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Updated November 2019
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Protein Info
Short Name:
WHSC1L1
Full Name:
Histone-lysine N-methyltransferase NSD3
Alias:
FLJ20353; NSD3; Nuclear SET domain-containing protein 3; Whistle; WHSC1-like 1; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; Wolf-Hirschhorn syndrome candidate 1-like 1; Wolf-Hirschhorn syndrome candidate 1-like 1 (NSD3); Wolf-Hirschhorn syndrome candidate 1-like protein 1
Type:
EC 2.1.1.43; Histone-binding protein; Methyltransferase; Amino Acid Metabolism - lysine degradation
Mass (Da):
161594
Number AA:
1437
UniProt ID:
Q9BZ95
International Prot ID:
IPI00307783
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0018024
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0016049
GO:0016571
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
Q
P
P
Q
L
I
D
S
A
N
I
R
Q
E
D
Site 2
S38
E
D
A
F
D
N
N
S
D
I
A
E
D
G
G
Site 3
T47
I
A
E
D
G
G
Q
T
P
Y
E
A
T
L
Q
Site 4
Y49
E
D
G
G
Q
T
P
Y
E
A
T
L
Q
Q
G
Site 5
Y59
T
L
Q
Q
G
F
Q
Y
P
A
T
T
E
D
L
Site 6
T62
Q
G
F
Q
Y
P
A
T
T
E
D
L
P
P
L
Site 7
T70
T
E
D
L
P
P
L
T
N
G
Y
P
S
S
I
Site 8
Y73
L
P
P
L
T
N
G
Y
P
S
S
I
S
V
Y
Site 9
S76
L
T
N
G
Y
P
S
S
I
S
V
Y
E
T
Q
Site 10
S78
N
G
Y
P
S
S
I
S
V
Y
E
T
Q
T
K
Site 11
Y80
Y
P
S
S
I
S
V
Y
E
T
Q
T
K
Y
Q
Site 12
T82
S
S
I
S
V
Y
E
T
Q
T
K
Y
Q
S
Y
Site 13
Y86
V
Y
E
T
Q
T
K
Y
Q
S
Y
N
Q
Y
P
Site 14
Y92
K
Y
Q
S
Y
N
Q
Y
P
N
G
S
A
N
G
Site 15
S107
F
G
A
V
R
N
F
S
P
T
D
Y
Y
H
S
Site 16
T109
A
V
R
N
F
S
P
T
D
Y
Y
H
S
E
I
Site 17
Y111
R
N
F
S
P
T
D
Y
Y
H
S
E
I
P
N
Site 18
Y112
N
F
S
P
T
D
Y
Y
H
S
E
I
P
N
T
Site 19
S114
S
P
T
D
Y
Y
H
S
E
I
P
N
T
R
P
Site 20
T119
Y
H
S
E
I
P
N
T
R
P
H
E
I
L
E
Site 21
S129
H
E
I
L
E
K
P
S
P
P
Q
P
P
P
P
Site 22
S138
P
Q
P
P
P
P
P
S
V
P
Q
T
V
I
P
Site 23
T142
P
P
P
S
V
P
Q
T
V
I
P
K
K
T
G
Site 24
S150
V
I
P
K
K
T
G
S
P
E
I
K
L
K
I
Site 25
T160
I
K
L
K
I
T
K
T
I
Q
N
G
R
E
L
Site 26
S170
N
G
R
E
L
F
E
S
S
L
C
G
D
L
L
Site 27
S171
G
R
E
L
F
E
S
S
L
C
G
D
L
L
N
Site 28
S183
L
L
N
E
V
Q
A
S
E
H
T
K
S
K
H
Site 29
S188
Q
A
S
E
H
T
K
S
K
H
E
S
R
K
E
Site 30
S192
H
T
K
S
K
H
E
S
R
K
E
K
R
K
K
Site 31
S200
R
K
E
K
R
K
K
S
N
K
H
D
S
S
R
Site 32
S205
K
K
S
N
K
H
D
S
S
R
S
E
E
R
K
Site 33
S206
K
S
N
K
H
D
S
S
R
S
E
E
R
K
S
Site 34
S208
N
K
H
D
S
S
R
S
E
E
R
K
S
H
K
Site 35
S213
S
R
S
E
E
R
K
S
H
K
I
P
K
L
E
Site 36
T233
R
P
N
E
R
V
D
T
V
S
E
K
P
R
E
Site 37
S235
N
E
R
V
D
T
V
S
E
K
P
R
E
E
P
Site 38
Y308
N
T
R
G
A
R
E
Y
H
V
Q
F
F
S
N
Site 39
Y330
H
E
K
R
V
R
E
Y
K
G
H
K
Q
Y
E
Site 40
T344
E
E
L
L
A
E
A
T
K
Q
A
S
N
H
S
Site 41
Y390
R
E
E
R
I
E
Q
Y
T
F
I
Y
I
D
K
Site 42
T391
E
E
R
I
E
Q
Y
T
F
I
Y
I
D
K
Q
Site 43
Y394
I
E
Q
Y
T
F
I
Y
I
D
K
Q
P
E
E
Site 44
S404
K
Q
P
E
E
A
L
S
Q
A
K
K
S
V
A
Site 45
S409
A
L
S
Q
A
K
K
S
V
A
S
K
T
E
V
Site 46
T414
K
K
S
V
A
S
K
T
E
V
K
K
T
R
R
Site 47
T419
S
K
T
E
V
K
K
T
R
R
P
R
S
V
L
Site 48
S424
K
K
T
R
R
P
R
S
V
L
N
T
Q
P
E
Site 49
T428
R
P
R
S
V
L
N
T
Q
P
E
Q
T
N
A
Site 50
S441
N
A
G
E
V
A
S
S
L
S
S
T
E
I
R
Site 51
S444
E
V
A
S
S
L
S
S
T
E
I
R
R
H
S
Site 52
T445
V
A
S
S
L
S
S
T
E
I
R
R
H
S
Q
Site 53
S451
S
T
E
I
R
R
H
S
Q
R
R
H
T
S
A
Site 54
T456
R
H
S
Q
R
R
H
T
S
A
E
E
E
E
P
Site 55
S457
H
S
Q
R
R
H
T
S
A
E
E
E
E
P
P
Site 56
T472
P
V
K
I
A
W
K
T
A
A
A
R
K
S
L
Site 57
S478
K
T
A
A
A
R
K
S
L
P
A
S
I
T
M
Site 58
S482
A
R
K
S
L
P
A
S
I
T
M
H
K
G
S
Site 59
T484
K
S
L
P
A
S
I
T
M
H
K
G
S
L
D
Site 60
S498
D
L
Q
K
C
N
M
S
P
V
V
K
I
E
Q
Site 61
Y524
K
F
I
D
Q
F
V
Y
S
T
K
G
I
G
N
Site 62
T533
T
K
G
I
G
N
K
T
E
I
S
V
R
G
Q
Site 63
S536
I
G
N
K
T
E
I
S
V
R
G
Q
D
R
L
Site 64
S546
G
Q
D
R
L
I
I
S
T
P
N
Q
R
N
E
Site 65
T547
Q
D
R
L
I
I
S
T
P
N
Q
R
N
E
K
Site 66
T556
N
Q
R
N
E
K
P
T
Q
S
V
S
S
P
E
Site 67
S558
R
N
E
K
P
T
Q
S
V
S
S
P
E
A
T
Site 68
S560
E
K
P
T
Q
S
V
S
S
P
E
A
T
S
G
Site 69
S561
K
P
T
Q
S
V
S
S
P
E
A
T
S
G
S
Site 70
T565
S
V
S
S
P
E
A
T
S
G
S
T
G
S
V
Site 71
S566
V
S
S
P
E
A
T
S
G
S
T
G
S
V
E
Site 72
S571
A
T
S
G
S
T
G
S
V
E
K
K
Q
Q
R
Site 73
S580
E
K
K
Q
Q
R
R
S
I
R
T
R
S
E
S
Site 74
T583
Q
Q
R
R
S
I
R
T
R
S
E
S
E
K
S
Site 75
S585
R
R
S
I
R
T
R
S
E
S
E
K
S
T
E
Site 76
S587
S
I
R
T
R
S
E
S
E
K
S
T
E
V
V
Site 77
S590
T
R
S
E
S
E
K
S
T
E
V
V
P
K
K
Site 78
T591
R
S
E
S
E
K
S
T
E
V
V
P
K
K
K
Site 79
T606
I
K
K
E
Q
V
E
T
V
P
Q
A
T
V
K
Site 80
T611
V
E
T
V
P
Q
A
T
V
K
T
G
L
Q
K
Site 81
S621
T
G
L
Q
K
G
A
S
E
I
S
D
S
C
K
Site 82
S626
G
A
S
E
I
S
D
S
C
K
P
L
K
K
R
Site 83
S634
C
K
P
L
K
K
R
S
R
A
S
T
D
V
E
Site 84
S637
L
K
K
R
S
R
A
S
T
D
V
E
M
T
S
Site 85
T638
K
K
R
S
R
A
S
T
D
V
E
M
T
S
S
Site 86
S645
T
D
V
E
M
T
S
S
A
Y
R
D
T
S
D
Site 87
T650
T
S
S
A
Y
R
D
T
S
D
S
D
S
R
G
Site 88
S651
S
S
A
Y
R
D
T
S
D
S
D
S
R
G
L
Site 89
S653
A
Y
R
D
T
S
D
S
D
S
R
G
L
S
D
Site 90
S655
R
D
T
S
D
S
D
S
R
G
L
S
D
L
Q
Site 91
S659
D
S
D
S
R
G
L
S
D
L
Q
V
G
F
G
Site 92
S671
G
F
G
K
Q
V
D
S
P
S
A
T
A
D
A
Site 93
S673
G
K
Q
V
D
S
P
S
A
T
A
D
A
D
V
Site 94
T675
Q
V
D
S
P
S
A
T
A
D
A
D
V
S
D
Site 95
S681
A
T
A
D
A
D
V
S
D
V
Q
S
M
D
S
Site 96
S685
A
D
V
S
D
V
Q
S
M
D
S
S
L
S
R
Site 97
S688
S
D
V
Q
S
M
D
S
S
L
S
R
R
G
T
Site 98
S689
D
V
Q
S
M
D
S
S
L
S
R
R
G
T
G
Site 99
S691
Q
S
M
D
S
S
L
S
R
R
G
T
G
M
S
Site 100
T695
S
S
L
S
R
R
G
T
G
M
S
K
K
D
T
Site 101
S698
S
R
R
G
T
G
M
S
K
K
D
T
V
C
Q
Site 102
T702
T
G
M
S
K
K
D
T
V
C
Q
I
C
E
S
Site 103
S713
I
C
E
S
S
G
D
S
L
I
P
C
E
G
E
Site 104
S766
G
K
D
V
K
R
C
S
V
G
A
C
G
K
F
Site 105
Y774
V
G
A
C
G
K
F
Y
H
E
A
C
V
R
K
Site 106
S848
S
S
Y
I
L
I
C
S
N
H
S
K
R
S
S
Site 107
S851
I
L
I
C
S
N
H
S
K
R
S
S
N
S
S
Site 108
S854
C
S
N
H
S
K
R
S
S
N
S
S
A
V
N
Site 109
S855
S
N
H
S
K
R
S
S
N
S
S
A
V
N
V
Site 110
S857
H
S
K
R
S
S
N
S
S
A
V
N
V
G
F
Site 111
S858
S
K
R
S
S
N
S
S
A
V
N
V
G
F
C
Site 112
S878
G
L
I
V
Q
D
H
S
D
P
M
F
S
S
Y
Site 113
S883
D
H
S
D
P
M
F
S
S
Y
A
Y
K
S
H
Site 114
Y885
S
D
P
M
F
S
S
Y
A
Y
K
S
H
Y
L
Site 115
Y887
P
M
F
S
S
Y
A
Y
K
S
H
Y
L
L
N
Site 116
S889
F
S
S
Y
A
Y
K
S
H
Y
L
L
N
E
S
Site 117
Y891
S
Y
A
Y
K
S
H
Y
L
L
N
E
S
N
R
Site 118
S896
S
H
Y
L
L
N
E
S
N
R
A
E
L
M
K
Site 119
S909
M
K
L
P
M
I
P
S
S
S
A
S
K
K
K
Site 120
S910
K
L
P
M
I
P
S
S
S
A
S
K
K
K
C
Site 121
S911
L
P
M
I
P
S
S
S
A
S
K
K
K
C
E
Site 122
S913
M
I
P
S
S
S
A
S
K
K
K
C
E
K
G
Site 123
Y960
K
A
G
K
K
L
H
Y
K
Q
I
V
W
V
K
Site 124
Y971
V
W
V
K
L
G
N
Y
R
W
W
P
A
E
I
Site 125
S983
A
E
I
C
N
P
R
S
V
P
L
N
I
Q
G
Site 126
Y1019
H
Q
G
R
V
F
P
Y
V
E
G
D
K
S
F
Site 127
S1025
P
Y
V
E
G
D
K
S
F
A
E
G
Q
T
S
Site 128
S1032
S
F
A
E
G
Q
T
S
I
N
K
T
F
K
K
Site 129
T1036
G
Q
T
S
I
N
K
T
F
K
K
A
L
E
E
Site 130
S1057
E
L
K
A
Q
R
E
S
K
E
A
L
E
I
E
Site 131
S1067
A
L
E
I
E
K
N
S
R
K
P
P
P
Y
K
Site 132
Y1073
N
S
R
K
P
P
P
Y
K
H
I
K
A
N
K
Site 133
S1112
E
N
P
C
G
L
E
S
E
C
L
N
R
M
L
Site 134
Y1144
Q
C
F
T
K
R
L
Y
P
D
A
E
I
I
K
Site 135
T1152
P
D
A
E
I
I
K
T
E
R
R
G
W
G
L
Site 136
T1161
R
R
G
W
G
L
R
T
K
R
S
I
K
K
G
Site 137
S1164
W
G
L
R
T
K
R
S
I
K
K
G
E
F
V
Site 138
Y1174
K
G
E
F
V
N
E
Y
V
G
E
L
I
D
E
Site 139
T1197
R
A
H
E
N
S
V
T
N
F
Y
M
L
T
V
Site 140
Y1218
D
A
G
P
K
G
N
Y
S
R
F
M
N
H
S
Site 141
Y1261
G
M
E
L
T
F
N
Y
N
L
D
C
L
G
N
Site 142
S1290
F
L
G
V
R
P
K
S
A
C
A
S
T
N
E
Site 143
S1294
R
P
K
S
A
C
A
S
T
N
E
E
K
A
K
Site 144
T1314
Q
K
R
R
K
I
K
T
E
P
K
Q
M
H
E
Site 145
T1353
H
L
L
C
L
N
L
T
Q
P
P
Y
G
K
W
Site 146
Y1357
L
N
L
T
Q
P
P
Y
G
K
W
E
C
P
W
Site 147
S1415
H
D
P
M
A
P
V
S
P
E
Y
W
S
K
I
Site 148
Y1418
M
A
P
V
S
P
E
Y
W
S
K
I
K
C
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation