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Updated November 2019
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Protein Info
Short Name:
GREB1L
Full Name:
GREB1-like protein
Alias:
Type:
Mass (Da):
214354
Number AA:
1923
UniProt ID:
Q9C091
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
S
Y
A
G
Q
L
K
S
A
R
F
E
E
A
L
Site 2
S21
F
E
E
A
L
H
N
S
I
E
A
S
L
R
C
Site 3
Y41
R
P
I
F
S
Q
L
Y
L
D
P
D
Q
H
P
Site 4
S50
D
P
D
Q
H
P
F
S
S
A
D
V
K
P
K
Site 5
Y69
D
K
D
L
V
N
R
Y
T
Q
N
G
S
L
D
Site 6
T70
K
D
L
V
N
R
Y
T
Q
N
G
S
L
D
F
Site 7
S74
N
R
Y
T
Q
N
G
S
L
D
F
S
N
N
L
Site 8
S78
Q
N
G
S
L
D
F
S
N
N
L
T
V
N
E
Site 9
T82
L
D
F
S
N
N
L
T
V
N
E
M
E
D
D
Site 10
S96
D
E
D
D
E
E
M
S
D
S
N
S
P
P
I
Site 11
S98
D
D
E
E
M
S
D
S
N
S
P
P
I
P
Y
Site 12
S100
E
E
M
S
D
S
N
S
P
P
I
P
Y
S
Q
Site 13
S106
N
S
P
P
I
P
Y
S
Q
K
P
A
P
E
G
Site 14
S114
Q
K
P
A
P
E
G
S
C
T
T
D
G
F
C
Site 15
T116
P
A
P
E
G
S
C
T
T
D
G
F
C
Q
A
Site 16
S131
G
K
D
L
R
L
V
S
L
C
M
E
Q
I
D
Site 17
Y193
C
G
E
R
G
F
R
Y
F
T
E
F
S
N
H
Site 18
T206
N
H
I
N
L
K
L
T
T
Q
P
K
K
Q
K
Site 19
Y217
K
K
Q
K
H
L
K
Y
Y
L
V
R
S
S
Q
Site 20
Y218
K
Q
K
H
L
K
Y
Y
L
V
R
S
S
Q
G
Site 21
S222
L
K
Y
Y
L
V
R
S
S
Q
G
V
L
S
K
Site 22
S223
K
Y
Y
L
V
R
S
S
Q
G
V
L
S
K
G
Site 23
S228
R
S
S
Q
G
V
L
S
K
G
P
L
I
C
W
Site 24
S243
K
E
C
R
S
R
Q
S
S
A
S
C
H
S
I
Site 25
S244
E
C
R
S
R
Q
S
S
A
S
C
H
S
I
K
Site 26
S246
R
S
R
Q
S
S
A
S
C
H
S
I
K
P
S
Site 27
S249
Q
S
S
A
S
C
H
S
I
K
P
S
S
S
V
Site 28
S253
S
C
H
S
I
K
P
S
S
S
V
S
S
T
V
Site 29
S254
C
H
S
I
K
P
S
S
S
V
S
S
T
V
T
Site 30
S255
H
S
I
K
P
S
S
S
V
S
S
T
V
T
P
Site 31
S257
I
K
P
S
S
S
V
S
S
T
V
T
P
E
N
Site 32
S258
K
P
S
S
S
V
S
S
T
V
T
P
E
N
G
Site 33
T259
P
S
S
S
V
S
S
T
V
T
P
E
N
G
T
Site 34
T261
S
S
V
S
S
T
V
T
P
E
N
G
T
T
N
Site 35
T267
V
T
P
E
N
G
T
T
N
G
Y
K
S
G
F
Site 36
Y270
E
N
G
T
T
N
G
Y
K
S
G
F
T
Q
T
Site 37
S272
G
T
T
N
G
Y
K
S
G
F
T
Q
T
D
A
Site 38
S285
D
A
A
N
G
N
S
S
H
G
G
K
G
S
A
Site 39
S291
S
S
H
G
G
K
G
S
A
S
S
S
T
P
A
Site 40
S293
H
G
G
K
G
S
A
S
S
S
T
P
A
H
T
Site 41
S294
G
G
K
G
S
A
S
S
S
T
P
A
H
T
G
Site 42
S295
G
K
G
S
A
S
S
S
T
P
A
H
T
G
N
Site 43
T296
K
G
S
A
S
S
S
T
P
A
H
T
G
N
Y
Site 44
T300
S
S
S
T
P
A
H
T
G
N
Y
S
L
S
P
Site 45
S304
P
A
H
T
G
N
Y
S
L
S
P
R
P
S
Y
Site 46
S306
H
T
G
N
Y
S
L
S
P
R
P
S
Y
A
S
Site 47
S310
Y
S
L
S
P
R
P
S
Y
A
S
G
D
Q
A
Site 48
Y311
S
L
S
P
R
P
S
Y
A
S
G
D
Q
A
T
Site 49
S313
S
P
R
P
S
Y
A
S
G
D
Q
A
T
M
F
Site 50
T318
Y
A
S
G
D
Q
A
T
M
F
I
S
G
P
P
Site 51
Y333
K
K
R
H
R
G
W
Y
P
G
S
P
L
P
Q
Site 52
S336
H
R
G
W
Y
P
G
S
P
L
P
Q
P
G
L
Site 53
S354
V
P
T
V
R
P
L
S
R
T
E
P
L
L
S
Site 54
T356
T
V
R
P
L
S
R
T
E
P
L
L
S
A
P
Site 55
S361
S
R
T
E
P
L
L
S
A
P
V
P
Q
T
P
Site 56
T370
P
V
P
Q
T
P
L
T
G
I
L
Q
P
R
P
Site 57
Y409
I
G
Y
G
T
L
P
Y
F
Y
G
N
V
G
D
Site 58
Y427
S
P
L
L
V
N
C
Y
K
I
P
Q
L
E
N
Site 59
S445
E
K
L
G
L
T
G
S
Q
F
L
S
V
E
N
Site 60
T487
L
K
A
M
Q
E
F
T
L
R
E
R
A
L
Q
Site 61
S536
N
S
L
A
E
G
I
S
E
T
L
R
T
L
S
Site 62
T538
L
A
E
G
I
S
E
T
L
R
T
L
S
E
M
Site 63
T541
G
I
S
E
T
L
R
T
L
S
E
M
R
H
Y
Site 64
S543
S
E
T
L
R
T
L
S
E
M
R
H
Y
Q
R
Site 65
Y548
T
L
S
E
M
R
H
Y
Q
R
L
P
D
Y
V
Site 66
S578
V
V
L
G
Q
H
Q
S
R
A
L
A
E
S
M
Site 67
S584
Q
S
R
A
L
A
E
S
M
L
T
T
S
E
F
Site 68
T613
F
L
A
S
H
F
K
T
T
S
L
G
D
D
L
Site 69
S615
A
S
H
F
K
T
T
S
L
G
D
D
L
D
K
Site 70
S634
M
Q
Q
R
R
G
D
S
V
V
T
P
F
D
G
Site 71
T637
R
R
G
D
S
V
V
T
P
F
D
G
D
L
N
Site 72
S648
G
D
L
N
E
C
V
S
P
Q
E
A
A
A
M
Site 73
Y671
D
N
E
T
F
H
I
Y
Q
P
Q
L
T
V
A
Site 74
T676
H
I
Y
Q
P
Q
L
T
V
A
R
K
L
L
S
Site 75
S693
C
A
I
A
D
S
G
S
Q
S
L
D
L
G
H
Site 76
S695
I
A
D
S
G
S
Q
S
L
D
L
G
H
F
S
Site 77
T740
L
G
L
E
E
N
G
T
A
H
Q
R
A
E
K
Site 78
Y748
A
H
Q
R
A
E
K
Y
V
V
R
L
D
N
E
Site 79
T773
R
V
K
Q
N
P
Y
T
L
F
V
L
V
H
D
Site 80
T787
D
N
S
H
V
E
L
T
S
V
I
S
G
S
L
Site 81
S793
L
T
S
V
I
S
G
S
L
S
H
S
E
P
S
Site 82
S795
S
V
I
S
G
S
L
S
H
S
E
P
S
H
G
Site 83
S797
I
S
G
S
L
S
H
S
E
P
S
H
G
L
A
Site 84
T830
Q
V
S
S
F
P
Y
T
L
Q
T
Q
Q
S
R
Site 85
T833
S
F
P
Y
T
L
Q
T
Q
Q
S
R
I
S
S
Site 86
S836
Y
T
L
Q
T
Q
Q
S
R
I
S
S
S
N
E
Site 87
S839
Q
T
Q
Q
S
R
I
S
S
S
N
E
V
H
W
Site 88
S840
T
Q
Q
S
R
I
S
S
S
N
E
V
H
W
I
Site 89
S841
Q
Q
S
R
I
S
S
S
N
E
V
H
W
I
Q
Site 90
T851
V
H
W
I
Q
L
D
T
G
E
D
V
G
C
E
Site 91
Y862
V
G
C
E
E
K
L
Y
F
G
L
S
E
Y
S
Site 92
S866
E
K
L
Y
F
G
L
S
E
Y
S
K
S
L
Q
Site 93
S871
G
L
S
E
Y
S
K
S
L
Q
W
G
I
T
S
Site 94
S878
S
L
Q
W
G
I
T
S
P
L
L
R
C
D
E
Site 95
T886
P
L
L
R
C
D
E
T
F
E
K
M
V
N
T
Site 96
Y898
V
N
T
L
L
E
R
Y
P
R
L
H
S
M
V
Site 97
S903
E
R
Y
P
R
L
H
S
M
V
V
R
C
Y
L
Site 98
S927
M
A
L
T
T
M
A
S
L
R
D
H
S
T
P
Site 99
S932
M
A
S
L
R
D
H
S
T
P
E
T
L
S
I
Site 100
T933
A
S
L
R
D
H
S
T
P
E
T
L
S
I
M
Site 101
T936
R
D
H
S
T
P
E
T
L
S
I
M
D
D
L
Site 102
S938
H
S
T
P
E
T
L
S
I
M
D
D
L
I
S
Site 103
S945
S
I
M
D
D
L
I
S
S
P
G
K
N
K
S
Site 104
S946
I
M
D
D
L
I
S
S
P
G
K
N
K
S
G
Site 105
S952
S
S
P
G
K
N
K
S
G
R
G
H
M
L
I
Site 106
S1011
H
F
V
A
R
L
K
S
W
R
G
N
E
P
E
Site 107
T1024
P
E
E
W
I
P
R
T
Y
Q
D
L
D
G
L
Site 108
Y1025
E
E
W
I
P
R
T
Y
Q
D
L
D
G
L
P
Site 109
T1046
G
K
D
P
L
G
E
T
F
P
R
S
L
K
Y
Site 110
S1050
L
G
E
T
F
P
R
S
L
K
Y
C
D
L
R
Site 111
Y1053
T
F
P
R
S
L
K
Y
C
D
L
R
L
I
D
Site 112
S1061
C
D
L
R
L
I
D
S
S
Y
L
T
R
T
A
Site 113
S1062
D
L
R
L
I
D
S
S
Y
L
T
R
T
A
L
Site 114
Y1063
L
R
L
I
D
S
S
Y
L
T
R
T
A
L
E
Site 115
T1065
L
I
D
S
S
Y
L
T
R
T
A
L
E
Q
E
Site 116
S1095
P
T
V
A
L
D
L
S
G
K
E
Q
E
R
A
Site 117
S1105
E
Q
E
R
A
A
V
S
E
N
D
S
D
E
L
Site 118
S1109
A
A
V
S
E
N
D
S
D
E
L
L
I
D
L
Site 119
S1121
I
D
L
E
R
P
Q
S
N
S
S
A
V
T
G
Site 120
S1123
L
E
R
P
Q
S
N
S
S
A
V
T
G
T
S
Site 121
S1124
E
R
P
Q
S
N
S
S
A
V
T
G
T
S
G
Site 122
T1127
Q
S
N
S
S
A
V
T
G
T
S
G
S
I
M
Site 123
S1130
S
S
A
V
T
G
T
S
G
S
I
M
E
N
G
Site 124
S1139
S
I
M
E
N
G
V
S
S
S
S
T
A
D
K
Site 125
S1142
E
N
G
V
S
S
S
S
T
A
D
K
S
Q
K
Site 126
T1143
N
G
V
S
S
S
S
T
A
D
K
S
Q
K
Q
Site 127
S1147
S
S
S
T
A
D
K
S
Q
K
Q
S
L
T
P
Site 128
S1151
A
D
K
S
Q
K
Q
S
L
T
P
S
F
Q
S
Site 129
T1153
K
S
Q
K
Q
S
L
T
P
S
F
Q
S
P
A
Site 130
S1155
Q
K
Q
S
L
T
P
S
F
Q
S
P
A
T
S
Site 131
S1162
S
F
Q
S
P
A
T
S
L
G
L
D
E
G
V
Site 132
S1188
T
L
K
Q
E
C
D
S
L
G
P
Q
M
A
S
Site 133
S1195
S
L
G
P
Q
M
A
S
S
T
T
S
K
P
S
Site 134
S1196
L
G
P
Q
M
A
S
S
T
T
S
K
P
S
S
Site 135
T1197
G
P
Q
M
A
S
S
T
T
S
K
P
S
S
S
Site 136
T1198
P
Q
M
A
S
S
T
T
S
K
P
S
S
S
S
Site 137
S1199
Q
M
A
S
S
T
T
S
K
P
S
S
S
S
S
Site 138
S1202
S
S
T
T
S
K
P
S
S
S
S
S
G
P
R
Site 139
S1203
S
T
T
S
K
P
S
S
S
S
S
G
P
R
T
Site 140
S1204
T
T
S
K
P
S
S
S
S
S
G
P
R
T
L
Site 141
S1205
T
S
K
P
S
S
S
S
S
G
P
R
T
L
P
Site 142
S1206
S
K
P
S
S
S
S
S
G
P
R
T
L
P
W
Site 143
T1210
S
S
S
S
G
P
R
T
L
P
W
P
G
Q
P
Site 144
S1240
I
L
S
K
A
A
Y
S
L
L
G
S
Q
K
S
Site 145
S1244
A
A
Y
S
L
L
G
S
Q
K
S
G
K
L
P
Site 146
S1247
S
L
L
G
S
Q
K
S
G
K
L
P
S
S
S
Site 147
S1252
Q
K
S
G
K
L
P
S
S
S
S
L
L
P
H
Site 148
S1253
K
S
G
K
L
P
S
S
S
S
L
L
P
H
A
Site 149
S1254
S
G
K
L
P
S
S
S
S
L
L
P
H
A
D
Site 150
S1255
G
K
L
P
S
S
S
S
L
L
P
H
A
D
V
Site 151
S1277
P
L
L
N
K
D
M
S
S
E
E
Q
S
L
Y
Site 152
S1278
L
L
N
K
D
M
S
S
E
E
Q
S
L
Y
Y
Site 153
Y1284
S
S
E
E
Q
S
L
Y
Y
R
Q
W
T
L
A
Site 154
Y1285
S
E
E
Q
S
L
Y
Y
R
Q
W
T
L
A
R
Site 155
Y1298
A
R
Q
H
H
A
D
Y
S
N
Q
L
D
P
A
Site 156
S1299
R
Q
H
H
A
D
Y
S
N
Q
L
D
P
A
S
Site 157
S1306
S
N
Q
L
D
P
A
S
G
T
R
N
F
H
P
Site 158
T1319
H
P
R
R
L
L
L
T
G
P
P
Q
V
G
K
Site 159
T1327
G
P
P
Q
V
G
K
T
G
S
Y
L
Q
F
L
Site 160
S1329
P
Q
V
G
K
T
G
S
Y
L
Q
F
L
R
I
Site 161
Y1350
R
L
L
E
V
D
V
Y
D
E
E
E
I
N
T
Site 162
T1357
Y
D
E
E
E
I
N
T
D
H
N
E
S
S
E
Site 163
S1362
I
N
T
D
H
N
E
S
S
E
V
S
Q
S
E
Site 164
S1363
N
T
D
H
N
E
S
S
E
V
S
Q
S
E
G
Site 165
S1366
H
N
E
S
S
E
V
S
Q
S
E
G
E
P
W
Site 166
S1368
E
S
S
E
V
S
Q
S
E
G
E
P
W
P
D
Site 167
S1378
E
P
W
P
D
I
E
S
F
S
K
M
P
F
D
Site 168
S1387
S
K
M
P
F
D
V
S
V
H
D
P
K
Y
S
Site 169
S1394
S
V
H
D
P
K
Y
S
L
M
S
L
V
Y
T
Site 170
S1415
K
Q
E
V
I
K
E
S
K
V
E
E
P
R
K
Site 171
T1425
E
E
P
R
K
R
E
T
V
S
I
M
L
T
K
Site 172
S1453
R
Q
Y
M
D
F
T
S
A
S
Q
M
S
D
S
Site 173
S1455
Y
M
D
F
T
S
A
S
Q
M
S
D
S
T
L
Site 174
S1458
F
T
S
A
S
Q
M
S
D
S
T
L
H
A
F
Site 175
T1461
A
S
Q
M
S
D
S
T
L
H
A
F
T
F
S
Site 176
S1468
T
L
H
A
F
T
F
S
S
S
M
L
G
E
E
Site 177
S1470
H
A
F
T
F
S
S
S
M
L
G
E
E
V
Q
Site 178
Y1479
L
G
E
E
V
Q
L
Y
F
I
I
P
K
S
K
Site 179
S1488
I
I
P
K
S
K
E
S
H
F
V
F
S
K
Q
Site 180
S1501
K
Q
G
K
H
L
E
S
M
R
L
P
L
V
S
Site 181
S1508
S
M
R
L
P
L
V
S
D
K
N
L
N
A
V
Site 182
S1517
K
N
L
N
A
V
K
S
P
I
F
T
P
S
S
Site 183
T1521
A
V
K
S
P
I
F
T
P
S
S
G
R
H
E
Site 184
S1523
K
S
P
I
F
T
P
S
S
G
R
H
E
H
G
Site 185
S1524
S
P
I
F
T
P
S
S
G
R
H
E
H
G
L
Site 186
Y1552
H
L
L
V
V
K
E
Y
E
M
P
L
Y
R
K
Site 187
Y1557
K
E
Y
E
M
P
L
Y
R
K
Y
W
P
N
H
Site 188
S1589
R
F
L
I
K
E
L
S
Y
H
N
L
E
L
E
Site 189
S1634
H
S
V
Q
E
P
S
S
Q
P
M
E
V
G
V
Site 190
S1643
P
M
E
V
G
V
S
S
K
N
V
S
L
K
T
Site 191
S1647
G
V
S
S
K
N
V
S
L
K
T
V
L
Q
H
Site 192
T1650
S
K
N
V
S
L
K
T
V
L
Q
H
I
E
A
Site 193
S1674
L
G
I
Q
K
W
S
S
K
L
T
S
Q
S
L
Site 194
T1677
Q
K
W
S
S
K
L
T
S
Q
S
L
K
A
P
Site 195
S1678
K
W
S
S
K
L
T
S
Q
S
L
K
A
P
F
Site 196
S1680
S
S
K
L
T
S
Q
S
L
K
A
P
F
S
R
Site 197
S1686
Q
S
L
K
A
P
F
S
R
C
H
V
H
D
F
Site 198
T1701
I
L
L
N
T
D
L
T
Q
N
V
Q
Y
D
F
Site 199
Y1711
V
Q
Y
D
F
N
R
Y
F
C
E
D
A
D
F
Site 200
T1722
D
A
D
F
N
L
R
T
N
S
S
G
L
L
I
Site 201
S1724
D
F
N
L
R
T
N
S
S
G
L
L
I
C
R
Site 202
S1797
E
K
F
L
Q
H
A
S
Y
K
L
F
P
K
A
Site 203
Y1829
G
P
E
V
A
I
C
Y
I
S
S
R
P
H
S
Site 204
S1831
E
V
A
I
C
Y
I
S
S
R
P
H
S
S
N
Site 205
S1836
Y
I
S
S
R
P
H
S
S
N
V
N
C
E
G
Site 206
S1837
I
S
S
R
P
H
S
S
N
V
N
C
E
G
V
Site 207
S1882
V
I
C
Q
D
R
S
S
L
R
Q
T
I
V
R
Site 208
T1886
D
R
S
S
L
R
Q
T
I
V
R
L
E
L
E
Site 209
T1906
R
L
R
D
E
F
Q
T
A
N
S
S
D
D
K
Site 210
S1909
D
E
F
Q
T
A
N
S
S
D
D
K
P
L
Y
Site 211
S1910
E
F
Q
T
A
N
S
S
D
D
K
P
L
Y
F
Site 212
Y1916
S
S
D
D
K
P
L
Y
F
L
T
G
R
H
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation