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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRRCC1
Full Name:
Leucine-rich repeat and coiled-coil domain-containing protein 1
Alias:
SAP2; sodium channel associated 2
Type:
Mass (Da):
119885
Number AA:
1029
UniProt ID:
Q9C099
International Prot ID:
IPI00477245
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005814
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
V
E
N
E
D
G
D
S
S
C
G
D
V
C
F
Site 2
S35
F
M
D
K
G
L
Q
S
I
S
E
L
S
L
D
Site 3
S37
D
K
G
L
Q
S
I
S
E
L
S
L
D
S
T
Site 4
T44
S
E
L
S
L
D
S
T
L
H
A
V
N
L
H
Site 5
S73
N
L
Q
H
L
D
L
S
S
N
Q
I
S
R
I
Site 6
S74
L
Q
H
L
D
L
S
S
N
Q
I
S
R
I
E
Site 7
S78
D
L
S
S
N
Q
I
S
R
I
E
G
L
N
T
Site 8
T91
N
T
L
T
K
L
C
T
L
N
L
S
C
N
L
Site 9
S95
K
L
C
T
L
N
L
S
C
N
L
I
T
K
V
Site 10
Y118
L
T
R
L
N
V
S
Y
N
H
I
D
D
L
S
Site 11
S125
Y
N
H
I
D
D
L
S
G
L
I
P
L
H
G
Site 12
Y139
G
I
K
H
K
L
R
Y
I
D
L
H
S
N
R
Site 13
T210
F
G
E
P
V
N
L
T
E
I
N
S
S
Q
L
Site 14
S215
N
L
T
E
I
N
S
S
Q
L
Q
C
L
E
G
Site 15
S232
D
N
L
V
S
S
D
S
P
L
N
I
S
E
D
Site 16
S237
S
D
S
P
L
N
I
S
E
D
E
I
I
D
R
Site 17
T264
P
L
E
Q
F
A
S
T
P
S
D
A
V
L
T
Site 18
S266
E
Q
F
A
S
T
P
S
D
A
V
L
T
S
F
Site 19
S279
S
F
M
S
V
C
Q
S
S
E
P
E
K
N
N
Site 20
S280
F
M
S
V
C
Q
S
S
E
P
E
K
N
N
H
Site 21
S312
L
Q
L
L
N
E
T
S
N
S
I
D
N
V
L
Site 22
S314
L
L
N
E
T
S
N
S
I
D
N
V
L
E
K
Site 23
T329
D
P
R
P
K
R
D
T
D
I
T
S
E
S
D
Site 24
T332
P
K
R
D
T
D
I
T
S
E
S
D
Y
G
N
Site 25
S333
K
R
D
T
D
I
T
S
E
S
D
Y
G
N
R
Site 26
S335
D
T
D
I
T
S
E
S
D
Y
G
N
R
K
E
Site 27
Y337
D
I
T
S
E
S
D
Y
G
N
R
K
E
C
N
Site 28
S351
N
R
K
V
P
R
R
S
K
I
P
Y
D
A
K
Site 29
Y355
P
R
R
S
K
I
P
Y
D
A
K
T
I
Q
T
Site 30
T359
K
I
P
Y
D
A
K
T
I
Q
T
I
K
H
H
Site 31
Y370
I
K
H
H
N
K
N
Y
N
S
F
V
S
C
N
Site 32
Y384
N
R
K
M
K
P
P
Y
L
K
E
L
Y
V
S
Site 33
Y389
P
P
Y
L
K
E
L
Y
V
S
S
S
L
A
N
Site 34
T408
Q
E
S
E
K
P
K
T
E
I
I
K
V
D
Q
Site 35
S416
E
I
I
K
V
D
Q
S
H
S
E
D
N
T
Y
Site 36
S418
I
K
V
D
Q
S
H
S
E
D
N
T
Y
Q
S
Site 37
T422
Q
S
H
S
E
D
N
T
Y
Q
S
L
V
E
Q
Site 38
Y423
S
H
S
E
D
N
T
Y
Q
S
L
V
E
Q
L
Site 39
S425
S
E
D
N
T
Y
Q
S
L
V
E
Q
L
D
Q
Site 40
Y450
A
E
N
K
L
M
D
Y
I
D
E
L
H
K
H
Site 41
S466
N
E
K
E
D
I
H
S
L
A
L
L
T
T
D
Site 42
S485
I
I
F
R
E
R
N
S
K
G
Q
L
E
V
M
Site 43
T504
Q
N
E
I
K
K
L
T
V
E
L
M
K
A
K
Site 44
T523
D
H
L
K
H
L
R
T
L
E
K
T
L
E
K
Site 45
T527
H
L
R
T
L
E
K
T
L
E
K
M
E
R
Q
Site 46
S554
Q
E
V
E
L
K
A
S
A
A
D
R
E
I
Y
Site 47
Y561
S
A
A
D
R
E
I
Y
L
L
R
T
S
L
H
Site 48
S566
E
I
Y
L
L
R
T
S
L
H
R
E
R
E
Q
Site 49
T594
E
H
R
K
E
L
E
T
R
E
F
F
T
D
A
Site 50
S633
Q
E
K
I
D
V
L
S
Q
Q
Y
M
D
L
E
Site 51
T648
N
E
F
R
I
A
L
T
V
E
A
R
R
F
Q
Site 52
T666
D
G
F
E
N
V
A
T
E
L
A
K
S
K
H
Site 53
S685
A
Q
R
K
E
N
E
S
S
S
L
I
K
D
L
Site 54
S686
Q
R
K
E
N
E
S
S
S
L
I
K
D
L
T
Site 55
S687
R
K
E
N
E
S
S
S
L
I
K
D
L
T
C
Site 56
T693
S
S
L
I
K
D
L
T
C
M
V
K
E
Q
K
Site 57
S735
I
E
D
D
K
Q
K
S
I
Q
I
E
L
L
K
Site 58
T764
S
L
I
F
G
L
R
T
E
R
K
V
W
G
H
Site 59
S793
K
L
E
A
Q
I
E
S
L
S
R
E
N
E
C
Site 60
S795
E
A
Q
I
E
S
L
S
R
E
N
E
C
L
R
Site 61
T804
E
N
E
C
L
R
K
T
N
E
S
D
S
D
A
Site 62
S807
C
L
R
K
T
N
E
S
D
S
D
A
L
R
I
Site 63
S809
R
K
T
N
E
S
D
S
D
A
L
R
I
K
C
Site 64
T823
C
K
I
I
D
D
Q
T
E
T
I
R
K
L
K
Site 65
S863
E
Q
L
D
E
K
S
S
Q
L
D
E
V
L
E
Site 66
Y900
L
E
E
I
R
K
A
Y
S
T
L
N
R
K
W
Site 67
T902
E
I
R
K
A
Y
S
T
L
N
R
K
W
H
D
Site 68
S942
L
K
A
E
R
D
K
S
I
E
L
Q
K
N
A
Site 69
S955
N
A
M
E
K
L
H
S
M
D
D
A
F
K
R
Site 70
S988
E
K
Q
K
C
I
D
S
A
N
L
K
V
H
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation