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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OSBPL6
Full Name:
Oxysterol-binding protein-related protein 6
Alias:
ORP6; ORP-6; OSBL6; OSBP-related 6; OSBP-related protein 6; Oxysterol binding protein-like 6; Oxysterol-binding protein-related 6
Type:
Unknown function
Mass (Da):
106306
Number AA:
934
UniProt ID:
Q9BZF3
International Prot ID:
IPI00220568
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006869
GO:0008202
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
D
E
K
G
I
S
Site 2
S9
S
S
D
E
K
G
I
S
P
A
H
K
T
S
T
Site 3
T14
G
I
S
P
A
H
K
T
S
T
P
T
H
R
S
Site 4
S15
I
S
P
A
H
K
T
S
T
P
T
H
R
S
A
Site 5
T16
S
P
A
H
K
T
S
T
P
T
H
R
S
A
S
Site 6
T18
A
H
K
T
S
T
P
T
H
R
S
A
S
S
S
Site 7
S21
T
S
T
P
T
H
R
S
A
S
S
S
T
S
S
Site 8
S23
T
P
T
H
R
S
A
S
S
S
T
S
S
Q
R
Site 9
S24
P
T
H
R
S
A
S
S
S
T
S
S
Q
R
D
Site 10
S25
T
H
R
S
A
S
S
S
T
S
S
Q
R
D
S
Site 11
S27
R
S
A
S
S
S
T
S
S
Q
R
D
S
R
Q
Site 12
S28
S
A
S
S
S
T
S
S
Q
R
D
S
R
Q
S
Site 13
S32
S
T
S
S
Q
R
D
S
R
Q
S
I
H
I
L
Site 14
S35
S
Q
R
D
S
R
Q
S
I
H
I
L
E
R
T
Site 15
T42
S
I
H
I
L
E
R
T
A
S
S
S
T
E
P
Site 16
S44
H
I
L
E
R
T
A
S
S
S
T
E
P
S
V
Site 17
S46
L
E
R
T
A
S
S
S
T
E
P
S
V
S
R
Site 18
S50
A
S
S
S
T
E
P
S
V
S
R
Q
L
L
E
Site 19
S52
S
S
T
E
P
S
V
S
R
Q
L
L
E
P
E
Site 20
S64
E
P
E
P
V
P
L
S
K
E
A
D
S
W
E
Site 21
S69
P
L
S
K
E
A
D
S
W
E
I
I
E
G
L
Site 22
T81
E
G
L
K
I
G
Q
T
N
V
Q
K
P
D
K
Site 23
S119
D
N
G
M
L
K
Y
S
K
A
P
L
D
I
Q
Site 24
S133
Q
K
G
K
V
H
G
S
I
D
V
G
L
S
V
Site 25
T154
A
R
R
I
D
L
D
T
E
E
H
I
Y
H
L
Site 26
Y159
L
D
T
E
E
H
I
Y
H
L
K
V
K
S
Q
Site 27
Y182
K
L
R
H
H
R
L
Y
R
Q
N
E
I
V
R
Site 28
S190
R
Q
N
E
I
V
R
S
P
R
D
A
S
F
H
Site 29
S195
V
R
S
P
R
D
A
S
F
H
I
F
P
S
T
Site 30
S201
A
S
F
H
I
F
P
S
T
S
T
A
E
S
S
Site 31
T202
S
F
H
I
F
P
S
T
S
T
A
E
S
S
P
Site 32
S203
F
H
I
F
P
S
T
S
T
A
E
S
S
P
A
Site 33
T204
H
I
F
P
S
T
S
T
A
E
S
S
P
A
A
Site 34
S207
P
S
T
S
T
A
E
S
S
P
A
A
N
V
S
Site 35
S208
S
T
S
T
A
E
S
S
P
A
A
N
V
S
V
Site 36
S214
S
S
P
A
A
N
V
S
V
M
D
G
K
M
Q
Site 37
S224
D
G
K
M
Q
P
N
S
F
P
W
Q
S
P
L
Site 38
S229
P
N
S
F
P
W
Q
S
P
L
P
C
S
N
S
Site 39
S234
W
Q
S
P
L
P
C
S
N
S
L
P
A
T
C
Site 40
S236
S
P
L
P
C
S
N
S
L
P
A
T
C
T
T
Site 41
T240
C
S
N
S
L
P
A
T
C
T
T
G
Q
S
K
Site 42
T242
N
S
L
P
A
T
C
T
T
G
Q
S
K
V
A
Site 43
S255
V
A
A
W
L
Q
D
S
E
E
M
D
R
C
A
Site 44
S270
E
D
L
A
H
C
Q
S
N
L
V
E
L
S
K
Site 45
S290
E
I
L
Q
R
T
Q
S
A
P
N
F
T
D
M
Site 46
T312
S
K
K
D
K
R
V
T
R
R
W
R
T
K
S
Site 47
T317
R
V
T
R
R
W
R
T
K
S
V
S
K
D
T
Site 48
S319
T
R
R
W
R
T
K
S
V
S
K
D
T
K
I
Site 49
S321
R
W
R
T
K
S
V
S
K
D
T
K
I
Q
L
Site 50
T335
L
Q
V
P
F
S
A
T
M
S
P
V
R
L
H
Site 51
S343
M
S
P
V
R
L
H
S
S
N
P
N
L
C
A
Site 52
S344
S
P
V
R
L
H
S
S
N
P
N
L
C
A
D
Site 53
T356
C
A
D
I
E
F
Q
T
P
P
S
H
L
T
D
Site 54
S359
I
E
F
Q
T
P
P
S
H
L
T
D
P
L
E
Site 55
T362
Q
T
P
P
S
H
L
T
D
P
L
E
S
S
T
Site 56
Y371
P
L
E
S
S
T
D
Y
T
K
L
Q
E
E
F
Site 57
T372
L
E
S
S
T
D
Y
T
K
L
Q
E
E
F
C
Site 58
S395
L
L
K
S
A
F
N
S
I
A
I
E
K
E
K
Site 59
S408
E
K
L
K
Q
M
V
S
E
Q
D
H
S
K
G
Site 60
S413
M
V
S
E
Q
D
H
S
K
G
H
S
T
Q
M
Site 61
S417
Q
D
H
S
K
G
H
S
T
Q
M
A
R
L
R
Site 62
S426
Q
M
A
R
L
R
Q
S
L
S
Q
A
L
N
Q
Site 63
S428
A
R
L
R
Q
S
L
S
Q
A
L
N
Q
N
A
Site 64
S446
S
R
L
N
R
I
H
S
E
S
I
I
C
D
Q
Site 65
S462
V
S
V
N
I
I
P
S
P
D
E
A
G
E
Q
Site 66
S473
A
G
E
Q
I
H
V
S
L
P
L
S
Q
Q
V
Site 67
S477
I
H
V
S
L
P
L
S
Q
Q
V
A
N
E
S
Site 68
S487
V
A
N
E
S
R
L
S
M
S
E
S
V
S
E
Site 69
S489
N
E
S
R
L
S
M
S
E
S
V
S
E
F
F
Site 70
S491
S
R
L
S
M
S
E
S
V
S
E
F
F
D
A
Site 71
S493
L
S
M
S
E
S
V
S
E
F
F
D
A
Q
E
Site 72
S504
D
A
Q
E
V
L
L
S
A
S
S
S
E
N
E
Site 73
S507
E
V
L
L
S
A
S
S
S
E
N
E
A
S
D
Site 74
S508
V
L
L
S
A
S
S
S
E
N
E
A
S
D
D
Site 75
S513
S
S
S
E
N
E
A
S
D
D
E
S
Y
I
S
Site 76
S517
N
E
A
S
D
D
E
S
Y
I
S
D
V
S
D
Site 77
Y518
E
A
S
D
D
E
S
Y
I
S
D
V
S
D
N
Site 78
S520
S
D
D
E
S
Y
I
S
D
V
S
D
N
I
S
Site 79
S523
E
S
Y
I
S
D
V
S
D
N
I
S
E
D
N
Site 80
S527
S
D
V
S
D
N
I
S
E
D
N
T
S
V
A
Site 81
T531
D
N
I
S
E
D
N
T
S
V
A
D
N
I
S
Site 82
S532
N
I
S
E
D
N
T
S
V
A
D
N
I
S
R
Site 83
T547
Q
I
L
N
G
E
L
T
G
G
A
F
R
N
G
Site 84
S584
N
N
I
G
K
D
L
S
K
V
S
M
P
V
E
Site 85
S587
G
K
D
L
S
K
V
S
M
P
V
E
L
N
E
Site 86
T598
E
L
N
E
P
L
N
T
L
Q
H
L
C
E
E
Site 87
Y608
H
L
C
E
E
M
E
Y
S
E
L
L
D
K
A
Site 88
S609
L
C
E
E
M
E
Y
S
E
L
L
D
K
A
S
Site 89
S616
S
E
L
L
D
K
A
S
E
T
D
D
P
Y
E
Site 90
T618
L
L
D
K
A
S
E
T
D
D
P
Y
E
R
M
Site 91
Y622
A
S
E
T
D
D
P
Y
E
R
M
V
L
V
A
Site 92
T639
A
V
S
G
Y
C
S
T
Y
F
R
A
G
S
K
Site 93
Y640
V
S
G
Y
C
S
T
Y
F
R
A
G
S
K
P
Site 94
S645
S
T
Y
F
R
A
G
S
K
P
F
N
P
V
L
Site 95
Y656
N
P
V
L
G
E
T
Y
E
C
I
R
E
D
K
Site 96
S669
D
K
G
F
R
F
F
S
E
Q
V
S
H
H
P
Site 97
S673
R
F
F
S
E
Q
V
S
H
H
P
P
I
S
A
Site 98
S704
K
N
K
F
W
G
K
S
M
E
I
L
P
V
G
Site 99
T712
M
E
I
L
P
V
G
T
L
N
V
M
L
P
K
Site 100
Y720
L
N
V
M
L
P
K
Y
G
D
Y
Y
V
W
N
Site 101
Y723
M
L
P
K
Y
G
D
Y
Y
V
W
N
K
V
T
Site 102
Y724
L
P
K
Y
G
D
Y
Y
V
W
N
K
V
T
T
Site 103
Y746
G
R
R
W
I
E
H
Y
G
E
V
T
I
R
N
Site 104
Y770
L
T
F
V
K
V
N
Y
W
N
S
N
M
N
E
Site 105
Y802
G
K
W
H
E
G
L
Y
C
G
V
A
P
S
A
Site 106
Y822
P
G
S
M
P
T
N
Y
E
L
Y
Y
G
F
T
Site 107
T849
L
K
D
L
L
P
P
T
D
A
R
F
R
P
D
Site 108
S870
G
N
L
E
A
A
A
S
E
K
Q
R
V
E
E
Site 109
S881
R
V
E
E
L
Q
R
S
R
R
R
Y
M
E
E
Site 110
Y885
L
Q
R
S
R
R
R
Y
M
E
E
N
N
L
E
Site 111
Y916
A
W
V
S
N
D
T
Y
W
E
L
R
K
D
P
Site 112
S926
L
R
K
D
P
G
F
S
K
V
D
S
P
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation