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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CD244
Full Name:
Natural killer cell receptor 2B4
Alias:
2B4; CD244 molecule, natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; NAIL; NK cell activation inducing ligand NAIL; NKR2B4; Nmrk; SLAMF4
Type:
Regulatory protein. Modulates other receptor-ligand interactions to enhance leukocyte activation.
Mass (Da):
41616
Number AA:
370
UniProt ID:
Q9BZW8
International Prot ID:
IPI00411526
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S76
W
E
N
G
S
L
P
S
N
T
S
N
D
R
F
Site 2
S260
R
K
R
K
E
K
Q
S
E
T
S
P
K
E
F
Site 3
S263
K
E
K
Q
S
E
T
S
P
K
E
F
L
T
I
Site 4
Y271
P
K
E
F
L
T
I
Y
E
D
V
K
D
L
K
Site 5
T279
E
D
V
K
D
L
K
T
R
R
N
H
E
Q
E
Site 6
T288
R
N
H
E
Q
E
Q
T
F
P
G
G
G
S
T
Site 7
S294
Q
T
F
P
G
G
G
S
T
I
Y
S
M
I
Q
Site 8
Y297
P
G
G
G
S
T
I
Y
S
M
I
Q
S
Q
S
Site 9
S298
G
G
G
S
T
I
Y
S
M
I
Q
S
Q
S
S
Site 10
S302
T
I
Y
S
M
I
Q
S
Q
S
S
A
P
T
S
Site 11
S304
Y
S
M
I
Q
S
Q
S
S
A
P
T
S
Q
E
Site 12
S305
S
M
I
Q
S
Q
S
S
A
P
T
S
Q
E
P
Site 13
S309
S
Q
S
S
A
P
T
S
Q
E
P
A
Y
T
L
Site 14
Y314
P
T
S
Q
E
P
A
Y
T
L
Y
S
L
I
Q
Site 15
T315
T
S
Q
E
P
A
Y
T
L
Y
S
L
I
Q
P
Site 16
Y317
Q
E
P
A
Y
T
L
Y
S
L
I
Q
P
S
R
Site 17
S318
E
P
A
Y
T
L
Y
S
L
I
Q
P
S
R
K
Site 18
S326
L
I
Q
P
S
R
K
S
G
S
R
K
R
N
H
Site 19
S328
Q
P
S
R
K
S
G
S
R
K
R
N
H
S
P
Site 20
S334
G
S
R
K
R
N
H
S
P
S
F
N
S
T
I
Site 21
S336
R
K
R
N
H
S
P
S
F
N
S
T
I
Y
E
Site 22
T340
H
S
P
S
F
N
S
T
I
Y
E
V
I
G
K
Site 23
Y342
P
S
F
N
S
T
I
Y
E
V
I
G
K
S
Q
Site 24
S348
I
Y
E
V
I
G
K
S
Q
P
K
A
Q
N
P
Site 25
S359
A
Q
N
P
A
R
L
S
R
K
E
L
E
N
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation