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Updated November 2019
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Protein Info
Short Name:
FHDC1
Full Name:
FH2 domain-containing protein 1
Alias:
Type:
Mass (Da):
124762
Number AA:
1143
UniProt ID:
Q9C0D6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T29
P
G
F
M
I
G
Q
T
P
P
P
A
P
P
P
Site 2
S44
P
P
P
P
P
P
P
S
P
P
C
S
C
S
R
Site 3
S48
P
P
P
S
P
P
C
S
C
S
R
E
E
C
P
Site 4
S50
P
S
P
P
C
S
C
S
R
E
E
C
P
S
S
Site 5
S56
C
S
R
E
E
C
P
S
S
P
P
P
P
P
P
Site 6
S57
S
R
E
E
C
P
S
S
P
P
P
P
P
P
P
Site 7
T82
P
P
P
G
L
P
P
T
T
H
M
N
G
Y
S
Site 8
T83
P
P
G
L
P
P
T
T
H
M
N
G
Y
S
H
Site 9
S99
G
K
K
K
R
M
R
S
F
F
W
K
T
I
P
Site 10
T104
M
R
S
F
F
W
K
T
I
P
E
E
Q
V
R
Site 11
T114
E
E
Q
V
R
G
K
T
N
I
W
T
L
A
A
Site 12
T118
R
G
K
T
N
I
W
T
L
A
A
R
Q
E
H
Site 13
Y127
A
A
R
Q
E
H
H
Y
Q
I
D
T
K
T
I
Site 14
T131
E
H
H
Y
Q
I
D
T
K
T
I
E
E
L
F
Site 15
T133
H
Y
Q
I
D
T
K
T
I
E
E
L
F
G
Q
Site 16
T144
L
F
G
Q
Q
E
D
T
T
K
S
S
L
P
R
Site 17
T145
F
G
Q
Q
E
D
T
T
K
S
S
L
P
R
R
Site 18
S147
Q
Q
E
D
T
T
K
S
S
L
P
R
R
G
R
Site 19
S148
Q
E
D
T
T
K
S
S
L
P
R
R
G
R
T
Site 20
T155
S
L
P
R
R
G
R
T
L
N
S
S
F
R
E
Site 21
S158
R
R
G
R
T
L
N
S
S
F
R
E
A
R
E
Site 22
S159
R
G
R
T
L
N
S
S
F
R
E
A
R
E
E
Site 23
S188
F
L
K
Q
F
K
K
S
P
R
S
I
V
E
D
Site 24
S191
Q
F
K
K
S
P
R
S
I
V
E
D
I
H
Q
Site 25
S201
E
D
I
H
Q
G
K
S
E
H
Y
G
S
E
T
Site 26
S206
G
K
S
E
H
Y
G
S
E
T
L
R
E
F
L
Site 27
T208
S
E
H
Y
G
S
E
T
L
R
E
F
L
K
F
Site 28
S219
F
L
K
F
L
P
E
S
E
E
V
K
K
L
K
Site 29
S229
V
K
K
L
K
A
F
S
G
D
V
S
K
L
S
Site 30
S233
K
A
F
S
G
D
V
S
K
L
S
L
A
D
S
Site 31
S267
L
K
K
E
F
L
P
S
C
S
S
L
Y
T
D
Site 32
T328
S
L
L
K
L
A
D
T
K
A
N
K
P
G
M
Site 33
T350
Q
E
A
Q
K
K
D
T
I
L
L
N
F
S
E
Site 34
S356
D
T
I
L
L
N
F
S
E
K
L
H
H
V
Q
Site 35
T365
K
L
H
H
V
Q
K
T
A
R
L
S
L
E
N
Site 36
S369
V
Q
K
T
A
R
L
S
L
E
N
T
E
A
E
Site 37
T373
A
R
L
S
L
E
N
T
E
A
E
L
H
L
L
Site 38
S386
L
L
F
V
R
T
K
S
L
K
E
N
I
Q
R
Site 39
Y427
Q
E
L
Q
D
E
A
Y
T
L
I
D
F
F
C
Site 40
S486
E
Q
E
Q
K
Q
R
S
W
A
T
G
E
L
G
Site 41
S499
L
G
A
F
G
R
S
S
S
E
N
D
V
E
L
Site 42
S500
G
A
F
G
R
S
S
S
E
N
D
V
E
L
L
Site 43
S525
F
L
H
P
R
P
I
S
P
S
S
P
S
Y
R
Site 44
S527
H
P
R
P
I
S
P
S
S
P
S
Y
R
P
P
Site 45
S528
P
R
P
I
S
P
S
S
P
S
Y
R
P
P
N
Site 46
S530
P
I
S
P
S
S
P
S
Y
R
P
P
N
T
R
Site 47
Y531
I
S
P
S
S
P
S
Y
R
P
P
N
T
R
R
Site 48
T536
P
S
Y
R
P
P
N
T
R
R
S
R
L
S
L
Site 49
S539
R
P
P
N
T
R
R
S
R
L
S
L
G
P
S
Site 50
S542
N
T
R
R
S
R
L
S
L
G
P
S
A
D
R
Site 51
S546
S
R
L
S
L
G
P
S
A
D
R
E
L
L
T
Site 52
T553
S
A
D
R
E
L
L
T
F
L
E
S
S
T
G
Site 53
S557
E
L
L
T
F
L
E
S
S
T
G
S
P
E
E
Site 54
T559
L
T
F
L
E
S
S
T
G
S
P
E
E
P
N
Site 55
S561
F
L
E
S
S
T
G
S
P
E
E
P
N
K
F
Site 56
S570
E
E
P
N
K
F
H
S
L
P
R
S
S
P
R
Site 57
S574
K
F
H
S
L
P
R
S
S
P
R
Q
A
R
P
Site 58
S575
F
H
S
L
P
R
S
S
P
R
Q
A
R
P
T
Site 59
T582
S
P
R
Q
A
R
P
T
I
A
C
L
E
P
A
Site 60
S597
E
V
R
H
Q
D
S
S
F
A
H
K
P
Q
A
Site 61
S616
E
E
A
P
N
P
P
S
A
Q
A
H
Q
L
A
Site 62
S632
A
Q
P
E
N
H
A
S
A
F
P
R
A
R
R
Site 63
S643
R
A
R
R
Q
G
V
S
V
L
R
K
R
Y
S
Site 64
Y649
V
S
V
L
R
K
R
Y
S
E
P
V
S
L
G
Site 65
S650
S
V
L
R
K
R
Y
S
E
P
V
S
L
G
S
Site 66
S654
K
R
Y
S
E
P
V
S
L
G
S
A
Q
S
P
Site 67
S657
S
E
P
V
S
L
G
S
A
Q
S
P
P
L
S
Site 68
S660
V
S
L
G
S
A
Q
S
P
P
L
S
P
L
A
Site 69
S664
S
A
Q
S
P
P
L
S
P
L
A
L
G
I
K
Site 70
S687
A
Q
F
N
L
Q
G
S
Q
G
M
E
E
T
S
Site 71
S694
S
Q
G
M
E
E
T
S
Q
L
T
L
S
D
F
Site 72
T697
M
E
E
T
S
Q
L
T
L
S
D
F
S
P
M
Site 73
S699
E
T
S
Q
L
T
L
S
D
F
S
P
M
E
L
Site 74
S702
Q
L
T
L
S
D
F
S
P
M
E
L
E
S
V
Site 75
S716
V
G
H
R
G
P
Q
S
L
S
A
S
S
S
S
Site 76
S718
H
R
G
P
Q
S
L
S
A
S
S
S
S
L
T
Site 77
S720
G
P
Q
S
L
S
A
S
S
S
S
L
T
P
M
Site 78
S721
P
Q
S
L
S
A
S
S
S
S
L
T
P
M
G
Site 79
S722
Q
S
L
S
A
S
S
S
S
L
T
P
M
G
R
Site 80
S723
S
L
S
A
S
S
S
S
L
T
P
M
G
R
D
Site 81
T725
S
A
S
S
S
S
L
T
P
M
G
R
D
A
L
Site 82
S734
M
G
R
D
A
L
G
S
L
S
P
A
L
E
D
Site 83
S736
R
D
A
L
G
S
L
S
P
A
L
E
D
G
K
Site 84
S756
P
G
S
A
A
L
G
S
V
G
S
S
D
P
E
Site 85
S759
A
A
L
G
S
V
G
S
S
D
P
E
N
K
D
Site 86
S760
A
L
G
S
V
G
S
S
D
P
E
N
K
D
P
Site 87
S780
I
S
D
T
T
D
C
S
L
T
L
D
C
S
E
Site 88
T782
D
T
T
D
C
S
L
T
L
D
C
S
E
G
T
Site 89
S786
C
S
L
T
L
D
C
S
E
G
T
D
S
R
P
Site 90
S791
D
C
S
E
G
T
D
S
R
P
R
G
G
D
P
Site 91
S807
E
G
G
E
G
D
G
S
M
S
S
G
V
G
E
Site 92
S809
G
E
G
D
G
S
M
S
S
G
V
G
E
M
G
Site 93
S810
E
G
D
G
S
M
S
S
G
V
G
E
M
G
D
Site 94
S818
G
V
G
E
M
G
D
S
Q
V
S
S
N
P
T
Site 95
S821
E
M
G
D
S
Q
V
S
S
N
P
T
S
S
P
Site 96
S822
M
G
D
S
Q
V
S
S
N
P
T
S
S
P
P
Site 97
T825
S
Q
V
S
S
N
P
T
S
S
P
P
G
E
A
Site 98
S826
Q
V
S
S
N
P
T
S
S
P
P
G
E
A
P
Site 99
S827
V
S
S
N
P
T
S
S
P
P
G
E
A
P
A
Site 100
S837
G
E
A
P
A
P
V
S
V
D
S
E
P
S
C
Site 101
S840
P
A
P
V
S
V
D
S
E
P
S
C
K
G
G
Site 102
S843
V
S
V
D
S
E
P
S
C
K
G
G
L
P
R
Site 103
T854
G
L
P
R
D
K
P
T
K
R
K
D
V
V
A
Site 104
S866
V
V
A
P
K
R
G
S
L
K
E
A
S
P
G
Site 105
S871
R
G
S
L
K
E
A
S
P
G
A
S
K
P
G
Site 106
S875
K
E
A
S
P
G
A
S
K
P
G
S
A
R
R
Site 107
S879
P
G
A
S
K
P
G
S
A
R
R
S
Q
G
A
Site 108
S883
K
P
G
S
A
R
R
S
Q
G
A
V
A
K
S
Site 109
S890
S
Q
G
A
V
A
K
S
V
R
T
L
T
A
S
Site 110
T895
A
K
S
V
R
T
L
T
A
S
E
N
E
S
M
Site 111
S897
S
V
R
T
L
T
A
S
E
N
E
S
M
R
K
Site 112
S901
L
T
A
S
E
N
E
S
M
R
K
V
M
P
I
Site 113
T909
M
R
K
V
M
P
I
T
K
S
S
R
G
A
G
Site 114
S911
K
V
M
P
I
T
K
S
S
R
G
A
G
W
R
Site 115
S923
G
W
R
R
P
E
L
S
S
R
G
P
S
Q
N
Site 116
S924
W
R
R
P
E
L
S
S
R
G
P
S
Q
N
P
Site 117
S928
E
L
S
S
R
G
P
S
Q
N
P
P
S
S
T
Site 118
S933
G
P
S
Q
N
P
P
S
S
T
D
T
V
W
S
Site 119
S934
P
S
Q
N
P
P
S
S
T
D
T
V
W
S
R
Site 120
T935
S
Q
N
P
P
S
S
T
D
T
V
W
S
R
Q
Site 121
T937
N
P
P
S
S
T
D
T
V
W
S
R
Q
N
S
Site 122
S940
S
S
T
D
T
V
W
S
R
Q
N
S
V
R
R
Site 123
S944
T
V
W
S
R
Q
N
S
V
R
R
A
S
T
G
Site 124
S949
Q
N
S
V
R
R
A
S
T
G
A
E
E
Q
R
Site 125
T950
N
S
V
R
R
A
S
T
G
A
E
E
Q
R
L
Site 126
S961
E
Q
R
L
P
R
G
S
S
G
S
S
S
T
R
Site 127
S962
Q
R
L
P
R
G
S
S
G
S
S
S
T
R
P
Site 128
S964
L
P
R
G
S
S
G
S
S
S
T
R
P
G
R
Site 129
S965
P
R
G
S
S
G
S
S
S
T
R
P
G
R
D
Site 130
S966
R
G
S
S
G
S
S
S
T
R
P
G
R
D
V
Site 131
S980
V
P
L
Q
P
R
G
S
F
K
K
P
S
A
K
Site 132
S985
R
G
S
F
K
K
P
S
A
K
P
L
R
N
L
Site 133
T1002
Q
K
P
E
E
N
K
T
C
R
A
H
S
E
G
Site 134
S1007
N
K
T
C
R
A
H
S
E
G
P
E
S
P
K
Site 135
S1012
A
H
S
E
G
P
E
S
P
K
E
E
P
K
T
Site 136
T1019
S
P
K
E
E
P
K
T
P
S
V
P
S
V
P
Site 137
S1021
K
E
E
P
K
T
P
S
V
P
S
V
P
H
E
Site 138
S1024
P
K
T
P
S
V
P
S
V
P
H
E
L
P
R
Site 139
S1034
H
E
L
P
R
V
P
S
F
A
R
N
T
V
A
Site 140
T1039
V
P
S
F
A
R
N
T
V
A
S
S
S
R
S
Site 141
S1042
F
A
R
N
T
V
A
S
S
S
R
S
M
R
T
Site 142
S1043
A
R
N
T
V
A
S
S
S
R
S
M
R
T
D
Site 143
S1044
R
N
T
V
A
S
S
S
R
S
M
R
T
D
L
Site 144
S1046
T
V
A
S
S
S
R
S
M
R
T
D
L
P
P
Site 145
T1049
S
S
S
R
S
M
R
T
D
L
P
P
V
A
K
Site 146
T1063
K
A
P
G
I
T
R
T
V
S
Q
R
Q
L
R
Site 147
S1065
P
G
I
T
R
T
V
S
Q
R
Q
L
R
V
K
Site 148
S1083
E
D
A
A
P
K
D
S
S
T
L
R
R
A
S
Site 149
T1085
A
A
P
K
D
S
S
T
L
R
R
A
S
S
A
Site 150
S1090
S
S
T
L
R
R
A
S
S
A
R
A
P
K
K
Site 151
S1091
S
T
L
R
R
A
S
S
A
R
A
P
K
K
R
Site 152
S1101
A
P
K
K
R
P
E
S
A
E
G
P
S
A
N
Site 153
S1123
R
G
A
G
E
R
A
S
L
R
R
K
D
S
S
Site 154
S1129
A
S
L
R
R
K
D
S
S
R
T
T
L
G
R
Site 155
S1130
S
L
R
R
K
D
S
S
R
T
T
L
G
R
I
Site 156
T1133
R
K
D
S
S
R
T
T
L
G
R
I
L
N
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation