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Updated November 2019
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Protein Info
Short Name:
UBE2O
Full Name:
Ubiquitin-conjugating enzyme E2 O
Alias:
E2-230K; EC 6.3.2.19; FLJ12878; KIAA1734; Ubiquitin carrier protein O; Ubiquitin-conjugating enzyme E2 of 230 kDa; Ubiquitin-conjugating enzyme E2O; Ubiquitin-protein ligase O
Type:
Ligase, Ubiquitin conjugating system
Mass (Da):
141293
Number AA:
1292
UniProt ID:
Q9C0C9
International Prot ID:
IPI00028307
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0043687
GO:0051246
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S40
V
P
A
P
A
P
A
S
D
S
A
S
G
P
S
Site 2
S42
A
P
A
P
A
S
D
S
A
S
G
P
S
S
D
Site 3
S44
A
P
A
S
D
S
A
S
G
P
S
S
D
S
G
Site 4
S47
S
D
S
A
S
G
P
S
S
D
S
G
P
E
A
Site 5
S48
D
S
A
S
G
P
S
S
D
S
G
P
E
A
G
Site 6
S50
A
S
G
P
S
S
D
S
G
P
E
A
G
S
Q
Site 7
S56
D
S
G
P
E
A
G
S
Q
R
L
L
F
S
H
Site 8
S62
G
S
Q
R
L
L
F
S
H
D
L
V
S
G
R
Site 9
S67
L
F
S
H
D
L
V
S
G
R
Y
R
G
S
V
Site 10
S73
V
S
G
R
Y
R
G
S
V
H
F
G
L
V
R
Site 11
S87
R
L
I
H
G
E
D
S
D
S
E
G
E
E
E
Site 12
S89
I
H
G
E
D
S
D
S
E
G
E
E
E
G
R
Site 13
S98
G
E
E
E
G
R
G
S
S
G
C
S
E
A
G
Site 14
S99
E
E
E
G
R
G
S
S
G
C
S
E
A
G
G
Site 15
S102
G
R
G
S
S
G
C
S
E
A
G
G
A
G
H
Site 16
S115
G
H
E
E
G
R
A
S
P
L
R
R
G
Y
V
Site 17
Y121
A
S
P
L
R
R
G
Y
V
R
V
Q
W
Y
P
Site 18
Y127
G
Y
V
R
V
Q
W
Y
P
E
G
V
K
Q
H
Site 19
S146
K
L
K
L
E
D
R
S
V
V
P
R
D
V
V
Site 20
T159
V
V
R
H
M
R
S
T
D
S
Q
C
G
T
V
Site 21
S161
R
H
M
R
S
T
D
S
Q
C
G
T
V
I
D
Site 22
T165
S
T
D
S
Q
C
G
T
V
I
D
V
N
I
D
Site 23
T180
C
A
V
K
L
I
G
T
N
C
I
I
Y
P
V
Site 24
Y185
I
G
T
N
C
I
I
Y
P
V
N
S
K
D
L
Site 25
S189
C
I
I
Y
P
V
N
S
K
D
L
Q
H
I
W
Site 26
S225
N
Q
I
I
L
K
L
S
N
G
A
R
C
S
M
Site 27
S231
L
S
N
G
A
R
C
S
M
N
T
E
D
G
A
Site 28
T234
G
A
R
C
S
M
N
T
E
D
G
A
K
L
Y
Site 29
Y241
T
E
D
G
A
K
L
Y
D
V
C
P
H
V
S
Site 30
S257
S
G
L
F
F
D
D
S
Y
G
F
Y
P
G
Q
Site 31
Y258
G
L
F
F
D
D
S
Y
G
F
Y
P
G
Q
V
Site 32
S287
S
G
V
K
P
V
L
S
T
K
S
K
F
R
V
Site 33
S290
K
P
V
L
S
T
K
S
K
F
R
V
V
V
E
Site 34
T318
K
S
F
C
P
G
G
T
D
S
V
S
P
P
P
Site 35
S320
F
C
P
G
G
T
D
S
V
S
P
P
P
S
V
Site 36
S322
P
G
G
T
D
S
V
S
P
P
P
S
V
I
T
Site 37
S326
D
S
V
S
P
P
P
S
V
I
T
Q
E
N
L
Site 38
S381
N
C
A
Q
G
E
G
S
M
A
K
K
V
K
R
Site 39
S399
K
Q
V
V
R
I
M
S
C
S
P
D
T
Q
C
Site 40
S401
V
V
R
I
M
S
C
S
P
D
T
Q
C
S
R
Site 41
T404
I
M
S
C
S
P
D
T
Q
C
S
R
D
H
S
Site 42
S407
C
S
P
D
T
Q
C
S
R
D
H
S
M
E
D
Site 43
S411
T
Q
C
S
R
D
H
S
M
E
D
P
D
K
K
Site 44
S421
D
P
D
K
K
G
E
S
K
T
K
S
E
A
E
Site 45
S425
K
G
E
S
K
T
K
S
E
A
E
S
A
S
P
Site 46
S429
K
T
K
S
E
A
E
S
A
S
P
E
E
T
P
Site 47
S431
K
S
E
A
E
S
A
S
P
E
E
T
P
D
G
Site 48
T435
E
S
A
S
P
E
E
T
P
D
G
S
A
S
P
Site 49
S439
P
E
E
T
P
D
G
S
A
S
P
V
E
M
Q
Site 50
S441
E
T
P
D
G
S
A
S
P
V
E
M
Q
D
E
Site 51
S475
G
R
D
D
R
L
H
S
A
E
Q
D
A
D
D
Site 52
T488
D
D
E
A
A
D
D
T
D
D
T
S
S
V
T
Site 53
T491
A
A
D
D
T
D
D
T
S
S
V
T
S
S
A
Site 54
S492
A
D
D
T
D
D
T
S
S
V
T
S
S
A
S
Site 55
S493
D
D
T
D
D
T
S
S
V
T
S
S
A
S
S
Site 56
T495
T
D
D
T
S
S
V
T
S
S
A
S
S
T
T
Site 57
S496
D
D
T
S
S
V
T
S
S
A
S
S
T
T
S
Site 58
S497
D
T
S
S
V
T
S
S
A
S
S
T
T
S
S
Site 59
S499
S
S
V
T
S
S
A
S
S
T
T
S
S
Q
S
Site 60
S500
S
V
T
S
S
A
S
S
T
T
S
S
Q
S
G
Site 61
T501
V
T
S
S
A
S
S
T
T
S
S
Q
S
G
S
Site 62
T502
T
S
S
A
S
S
T
T
S
S
Q
S
G
S
G
Site 63
S503
S
S
A
S
S
T
T
S
S
Q
S
G
S
G
T
Site 64
S504
S
A
S
S
T
T
S
S
Q
S
G
S
G
T
S
Site 65
S506
S
S
T
T
S
S
Q
S
G
S
G
T
S
R
K
Site 66
S508
T
T
S
S
Q
S
G
S
G
T
S
R
K
K
S
Site 67
T510
S
S
Q
S
G
S
G
T
S
R
K
K
S
I
P
Site 68
S511
S
Q
S
G
S
G
T
S
R
K
K
S
I
P
L
Site 69
S515
S
G
T
S
R
K
K
S
I
P
L
S
I
K
N
Site 70
S519
R
K
K
S
I
P
L
S
I
K
N
L
K
R
K
Site 71
T535
K
R
K
K
N
K
I
T
R
D
F
K
P
G
D
Site 72
S597
V
V
D
K
R
V
Q
S
C
P
D
P
A
V
Y
Site 73
Y604
S
C
P
D
P
A
V
Y
G
V
V
Q
S
G
D
Site 74
S609
A
V
Y
G
V
V
Q
S
G
D
H
I
G
R
T
Site 75
S627
K
W
F
K
L
R
P
S
G
D
D
V
E
L
I
Site 76
S641
I
G
E
E
E
D
V
S
V
Y
D
I
A
D
H
Site 77
Y643
E
E
E
D
V
S
V
Y
D
I
A
D
H
P
D
Site 78
T655
H
P
D
F
R
F
R
T
T
D
I
V
I
R
I
Site 79
T656
P
D
F
R
F
R
T
T
D
I
V
I
R
I
G
Site 80
S677
P
H
K
E
D
E
P
S
V
G
Q
V
A
R
V
Site 81
S698
E
V
V
W
A
D
N
S
K
T
I
I
L
P
Q
Site 82
Y708
I
I
L
P
Q
H
L
Y
N
I
E
S
E
I
E
Site 83
S712
Q
H
L
Y
N
I
E
S
E
I
E
E
S
D
Y
Site 84
S717
I
E
S
E
I
E
E
S
D
Y
D
S
V
E
G
Site 85
Y719
S
E
I
E
E
S
D
Y
D
S
V
E
G
S
T
Site 86
S721
I
E
E
S
D
Y
D
S
V
E
G
S
T
S
G
Site 87
S725
D
Y
D
S
V
E
G
S
T
S
G
A
S
S
D
Site 88
S727
D
S
V
E
G
S
T
S
G
A
S
S
D
E
W
Site 89
S731
G
S
T
S
G
A
S
S
D
E
W
E
D
D
S
Site 90
S738
S
D
E
W
E
D
D
S
D
S
W
E
T
D
N
Site 91
S740
E
W
E
D
D
S
D
S
W
E
T
D
N
G
L
Site 92
S810
G
K
D
G
P
P
K
S
F
R
E
L
K
E
A
Site 93
S823
E
A
I
K
I
L
E
S
L
K
N
M
T
V
E
Site 94
T834
M
T
V
E
Q
L
L
T
G
S
P
T
S
P
T
Site 95
S836
V
E
Q
L
L
T
G
S
P
T
S
P
T
V
E
Site 96
T838
Q
L
L
T
G
S
P
T
S
P
T
V
E
P
E
Site 97
S839
L
L
T
G
S
P
T
S
P
T
V
E
P
E
K
Site 98
T841
T
G
S
P
T
S
P
T
V
E
P
E
K
P
T
Site 99
T867
L
Q
E
N
L
K
K
T
L
D
N
V
A
I
V
Site 100
S896
E
D
K
P
E
G
Q
S
P
V
K
A
E
W
P
Site 101
T906
K
A
E
W
P
S
E
T
P
V
L
C
Q
Q
C
Site 102
T920
C
G
G
K
P
G
V
T
F
T
S
A
K
G
E
Site 103
S937
S
V
L
E
F
A
P
S
N
H
S
F
K
K
I
Site 104
S940
E
F
A
P
S
N
H
S
F
K
K
I
E
F
Q
Site 105
S956
P
E
A
K
K
F
F
S
T
V
R
K
E
M
A
Site 106
T957
E
A
K
K
F
F
S
T
V
R
K
E
M
A
L
Site 107
T977
P
E
G
I
M
V
K
T
F
E
D
R
M
D
L
Site 108
S986
E
D
R
M
D
L
F
S
A
L
I
K
G
P
T
Site 109
T995
L
I
K
G
P
T
R
T
P
Y
E
D
G
L
Y
Site 110
Y997
K
G
P
T
R
T
P
Y
E
D
G
L
Y
L
F
Site 111
Y1002
T
P
Y
E
D
G
L
Y
L
F
D
I
Q
L
P
Site 112
Y1012
D
I
Q
L
P
N
I
Y
P
A
V
P
P
H
F
Site 113
Y1021
A
V
P
P
H
F
C
Y
L
S
Q
C
S
G
R
Site 114
Y1034
G
R
L
N
P
N
L
Y
D
N
G
K
V
C
V
Site 115
T1052
G
T
W
I
G
K
G
T
E
R
W
T
S
K
S
Site 116
T1056
G
K
G
T
E
R
W
T
S
K
S
S
L
L
Q
Site 117
S1057
K
G
T
E
R
W
T
S
K
S
S
L
L
Q
V
Site 118
S1059
T
E
R
W
T
S
K
S
S
L
L
Q
V
L
I
Site 119
S1060
E
R
W
T
S
K
S
S
L
L
Q
V
L
I
S
Site 120
Y1078
L
I
L
V
N
E
P
Y
Y
N
E
A
G
F
D
Site 121
Y1079
I
L
V
N
E
P
Y
Y
N
E
A
G
F
D
S
Site 122
S1086
Y
N
E
A
G
F
D
S
D
R
G
L
Q
E
G
Site 123
Y1094
D
R
G
L
Q
E
G
Y
E
N
S
R
C
Y
N
Site 124
Y1100
G
Y
E
N
S
R
C
Y
N
E
M
A
L
I
R
Site 125
T1133
E
I
R
Q
H
F
S
T
G
G
W
R
L
V
N
Site 126
S1144
R
L
V
N
R
I
E
S
W
L
E
T
H
A
L
Site 127
T1148
R
I
E
S
W
L
E
T
H
A
L
L
E
K
A
Site 128
S1166
P
N
G
V
P
K
A
S
S
S
P
E
P
P
A
Site 129
S1168
G
V
P
K
A
S
S
S
P
E
P
P
A
V
A
Site 130
S1178
P
P
A
V
A
E
L
S
D
S
G
Q
Q
E
P
Site 131
S1180
A
V
A
E
L
S
D
S
G
Q
Q
E
P
E
D
Site 132
S1196
G
P
A
P
G
E
A
S
Q
G
S
D
S
E
G
Site 133
S1199
P
G
E
A
S
Q
G
S
D
S
E
G
G
A
Q
Site 134
S1201
E
A
S
Q
G
S
D
S
E
G
G
A
Q
G
L
Site 135
S1210
G
G
A
Q
G
L
A
S
A
S
R
D
H
T
D
Site 136
T1216
A
S
A
S
R
D
H
T
D
Q
T
S
E
T
A
Site 137
T1219
S
R
D
H
T
D
Q
T
S
E
T
A
P
D
A
Site 138
S1220
R
D
H
T
D
Q
T
S
E
T
A
P
D
A
S
Site 139
S1227
S
E
T
A
P
D
A
S
V
P
P
S
V
K
P
Site 140
S1231
P
D
A
S
V
P
P
S
V
K
P
K
K
R
R
Site 141
S1240
K
P
K
K
R
R
K
S
Y
R
S
F
L
P
E
Site 142
Y1241
P
K
K
R
R
K
S
Y
R
S
F
L
P
E
K
Site 143
S1243
K
R
R
K
S
Y
R
S
F
L
P
E
K
S
G
Site 144
S1249
R
S
F
L
P
E
K
S
G
Y
P
D
I
G
F
Site 145
Y1251
F
L
P
E
K
S
G
Y
P
D
I
G
F
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation