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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPEF2
Full Name:
Sperm flagellar protein 2
Alias:
FLJ23164; FLJ23577; FLJ25395; KIAA1770; KPL2; MGC102842; Protein KPL2; Sperm flagellar 2
Type:
Mass (Da):
209792
Number AA:
1822
UniProt ID:
Q9C093
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0046983
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
L
N
K
E
L
K
V
S
R
T
V
S
P
K
S
Site 2
T18
K
E
L
K
V
S
R
T
V
S
P
K
S
F
A
Site 3
S20
L
K
V
S
R
T
V
S
P
K
S
F
A
K
A
Site 4
S23
S
R
T
V
S
P
K
S
F
A
K
A
F
S
S
Site 5
S48
F
E
L
Q
D
D
F
S
E
F
L
D
S
R
V
Site 6
S53
D
F
S
E
F
L
D
S
R
V
S
S
A
K
L
Site 7
S56
E
F
L
D
S
R
V
S
S
A
K
L
N
N
F
Site 8
S57
F
L
D
S
R
V
S
S
A
K
L
N
N
F
S
Site 9
Y101
T
K
L
L
Y
Q
L
Y
I
A
L
Q
K
K
K
Site 10
S110
A
L
Q
K
K
K
K
S
G
L
T
G
V
E
M
Site 11
T113
K
K
K
K
S
G
L
T
G
V
E
M
Q
T
M
Site 12
S133
L
R
L
Q
N
M
K
S
D
T
F
Q
E
R
L
Site 13
T135
L
Q
N
M
K
S
D
T
F
Q
E
R
L
R
H
Site 14
Y157
F
N
L
M
R
I
T
Y
R
F
Q
E
K
Y
K
Site 15
Y163
T
Y
R
F
Q
E
K
Y
K
H
V
K
E
D
L
Site 16
Y197
C
F
D
I
E
K
Q
Y
L
N
R
R
R
Q
N
Site 17
S222
I
Q
I
P
K
P
A
S
N
R
T
L
K
A
L
Site 18
S264
K
D
L
Q
A
K
E
S
A
S
K
T
S
L
D
Site 19
T268
A
K
E
S
A
S
K
T
S
L
D
T
A
G
Q
Site 20
Y284
T
T
D
L
L
N
T
Y
S
D
D
E
Y
I
K
Site 21
S285
T
D
L
L
N
T
Y
S
D
D
E
Y
I
K
K
Site 22
Y289
N
T
Y
S
D
D
E
Y
I
K
K
I
Q
K
R
Site 23
S342
I
N
R
L
M
R
Q
S
Q
Q
E
R
R
I
A
Site 24
Y422
V
E
R
A
Q
A
R
Y
E
K
H
Y
S
V
C
Site 25
Y426
Q
A
R
Y
E
K
H
Y
S
V
C
A
E
I
L
Site 26
S427
A
R
Y
E
K
H
Y
S
V
C
A
E
I
L
D
Site 27
S440
L
D
Q
I
V
D
L
S
T
K
V
A
D
Y
R
Site 28
Y446
L
S
T
K
V
A
D
Y
R
M
L
T
N
N
L
Site 29
T450
V
A
D
Y
R
M
L
T
N
N
L
I
P
Y
K
Site 30
Y473
F
F
N
A
K
P
I
Y
E
Q
A
S
V
K
T
Site 31
T480
Y
E
Q
A
S
V
K
T
L
P
A
N
P
S
R
Site 32
S486
K
T
L
P
A
N
P
S
R
E
Q
L
T
E
L
Site 33
T501
E
K
R
D
L
L
D
T
N
D
Y
E
E
Y
K
Site 34
Y504
D
L
L
D
T
N
D
Y
E
E
Y
K
N
M
V
Site 35
Y507
D
T
N
D
Y
E
E
Y
K
N
M
V
G
E
W
Site 36
S543
L
H
R
L
A
E
K
S
L
P
P
R
A
E
S
Site 37
S550
S
L
P
P
R
A
E
S
T
T
P
E
L
P
S
Site 38
T551
L
P
P
R
A
E
S
T
T
P
E
L
P
S
F
Site 39
T552
P
P
R
A
E
S
T
T
P
E
L
P
S
F
A
Site 40
S570
C
L
L
G
K
T
L
S
G
K
T
T
I
L
R
Site 41
T574
K
T
L
S
G
K
T
T
I
L
R
S
L
Q
K
Site 42
S578
G
K
T
T
I
L
R
S
L
Q
K
D
F
P
I
Site 43
S632
L
Q
E
E
I
K
E
S
Q
D
P
Q
H
V
F
Site 44
S640
Q
D
P
Q
H
V
F
S
A
G
P
V
S
D
E
Site 45
T652
S
D
E
V
L
P
E
T
E
G
E
T
M
L
S
Site 46
S659
T
E
G
E
T
M
L
S
A
N
A
D
K
T
P
Site 47
T665
L
S
A
N
A
D
K
T
P
K
A
E
E
V
K
Site 48
S673
P
K
A
E
E
V
K
S
S
D
S
F
L
K
L
Site 49
S674
K
A
E
E
V
K
S
S
D
S
F
L
K
L
T
Site 50
S676
E
E
V
K
S
S
D
S
F
L
K
L
T
T
R
Site 51
T681
S
D
S
F
L
K
L
T
T
R
A
Q
L
G
A
Site 52
T742
Q
L
L
E
E
A
L
T
G
C
N
R
N
L
T
Site 53
T749
T
G
C
N
R
N
L
T
E
V
E
R
K
K
A
Site 54
T789
I
L
L
D
V
S
D
T
S
S
M
S
R
M
N
Site 55
S790
L
L
D
V
S
D
T
S
S
M
S
R
M
N
D
Site 56
S791
L
D
V
S
D
T
S
S
M
S
R
M
N
D
I
Site 57
S804
D
I
I
A
E
E
L
S
Y
K
T
A
H
E
D
Site 58
Y805
I
I
A
E
E
L
S
Y
K
T
A
H
E
D
I
Site 59
S813
K
T
A
H
E
D
I
S
Q
R
V
A
A
E
N
Site 60
S852
P
L
L
E
Q
W
F
S
E
P
E
N
I
L
I
Site 61
T880
K
V
K
E
I
L
T
T
E
I
A
K
K
K
N
Site 62
T913
L
A
E
L
P
L
P
T
P
P
P
A
P
P
P
Site 63
S931
K
E
K
E
I
H
Q
S
H
V
A
S
K
T
P
Site 64
S935
I
H
Q
S
H
V
A
S
K
T
P
T
A
K
G
Site 65
T937
Q
S
H
V
A
S
K
T
P
T
A
K
G
K
P
Site 66
T939
H
V
A
S
K
T
P
T
A
K
G
K
P
Q
S
Site 67
S946
T
A
K
G
K
P
Q
S
E
A
P
H
G
K
Q
Site 68
S955
A
P
H
G
K
Q
E
S
L
Q
E
G
K
G
K
Site 69
S973
T
A
L
K
R
K
G
S
P
K
G
K
S
S
G
Site 70
S978
K
G
S
P
K
G
K
S
S
G
G
K
V
P
V
Site 71
S979
G
S
P
K
G
K
S
S
G
G
K
V
P
V
K
Site 72
S988
G
K
V
P
V
K
K
S
P
A
D
S
T
D
T
Site 73
S992
V
K
K
S
P
A
D
S
T
D
T
S
P
V
A
Site 74
T993
K
K
S
P
A
D
S
T
D
T
S
P
V
A
I
Site 75
S996
P
A
D
S
T
D
T
S
P
V
A
I
V
P
Q
Site 76
S1009
P
Q
P
P
K
P
G
S
E
E
W
V
Y
V
N
Site 77
Y1014
P
G
S
E
E
W
V
Y
V
N
E
P
V
P
E
Site 78
T1041
I
E
N
S
Y
I
N
T
I
K
T
V
L
R
H
Site 79
T1044
S
Y
I
N
T
I
K
T
V
L
R
H
L
R
E
Site 80
T1055
H
L
R
E
D
Q
H
T
V
L
A
Y
L
Y
E
Site 81
S1066
Y
L
Y
E
I
R
T
S
F
Q
E
F
L
K
R
Site 82
T1165
E
L
N
R
F
Q
D
T
K
R
L
L
Q
D
Y
Site 83
Y1172
T
K
R
L
L
Q
D
Y
Y
W
G
M
E
S
K
Site 84
Y1173
K
R
L
L
Q
D
Y
Y
W
G
M
E
S
K
I
Site 85
T1189
V
E
D
N
K
R
F
T
R
I
P
L
V
Q
L
Site 86
S1198
I
P
L
V
Q
L
D
S
K
D
N
S
E
S
Q
Site 87
S1202
Q
L
D
S
K
D
N
S
E
S
Q
L
R
I
P
Site 88
S1204
D
S
K
D
N
S
E
S
Q
L
R
I
P
L
V
Site 89
T1220
R
I
S
I
S
L
E
T
V
T
P
K
P
K
T
Site 90
T1222
S
I
S
L
E
T
V
T
P
K
P
K
T
K
S
Site 91
T1227
T
V
T
P
K
P
K
T
K
S
V
L
K
G
K
Site 92
S1229
T
P
K
P
K
T
K
S
V
L
K
G
K
M
D
Site 93
S1238
L
K
G
K
M
D
N
S
L
E
N
V
E
S
N
Site 94
S1244
N
S
L
E
N
V
E
S
N
F
E
A
D
E
K
Site 95
S1292
P
A
D
P
K
E
K
S
P
Q
M
G
A
N
K
Site 96
S1319
D
K
K
P
K
G
K
S
P
P
M
A
E
A
T
Site 97
Y1400
E
K
W
L
G
E
R
Y
L
N
E
M
A
S
T
Site 98
S1406
R
Y
L
N
E
M
A
S
T
E
K
L
T
D
V
Site 99
Y1429
T
K
I
Q
N
E
L
Y
L
S
Q
E
D
F
F
Site 100
S1450
V
F
P
D
P
P
P
S
I
R
P
P
P
V
E
Site 101
T1463
V
E
K
E
E
D
G
T
L
T
I
E
Q
L
D
Site 102
S1471
L
T
I
E
Q
L
D
S
L
R
D
Q
F
L
D
Site 103
T1515
P
S
N
W
M
H
L
T
Q
P
E
L
Q
E
L
Site 104
S1524
P
E
L
Q
E
L
T
S
L
L
T
V
N
S
E
Site 105
T1527
Q
E
L
T
S
L
L
T
V
N
S
E
F
V
D
Site 106
S1530
T
S
L
L
T
V
N
S
E
F
V
D
W
R
K
Site 107
T1557
L
E
E
E
L
L
E
T
L
Q
K
F
K
A
V
Site 108
T1571
V
D
K
E
Q
L
G
T
I
T
F
E
Q
Y
M
Site 109
T1573
K
E
Q
L
G
T
I
T
F
E
Q
Y
M
Q
A
Site 110
Y1619
F
F
R
L
F
A
D
Y
E
K
D
P
P
Q
L
Site 111
Y1628
K
D
P
P
Q
L
D
Y
T
Q
M
L
L
Y
F
Site 112
T1629
D
P
P
Q
L
D
Y
T
Q
M
L
L
Y
F
A
Site 113
Y1634
D
Y
T
Q
M
L
L
Y
F
A
C
H
P
D
T
Site 114
T1641
Y
F
A
C
H
P
D
T
V
E
G
V
Y
R
A
Site 115
Y1646
P
D
T
V
E
G
V
Y
R
A
L
S
V
A
V
Site 116
T1671
S
I
P
S
A
E
K
T
S
S
T
D
A
G
P
Site 117
S1673
P
S
A
E
K
T
S
S
T
D
A
G
P
A
E
Site 118
T1700
E
R
K
L
K
D
D
T
E
K
R
E
Q
K
D
Site 119
S1732
L
K
V
F
K
G
G
S
E
A
Q
D
S
N
R
Site 120
S1737
G
G
S
E
A
Q
D
S
N
R
F
A
S
H
L
Site 121
S1742
Q
D
S
N
R
F
A
S
H
L
K
I
E
N
I
Site 122
Y1750
H
L
K
I
E
N
I
Y
A
E
G
F
I
K
T
Site 123
T1757
Y
A
E
G
F
I
K
T
F
Q
D
L
G
A
K
Site 124
S1788
Q
D
L
I
S
N
Y
S
D
Y
K
F
P
D
I
Site 125
Y1790
L
I
S
N
Y
S
D
Y
K
F
P
D
I
K
I
Site 126
S1808
R
S
E
H
V
Q
G
S
D
G
E
R
S
P
S
Site 127
S1813
Q
G
S
D
G
E
R
S
P
S
R
H
T
E
E
Site 128
S1815
S
D
G
E
R
S
P
S
R
H
T
E
E
K
K
Site 129
T1818
E
R
S
P
S
R
H
T
E
E
K
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation