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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NLRP1
Full Name:
NACHT, LRR and PYD domains-containing protein 1
Alias:
Caspase recruitment domain-containing protein 7;Death effector filament-forming ced-4-like apoptosis protein;Nucleotide-binding domain and caspase recruitment domain
Type:
Mass (Da):
165866
Number AA:
1473
UniProt ID:
Q9C000
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
A
W
G
R
L
A
C
Y
L
E
F
L
K
K
E
Site 2
S34
L
L
A
N
K
A
H
S
R
S
S
S
G
E
T
Site 3
S36
A
N
K
A
H
S
R
S
S
S
G
E
T
P
A
Site 4
S37
N
K
A
H
S
R
S
S
S
G
E
T
P
A
Q
Site 5
S38
K
A
H
S
R
S
S
S
G
E
T
P
A
Q
P
Site 6
T41
S
R
S
S
S
G
E
T
P
A
Q
P
E
K
T
Site 7
S81
W
E
Q
M
G
L
R
S
L
C
A
Q
A
Q
E
Site 8
S93
A
Q
E
G
A
G
H
S
P
S
F
P
Y
S
P
Site 9
S95
E
G
A
G
H
S
P
S
F
P
Y
S
P
S
E
Site 10
Y98
G
H
S
P
S
F
P
Y
S
P
S
E
P
H
L
Site 11
S99
H
S
P
S
F
P
Y
S
P
S
E
P
H
L
G
Site 12
S101
P
S
F
P
Y
S
P
S
E
P
H
L
G
S
P
Site 13
S107
P
S
E
P
H
L
G
S
P
S
Q
P
T
S
T
Site 14
S109
E
P
H
L
G
S
P
S
Q
P
T
S
T
A
V
Site 15
S113
G
S
P
S
Q
P
T
S
T
A
V
L
M
P
W
Site 16
S132
P
A
G
C
T
Q
G
S
E
R
R
V
L
R
Q
Site 17
T143
V
L
R
Q
L
P
D
T
S
G
R
R
W
R
E
Site 18
S144
L
R
Q
L
P
D
T
S
G
R
R
W
R
E
I
Site 19
S152
G
R
R
W
R
E
I
S
A
S
L
L
Y
Q
A
Site 20
S154
R
W
R
E
I
S
A
S
L
L
Y
Q
A
L
P
Site 21
S162
L
L
Y
Q
A
L
P
S
S
P
D
H
E
S
P
Site 22
S163
L
Y
Q
A
L
P
S
S
P
D
H
E
S
P
S
Site 23
S168
P
S
S
P
D
H
E
S
P
S
Q
E
S
P
N
Site 24
S170
S
P
D
H
E
S
P
S
Q
E
S
P
N
A
P
Site 25
S173
H
E
S
P
S
Q
E
S
P
N
A
P
T
S
T
Site 26
S179
E
S
P
N
A
P
T
S
T
A
V
L
G
S
W
Site 27
T180
S
P
N
A
P
T
S
T
A
V
L
G
S
W
G
Site 28
S185
T
S
T
A
V
L
G
S
W
G
S
P
P
Q
P
Site 29
S193
W
G
S
P
P
Q
P
S
L
A
P
R
E
Q
E
Site 30
T204
R
E
Q
E
A
P
G
T
Q
W
P
L
D
E
T
Site 31
Y216
D
E
T
S
G
I
Y
Y
T
E
I
R
E
R
E
Site 32
S227
R
E
R
E
R
E
K
S
E
K
G
R
P
P
W
Site 33
T240
P
W
A
A
V
V
G
T
P
P
Q
A
H
T
S
Site 34
S247
T
P
P
Q
A
H
T
S
L
Q
P
H
H
H
P
Site 35
S258
H
H
H
P
W
E
P
S
V
R
E
S
L
C
S
Site 36
T266
V
R
E
S
L
C
S
T
W
P
W
K
N
E
D
Site 37
S291
L
Q
R
P
H
P
R
S
Q
D
P
L
V
K
R
Site 38
Y303
V
K
R
S
W
P
D
Y
V
E
E
N
R
G
H
Site 39
S341
G
A
A
G
I
G
K
S
T
L
A
R
Q
V
K
Site 40
Y357
A
W
G
R
G
Q
L
Y
G
D
R
F
Q
H
V
Site 41
Y366
D
R
F
Q
H
V
F
Y
F
S
C
R
E
L
A
Site 42
S375
S
C
R
E
L
A
Q
S
K
V
V
S
L
A
E
Site 43
T389
E
L
I
G
K
D
G
T
A
T
P
A
P
I
R
Site 44
T391
I
G
K
D
G
T
A
T
P
A
P
I
R
Q
I
Site 45
S400
A
P
I
R
Q
I
L
S
R
P
E
R
L
L
F
Site 46
S431
S
E
L
C
L
H
W
S
Q
P
Q
P
A
D
A
Site 47
S482
W
V
E
V
L
G
F
S
E
S
S
R
K
E
Y
Site 48
S484
E
V
L
G
F
S
E
S
S
R
K
E
Y
F
Y
Site 49
Y489
S
E
S
S
R
K
E
Y
F
Y
R
Y
F
T
D
Site 50
Y491
S
S
R
K
E
Y
F
Y
R
Y
F
T
D
E
R
Site 51
Y493
R
K
E
Y
F
Y
R
Y
F
T
D
E
R
Q
A
Site 52
T495
E
Y
F
Y
R
Y
F
T
D
E
R
Q
A
I
R
Site 53
S509
R
A
F
R
L
V
K
S
N
K
E
L
W
A
L
Site 54
T541
M
K
R
K
E
K
L
T
L
T
S
K
T
T
T
Site 55
T584
E
G
I
W
Q
K
K
T
L
F
S
P
D
D
L
Site 56
S587
W
Q
K
K
T
L
F
S
P
D
D
L
R
K
H
Site 57
Y635
E
F
F
A
A
M
S
Y
V
L
E
D
E
K
G
Site 58
S647
E
K
G
R
G
K
H
S
N
C
I
I
D
L
E
Site 59
S679
R
F
L
L
G
L
L
S
D
E
G
E
R
E
M
Site 60
S718
L
Q
P
H
S
L
E
S
L
H
C
L
Y
E
T
Site 61
Y723
L
E
S
L
H
C
L
Y
E
T
R
N
K
T
F
Site 62
T729
L
Y
E
T
R
N
K
T
F
L
T
Q
V
M
A
Site 63
T778
E
G
R
Q
H
R
S
T
W
S
P
T
M
V
V
Site 64
S780
R
Q
H
R
S
T
W
S
P
T
M
V
V
L
F
Site 65
S816
N
L
K
E
L
D
L
S
G
N
S
L
S
H
S
Site 66
S819
E
L
D
L
S
G
N
S
L
S
H
S
A
V
K
Site 67
S821
D
L
S
G
N
S
L
S
H
S
A
V
K
S
L
Site 68
S823
S
G
N
S
L
S
H
S
A
V
K
S
L
C
K
Site 69
S827
L
S
H
S
A
V
K
S
L
C
K
T
L
R
R
Site 70
T831
A
V
K
S
L
C
K
T
L
R
R
P
R
C
L
Site 71
T866
F
G
L
R
A
N
Q
T
L
T
E
L
D
L
S
Site 72
T868
L
R
A
N
Q
T
L
T
E
L
D
L
S
F
N
Site 73
S893
C
Q
R
L
R
Q
P
S
C
K
L
Q
R
L
Q
Site 74
S919
Q
D
L
A
S
V
L
S
A
S
P
S
L
K
E
Site 75
S923
S
V
L
S
A
S
P
S
L
K
E
L
D
L
Q
Site 76
T961
I
R
L
G
L
D
Q
T
T
L
S
D
E
M
R
Site 77
T962
R
L
G
L
D
Q
T
T
L
S
D
E
M
R
Q
Site 78
S964
G
L
D
Q
T
T
L
S
D
E
M
R
Q
E
L
Site 79
S985
K
P
Q
L
L
I
F
S
R
R
K
P
S
V
M
Site 80
S990
I
F
S
R
R
K
P
S
V
M
T
P
T
E
G
Site 81
T993
R
R
K
P
S
V
M
T
P
T
E
G
L
D
T
Site 82
T1000
T
P
T
E
G
L
D
T
G
E
M
S
N
S
T
Site 83
S1004
G
L
D
T
G
E
M
S
N
S
T
S
S
L
K
Site 84
S1006
D
T
G
E
M
S
N
S
T
S
S
L
K
R
Q
Site 85
S1008
G
E
M
S
N
S
T
S
S
L
K
R
Q
R
L
Site 86
S1009
E
M
S
N
S
T
S
S
L
K
R
Q
R
L
G
Site 87
S1017
L
K
R
Q
R
L
G
S
E
R
A
A
S
H
V
Site 88
S1022
L
G
S
E
R
A
A
S
H
V
A
Q
A
N
L
Site 89
S1048
A
E
I
A
E
E
S
S
P
E
V
V
P
V
E
Site 90
S1064
L
C
V
P
S
P
A
S
Q
G
D
L
H
T
K
Site 91
Y1098
V
D
K
E
K
N
L
Y
R
V
H
F
P
V
A
Site 92
Y1108
H
F
P
V
A
G
S
Y
R
W
P
N
T
G
L
Site 93
T1247
R
V
H
P
E
E
V
T
F
H
L
Y
L
I
P
Site 94
S1258
Y
L
I
P
S
D
C
S
I
R
K
A
I
D
D
Site 95
T1282
I
H
K
P
P
P
L
T
P
L
Y
M
G
C
R
Site 96
Y1290
P
L
Y
M
G
C
R
Y
T
V
S
G
S
G
S
Site 97
T1291
L
Y
M
G
C
R
Y
T
V
S
G
S
G
S
G
Site 98
Y1311
P
K
E
L
E
L
C
Y
R
S
P
G
E
D
Q
Site 99
S1313
E
L
E
L
C
Y
R
S
P
G
E
D
Q
L
F
Site 100
S1321
P
G
E
D
Q
L
F
S
E
F
Y
V
G
H
L
Site 101
Y1324
D
Q
L
F
S
E
F
Y
V
G
H
L
G
S
G
Site 102
T1343
V
K
D
K
K
D
E
T
L
V
W
E
A
L
V
Site 103
Y1385
L
L
H
F
V
D
Q
Y
R
E
Q
L
I
A
R
Site 104
S1409
K
L
H
G
Q
V
L
S
Q
E
Q
Y
E
R
V
Site 105
Y1413
Q
V
L
S
Q
E
Q
Y
E
R
V
L
A
E
N
Site 106
S1424
L
A
E
N
T
R
P
S
Q
M
R
K
L
F
S
Site 107
S1431
S
Q
M
R
K
L
F
S
L
S
Q
S
W
D
R
Site 108
S1433
M
R
K
L
F
S
L
S
Q
S
W
D
R
K
C
Site 109
S1435
K
L
F
S
L
S
Q
S
W
D
R
K
C
K
D
Site 110
Y1445
R
K
C
K
D
G
L
Y
Q
A
L
K
E
T
H
Site 111
S1464
M
E
L
W
E
K
G
S
K
K
G
L
L
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation