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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OSBPL8
Full Name:
Oxysterol-binding protein-related protein 8
Alias:
MST120; MSTP120; ORP8; OSBL8; OSBP10; Oxysterol binding protein-like 8; Oxysterol-binding protein-like protein OSBPL8; Oxysterol-binding protein-related protein 8: Oxysterol-binding protein-related protein 8: Oxysterol-binding protein: cDNA FLJ23974 fis, clone HEP18860
Type:
Unknown function
Mass (Da):
101196
Number AA:
889
UniProt ID:
Q9BZF1
International Prot ID:
IPI00394737
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005730
GO:0005737
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006869
GO:0008202
GO:0006869
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
A
D
G
E
P
D
R
T
S
L
L
G
D
S
K
Site 2
S14
D
G
E
P
D
R
T
S
L
L
G
D
S
K
D
Site 3
S26
S
K
D
V
L
G
P
S
T
V
V
A
N
S
D
Site 4
T27
K
D
V
L
G
P
S
T
V
V
A
N
S
D
E
Site 5
S32
P
S
T
V
V
A
N
S
D
E
S
Q
L
L
T
Site 6
S35
V
V
A
N
S
D
E
S
Q
L
L
T
P
G
K
Site 7
T39
S
D
E
S
Q
L
L
T
P
G
K
M
S
Q
R
Site 8
S44
L
L
T
P
G
K
M
S
Q
R
Q
G
K
E
A
Site 9
Y52
Q
R
Q
G
K
E
A
Y
P
T
P
T
K
D
L
Site 10
T54
Q
G
K
E
A
Y
P
T
P
T
K
D
L
H
Q
Site 11
S63
T
K
D
L
H
Q
P
S
L
S
P
A
S
P
H
Site 12
S65
D
L
H
Q
P
S
L
S
P
A
S
P
H
S
Q
Site 13
S68
Q
P
S
L
S
P
A
S
P
H
S
Q
G
F
E
Site 14
S71
L
S
P
A
S
P
H
S
Q
G
F
E
R
G
K
Site 15
S82
E
R
G
K
E
D
I
S
Q
N
K
D
E
S
S
Site 16
S88
I
S
Q
N
K
D
E
S
S
L
S
M
S
K
S
Site 17
S89
S
Q
N
K
D
E
S
S
L
S
M
S
K
S
K
Site 18
S91
N
K
D
E
S
S
L
S
M
S
K
S
K
S
E
Site 19
S93
D
E
S
S
L
S
M
S
K
S
K
S
E
S
K
Site 20
S95
S
S
L
S
M
S
K
S
K
S
E
S
K
L
Y
Site 21
S97
L
S
M
S
K
S
K
S
E
S
K
L
Y
N
G
Site 22
S99
M
S
K
S
K
S
E
S
K
L
Y
N
G
S
E
Site 23
Y102
S
K
S
E
S
K
L
Y
N
G
S
E
K
D
S
Site 24
S105
E
S
K
L
Y
N
G
S
E
K
D
S
S
T
S
Site 25
S109
Y
N
G
S
E
K
D
S
S
T
S
S
K
L
T
Site 26
S110
N
G
S
E
K
D
S
S
T
S
S
K
L
T
K
Site 27
T111
G
S
E
K
D
S
S
T
S
S
K
L
T
K
K
Site 28
S113
E
K
D
S
S
T
S
S
K
L
T
K
K
E
S
Site 29
T116
S
S
T
S
S
K
L
T
K
K
E
S
L
K
V
Site 30
S120
S
K
L
T
K
K
E
S
L
K
V
Q
K
K
N
Site 31
T136
R
E
E
K
K
R
A
T
K
E
L
L
S
T
I
Site 32
S141
R
A
T
K
E
L
L
S
T
I
T
D
P
S
V
Site 33
T160
D
W
L
K
I
R
G
T
L
K
S
W
T
K
L
Site 34
Y179
K
P
G
V
L
L
I
Y
K
T
Q
K
N
G
Q
Site 35
S233
P
K
G
E
A
V
G
S
I
T
Q
P
L
P
S
Site 36
T235
G
E
A
V
G
S
I
T
Q
P
L
P
S
S
Y
Site 37
S240
S
I
T
Q
P
L
P
S
S
Y
L
I
I
R
A
Site 38
T248
S
Y
L
I
I
R
A
T
S
E
S
D
G
R
C
Site 39
S249
Y
L
I
I
R
A
T
S
E
S
D
G
R
C
W
Site 40
S284
E
G
K
E
H
D
L
S
V
S
S
D
S
T
H
Site 41
S287
E
H
D
L
S
V
S
S
D
S
T
H
V
T
F
Site 42
S289
D
L
S
V
S
S
D
S
T
H
V
T
F
Y
G
Site 43
T293
S
S
D
S
T
H
V
T
F
Y
G
L
L
R
A
Site 44
S305
L
R
A
N
N
L
H
S
G
D
N
F
Q
L
N
Site 45
S314
D
N
F
Q
L
N
D
S
E
I
E
R
Q
H
F
Site 46
Y327
H
F
K
D
Q
D
M
Y
S
D
K
S
D
K
E
Site 47
S328
F
K
D
Q
D
M
Y
S
D
K
S
D
K
E
N
Site 48
S331
Q
D
M
Y
S
D
K
S
D
K
E
N
D
Q
E
Site 49
S342
N
D
Q
E
H
D
E
S
D
N
E
V
M
G
K
Site 50
S350
D
N
E
V
M
G
K
S
E
E
S
D
T
D
T
Site 51
S353
V
M
G
K
S
E
E
S
D
T
D
T
S
E
R
Site 52
T355
G
K
S
E
E
S
D
T
D
T
S
E
R
Q
D
Site 53
T357
S
E
E
S
D
T
D
T
S
E
R
Q
D
D
S
Site 54
S358
E
E
S
D
T
D
T
S
E
R
Q
D
D
S
Y
Site 55
S364
T
S
E
R
Q
D
D
S
Y
I
E
P
E
P
V
Site 56
Y365
S
E
R
Q
D
D
S
Y
I
E
P
E
P
V
E
Site 57
Y379
E
P
L
K
E
T
T
Y
T
E
Q
S
H
E
E
Site 58
T380
P
L
K
E
T
T
Y
T
E
Q
S
H
E
E
L
Site 59
S383
E
T
T
Y
T
E
Q
S
H
E
E
L
G
E
A
Site 60
S394
L
G
E
A
G
E
A
S
Q
T
E
T
V
S
E
Site 61
T396
E
A
G
E
A
S
Q
T
E
T
V
S
E
E
N
Site 62
T398
G
E
A
S
Q
T
E
T
V
S
E
E
N
K
S
Site 63
S405
T
V
S
E
E
N
K
S
L
I
W
T
L
L
K
Site 64
T409
E
N
K
S
L
I
W
T
L
L
K
Q
V
R
P
Site 65
S421
V
R
P
G
M
D
L
S
K
V
V
L
P
T
F
Site 66
S434
T
F
I
L
E
P
R
S
F
L
D
K
L
S
D
Site 67
S440
R
S
F
L
D
K
L
S
D
Y
Y
Y
H
A
D
Site 68
Y442
F
L
D
K
L
S
D
Y
Y
Y
H
A
D
F
L
Site 69
Y443
L
D
K
L
S
D
Y
Y
Y
H
A
D
F
L
S
Site 70
Y444
D
K
L
S
D
Y
Y
Y
H
A
D
F
L
S
E
Site 71
S450
Y
Y
H
A
D
F
L
S
E
A
A
L
E
E
N
Site 72
Y459
A
A
L
E
E
N
P
Y
F
R
L
K
K
V
V
Site 73
Y469
L
K
K
V
V
K
W
Y
L
S
G
F
Y
K
K
Site 74
Y474
K
W
Y
L
S
G
F
Y
K
K
P
K
G
L
K
Site 75
Y484
P
K
G
L
K
K
P
Y
N
P
I
L
G
E
T
Site 76
T505
H
P
R
T
N
S
K
T
F
Y
I
A
E
Q
V
Site 77
Y507
R
T
N
S
K
T
F
Y
I
A
E
Q
V
S
H
Site 78
S513
F
Y
I
A
E
Q
V
S
H
H
P
P
I
S
A
Site 79
S519
V
S
H
H
P
P
I
S
A
F
Y
V
S
N
R
Site 80
Y522
H
P
P
I
S
A
F
Y
V
S
N
R
K
D
G
Site 81
S533
R
K
D
G
F
C
L
S
G
S
I
L
A
K
S
Site 82
S540
S
G
S
I
L
A
K
S
K
F
Y
G
N
S
L
Site 83
S546
K
S
K
F
Y
G
N
S
L
S
A
I
L
E
G
Site 84
S548
K
F
Y
G
N
S
L
S
A
I
L
E
G
E
A
Site 85
T558
L
E
G
E
A
R
L
T
F
L
N
R
G
E
D
Site 86
Y566
F
L
N
R
G
E
D
Y
V
M
T
M
P
Y
A
Site 87
T594
L
G
G
T
V
N
I
T
C
Q
K
T
G
Y
S
Site 88
S615
L
K
P
F
L
G
S
S
D
C
V
N
Q
I
S
Site 89
T634
L
G
K
E
V
L
A
T
L
E
G
H
W
D
S
Site 90
S641
T
L
E
G
H
W
D
S
E
V
F
I
T
D
K
Site 91
T646
W
D
S
E
V
F
I
T
D
K
K
T
D
N
S
Site 92
T650
V
F
I
T
D
K
K
T
D
N
S
E
V
F
W
Site 93
T672
Q
W
R
L
I
R
H
T
V
K
F
E
E
Q
G
Site 94
S683
E
E
Q
G
D
F
E
S
E
K
L
W
Q
R
V
Site 95
T691
E
K
L
W
Q
R
V
T
R
A
I
N
A
K
D
Site 96
T700
A
I
N
A
K
D
Q
T
E
A
T
Q
E
K
Y
Site 97
Y707
T
E
A
T
Q
E
K
Y
V
L
E
E
A
Q
R
Site 98
T722
Q
A
A
R
D
R
K
T
K
N
E
E
W
S
C
Site 99
T738
L
F
E
L
D
P
L
T
G
E
W
H
Y
K
F
Site 100
T774
Q
T
K
V
K
H
R
T
P
M
V
S
V
P
K
Site 101
S778
K
H
R
T
P
M
V
S
V
P
K
M
K
H
K
Site 102
Y797
Q
K
K
V
A
K
G
Y
S
S
P
E
P
D
I
Site 103
S798
K
K
V
A
K
G
Y
S
S
P
E
P
D
I
Q
Site 104
S799
K
V
A
K
G
Y
S
S
P
E
P
D
I
Q
D
Site 105
S807
P
E
P
D
I
Q
D
S
S
G
S
E
A
Q
S
Site 106
S808
E
P
D
I
Q
D
S
S
G
S
E
A
Q
S
V
Site 107
S810
D
I
Q
D
S
S
G
S
E
A
Q
S
V
K
P
Site 108
S814
S
S
G
S
E
A
Q
S
V
K
P
S
T
R
R
Site 109
S818
E
A
Q
S
V
K
P
S
T
R
R
K
K
G
I
Site 110
T819
A
Q
S
V
K
P
S
T
R
R
K
K
G
I
E
Site 111
S832
I
E
L
G
D
I
Q
S
S
I
E
S
I
K
Q
Site 112
S836
D
I
Q
S
S
I
E
S
I
K
Q
T
Q
E
E
Site 113
T840
S
I
E
S
I
K
Q
T
Q
E
E
I
K
R
N
Site 114
S857
A
L
R
N
H
L
V
S
S
T
P
A
T
D
Y
Site 115
S858
L
R
N
H
L
V
S
S
T
P
A
T
D
Y
F
Site 116
T859
R
N
H
L
V
S
S
T
P
A
T
D
Y
F
L
Site 117
T862
L
V
S
S
T
P
A
T
D
Y
F
L
Q
Q
K
Site 118
Y864
S
S
T
P
A
T
D
Y
F
L
Q
Q
K
D
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation