
N
P
S
M
Site 11
T62
S
P
A
V
P
W
S
T
V
E
N
P
S
M
D
Site 12
T70
V
E
N
P
S
M
D
T
V
N
V
G
K
D
E
Site 13
S81
G
K
D
E
K
E
A
S
E
E
N
A
S
S
G
Site 14
S86
E
A
S
E
E
N
A
S
S
G
D
S
E
E
N
Site 15
S87
A
S
E
E
N
A
S
S
G
D
S
E
E
N
T
Site 16
S90
E
N
A
S
S
G
D
S
E
E
N
T
N
S
D
Site 17
T94
S
G
D
S
E
E
N
T
N
S
D
H
E
S
E
Site 18
S96
D
S
E
E
N
T
N
S
D
H
E
S
E
Q
L
Site 19
S100
N
T
N
S
D
H
E
S
E
Q
L
G
S
I
S
Site 20
S105
H
E
S
E
Q
L
G
S
I
S
V
E
P
G
L
Site 21
T116
E
P
G
L
I
T
K
T
H
R
Q
L
C
R
S
Site 22
S123
T
H
R
Q
L
C
R
S
P
C
L
E
P
H
I
Site 23
S145
Q
D
F
K
P
E
E
S
Q
T
T
S
K
E
A
Site 24
T147
F
K
P
E
E
S
Q
T
T
S
K
E
A
K
K
Site 25
S149
P
E
E
S
Q
T
T
S
K
E
A
K
K
P
P
Site 26
Y162
P
P
D
V
V
R
E
Y
Q
T
K
L
E
F
A
Site 27
S206
L
V
K
L
G
N
K
S
E
A
D
Q
T
V
S
Site 28
T211
N
K
S
E
A
D
Q
T
V
S
T
I
N
T
I
Site 29
T217
Q
T
V
S
T
I
N
T
I
T
R
E
T
S
S
Site 30
T219
V
S
T
I
N
T
I
T
R
E
T
S
S
L
E
Site 31
T222
I
N
T
I
T
R
E
T
S
S
L
E
S
Q
R
Site 32
S223
N
T
I
T
R
E
T
S
S
L
E
S
Q
R
S
Site 33
S224
T
I
T
R
E
T
S
S
L
E
S
Q
R
S
E
Site 34
S227
R
E
T
S
S
L
E
S
Q
R
S
E
S
P
M
Site 35
S230
S
S
L
E
S
Q
R
S
E
S
P
M
Q
E
I
Site 36
S232
L
E
S
Q
R
S
E
S
P
M
Q
E
I
V
T
Site 37
S258
D
G
S
N
V
A
M
S
H
G
N
K
E
V
F
Site 38
S266
H
G
N
K
E
V
F
S
C
R
G
I
K
L
A
Site 39
T286
E
R
G
H
K
D
I
T
V
F
V
P
A
W
R
Site 40
T304
S
R
P
D
A
L
I
T
D
Q
E
I
L
R
K
Site 41
T321
K
E
K
I
L
V
F
T
P
S
R
R
V
Q
G
Site 42
S323
K
I
L
V
F
T
P
S
R
R
V
Q
G
R
R
Site 43
Y334
Q
G
R
R
V
V
C
Y
D
D
R
F
I
V
K
Site 44
S352
E
S
D
G
I
I
V
S
N
D
N
Y
R
D
L
Site 45
Y356
I
I
V
S
N
D
N
Y
R
D
L
A
N
E
K
Site 46
S397
P
L
G
R
H
G
P
S
L
D
N
F
L
R
K
Site 47
Y424
P
Y
G
K
K
C
T
Y
G
H
K
C
K
Y
Y
Site 48
Y430
T
Y
G
H
K
C
K
Y
Y
H
P
E
R
G
S
Site 49
Y431
Y
G
H
K
C
K
Y
Y
H
P
E
R
G
S
Q
Site 50
S437
Y
Y
H
P
E
R
G
S
Q
P
Q
R
S
V
A
Site 51
S442
R
G
S
Q
P
Q
R
S
V
A
D
E
L
R
A
Site 52
S451
A
D
E
L
R
A
M
S
R
N
T
A
A
K
T
Site 53
T454
L
R
A
M
S
R
N
T
A
A
K
T
A
N
E
Site 54
T458
S
R
N
T
A
A
K
T
A
N
E
G
G
L
V
Site 55
S467
N
E
G
G
L
V
K
S
N
S
V
P
C
S
T
Site 56
S469
G
G
L
V
K
S
N
S
V
P
C
S
T
K
A
Site 57
S473
K
S
N
S
V
P
C
S
T
K
A
D
S
T
S
Site 58
T474
S
N
S
V
P
C
S
T
K
A
D
S
T
S
D
Site 59
S478
P
C
S
T
K
A
D
S
T
S
D
V
K
R
G
Site 60
S480
S
T
K
A
D
S
T
S
D
V
K
R
G
A
P
Site 61
S491
R
G
A
P
K
R
Q
S
D
P
S
I
R
T
Q
Site 62
S494
P
K
R
Q
S
D
P
S
I
R
T
Q
V
Y
Q
Site 63
Y500
P
S
I
R
T
Q
V
Y
Q
D
L
E
E
K
L
Site 64
T509
D
L
E
E
K
L
P
T
K
N
K
L
E
T
R
Site 65
S517
K
N
K
L
E
T
R
S
V
P
S
L
V
S
I
Site 66
T527
S
L
V
S
I
P
A
T
S
T
A
K
P
Q
S
Site 67
S534
T
S
T
A
K
P
Q
S
T
T
S
L
S
N
G
Site 68
T535
S
T
A
K
P
Q
S
T
T
S
L
S
N
G
L
Site 69
S537
A
K
P
Q
S
T
T
S
L
S
N
G
L
P
S
Site 70
S539
P
Q
S
T
T
S
L
S
N
G
L
P
S
G
V
Site 71
S544
S
L
S
N
G
L
P
S
G
V
H
F
P
P
Q
Site 72
Y559
D
Q
R
P
Q
G
Q
Y
P
S
M
M
M
A
T
Site 73
T571
M
A
T
K
N
H
G
T
P
M
P
Y
E
Q
Y
Site 74
Y578
T
P
M
P
Y
E
Q
Y
P
K
C
D
S
P
V
Site 75
S583
E
Q
Y
P
K
C
D
S
P
V
D
I
G
Y
Y
Site 76
Y589
D
S
P
V
D
I
G
Y
Y
S
M
L
N
A
Y
Site 77
Y596
Y
Y
S
M
L
N
A
Y
S
N
L
S
L
S
G
Site 78
S597
Y
S
M
L
N
A
Y
S
N
L
S
L
S
G
P
Site 79
S600
L
N
A
Y
S
N
L
S
L
S
G
P
R
S
P
Site 80
S602
A
Y
S
N
L
S
L
S
G
P
R
S
P
E
R
Site 81
S606
L
S
L
S
G
P
R
S
P
E
R
R
F
S
L
Site 82
S612
R
S
P
E
R
R
F
S
L
D
T
D
Y
R
I
Site 83
T615
E
R
R
F
S
L
D
T
D
Y
R
I
S
S
V
Site 84
Y617
R
F
S
L
D
T
D
Y
R
I
S
S
V
A
S
Site 85
S620
L
D
T
D
Y
R
I
S
S
V
A
S
D
C
S
Site 86
S621
D
T
D
Y
R
I
S
S
V
A
S
D
C
S
S
Site 87
S624
Y
R
I
S
S
V
A
S
D
C
S
S
E
G
S
Site 88
S627
S
S
V
A
S
D
C
S
S
E
G
S
M
S
C
Site 89
S628
S
V
A
S
D
C
S
S
E
G
S
M
S
C
G
Site 90
S631
S
D
C
S
S
E
G
S
M
S
C
G
S
S
D
Site 91
S633
C
S
S
E
G
S
M
S
C
G
S
S
D
S
Y
Site 92
S636
E
G
S
M
S
C
G
S
S
D
S
Y
V
G
Y
Site 93
S637
G
S
M
S
C
G
S
S
D
S
Y
V
G
Y
N
Site 94
S639
M
S
C
G
S
S
D
S
Y
V
G
Y
N
D
R
Site 95
Y640
S
C
G
S
S
D
S
Y
V
G
Y
N
D
R
S
Site 96
Y643
S
S
D
S
Y
V
G
Y
N
D
R
S
Y
V
S
Site 97
S647
Y
V
G
Y
N
D
R
S
Y
V
S
S
P
D
P
Site 98
Y648
V
G
Y
N
D
R
S
Y
V
S
S
P
D
P
Q
Site 99
S651
N
D
R
S
Y
V
S
S
P
D
P
Q
L
E
E
Site 100
T685
Q
N
F
H
D
P
L
T
R
G
Q
S
Y
S
H
Site 101
S689
D
P
L
T
R
G
Q
S
Y
S
H
E
E
P
K
Site 102
S691
L
T
R
G
Q
S
Y
S
H
E
E
P
K
F
H
Site 103
S719
H
S
A
V
G
A
R
S
S
C
P
G
D
Y
P
Site 104
S720
S
A
V
G
A
R
S
S
C
P
G
D
Y
P
S
Site 105
Y725
R
S
S
C
P
G
D
Y
P
S
P
P
S
S
A
Site 106
S727
S
C
P
G
D
Y
P
S
P
P
S
S
A
H
S
Site 107
S730
G
D
Y
P
S
P
P
S
S
A
H
S
K
A
P
Site 108
S731
D
Y
P
S
P
P
S
S
A
H
S
K
A
P
H
Site 109
S734
S
P
P
S
S
A
H
S
K
A
P
H
L
G
R
Site 110
S742
K
A
P
H
L
G
R
S
L
V
A
T
R
I
D
Site 111
S750
L
V
A
T
R
I
D
S
I
S
D
S
R
L
Y
Site 112
S752
A
T
R
I
D
S
I
S
D
S
R
L
Y
D
S
Site 113
S754
R
I
D
S
I
S
D
S
R
L
Y
D
S
S
P
Site 114
Y757
S
I
S
D
S
R
L
Y
D
S
S
P
S
R
Q
Site 115
S759
S
D
S
R
L
Y
D
S
S
P
S
R
Q
R
K
Site 116
S760
D
S
R
L
Y
D
S
S
P
S
R
Q
R
K
P
Site 117
S762
R
L
Y
D
S
S
P
S
R
Q
R
K
P
Y
S
Site 118
Y768
P
S
R
Q
R
K
P
Y
S
R
Q
E
G
L
G
Site 119
S769
S
R
Q
R
K
P
Y
S
R
Q
E
G
L
G
S
Site 120
S776
S
R
Q
E
G
L
G
S
W
E
R
P
G
Y
G
Site 121
Y782
G
S
W
E
R
P
G
Y
G
I
D
A
Y
G
Y
Site 122
Y787
P
G
Y
G
I
D
A
Y
G
Y
R
Q
T
Y
S
Site 123
Y789
Y
G
I
D
A
Y
G
Y
R
Q
T
Y
S
L
P
Site 124
T792
D
A
Y
G
Y
R
Q
T
Y
S
L
P
D
N
S
Site 125
Y793
A
Y
G
Y
R
Q
T
Y
S
L
P
D
N
S
T
Site 126
S794
Y
G
Y
R
Q
T
Y
S
L
P
D
N
S
T
Q
Site 127
S799
T
Y
S
L
P
D
N
S
T
Q
P
C
Y
E
Q
Site 128
T800
Y
S
L
P
D
N
S
T
Q
P
C
Y
E
Q
F
Site 129
Y804
D
N
S
T
Q
P
C
Y
E
Q
F
T
F
Q
S
Site 130
T808
Q
P
C
Y
E
Q
F
T
F
Q
S
L
P
E
Q
Site 131
Y824
E
P
A
W
R
I
P
Y
C
G
M
P
Q
D
P
Site 132
Y834
M
P
Q
D
P
P
R
Y
Q
D
N
R
E
K
I
Site 133
T865
M
K
R
N
P
H
M
T
D
A
Q
Q
L
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation