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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AMBRA1
Full Name:
Activating molecule in BECN1-regulated autophagy protein 1
Alias:
AMRA1; autophagy/beclin-1 regulator 1; DCAF3; DDB1 and CUL4 associated factor 3; FLJ20294; KIAA1736; LOC55626; WD repeat domain 94; WDR94
Type:
Autophagy; Unknown function
Mass (Da):
142507
Number AA:
1298
UniProt ID:
Q9C0C7
International Prot ID:
IPI00106552
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005776
GO:0031410
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006914
GO:0030154
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S52
K
R
V
E
L
P
D
S
P
R
S
T
F
L
L
Site 2
S55
E
L
P
D
S
P
R
S
T
F
L
L
A
F
S
Site 3
T56
L
P
D
S
P
R
S
T
F
L
L
A
F
S
P
Site 4
S70
P
D
R
T
L
L
A
S
T
H
V
N
H
N
I
Site 5
S90
K
T
G
K
C
V
H
S
L
I
G
H
R
R
T
Site 6
S131
D
L
H
G
G
S
E
S
W
F
T
D
S
N
N
Site 7
T134
G
G
S
E
S
W
F
T
D
S
N
N
A
I
A
Site 8
S136
S
E
S
W
F
T
D
S
N
N
A
I
A
S
L
Site 9
S142
D
S
N
N
A
I
A
S
L
A
F
H
P
T
A
Site 10
T218
P
E
I
P
I
D
G
T
E
L
S
H
Y
R
Q
Site 11
S221
P
I
D
G
T
E
L
S
H
Y
R
Q
R
A
L
Site 12
Y223
D
G
T
E
L
S
H
Y
R
Q
R
A
L
L
Q
Site 13
S231
R
Q
R
A
L
L
Q
S
Q
P
V
R
R
T
P
Site 14
T237
Q
S
Q
P
V
R
R
T
P
L
L
H
N
F
L
Site 15
S248
H
N
F
L
H
M
L
S
S
R
S
S
G
I
Q
Site 16
S249
N
F
L
H
M
L
S
S
R
S
S
G
I
Q
V
Site 17
S252
H
M
L
S
S
R
S
S
G
I
Q
V
G
E
Q
Site 18
S260
G
I
Q
V
G
E
Q
S
T
V
Q
D
S
A
T
Site 19
T261
I
Q
V
G
E
Q
S
T
V
Q
D
S
A
T
P
Site 20
S265
E
Q
S
T
V
Q
D
S
A
T
P
S
P
P
P
Site 21
T267
S
T
V
Q
D
S
A
T
P
S
P
P
P
P
P
Site 22
S269
V
Q
D
S
A
T
P
S
P
P
P
P
P
P
Q
Site 23
S278
P
P
P
P
P
Q
P
S
T
E
R
P
R
T
S
Site 24
T279
P
P
P
P
Q
P
S
T
E
R
P
R
T
S
A
Site 25
T284
P
S
T
E
R
P
R
T
S
A
Y
I
R
L
R
Site 26
S285
S
T
E
R
P
R
T
S
A
Y
I
R
L
R
Q
Site 27
Y287
E
R
P
R
T
S
A
Y
I
R
L
R
Q
R
V
Site 28
S295
I
R
L
R
Q
R
V
S
Y
P
T
A
E
C
C
Site 29
Y296
R
L
R
Q
R
V
S
Y
P
T
A
E
C
C
Q
Site 30
T298
R
Q
R
V
S
Y
P
T
A
E
C
C
Q
H
L
Site 31
S321
C
S
G
T
R
V
P
S
L
L
P
H
Q
D
S
Site 32
S328
S
L
L
P
H
Q
D
S
V
P
P
A
S
A
R
Site 33
S333
Q
D
S
V
P
P
A
S
A
R
A
T
T
P
S
Site 34
T337
P
P
A
S
A
R
A
T
T
P
S
F
S
F
V
Site 35
T338
P
A
S
A
R
A
T
T
P
S
F
S
F
V
Q
Site 36
S340
S
A
R
A
T
T
P
S
F
S
F
V
Q
T
E
Site 37
S342
R
A
T
T
P
S
F
S
F
V
Q
T
E
P
F
Site 38
T346
P
S
F
S
F
V
Q
T
E
P
F
H
P
P
E
Site 39
S357
H
P
P
E
Q
A
S
S
T
Q
Q
D
Q
G
L
Site 40
S369
Q
G
L
L
N
R
P
S
A
F
S
T
V
Q
S
Site 41
S372
L
N
R
P
S
A
F
S
T
V
Q
S
S
T
A
Site 42
T373
N
R
P
S
A
F
S
T
V
Q
S
S
T
A
G
Site 43
S376
S
A
F
S
T
V
Q
S
S
T
A
G
N
T
L
Site 44
T382
Q
S
S
T
A
G
N
T
L
R
N
L
S
L
G
Site 45
S387
G
N
T
L
R
N
L
S
L
G
P
T
R
R
S
Site 46
T391
R
N
L
S
L
G
P
T
R
R
S
L
G
G
P
Site 47
S394
S
L
G
P
T
R
R
S
L
G
G
P
L
S
S
Site 48
S400
R
S
L
G
G
P
L
S
S
H
P
S
R
Y
H
Site 49
S401
S
L
G
G
P
L
S
S
H
P
S
R
Y
H
R
Site 50
S404
G
P
L
S
S
H
P
S
R
Y
H
R
E
I
A
Site 51
Y406
L
S
S
H
P
S
R
Y
H
R
E
I
A
P
G
Site 52
T422
T
G
S
E
W
T
R
T
V
L
S
L
N
S
R
Site 53
S425
E
W
T
R
T
V
L
S
L
N
S
R
S
E
A
Site 54
S428
R
T
V
L
S
L
N
S
R
S
E
A
E
S
M
Site 55
S430
V
L
S
L
N
S
R
S
E
A
E
S
M
P
P
Site 56
S434
N
S
R
S
E
A
E
S
M
P
P
P
R
T
S
Site 57
T440
E
S
M
P
P
P
R
T
S
A
S
S
V
S
L
Site 58
S441
S
M
P
P
P
R
T
S
A
S
S
V
S
L
L
Site 59
S443
P
P
P
R
T
S
A
S
S
V
S
L
L
S
V
Site 60
S444
P
P
R
T
S
A
S
S
V
S
L
L
S
V
L
Site 61
S446
R
T
S
A
S
S
V
S
L
L
S
V
L
R
Q
Site 62
S449
A
S
S
V
S
L
L
S
V
L
R
Q
Q
E
G
Site 63
S458
L
R
Q
Q
E
G
G
S
Q
A
S
V
Y
T
S
Site 64
S461
Q
E
G
G
S
Q
A
S
V
Y
T
S
A
T
E
Site 65
Y463
G
G
S
Q
A
S
V
Y
T
S
A
T
E
G
R
Site 66
S465
S
Q
A
S
V
Y
T
S
A
T
E
G
R
G
F
Site 67
S475
E
G
R
G
F
P
A
S
G
L
A
T
E
S
D
Site 68
T479
F
P
A
S
G
L
A
T
E
S
D
G
G
N
G
Site 69
S481
A
S
G
L
A
T
E
S
D
G
G
N
G
S
S
Site 70
S487
E
S
D
G
G
N
G
S
S
Q
N
N
S
G
S
Site 71
S488
S
D
G
G
N
G
S
S
Q
N
N
S
G
S
I
Site 72
S492
N
G
S
S
Q
N
N
S
G
S
I
R
H
E
L
Site 73
S494
S
S
Q
N
N
S
G
S
I
R
H
E
L
Q
C
Site 74
Y510
L
R
R
F
F
L
E
Y
D
R
L
Q
E
L
D
Site 75
S519
R
L
Q
E
L
D
Q
S
L
S
G
E
A
P
Q
Site 76
S521
Q
E
L
D
Q
S
L
S
G
E
A
P
Q
T
Q
Site 77
T527
L
S
G
E
A
P
Q
T
Q
Q
A
Q
E
M
L
Site 78
S540
M
L
N
N
N
I
E
S
E
R
P
G
P
S
H
Site 79
S546
E
S
E
R
P
G
P
S
H
Q
P
T
P
H
S
Site 80
T550
P
G
P
S
H
Q
P
T
P
H
S
S
E
N
N
Site 81
S553
S
H
Q
P
T
P
H
S
S
E
N
N
S
N
L
Site 82
S554
H
Q
P
T
P
H
S
S
E
N
N
S
N
L
S
Site 83
S558
P
H
S
S
E
N
N
S
N
L
S
R
G
H
L
Site 84
T576
R
A
C
H
N
L
L
T
F
N
N
D
T
L
R
Site 85
T581
L
L
T
F
N
N
D
T
L
R
W
E
R
T
T
Site 86
T587
D
T
L
R
W
E
R
T
T
P
N
Y
S
S
G
Site 87
T588
T
L
R
W
E
R
T
T
P
N
Y
S
S
G
E
Site 88
Y591
W
E
R
T
T
P
N
Y
S
S
G
E
A
S
S
Site 89
S592
E
R
T
T
P
N
Y
S
S
G
E
A
S
S
S
Site 90
S593
R
T
T
P
N
Y
S
S
G
E
A
S
S
S
W
Site 91
S597
N
Y
S
S
G
E
A
S
S
S
W
Q
V
P
S
Site 92
S598
Y
S
S
G
E
A
S
S
S
W
Q
V
P
S
S
Site 93
S599
S
S
G
E
A
S
S
S
W
Q
V
P
S
S
F
Site 94
S604
S
S
S
W
Q
V
P
S
S
F
E
S
V
P
S
Site 95
S605
S
S
W
Q
V
P
S
S
F
E
S
V
P
S
S
Site 96
S608
Q
V
P
S
S
F
E
S
V
P
S
S
G
S
Q
Site 97
S611
S
S
F
E
S
V
P
S
S
G
S
Q
L
P
P
Site 98
S612
S
F
E
S
V
P
S
S
G
S
Q
L
P
P
L
Site 99
S614
E
S
V
P
S
S
G
S
Q
L
P
P
L
E
R
Site 100
T626
L
E
R
T
E
G
Q
T
P
S
S
S
R
L
E
Site 101
S628
R
T
E
G
Q
T
P
S
S
S
R
L
E
L
S
Site 102
S629
T
E
G
Q
T
P
S
S
S
R
L
E
L
S
S
Site 103
S630
E
G
Q
T
P
S
S
S
R
L
E
L
S
S
S
Site 104
S635
S
S
S
R
L
E
L
S
S
S
A
S
P
Q
E
Site 105
S636
S
S
R
L
E
L
S
S
S
A
S
P
Q
E
E
Site 106
S637
S
R
L
E
L
S
S
S
A
S
P
Q
E
E
R
Site 107
S639
L
E
L
S
S
S
A
S
P
Q
E
E
R
T
V
Site 108
T645
A
S
P
Q
E
E
R
T
V
G
V
A
F
N
Q
Site 109
Y661
T
G
H
W
E
R
I
Y
T
Q
S
S
R
S
G
Site 110
T662
G
H
W
E
R
I
Y
T
Q
S
S
R
S
G
T
Site 111
S664
W
E
R
I
Y
T
Q
S
S
R
S
G
T
V
S
Site 112
S665
E
R
I
Y
T
Q
S
S
R
S
G
T
V
S
Q
Site 113
T669
T
Q
S
S
R
S
G
T
V
S
Q
E
A
L
H
Site 114
S671
S
S
R
S
G
T
V
S
Q
E
A
L
H
Q
D
Site 115
S684
Q
D
M
P
E
E
S
S
E
E
D
S
L
R
R
Site 116
S688
E
E
S
S
E
E
D
S
L
R
R
R
L
L
E
Site 117
S696
L
R
R
R
L
L
E
S
S
L
I
S
L
S
R
Site 118
S697
R
R
R
L
L
E
S
S
L
I
S
L
S
R
Y
Site 119
S702
E
S
S
L
I
S
L
S
R
Y
D
G
A
G
S
Site 120
Y704
S
L
I
S
L
S
R
Y
D
G
A
G
S
R
E
Site 121
Y715
G
S
R
E
H
P
I
Y
P
D
P
A
R
L
S
Site 122
S722
Y
P
D
P
A
R
L
S
P
A
A
Y
Y
A
Q
Site 123
Y726
A
R
L
S
P
A
A
Y
Y
A
Q
R
M
I
Q
Site 124
Y727
R
L
S
P
A
A
Y
Y
A
Q
R
M
I
Q
Y
Site 125
Y734
Y
A
Q
R
M
I
Q
Y
L
S
R
R
D
S
I
Site 126
S736
Q
R
M
I
Q
Y
L
S
R
R
D
S
I
R
Q
Site 127
S740
Q
Y
L
S
R
R
D
S
I
R
Q
R
S
M
R
Site 128
S745
R
D
S
I
R
Q
R
S
M
R
Y
Q
Q
N
R
Site 129
S755
Y
Q
Q
N
R
L
R
S
S
T
S
S
S
S
S
Site 130
S756
Q
Q
N
R
L
R
S
S
T
S
S
S
S
S
D
Site 131
T757
Q
N
R
L
R
S
S
T
S
S
S
S
S
D
N
Site 132
S758
N
R
L
R
S
S
T
S
S
S
S
S
D
N
Q
Site 133
S759
R
L
R
S
S
T
S
S
S
S
S
D
N
Q
G
Site 134
S760
L
R
S
S
T
S
S
S
S
S
D
N
Q
G
P
Site 135
S761
R
S
S
T
S
S
S
S
S
D
N
Q
G
P
S
Site 136
S762
S
S
T
S
S
S
S
S
D
N
Q
G
P
S
V
Site 137
S768
S
S
D
N
Q
G
P
S
V
E
G
T
D
L
E
Site 138
T772
Q
G
P
S
V
E
G
T
D
L
E
F
E
D
F
Site 139
S786
F
E
D
N
G
D
R
S
R
H
R
A
P
R
N
Site 140
S797
A
P
R
N
A
R
M
S
A
P
S
L
G
R
F
Site 141
S800
N
A
R
M
S
A
P
S
L
G
R
F
V
P
R
Site 142
Y814
R
R
F
L
L
P
E
Y
L
P
Y
A
G
I
F
Site 143
Y817
L
L
P
E
Y
L
P
Y
A
G
I
F
H
E
R
Site 144
T831
R
G
Q
P
G
L
A
T
H
S
S
V
N
R
V
Site 145
S853
D
G
Q
S
A
V
A
S
N
I
A
N
T
T
Y
Site 146
Y890
L
V
Q
N
C
K
I
Y
N
D
A
S
C
D
I
Site 147
S898
N
D
A
S
C
D
I
S
A
D
G
Q
L
L
A
Site 148
S911
L
A
A
F
I
P
S
S
Q
R
G
F
P
D
E
Site 149
Y936
H
N
L
G
E
M
L
Y
T
K
R
F
G
P
N
Site 150
T937
N
L
G
E
M
L
Y
T
K
R
F
G
P
N
A
Site 151
S948
G
P
N
A
I
S
V
S
L
S
P
M
G
R
Y
Site 152
S990
Q
A
H
G
G
E
T
S
M
R
R
V
F
N
V
Site 153
Y999
R
R
V
F
N
V
L
Y
P
M
P
A
D
Q
R
Site 154
S1010
A
D
Q
R
R
H
V
S
I
N
S
A
R
W
L
Site 155
S1013
R
R
H
V
S
I
N
S
A
R
W
L
P
E
P
Site 156
Y1026
E
P
G
L
G
L
A
Y
G
T
N
K
G
D
L
Site 157
Y1047
A
L
N
S
G
V
E
Y
Y
W
D
Q
L
N
E
Site 158
T1058
Q
L
N
E
T
V
F
T
V
H
S
N
S
R
S
Site 159
S1061
E
T
V
F
T
V
H
S
N
S
R
S
S
E
R
Site 160
S1063
V
F
T
V
H
S
N
S
R
S
S
E
R
P
G
Site 161
S1065
T
V
H
S
N
S
R
S
S
E
R
P
G
T
S
Site 162
S1066
V
H
S
N
S
R
S
S
E
R
P
G
T
S
R
Site 163
T1071
R
S
S
E
R
P
G
T
S
R
A
T
W
R
T
Site 164
T1075
R
P
G
T
S
R
A
T
W
R
T
D
R
D
M
Site 165
T1078
T
S
R
A
T
W
R
T
D
R
D
M
G
L
M
Site 166
T1097
L
Q
P
R
N
P
A
T
S
V
T
S
Q
G
T
Site 167
S1098
Q
P
R
N
P
A
T
S
V
T
S
Q
G
T
Q
Site 168
T1127
R
E
V
P
E
P
G
T
A
A
S
G
P
G
E
Site 169
S1130
P
E
P
G
T
A
A
S
G
P
G
E
G
E
G
Site 170
S1138
G
P
G
E
G
E
G
S
E
Y
G
A
S
G
E
Site 171
Y1140
G
E
G
E
G
S
E
Y
G
A
S
G
E
D
A
Site 172
S1143
E
G
S
E
Y
G
A
S
G
E
D
A
L
S
R
Site 173
S1149
A
S
G
E
D
A
L
S
R
I
Q
R
L
M
A
Site 174
T1161
L
M
A
E
G
G
M
T
A
V
V
Q
R
E
Q
Site 175
S1169
A
V
V
Q
R
E
Q
S
T
T
M
A
S
M
G
Site 176
T1171
V
Q
R
E
Q
S
T
T
M
A
S
M
G
G
F
Site 177
S1174
E
Q
S
T
T
M
A
S
M
G
G
F
G
N
N
Site 178
S1192
S
H
R
I
H
R
S
S
Q
T
G
T
E
P
G
Site 179
T1196
H
R
S
S
Q
T
G
T
E
P
G
A
A
H
T
Site 180
T1203
T
E
P
G
A
A
H
T
S
S
P
Q
P
S
T
Site 181
S1204
E
P
G
A
A
H
T
S
S
P
Q
P
S
T
S
Site 182
S1205
P
G
A
A
H
T
S
S
P
Q
P
S
T
S
R
Site 183
S1209
H
T
S
S
P
Q
P
S
T
S
R
G
L
L
P
Site 184
T1210
T
S
S
P
Q
P
S
T
S
R
G
L
L
P
E
Site 185
S1211
S
S
P
Q
P
S
T
S
R
G
L
L
P
E
A
Site 186
S1227
Q
L
A
E
R
G
L
S
P
R
T
A
S
W
D
Site 187
S1232
G
L
S
P
R
T
A
S
W
D
Q
P
G
T
P
Site 188
T1238
A
S
W
D
Q
P
G
T
P
G
R
E
P
T
Q
Site 189
T1244
G
T
P
G
R
E
P
T
Q
P
T
L
P
S
S
Site 190
T1247
G
R
E
P
T
Q
P
T
L
P
S
S
S
P
V
Site 191
S1250
P
T
Q
P
T
L
P
S
S
S
P
V
P
I
P
Site 192
S1251
T
Q
P
T
L
P
S
S
S
P
V
P
I
P
V
Site 193
S1252
Q
P
T
L
P
S
S
S
P
V
P
I
P
V
S
Site 194
S1283
N
H
L
L
D
G
G
S
S
R
G
D
A
A
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation