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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BRWD2
Full Name:
WD repeat-containing protein 11
Alias:
Bromodomain and WD repeat domain containing 2; Bromodomain and WD-repeat domain-containing 2; DR11; FLJ10506; KIAA1351; WD repeat domain 11; WD repeat-containing protein 15; WDR11; WDR15
Type:
Membrane protein, integral
Mass (Da):
136685
Number AA:
1224
UniProt ID:
Q9BZH6
International Prot ID:
IPI00412224
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y4
_
_
_
_
M
L
P
Y
T
V
N
F
K
V
S
Site 2
T16
K
V
S
A
R
T
L
T
G
A
L
N
A
H
N
Site 3
Y74
V
K
W
A
R
E
N
Y
H
H
N
I
G
S
P
Site 4
T148
I
V
L
W
N
A
D
T
G
T
K
L
W
K
K
Site 5
S156
G
T
K
L
W
K
K
S
Y
A
D
N
I
L
S
Site 6
Y157
T
K
L
W
K
K
S
Y
A
D
N
I
L
S
F
Site 7
S163
S
Y
A
D
N
I
L
S
F
S
F
D
P
F
D
Site 8
S165
A
D
N
I
L
S
F
S
F
D
P
F
D
P
S
Site 9
S172
S
F
D
P
F
D
P
S
H
L
T
L
L
T
S
Site 10
T175
P
F
D
P
S
H
L
T
L
L
T
S
E
G
I
Site 11
S186
S
E
G
I
V
F
I
S
D
F
S
P
S
K
P
Site 12
S189
I
V
F
I
S
D
F
S
P
S
K
P
P
S
G
Site 13
S191
F
I
S
D
F
S
P
S
K
P
P
S
G
P
G
Site 14
S195
F
S
P
S
K
P
P
S
G
P
G
K
K
V
Y
Site 15
Y202
S
G
P
G
K
K
V
Y
I
S
S
P
H
S
S
Site 16
S204
P
G
K
K
V
Y
I
S
S
P
H
S
S
P
A
Site 17
S205
G
K
K
V
Y
I
S
S
P
H
S
S
P
A
H
Site 18
S208
V
Y
I
S
S
P
H
S
S
P
A
H
N
K
L
Site 19
S209
Y
I
S
S
P
H
S
S
P
A
H
N
K
L
A
Site 20
T219
H
N
K
L
A
T
A
T
G
A
K
K
A
L
N
Site 21
S255
L
Q
L
A
Y
L
P
S
K
R
N
H
M
L
L
Site 22
T313
L
H
E
N
G
C
I
T
L
R
V
R
R
S
Y
Site 23
S319
I
T
L
R
V
R
R
S
Y
N
N
I
F
T
T
Site 24
Y320
T
L
R
V
R
R
S
Y
N
N
I
F
T
T
S
Site 25
T340
P
D
P
V
Q
E
L
T
Y
D
L
R
S
Q
C
Site 26
Y341
D
P
V
Q
E
L
T
Y
D
L
R
S
Q
C
D
Site 27
S345
E
L
T
Y
D
L
R
S
Q
C
D
A
I
R
V
Site 28
T353
Q
C
D
A
I
R
V
T
K
T
V
R
P
F
S
Site 29
S394
S
A
V
C
N
R
N
S
R
N
S
S
S
G
V
Site 30
S397
C
N
R
N
S
R
N
S
S
S
G
V
S
P
L
Site 31
S398
N
R
N
S
R
N
S
S
S
G
V
S
P
L
Y
Site 32
S399
R
N
S
R
N
S
S
S
G
V
S
P
L
Y
S
Site 33
S402
R
N
S
S
S
G
V
S
P
L
Y
S
P
V
S
Site 34
S406
S
G
V
S
P
L
Y
S
P
V
S
F
C
G
I
Site 35
S409
S
P
L
Y
S
P
V
S
F
C
G
I
P
V
G
Site 36
S426
Q
N
K
L
P
D
L
S
L
D
N
M
I
G
Q
Site 37
S445
G
E
E
H
P
R
G
S
I
L
R
E
V
H
L
Site 38
Y500
S
N
G
S
V
L
V
Y
H
L
T
S
G
L
L
Site 39
T503
S
V
L
V
Y
H
L
T
S
G
L
L
H
K
E
Site 40
S504
V
L
V
Y
H
L
T
S
G
L
L
H
K
E
L
Site 41
S512
G
L
L
H
K
E
L
S
I
H
S
C
E
V
K
Site 42
S557
V
D
L
P
T
G
R
S
I
A
F
R
G
E
R
Site 43
S569
G
E
R
G
N
D
E
S
A
I
E
M
I
K
V
Site 44
Y582
K
V
S
H
L
K
Q
Y
L
A
V
V
F
R
D
Site 45
T599
L
E
L
W
D
V
R
T
C
T
L
L
R
E
M
Site 46
T601
L
W
D
V
R
T
C
T
L
L
R
E
M
S
K
Site 47
S607
C
T
L
L
R
E
M
S
K
N
F
P
T
I
T
Site 48
T614
S
K
N
F
P
T
I
T
A
L
E
W
S
P
S
Site 49
S619
T
I
T
A
L
E
W
S
P
S
H
N
L
K
S
Site 50
S621
T
A
L
E
W
S
P
S
H
N
L
K
S
L
R
Site 51
S626
S
P
S
H
N
L
K
S
L
R
K
K
Q
L
A
Site 52
T642
R
E
A
M
A
R
Q
T
V
V
S
D
T
E
L
Site 53
S665
S
L
L
Q
E
A
E
S
K
S
E
L
S
Q
N
Site 54
S667
L
Q
E
A
E
S
K
S
E
L
S
Q
N
I
S
Site 55
S670
A
E
S
K
S
E
L
S
Q
N
I
S
A
R
E
Site 56
S674
S
E
L
S
Q
N
I
S
A
R
E
H
F
V
F
Site 57
T692
D
G
Q
V
Y
H
L
T
V
E
G
N
S
V
K
Site 58
S697
H
L
T
V
E
G
N
S
V
K
D
S
A
R
I
Site 59
S701
E
G
N
S
V
K
D
S
A
R
I
P
P
D
G
Site 60
S712
P
P
D
G
S
M
G
S
I
T
C
I
A
W
K
Site 61
S742
W
D
L
K
G
R
V
S
R
G
I
P
T
H
R
Site 62
T747
R
V
S
R
G
I
P
T
H
R
S
W
V
R
K
Site 63
S750
R
G
I
P
T
H
R
S
W
V
R
K
I
R
F
Site 64
T779
D
G
A
E
V
W
D
T
K
E
V
Q
M
V
S
Site 65
S786
T
K
E
V
Q
M
V
S
S
L
R
S
G
R
N
Site 66
S787
K
E
V
Q
M
V
S
S
L
R
S
G
R
N
V
Site 67
S790
Q
M
V
S
S
L
R
S
G
R
N
V
T
F
R
Site 68
T795
L
R
S
G
R
N
V
T
F
R
I
L
D
V
D
Site 69
S873
G
Q
Y
S
L
D
I
S
H
V
D
Y
P
E
N
Site 70
Y877
L
D
I
S
H
V
D
Y
P
E
N
E
E
I
K
Site 71
S893
L
L
Q
E
Q
L
N
S
L
S
N
D
I
K
K
Site 72
S895
Q
E
Q
L
N
S
L
S
N
D
I
K
K
L
L
Site 73
S917
L
Q
R
C
L
L
V
S
R
L
Y
G
D
E
S
Site 74
Y920
C
L
L
V
S
R
L
Y
G
D
E
S
E
L
H
Site 75
S924
S
R
L
Y
G
D
E
S
E
L
H
F
W
T
V
Site 76
T930
E
S
E
L
H
F
W
T
V
A
A
H
Y
L
H
Site 77
S938
V
A
A
H
Y
L
H
S
L
S
Q
E
K
S
A
Site 78
S940
A
H
Y
L
H
S
L
S
Q
E
K
S
A
S
T
Site 79
S944
H
S
L
S
Q
E
K
S
A
S
T
T
A
P
K
Site 80
T948
Q
E
K
S
A
S
T
T
A
P
K
E
A
A
P
Site 81
S960
A
A
P
R
D
K
L
S
N
P
L
D
I
C
Y
Site 82
Y975
D
V
L
C
E
N
A
Y
F
Q
K
F
Q
L
E
Site 83
T993
L
Q
E
V
K
R
S
T
Y
D
H
T
R
K
C
Site 84
Y994
Q
E
V
K
R
S
T
Y
D
H
T
R
K
C
T
Site 85
T1001
Y
D
H
T
R
K
C
T
D
Q
L
L
L
L
G
Site 86
S1021
V
Q
L
L
L
E
T
S
A
D
N
Q
H
Y
Y
Site 87
Y1027
T
S
A
D
N
Q
H
Y
Y
C
D
S
L
K
A
Site 88
Y1028
S
A
D
N
Q
H
Y
Y
C
D
S
L
K
A
C
Site 89
S1042
C
L
V
T
T
V
T
S
S
G
P
S
Q
S
T
Site 90
S1046
T
V
T
S
S
G
P
S
Q
S
T
I
K
L
V
Site 91
S1048
T
S
S
G
P
S
Q
S
T
I
K
L
V
A
T
Site 92
Y1082
K
A
A
D
A
C
R
Y
L
Q
T
Y
G
E
W
Site 93
Y1086
A
C
R
Y
L
Q
T
Y
G
E
W
N
R
A
A
Site 94
S1118
R
W
V
D
H
L
C
S
P
Q
V
N
Q
K
S
Site 95
S1125
S
P
Q
V
N
Q
K
S
K
A
L
L
V
L
L
Site 96
S1146
S
V
A
E
T
L
H
S
M
R
Y
F
D
R
A
Site 97
Y1149
E
T
L
H
S
M
R
Y
F
D
R
A
A
L
F
Site 98
T1177
E
D
T
E
K
L
I
T
A
I
Y
A
D
Y
A
Site 99
S1201
Q
G
A
V
L
F
A
S
K
A
G
A
A
G
K
Site 100
S1216
D
L
L
N
E
L
E
S
P
K
E
E
P
I
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation