KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
DOCK9
Full Name:
Dedicator of cytokinesis protein 9
Alias:
Cdc42 guanine nucleotide exchange factor zizimin 1; Cdc42 guanine nucleotide exchange factor zizimin-1; Dedicator of cytokinesis 9; ZIZ1
Type:
Membrane, Endomembrane system protein
Mass (Da):
236446
Number AA:
2069
UniProt ID:
Q9BZ29
International Prot ID:
IPI00216408
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0012505
GO:0016020
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0005085
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
Q
P
P
L
L
P
A
S
A
E
T
R
K
F
T
Site 2
T13
L
L
P
A
S
A
E
T
R
K
F
T
R
A
L
Site 3
T17
S
A
E
T
R
K
F
T
R
A
L
S
K
P
G
Site 4
S21
R
K
F
T
R
A
L
S
K
P
G
T
A
A
E
Site 5
T25
R
A
L
S
K
P
G
T
A
A
E
L
R
Q
S
Site 6
S32
T
A
A
E
L
R
Q
S
V
S
E
V
V
R
G
Site 7
S34
A
E
L
R
Q
S
V
S
E
V
V
R
G
S
V
Site 8
Y54
K
L
I
E
P
L
D
Y
E
N
V
I
V
Q
K
Site 9
Y78
R
E
M
L
L
F
P
Y
D
D
F
Q
T
A
I
Site 10
Y92
I
L
R
R
Q
G
R
Y
I
C
S
T
V
P
A
Site 11
S95
R
Q
G
R
Y
I
C
S
T
V
P
A
K
A
E
Site 12
T96
Q
G
R
Y
I
C
S
T
V
P
A
K
A
E
E
Site 13
S107
K
A
E
E
E
A
Q
S
L
F
V
T
E
C
I
Site 14
T111
E
A
Q
S
L
F
V
T
E
C
I
K
T
Y
N
Site 15
Y117
V
T
E
C
I
K
T
Y
N
S
D
W
H
L
V
Site 16
Y126
S
D
W
H
L
V
N
Y
K
Y
E
D
Y
S
G
Site 17
Y128
W
H
L
V
N
Y
K
Y
E
D
Y
S
G
E
F
Site 18
Y131
V
N
Y
K
Y
E
D
Y
S
G
E
F
R
Q
L
Site 19
Y153
D
K
L
P
V
H
V
Y
E
V
D
E
E
V
D
Site 20
S167
D
K
D
E
D
A
A
S
L
G
S
Q
K
G
G
Site 21
Y182
I
T
K
H
G
W
L
Y
K
G
N
M
N
S
A
Site 22
S188
L
Y
K
G
N
M
N
S
A
I
S
V
T
M
R
Site 23
S191
G
N
M
N
S
A
I
S
V
T
M
R
S
F
K
Site 24
S196
A
I
S
V
T
M
R
S
F
K
R
R
F
F
H
Site 25
S211
L
I
Q
L
G
D
G
S
Y
N
L
N
F
Y
K
Site 26
Y212
I
Q
L
G
D
G
S
Y
N
L
N
F
Y
K
D
Site 27
Y217
G
S
Y
N
L
N
F
Y
K
D
E
K
I
S
K
Site 28
S229
I
S
K
E
P
K
G
S
I
F
L
D
S
C
M
Site 29
S257
E
L
K
M
Q
D
K
S
S
Y
L
L
A
A
D
Site 30
S265
S
Y
L
L
A
A
D
S
E
V
E
M
E
E
W
Site 31
S296
Q
E
K
R
N
G
D
S
H
E
D
D
E
Q
S
Site 32
S303
S
H
E
D
D
E
Q
S
K
L
E
G
S
G
S
Site 33
S308
E
Q
S
K
L
E
G
S
G
S
G
L
D
S
Y
Site 34
S310
S
K
L
E
G
S
G
S
G
L
D
S
Y
L
P
Site 35
S314
G
S
G
S
G
L
D
S
Y
L
P
E
L
A
K
Site 36
Y315
S
G
S
G
L
D
S
Y
L
P
E
L
A
K
S
Site 37
S322
Y
L
P
E
L
A
K
S
A
R
E
A
E
I
K
Site 38
S332
E
A
E
I
K
L
K
S
E
S
R
V
K
L
F
Site 39
Y340
E
S
R
V
K
L
F
Y
L
D
P
D
A
Q
K
Site 40
S351
D
A
Q
K
L
D
F
S
S
A
E
P
E
V
K
Site 41
S352
A
Q
K
L
D
F
S
S
A
E
P
E
V
K
S
Site 42
S359
S
A
E
P
E
V
K
S
F
E
E
K
F
G
K
Site 43
T391
A
E
N
E
E
G
P
T
T
N
V
E
P
F
F
Site 44
T392
E
N
E
E
G
P
T
T
N
V
E
P
F
F
V
Site 45
Y408
L
S
L
F
D
I
K
Y
N
R
K
I
S
A
D
Site 46
S413
I
K
Y
N
R
K
I
S
A
D
F
H
V
D
L
Site 47
S433
R
Q
M
L
A
T
T
S
P
A
L
M
N
G
S
Site 48
S440
S
P
A
L
M
N
G
S
G
Q
S
P
S
V
L
Site 49
S443
L
M
N
G
S
G
Q
S
P
S
V
L
K
G
I
Site 50
S445
N
G
S
G
Q
S
P
S
V
L
K
G
I
L
H
Site 51
Y458
L
H
E
A
A
M
Q
Y
P
K
Q
G
I
F
S
Site 52
T488
K
V
L
Q
G
S
I
T
H
C
A
E
P
Y
M
Site 53
Y494
I
T
H
C
A
E
P
Y
M
K
S
S
D
S
S
Site 54
S497
C
A
E
P
Y
M
K
S
S
D
S
S
K
V
A
Site 55
S498
A
E
P
Y
M
K
S
S
D
S
S
K
V
A
Q
Site 56
S500
P
Y
M
K
S
S
D
S
S
K
V
A
Q
K
V
Site 57
S501
Y
M
K
S
S
D
S
S
K
V
A
Q
K
V
L
Site 58
Y521
A
C
Q
R
L
G
Q
Y
R
M
P
F
A
W
A
Site 59
S537
R
T
L
F
K
D
A
S
G
N
L
D
K
N
A
Site 60
S547
L
D
K
N
A
R
F
S
A
I
Y
R
Q
D
S
Site 61
Y550
N
A
R
F
S
A
I
Y
R
Q
D
S
N
K
L
Site 62
S554
S
A
I
Y
R
Q
D
S
N
K
L
S
N
D
D
Site 63
S558
R
Q
D
S
N
K
L
S
N
D
D
M
L
K
L
Site 64
Y599
V
S
S
D
F
P
N
Y
V
N
S
S
Y
I
P
Site 65
S602
D
F
P
N
Y
V
N
S
S
Y
I
P
T
K
Q
Site 66
T607
V
N
S
S
Y
I
P
T
K
Q
F
E
T
C
S
Site 67
S614
T
K
Q
F
E
T
C
S
K
T
P
I
T
F
E
Site 68
T616
Q
F
E
T
C
S
K
T
P
I
T
F
E
V
E
Site 69
T637
P
K
H
T
Q
P
Y
T
I
Y
T
N
H
L
Y
Site 70
Y639
H
T
Q
P
Y
T
I
Y
T
N
H
L
Y
V
Y
Site 71
Y644
T
I
Y
T
N
H
L
Y
V
Y
P
K
Y
L
K
Site 72
Y646
Y
T
N
H
L
Y
V
Y
P
K
Y
L
K
Y
D
Site 73
Y649
H
L
Y
V
Y
P
K
Y
L
K
Y
D
S
Q
K
Site 74
Y652
V
Y
P
K
Y
L
K
Y
D
S
Q
K
S
F
A
Site 75
S654
P
K
Y
L
K
Y
D
S
Q
K
S
F
A
K
A
Site 76
S657
L
K
Y
D
S
Q
K
S
F
A
K
A
R
N
I
Site 77
S673
I
C
I
E
F
K
D
S
D
E
E
D
S
Q
P
Site 78
S678
K
D
S
D
E
E
D
S
Q
P
L
K
C
I
Y
Site 79
Y685
S
Q
P
L
K
C
I
Y
G
R
P
G
G
P
V
Site 80
S736
L
L
T
F
F
H
V
S
C
D
N
S
S
K
G
Site 81
S740
F
H
V
S
C
D
N
S
S
K
G
S
T
K
K
Site 82
S741
H
V
S
C
D
N
S
S
K
G
S
T
K
K
R
Site 83
S744
C
D
N
S
S
K
G
S
T
K
K
R
D
V
V
Site 84
T753
K
K
R
D
V
V
E
T
Q
V
G
Y
S
W
L
Site 85
T770
L
K
D
G
R
V
V
T
S
E
Q
H
I
P
V
Site 86
S771
K
D
G
R
V
V
T
S
E
Q
H
I
P
V
S
Site 87
S778
S
E
Q
H
I
P
V
S
A
N
L
P
S
G
Y
Site 88
Y785
S
A
N
L
P
S
G
Y
L
G
Y
Q
E
L
G
Site 89
Y788
L
P
S
G
Y
L
G
Y
Q
E
L
G
M
G
R
Site 90
Y797
E
L
G
M
G
R
H
Y
G
P
E
I
K
W
V
Site 91
Y822
T
H
L
V
S
T
V
Y
T
Q
D
Q
H
L
H
Site 92
T823
H
L
V
S
T
V
Y
T
Q
D
Q
H
L
H
N
Site 93
S855
E
L
V
K
Y
L
K
S
L
H
A
M
E
G
H
Site 94
T880
N
Q
L
F
R
V
L
T
R
A
T
Q
E
E
V
Site 95
T883
F
R
V
L
T
R
A
T
Q
E
E
V
A
V
N
Site 96
S909
C
H
E
E
G
L
E
S
H
L
R
S
Y
V
K
Site 97
S913
G
L
E
S
H
L
R
S
Y
V
K
Y
A
Y
K
Site 98
Y914
L
E
S
H
L
R
S
Y
V
K
Y
A
Y
K
A
Site 99
Y917
H
L
R
S
Y
V
K
Y
A
Y
K
A
E
P
Y
Site 100
Y924
Y
A
Y
K
A
E
P
Y
V
A
S
E
Y
K
T
Site 101
S927
K
A
E
P
Y
V
A
S
E
Y
K
T
V
H
E
Site 102
T931
Y
V
A
S
E
Y
K
T
V
H
E
E
L
T
K
Site 103
S939
V
H
E
E
L
T
K
S
M
T
T
I
L
K
P
Site 104
T941
E
E
L
T
K
S
M
T
T
I
L
K
P
S
A
Site 105
T952
K
P
S
A
D
F
L
T
S
N
K
L
L
K
Y
Site 106
S953
P
S
A
D
F
L
T
S
N
K
L
L
K
Y
S
Site 107
Y959
T
S
N
K
L
L
K
Y
S
W
F
F
F
D
V
Site 108
S992
R
N
Q
R
F
P
A
S
Y
H
H
A
V
E
T
Site 109
Y993
N
Q
R
F
P
A
S
Y
H
H
A
V
E
T
V
Site 110
S1025
A
S
K
N
A
N
H
S
L
A
V
F
I
K
R
Site 111
T1060
F
A
P
G
D
P
K
T
L
F
E
Y
K
F
E
Site 112
Y1064
D
P
K
T
L
F
E
Y
K
F
E
F
L
R
V
Site 113
Y1095
G
K
G
R
I
Q
R
Y
Q
D
L
Q
L
D
Y
Site 114
Y1102
Y
Q
D
L
Q
L
D
Y
S
L
T
D
E
F
C
Site 115
S1103
Q
D
L
Q
L
D
Y
S
L
T
D
E
F
C
R
Site 116
T1105
L
Q
L
D
Y
S
L
T
D
E
F
C
R
N
H
Site 117
S1148
K
N
L
L
I
K
H
S
F
D
D
R
Y
A
S
Site 118
Y1153
K
H
S
F
D
D
R
Y
A
S
R
S
H
Q
A
Site 119
S1155
S
F
D
D
R
Y
A
S
R
S
H
Q
A
R
I
Site 120
S1157
D
D
R
Y
A
S
R
S
H
Q
A
R
I
A
T
Site 121
S1186
R
I
N
V
R
D
V
S
P
F
P
V
N
A
G
Site 122
T1211
P
A
V
N
P
L
V
T
P
Q
K
G
S
T
L
Site 123
T1217
V
T
P
Q
K
G
S
T
L
D
N
S
L
H
K
Site 124
S1221
K
G
S
T
L
D
N
S
L
H
K
D
L
L
G
Site 125
S1235
G
A
I
S
G
I
A
S
P
Y
T
T
S
T
P
Site 126
Y1237
I
S
G
I
A
S
P
Y
T
T
S
T
P
N
I
Site 127
T1238
S
G
I
A
S
P
Y
T
T
S
T
P
N
I
N
Site 128
T1239
G
I
A
S
P
Y
T
T
S
T
P
N
I
N
S
Site 129
S1240
I
A
S
P
Y
T
T
S
T
P
N
I
N
S
V
Site 130
T1241
A
S
P
Y
T
T
S
T
P
N
I
N
S
V
R
Site 131
S1246
T
S
T
P
N
I
N
S
V
R
N
A
D
S
R
Site 132
S1252
N
S
V
R
N
A
D
S
R
G
S
L
I
S
T
Site 133
S1255
R
N
A
D
S
R
G
S
L
I
S
T
D
S
G
Site 134
S1258
D
S
R
G
S
L
I
S
T
D
S
G
N
S
L
Site 135
T1259
S
R
G
S
L
I
S
T
D
S
G
N
S
L
P
Site 136
S1261
G
S
L
I
S
T
D
S
G
N
S
L
P
E
R
Site 137
S1264
I
S
T
D
S
G
N
S
L
P
E
R
N
S
E
Site 138
S1270
N
S
L
P
E
R
N
S
E
K
S
N
S
L
D
Site 139
S1273
P
E
R
N
S
E
K
S
N
S
L
D
K
H
Q
Site 140
S1275
R
N
S
E
K
S
N
S
L
D
K
H
Q
Q
S
Site 141
T1284
D
K
H
Q
Q
S
S
T
L
G
N
S
V
V
R
Site 142
S1288
Q
S
S
T
L
G
N
S
V
V
R
C
D
K
L
Site 143
S1298
R
C
D
K
L
D
Q
S
E
I
K
S
L
L
M
Site 144
Y1322
S
D
D
A
L
F
T
Y
W
N
K
A
S
T
S
Site 145
Y1347
V
C
L
H
Q
F
Q
Y
M
G
K
R
Y
I
A
Site 146
Y1352
F
Q
Y
M
G
K
R
Y
I
A
R
T
G
M
M
Site 147
T1356
G
K
R
Y
I
A
R
T
G
M
M
H
A
R
L
Site 148
S1368
A
R
L
Q
Q
L
G
S
L
D
N
S
L
T
F
Site 149
S1372
Q
L
G
S
L
D
N
S
L
T
F
N
H
S
Y
Site 150
T1374
G
S
L
D
N
S
L
T
F
N
H
S
Y
G
H
Site 151
S1378
N
S
L
T
F
N
H
S
Y
G
H
S
D
A
D
Site 152
S1382
F
N
H
S
Y
G
H
S
D
A
D
V
L
H
Q
Site 153
S1445
C
F
L
Q
K
H
Q
S
E
T
A
L
K
N
V
Site 154
T1466
L
I
Y
K
F
P
S
T
F
Y
E
G
R
A
D
Site 155
Y1468
Y
K
F
P
S
T
F
Y
E
G
R
A
D
M
C
Site 156
Y1480
D
M
C
A
A
L
C
Y
E
I
L
K
C
C
N
Site 157
S1488
E
I
L
K
C
C
N
S
K
L
S
S
I
R
T
Site 158
S1491
K
C
C
N
S
K
L
S
S
I
R
T
E
A
S
Site 159
S1492
C
C
N
S
K
L
S
S
I
R
T
E
A
S
Q
Site 160
T1495
S
K
L
S
S
I
R
T
E
A
S
Q
L
L
Y
Site 161
Y1502
T
E
A
S
Q
L
L
Y
F
L
M
R
N
N
F
Site 162
Y1511
L
M
R
N
N
F
D
Y
T
G
K
K
S
F
V
Site 163
T1512
M
R
N
N
F
D
Y
T
G
K
K
S
F
V
R
Site 164
S1516
F
D
Y
T
G
K
K
S
F
V
R
T
H
L
Q
Site 165
S1546
G
G
T
R
F
Q
Q
S
L
S
I
I
N
N
C
Site 166
T1563
S
D
R
L
I
K
H
T
S
F
S
S
D
V
K
Site 167
S1564
D
R
L
I
K
H
T
S
F
S
S
D
V
K
D
Site 168
T1573
S
S
D
V
K
D
L
T
K
R
I
R
T
V
L
Site 169
T1578
D
L
T
K
R
I
R
T
V
L
M
A
T
A
Q
Site 170
Y1601
E
M
L
V
D
L
Q
Y
S
L
A
K
S
Y
A
Site 171
S1606
L
Q
Y
S
L
A
K
S
Y
A
S
T
P
E
L
Site 172
Y1607
Q
Y
S
L
A
K
S
Y
A
S
T
P
E
L
R
Site 173
T1610
L
A
K
S
Y
A
S
T
P
E
L
R
K
T
W
Site 174
T1616
S
T
P
E
L
R
K
T
W
L
D
S
M
A
R
Site 175
S1620
L
R
K
T
W
L
D
S
M
A
R
I
H
V
K
Site 176
S1665
E
P
P
L
L
P
H
S
H
S
A
C
L
R
R
Site 177
S1667
P
L
L
P
H
S
H
S
A
C
L
R
R
S
R
Site 178
S1673
H
S
A
C
L
R
R
S
R
G
G
V
F
R
Q
Site 179
Y1745
Y
K
L
I
I
P
I
Y
E
K
R
R
D
F
E
Site 180
Y1758
F
E
R
L
A
H
L
Y
D
T
L
H
R
A
Y
Site 181
T1760
R
L
A
H
L
Y
D
T
L
H
R
A
Y
S
K
Site 182
Y1765
Y
D
T
L
H
R
A
Y
S
K
V
T
E
V
M
Site 183
S1766
D
T
L
H
R
A
Y
S
K
V
T
E
V
M
H
Site 184
S1774
K
V
T
E
V
M
H
S
G
R
R
L
L
G
T
Site 185
S1799
A
Q
Y
Q
F
T
D
S
E
T
D
V
E
G
F
Site 186
Y1815
E
D
E
D
G
K
E
Y
I
Y
K
E
P
K
L
Site 187
Y1817
E
D
G
K
E
Y
I
Y
K
E
P
K
L
T
P
Site 188
T1823
I
Y
K
E
P
K
L
T
P
L
S
E
I
S
Q
Site 189
S1826
E
P
K
L
T
P
L
S
E
I
S
Q
R
L
L
Site 190
Y1836
S
Q
R
L
L
K
L
Y
S
D
K
F
G
S
E
Site 191
S1837
Q
R
L
L
K
L
Y
S
D
K
F
G
S
E
N
Site 192
S1851
N
V
K
M
I
Q
D
S
G
K
V
N
P
K
D
Site 193
S1861
V
N
P
K
D
L
D
S
K
Y
A
Y
I
Q
V
Site 194
Y1863
P
K
D
L
D
S
K
Y
A
Y
I
Q
V
T
H
Site 195
Y1865
D
L
D
S
K
Y
A
Y
I
Q
V
T
H
V
I
Site 196
T1885
K
E
L
Q
E
R
K
T
E
F
E
R
S
H
N
Site 197
T1903
F
M
F
E
M
P
F
T
Q
T
G
K
R
Q
G
Site 198
T1920
E
E
Q
C
K
R
R
T
I
L
T
A
I
H
C
Site 199
Y1939
K
K
R
I
P
V
M
Y
Q
H
H
T
D
L
N
Site 200
S1968
E
L
R
Q
L
C
S
S
A
E
V
D
M
I
K
Site 201
Y1995
V
N
A
G
P
L
A
Y
A
R
A
F
L
D
D
Site 202
T2003
A
R
A
F
L
D
D
T
N
T
K
R
Y
P
D
Site 203
T2005
A
F
L
D
D
T
N
T
K
R
Y
P
D
N
K
Site 204
Y2008
D
D
T
N
T
K
R
Y
P
D
N
K
V
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation