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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZDHHC5
Full Name:
Probable palmitoyltransferase ZDHHC5
Alias:
KIAA1748; ZDHC5; Zinc finger DHHC domain containing protein 5; Zinc finger DHHC domain-containing protein 5; Zinc finger protein 375; Zinc finger, DHHC-type containing 5; ZNF375
Type:
Transferase; EC 2.3.1.-
Mass (Da):
77545
Number AA:
715
UniProt ID:
Q9C0B5
International Prot ID:
IPI00328272
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0008415
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
S
G
K
R
F
K
P
S
K
Y
V
P
V
S
A
Site 2
Y14
K
R
F
K
P
S
K
Y
V
P
V
S
A
A
A
Site 3
Y91
D
D
F
R
A
P
L
Y
K
T
V
E
I
K
G
Site 4
T93
F
R
A
P
L
Y
K
T
V
E
I
K
G
I
Q
Site 5
Y146
N
C
I
G
R
R
N
Y
R
Y
F
F
L
F
L
Site 6
T216
V
L
V
A
R
G
R
T
T
N
E
Q
V
T
G
Site 7
T217
L
V
A
R
G
R
T
T
N
E
Q
V
T
G
K
Site 8
S247
V
S
R
V
L
C
S
S
P
A
P
R
Y
L
G
Site 9
Y252
C
S
S
P
A
P
R
Y
L
G
R
P
K
K
E
Site 10
T261
G
R
P
K
K
E
K
T
I
V
I
R
P
P
F
Site 11
S274
P
F
L
R
P
E
V
S
D
G
Q
I
T
V
K
Site 12
T279
E
V
S
D
G
Q
I
T
V
K
I
M
D
N
G
Site 13
T294
I
Q
G
E
L
R
R
T
K
S
K
G
S
L
E
Site 14
S296
G
E
L
R
R
T
K
S
K
G
S
L
E
I
T
Site 15
S299
R
R
T
K
S
K
G
S
L
E
I
T
E
S
Q
Site 16
T303
S
K
G
S
L
E
I
T
E
S
Q
S
A
D
A
Site 17
S305
G
S
L
E
I
T
E
S
Q
S
A
D
A
E
P
Site 18
S321
P
P
P
K
P
D
L
S
R
Y
T
G
L
R
T
Site 19
Y323
P
K
P
D
L
S
R
Y
T
G
L
R
T
H
L
Site 20
T324
K
P
D
L
S
R
Y
T
G
L
R
T
H
L
G
Site 21
T328
S
R
Y
T
G
L
R
T
H
L
G
L
A
T
N
Site 22
T334
R
T
H
L
G
L
A
T
N
E
D
S
S
L
L
Site 23
S339
L
A
T
N
E
D
S
S
L
L
A
K
D
S
P
Site 24
S345
S
S
L
L
A
K
D
S
P
P
T
P
T
M
Y
Site 25
T348
L
A
K
D
S
P
P
T
P
T
M
Y
K
Y
R
Site 26
T350
K
D
S
P
P
T
P
T
M
Y
K
Y
R
P
G
Site 27
Y352
S
P
P
T
P
T
M
Y
K
Y
R
P
G
Y
S
Site 28
Y354
P
T
P
T
M
Y
K
Y
R
P
G
Y
S
S
S
Site 29
Y358
M
Y
K
Y
R
P
G
Y
S
S
S
S
T
S
A
Site 30
S359
Y
K
Y
R
P
G
Y
S
S
S
S
T
S
A
A
Site 31
S360
K
Y
R
P
G
Y
S
S
S
S
T
S
A
A
M
Site 32
S361
Y
R
P
G
Y
S
S
S
S
T
S
A
A
M
P
Site 33
S362
R
P
G
Y
S
S
S
S
T
S
A
A
M
P
H
Site 34
T363
P
G
Y
S
S
S
S
T
S
A
A
M
P
H
S
Site 35
S364
G
Y
S
S
S
S
T
S
A
A
M
P
H
S
S
Site 36
S370
T
S
A
A
M
P
H
S
S
S
A
K
L
S
R
Site 37
S371
S
A
A
M
P
H
S
S
S
A
K
L
S
R
G
Site 38
S372
A
A
M
P
H
S
S
S
A
K
L
S
R
G
D
Site 39
S376
H
S
S
S
A
K
L
S
R
G
D
S
L
K
E
Site 40
S380
A
K
L
S
R
G
D
S
L
K
E
P
T
S
I
Site 41
T385
G
D
S
L
K
E
P
T
S
I
A
E
S
S
R
Site 42
S386
D
S
L
K
E
P
T
S
I
A
E
S
S
R
H
Site 43
S390
E
P
T
S
I
A
E
S
S
R
H
P
S
Y
R
Site 44
S391
P
T
S
I
A
E
S
S
R
H
P
S
Y
R
S
Site 45
S395
A
E
S
S
R
H
P
S
Y
R
S
E
P
S
L
Site 46
Y396
E
S
S
R
H
P
S
Y
R
S
E
P
S
L
E
Site 47
S398
S
R
H
P
S
Y
R
S
E
P
S
L
E
P
E
Site 48
S401
P
S
Y
R
S
E
P
S
L
E
P
E
S
F
R
Site 49
S406
E
P
S
L
E
P
E
S
F
R
S
P
T
F
G
Site 50
S409
L
E
P
E
S
F
R
S
P
T
F
G
K
S
F
Site 51
T411
P
E
S
F
R
S
P
T
F
G
K
S
F
H
F
Site 52
S415
R
S
P
T
F
G
K
S
F
H
F
D
P
L
S
Site 53
S422
S
F
H
F
D
P
L
S
S
G
S
R
S
S
S
Site 54
S423
F
H
F
D
P
L
S
S
G
S
R
S
S
S
L
Site 55
S425
F
D
P
L
S
S
G
S
R
S
S
S
L
K
S
Site 56
S427
P
L
S
S
G
S
R
S
S
S
L
K
S
A
Q
Site 57
S428
L
S
S
G
S
R
S
S
S
L
K
S
A
Q
G
Site 58
S429
S
S
G
S
R
S
S
S
L
K
S
A
Q
G
T
Site 59
S432
S
R
S
S
S
L
K
S
A
Q
G
T
G
F
E
Site 60
T436
S
L
K
S
A
Q
G
T
G
F
E
L
G
Q
L
Site 61
S445
F
E
L
G
Q
L
Q
S
I
R
S
E
G
T
T
Site 62
S448
G
Q
L
Q
S
I
R
S
E
G
T
T
S
T
S
Site 63
T451
Q
S
I
R
S
E
G
T
T
S
T
S
Y
K
S
Site 64
T452
S
I
R
S
E
G
T
T
S
T
S
Y
K
S
L
Site 65
S453
I
R
S
E
G
T
T
S
T
S
Y
K
S
L
A
Site 66
T454
R
S
E
G
T
T
S
T
S
Y
K
S
L
A
N
Site 67
S455
S
E
G
T
T
S
T
S
Y
K
S
L
A
N
Q
Site 68
Y456
E
G
T
T
S
T
S
Y
K
S
L
A
N
Q
T
Site 69
S458
T
T
S
T
S
Y
K
S
L
A
N
Q
T
R
N
Site 70
T463
Y
K
S
L
A
N
Q
T
R
N
G
S
L
S
Y
Site 71
S467
A
N
Q
T
R
N
G
S
L
S
Y
D
S
L
L
Site 72
S469
Q
T
R
N
G
S
L
S
Y
D
S
L
L
T
P
Site 73
Y470
T
R
N
G
S
L
S
Y
D
S
L
L
T
P
S
Site 74
S472
N
G
S
L
S
Y
D
S
L
L
T
P
S
D
S
Site 75
T475
L
S
Y
D
S
L
L
T
P
S
D
S
P
D
F
Site 76
S477
Y
D
S
L
L
T
P
S
D
S
P
D
F
E
S
Site 77
S479
S
L
L
T
P
S
D
S
P
D
F
E
S
V
Q
Site 78
S484
S
D
S
P
D
F
E
S
V
Q
A
G
P
E
P
Site 79
Y497
E
P
D
P
P
L
G
Y
T
S
P
F
L
S
A
Site 80
T498
P
D
P
P
L
G
Y
T
S
P
F
L
S
A
R
Site 81
S499
D
P
P
L
G
Y
T
S
P
F
L
S
A
R
L
Site 82
S503
G
Y
T
S
P
F
L
S
A
R
L
A
Q
Q
R
Site 83
T524
R
L
V
P
T
G
P
T
H
R
E
P
S
P
V
Site 84
S529
G
P
T
H
R
E
P
S
P
V
R
Y
D
N
L
Site 85
Y533
R
E
P
S
P
V
R
Y
D
N
L
S
R
H
I
Site 86
S537
P
V
R
Y
D
N
L
S
R
H
I
V
A
S
L
Site 87
S543
L
S
R
H
I
V
A
S
L
Q
E
R
E
K
L
Site 88
S554
R
E
K
L
L
R
Q
S
P
P
L
P
G
R
E
Site 89
S569
E
E
P
G
L
G
D
S
G
I
Q
S
T
P
G
Site 90
S573
L
G
D
S
G
I
Q
S
T
P
G
S
G
H
A
Site 91
T574
G
D
S
G
I
Q
S
T
P
G
S
G
H
A
P
Site 92
S577
G
I
Q
S
T
P
G
S
G
H
A
P
R
T
S
Site 93
T583
G
S
G
H
A
P
R
T
S
S
S
S
D
D
S
Site 94
S584
S
G
H
A
P
R
T
S
S
S
S
D
D
S
K
Site 95
S585
G
H
A
P
R
T
S
S
S
S
D
D
S
K
R
Site 96
S586
H
A
P
R
T
S
S
S
S
D
D
S
K
R
S
Site 97
S587
A
P
R
T
S
S
S
S
D
D
S
K
R
S
P
Site 98
S590
T
S
S
S
S
D
D
S
K
R
S
P
L
G
K
Site 99
S593
S
S
D
D
S
K
R
S
P
L
G
K
T
P
L
Site 100
T598
K
R
S
P
L
G
K
T
P
L
G
R
P
A
V
Site 101
S621
L
R
G
R
G
V
G
S
P
E
P
G
P
T
A
Site 102
T627
G
S
P
E
P
G
P
T
A
P
Y
L
G
R
S
Site 103
Y630
E
P
G
P
T
A
P
Y
L
G
R
S
M
S
Y
Site 104
S634
T
A
P
Y
L
G
R
S
M
S
Y
S
S
Q
K
Site 105
S636
P
Y
L
G
R
S
M
S
Y
S
S
Q
K
A
Q
Site 106
Y637
Y
L
G
R
S
M
S
Y
S
S
Q
K
A
Q
P
Site 107
S638
L
G
R
S
M
S
Y
S
S
Q
K
A
Q
P
G
Site 108
S639
G
R
S
M
S
Y
S
S
Q
K
A
Q
P
G
V
Site 109
T659
V
A
L
Q
P
L
L
T
P
K
D
E
V
Q
L
Site 110
T668
K
D
E
V
Q
L
K
T
T
Y
S
K
S
N
G
Site 111
T669
D
E
V
Q
L
K
T
T
Y
S
K
S
N
G
Q
Site 112
S671
V
Q
L
K
T
T
Y
S
K
S
N
G
Q
P
K
Site 113
S673
L
K
T
T
Y
S
K
S
N
G
Q
P
K
S
L
Site 114
S679
K
S
N
G
Q
P
K
S
L
G
S
A
S
P
G
Site 115
S682
G
Q
P
K
S
L
G
S
A
S
P
G
P
G
Q
Site 116
S684
P
K
S
L
G
S
A
S
P
G
P
G
Q
P
P
Site 117
S693
G
P
G
Q
P
P
L
S
S
P
T
R
G
G
V
Site 118
S694
P
G
Q
P
P
L
S
S
P
T
R
G
G
V
K
Site 119
T696
Q
P
P
L
S
S
P
T
R
G
G
V
K
K
V
Site 120
S704
R
G
G
V
K
K
V
S
G
V
G
G
T
T
Y
Site 121
T709
K
V
S
G
V
G
G
T
T
Y
E
I
S
V
_
Site 122
Y711
S
G
V
G
G
T
T
Y
E
I
S
V
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation