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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRIM8
Full Name:
Probable E3 ubiquitin-protein ligase TRIM8
Alias:
Glioblastoma-expressed RING finger protein;RING finger protein 27;Tripartite motif-containing protein 8
Type:
Mass (Da):
61489
Number AA:
551
UniProt ID:
Q9BZR9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T121
C
C
Q
S
H
V
Q
T
H
L
Q
Q
P
S
T
Site 2
T128
T
H
L
Q
Q
P
S
T
A
R
G
H
L
L
V
Site 3
Y154
Q
H
N
A
Y
R
L
Y
H
C
E
A
E
Q
V
Site 4
S178
S
G
A
H
Q
G
H
S
V
C
D
V
E
I
R
Site 5
Y212
Q
D
I
E
D
Q
L
Y
K
L
E
S
D
K
R
Site 6
S216
D
Q
L
Y
K
L
E
S
D
K
R
L
V
E
E
Site 7
Y236
K
E
E
V
R
L
Q
Y
E
K
L
H
Q
L
L
Site 8
T250
L
D
E
D
L
R
Q
T
V
E
V
L
D
K
A
Site 9
T293
L
Q
L
L
F
D
K
T
E
D
V
S
F
M
K
Site 10
S297
F
D
K
T
E
D
V
S
F
M
K
N
T
K
S
Site 11
S304
S
F
M
K
N
T
K
S
V
K
I
L
M
D
R
Site 12
T312
V
K
I
L
M
D
R
T
Q
T
C
T
S
S
S
Site 13
T314
I
L
M
D
R
T
Q
T
C
T
S
S
S
L
S
Site 14
T316
M
D
R
T
Q
T
C
T
S
S
S
L
S
P
T
Site 15
S317
D
R
T
Q
T
C
T
S
S
S
L
S
P
T
K
Site 16
S318
R
T
Q
T
C
T
S
S
S
L
S
P
T
K
I
Site 17
S319
T
Q
T
C
T
S
S
S
L
S
P
T
K
I
G
Site 18
S321
T
C
T
S
S
S
L
S
P
T
K
I
G
H
L
Site 19
T323
T
S
S
S
L
S
P
T
K
I
G
H
L
N
S
Site 20
S330
T
K
I
G
H
L
N
S
K
L
F
L
N
E
V
Site 21
S370
P
L
Y
P
C
G
V
S
S
S
G
A
E
K
R
Site 22
S372
Y
P
C
G
V
S
S
S
G
A
E
K
R
K
H
Site 23
S380
G
A
E
K
R
K
H
S
T
A
F
P
E
A
S
Site 24
S387
S
T
A
F
P
E
A
S
F
L
E
T
S
S
G
Site 25
T391
P
E
A
S
F
L
E
T
S
S
G
P
V
G
G
Site 26
S392
E
A
S
F
L
E
T
S
S
G
P
V
G
G
Q
Site 27
S393
A
S
F
L
E
T
S
S
G
P
V
G
G
Q
Y
Site 28
Y400
S
G
P
V
G
G
Q
Y
G
A
A
G
T
A
S
Site 29
S407
Y
G
A
A
G
T
A
S
G
E
G
Q
S
G
Q
Site 30
S412
T
A
S
G
E
G
Q
S
G
Q
P
L
G
P
C
Site 31
S420
G
Q
P
L
G
P
C
S
S
T
Q
H
L
V
A
Site 32
S437
G
G
A
Q
P
V
H
S
S
P
V
F
P
P
S
Site 33
S438
G
A
Q
P
V
H
S
S
P
V
F
P
P
S
Q
Site 34
S444
S
S
P
V
F
P
P
S
Q
Y
P
N
G
S
A
Site 35
Y446
P
V
F
P
P
S
Q
Y
P
N
G
S
A
A
Q
Site 36
S450
P
S
Q
Y
P
N
G
S
A
A
Q
Q
P
M
L
Site 37
Y460
Q
Q
P
M
L
P
Q
Y
G
G
R
K
I
L
V
Site 38
Y487
N
H
G
G
H
Q
P
Y
P
R
S
G
H
F
P
Site 39
T496
R
S
G
H
F
P
W
T
V
P
S
Q
E
Y
S
Site 40
S499
H
F
P
W
T
V
P
S
Q
E
Y
S
H
P
L
Site 41
Y502
W
T
V
P
S
Q
E
Y
S
H
P
L
P
P
T
Site 42
S503
T
V
P
S
Q
E
Y
S
H
P
L
P
P
T
P
Site 43
T509
Y
S
H
P
L
P
P
T
P
S
V
P
Q
S
L
Site 44
S511
H
P
L
P
P
T
P
S
V
P
Q
S
L
P
S
Site 45
S515
P
T
P
S
V
P
Q
S
L
P
S
L
A
V
R
Site 46
S528
V
R
D
W
L
D
A
S
Q
Q
P
G
H
Q
D
Site 47
Y537
Q
P
G
H
Q
D
F
Y
R
V
Y
G
Q
P
S
Site 48
Y540
H
Q
D
F
Y
R
V
Y
G
Q
P
S
T
K
H
Site 49
T545
R
V
Y
G
Q
P
S
T
K
H
Y
V
T
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation