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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
K23
Full Name:
Keratin, type I cytoskeletal 23
Alias:
CK23; CK-23; Cytokeratin-23; HAIK1; K1C23; KRT23
Type:
Cytoskeletal protein
Mass (Da):
48131
Number AA:
422
UniProt ID:
Q9C075
International Prot ID:
IPI00304458
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005882
Uniprot
OncoNet
Molecular Function:
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
N
S
G
H
S
F
S
Q
T
P
S
A
Site 2
S8
M
N
S
G
H
S
F
S
Q
T
P
S
A
S
F
Site 3
T10
S
G
H
S
F
S
Q
T
P
S
A
S
F
H
G
Site 4
S12
H
S
F
S
Q
T
P
S
A
S
F
H
G
A
G
Site 5
S14
F
S
Q
T
P
S
A
S
F
H
G
A
G
G
G
Site 6
S27
G
G
W
G
R
P
R
S
F
P
R
A
P
T
V
Site 7
T33
R
S
F
P
R
A
P
T
V
H
G
G
A
G
G
Site 8
S44
G
A
G
G
A
R
I
S
L
S
F
T
T
R
S
Site 9
S46
G
G
A
R
I
S
L
S
F
T
T
R
S
C
P
Site 10
T48
A
R
I
S
L
S
F
T
T
R
S
C
P
P
P
Site 11
S51
S
L
S
F
T
T
R
S
C
P
P
P
G
G
S
Site 12
S58
S
C
P
P
P
G
G
S
W
G
S
G
R
S
S
Site 13
S61
P
P
G
G
S
W
G
S
G
R
S
S
P
L
L
Site 14
S65
S
W
G
S
G
R
S
S
P
L
L
G
G
N
G
Site 15
S85
N
L
N
D
R
L
A
S
Y
L
E
K
V
R
A
Site 16
Y86
L
N
D
R
L
A
S
Y
L
E
K
V
R
A
L
Site 17
S115
H
Q
Q
R
D
P
G
S
K
K
D
Y
S
Q
Y
Site 18
Y119
D
P
G
S
K
K
D
Y
S
Q
Y
E
E
N
I
Site 19
S120
P
G
S
K
K
D
Y
S
Q
Y
E
E
N
I
T
Site 20
Y122
S
K
K
D
Y
S
Q
Y
E
E
N
I
T
H
L
Site 21
T127
S
Q
Y
E
E
N
I
T
H
L
Q
E
Q
I
V
Site 22
Y161
V
D
D
F
N
L
K
Y
E
N
E
H
S
F
K
Site 23
S166
L
K
Y
E
N
E
H
S
F
K
K
D
L
E
I
Site 24
T181
E
V
E
G
L
R
R
T
L
D
N
L
T
I
V
Site 25
T186
R
R
T
L
D
N
L
T
I
V
T
T
D
L
E
Site 26
T189
L
D
N
L
T
I
V
T
T
D
L
E
Q
E
V
Site 27
T190
D
N
L
T
I
V
T
T
D
L
E
Q
E
V
E
Site 28
Y248
L
E
D
M
R
Q
E
Y
E
L
I
I
K
K
K
Site 29
T261
K
K
H
R
D
L
D
T
W
Y
K
E
Q
S
A
Site 30
Y263
H
R
D
L
D
T
W
Y
K
E
Q
S
A
A
M
Site 31
S267
D
T
W
Y
K
E
Q
S
A
A
M
S
Q
E
A
Site 32
S271
K
E
Q
S
A
A
M
S
Q
E
A
A
S
P
A
Site 33
S276
A
M
S
Q
E
A
A
S
P
A
T
V
Q
S
R
Site 34
T279
Q
E
A
A
S
P
A
T
V
Q
S
R
Q
G
D
Site 35
T293
D
I
H
E
L
K
R
T
F
Q
A
L
E
I
D
Site 36
T303
A
L
E
I
D
L
Q
T
Q
Y
S
T
K
S
A
Site 37
Y305
E
I
D
L
Q
T
Q
Y
S
T
K
S
A
L
E
Site 38
S306
I
D
L
Q
T
Q
Y
S
T
K
S
A
L
E
N
Site 39
S309
Q
T
Q
Y
S
T
K
S
A
L
E
N
M
L
S
Site 40
S316
S
A
L
E
N
M
L
S
E
T
Q
S
R
Y
S
Site 41
T318
L
E
N
M
L
S
E
T
Q
S
R
Y
S
C
K
Site 42
S320
N
M
L
S
E
T
Q
S
R
Y
S
C
K
L
Q
Site 43
S323
S
E
T
Q
S
R
Y
S
C
K
L
Q
D
M
Q
Site 44
T341
S
H
Y
E
E
E
L
T
Q
L
R
H
E
L
E
Site 45
Y354
L
E
R
Q
N
N
E
Y
Q
V
L
L
G
I
K
Site 46
T369
T
H
L
E
K
E
I
T
T
Y
R
R
L
L
E
Site 47
T370
H
L
E
K
E
I
T
T
Y
R
R
L
L
E
G
Site 48
Y371
L
E
K
E
I
T
T
Y
R
R
L
L
E
G
E
Site 49
S379
R
R
L
L
E
G
E
S
E
G
T
R
E
E
S
Site 50
T382
L
E
G
E
S
E
G
T
R
E
E
S
K
S
S
Site 51
S386
S
E
G
T
R
E
E
S
K
S
S
M
K
V
S
Site 52
S388
G
T
R
E
E
S
K
S
S
M
K
V
S
A
T
Site 53
S389
T
R
E
E
S
K
S
S
M
K
V
S
A
T
P
Site 54
S393
S
K
S
S
M
K
V
S
A
T
P
K
I
K
A
Site 55
T395
S
S
M
K
V
S
A
T
P
K
I
K
A
I
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation