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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZC3HDC5
Full Name:
RING finger protein unkempt homolog
Alias:
KIAA1753; UNK; Unkempt; ZC3H5; Zinc finger CCCH domain-containing protein 5; Zinc finger CCCH type domain containing protein 5
Type:
Unknown function
Mass (Da):
88084
Number AA:
810
UniProt ID:
Q9C0B0
International Prot ID:
IPI00028276
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
K
G
P
G
P
G
G
S
A
A
S
S
A
P
P
Site 2
S14
P
G
G
S
A
A
S
S
A
P
P
A
A
T
A
Site 3
Y36
E
K
P
Q
H
Y
T
Y
L
K
E
F
R
T
E
Site 4
T42
T
Y
L
K
E
F
R
T
E
Q
C
P
L
F
V
Site 5
S74
V
N
Q
R
R
R
R
S
I
R
R
R
D
G
T
Site 6
T81
S
I
R
R
R
D
G
T
F
N
Y
S
P
D
V
Site 7
Y84
R
R
D
G
T
F
N
Y
S
P
D
V
Y
C
T
Site 8
S85
R
D
G
T
F
N
Y
S
P
D
V
Y
C
T
K
Site 9
Y89
F
N
Y
S
P
D
V
Y
C
T
K
Y
D
E
A
Site 10
Y93
P
D
V
Y
C
T
K
Y
D
E
A
T
G
L
C
Site 11
T113
C
P
F
L
H
R
T
T
G
D
T
E
R
R
Y
Site 12
T116
L
H
R
T
T
G
D
T
E
R
R
Y
H
L
R
Site 13
Y120
T
G
D
T
E
R
R
Y
H
L
R
Y
Y
K
T
Site 14
Y124
E
R
R
Y
H
L
R
Y
Y
K
T
G
I
C
I
Site 15
Y125
R
R
Y
H
L
R
Y
Y
K
T
G
I
C
I
H
Site 16
S158
H
G
P
H
D
L
R
S
P
V
Y
D
I
R
E
Site 17
Y161
H
D
L
R
S
P
V
Y
D
I
R
E
L
Q
A
Site 18
T178
A
L
Q
N
G
Q
T
T
V
E
G
S
I
E
G
Site 19
S182
G
Q
T
T
V
E
G
S
I
E
G
Q
S
A
G
Site 20
S187
E
G
S
I
E
G
Q
S
A
G
A
A
S
H
A
Site 21
S201
A
M
I
E
K
I
L
S
E
E
P
R
W
Q
E
Site 22
Y211
P
R
W
Q
E
T
A
Y
V
L
G
N
Y
K
T
Site 23
T218
Y
V
L
G
N
Y
K
T
E
P
C
K
K
P
P
Site 24
Y232
P
R
L
C
R
Q
G
Y
A
C
P
Y
Y
H
N
Site 25
Y236
R
Q
G
Y
A
C
P
Y
Y
H
N
S
K
D
R
Site 26
Y237
Q
G
Y
A
C
P
Y
Y
H
N
S
K
D
R
R
Site 27
S240
A
C
P
Y
Y
H
N
S
K
D
R
R
R
S
P
Site 28
S246
N
S
K
D
R
R
R
S
P
R
K
H
K
Y
R
Site 29
Y252
R
S
P
R
K
H
K
Y
R
S
S
P
C
P
N
Site 30
S255
R
K
H
K
Y
R
S
S
P
C
P
N
V
K
H
Site 31
Y280
E
N
G
D
A
C
Q
Y
C
H
T
R
T
E
Q
Site 32
S307
N
D
M
Q
Q
S
G
S
C
P
R
G
P
F
C
Site 33
S325
H
V
E
Q
P
P
L
S
D
D
L
Q
P
S
S
Site 34
S331
L
S
D
D
L
Q
P
S
S
A
V
S
S
P
T
Site 35
S332
S
D
D
L
Q
P
S
S
A
V
S
S
P
T
Q
Site 36
S335
L
Q
P
S
S
A
V
S
S
P
T
Q
P
G
P
Site 37
S336
Q
P
S
S
A
V
S
S
P
T
Q
P
G
P
V
Site 38
Y345
T
Q
P
G
P
V
L
Y
M
P
S
A
A
G
D
Site 39
S353
M
P
S
A
A
G
D
S
V
P
V
S
P
S
S
Site 40
S357
A
G
D
S
V
P
V
S
P
S
S
P
H
A
P
Site 41
S359
D
S
V
P
V
S
P
S
S
P
H
A
P
D
L
Site 42
S360
S
V
P
V
S
P
S
S
P
H
A
P
D
L
S
Site 43
S367
S
P
H
A
P
D
L
S
A
L
L
C
R
N
S
Site 44
S374
S
A
L
L
C
R
N
S
S
L
G
S
P
S
N
Site 45
S375
A
L
L
C
R
N
S
S
L
G
S
P
S
N
L
Site 46
S378
C
R
N
S
S
L
G
S
P
S
N
L
C
G
S
Site 47
S380
N
S
S
L
G
S
P
S
N
L
C
G
S
P
P
Site 48
S385
S
P
S
N
L
C
G
S
P
P
G
S
I
R
K
Site 49
S389
L
C
G
S
P
P
G
S
I
R
K
P
P
N
L
Site 50
S411
E
S
G
L
A
P
G
S
Y
K
K
A
P
G
F
Site 51
Y412
S
G
L
A
P
G
S
Y
K
K
A
P
G
F
E
Site 52
Y428
E
D
Q
V
G
A
E
Y
L
K
N
F
K
C
Q
Site 53
S442
Q
A
K
L
K
P
H
S
L
E
P
R
S
Q
E
Site 54
S447
P
H
S
L
E
P
R
S
Q
E
Q
P
L
L
Q
Site 55
S471
P
A
G
S
P
L
T
S
S
I
S
S
S
I
T
Site 56
S472
A
G
S
P
L
T
S
S
I
S
S
S
I
T
S
Site 57
T491
T
P
P
S
P
V
G
T
S
S
V
P
G
M
N
Site 58
S492
P
P
S
P
V
G
T
S
S
V
P
G
M
N
A
Site 59
S493
P
S
P
V
G
T
S
S
V
P
G
M
N
A
N
Site 60
Y505
N
A
N
A
L
P
F
Y
P
T
S
D
T
V
E
Site 61
T510
P
F
Y
P
T
S
D
T
V
E
S
V
I
E
S
Site 62
S513
P
T
S
D
T
V
E
S
V
I
E
S
A
L
D
Site 63
T535
G
V
A
A
L
E
K
T
F
D
N
S
T
V
P
Site 64
S539
L
E
K
T
F
D
N
S
T
V
P
H
P
G
S
Site 65
T540
E
K
T
F
D
N
S
T
V
P
H
P
G
S
I
Site 66
S568
N
I
P
G
S
L
G
S
S
A
S
F
H
S
A
Site 67
S569
I
P
G
S
L
G
S
S
A
S
F
H
S
A
S
Site 68
S571
G
S
L
G
S
S
A
S
F
H
S
A
S
P
S
Site 69
S574
G
S
S
A
S
F
H
S
A
S
P
S
P
P
V
Site 70
S576
S
A
S
F
H
S
A
S
P
S
P
P
V
S
L
Site 71
S578
S
F
H
S
A
S
P
S
P
P
V
S
L
S
S
Site 72
S582
A
S
P
S
P
P
V
S
L
S
S
H
F
L
Q
Site 73
S584
P
S
P
P
V
S
L
S
S
H
F
L
Q
Q
P
Site 74
S585
S
P
P
V
S
L
S
S
H
F
L
Q
Q
P
Q
Site 75
S596
Q
Q
P
Q
G
H
L
S
Q
S
E
N
T
F
L
Site 76
S598
P
Q
G
H
L
S
Q
S
E
N
T
F
L
G
T
Site 77
T601
H
L
S
Q
S
E
N
T
F
L
G
T
S
A
S
Site 78
S606
E
N
T
F
L
G
T
S
A
S
H
G
S
L
G
Site 79
S611
G
T
S
A
S
H
G
S
L
G
L
N
G
M
N
Site 80
S627
S
I
W
E
H
F
A
S
G
S
F
S
P
G
T
Site 81
S629
W
E
H
F
A
S
G
S
F
S
P
G
T
S
P
Site 82
S631
H
F
A
S
G
S
F
S
P
G
T
S
P
A
F
Site 83
T634
S
G
S
F
S
P
G
T
S
P
A
F
L
S
G
Site 84
S635
G
S
F
S
P
G
T
S
P
A
F
L
S
G
P
Site 85
T660
E
L
D
E
A
N
S
T
I
K
Q
W
E
E
S
Site 86
S690
E
E
A
G
E
R
A
S
A
A
G
A
E
C
E
Site 87
S741
D
L
E
A
L
S
L
S
T
L
Y
S
L
Q
K
Site 88
Y744
A
L
S
L
S
T
L
Y
S
L
Q
K
Q
L
R
Site 89
S745
L
S
L
S
T
L
Y
S
L
Q
K
Q
L
R
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation