PhosphoNET

           
Protein Info 
   
Short Name:  PANK2
Full Name:  Pantothenate kinase 2, mitochondrial
Alias:  C20orf48; EC 2.7.1.33; HARP; HSS; NBIA1; Neurodegeneration with brain iron accumulation; Neurodegeneration with brain iron accumulation 1 (Hallervorden-Spatz syndrome); Pantothenate kinase 2; Pantothenate kinase 2 (Hallervorden-Spatz syndrome); Pantothenate kinase 2, mitochondrial: Pantothenic acid kinase 2: Pantothenate kinase 2, mitochondrial: Pantothenic acid kinase 2; Pantothenic acid kinase; Pantothenic acid kinase 2; PKAN
Type:  Kinase (non-protein), Metabolism of Cofactors and Vitamins group, Pantothenate and CoA biosynthesis family
Mass (Da):  62681
Number AA:  570
UniProt ID:  Q9BZ23
International Prot ID:  IPI00171176
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005739     Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0004594  GO:0005515 PhosphoSite+ KinaseNET
Biological Process:  GO:0015937     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S18VHWAAPPSLSSGLHR
Site 2T32RLLFLRGTRIPSSTT
Site 3S36LRGTRIPSSTTLSPP
Site 4S37RGTRIPSSTTLSPPR
Site 5T38GTRIPSSTTLSPPRH
Site 6T39TRIPSSTTLSPPRHD
Site 7S41IPSSTTLSPPRHDSL
Site 8S47LSPPRHDSLSLDGGT
Site 9S49PPRHDSLSLDGGTVN
Site 10T54SLSLDGGTVNPPRVR
Site 11T64PPRVREPTGREAFGP
Site 12S72GREAFGPSPASSDWL
Site 13S75AFGPSPASSDWLPAR
Site 14S76FGPSPASSDWLPARW
Site 15S97RPRARLCSGWTAAEE
Site 16T110EEARRNPTLGGLLGR
Site 17S140MERHGRASATSVSSA
Site 18T142RHGRASATSVSSAGE
Site 19S143HGRASATSVSSAGEQ
Site 20S168EPLRRRASSASVPAV
Site 21S169PLRRRASSASVPAVG
Site 22S171RRRASSASVPAVGAS
Site 23S178SVPAVGASAEGTRRD
Site 24T182VGASAEGTRRDRLGS
Site 25S189TRRDRLGSYSGPTSV
Site 26Y190RRDRLGSYSGPTSVS
Site 27S191RDRLGSYSGPTSVSR
Site 28T194LGSYSGPTSVSRQRV
Site 29S195GSYSGPTSVSRQRVE
Site 30S197YSGPTSVSRQRVESL
Site 31S203VSRQRVESLRKKRPL
Site 32S244EEEEEVESLKSIRKY
Site 33S247EEVESLKSIRKYLTS
Site 34Y251SLKSIRKYLTSNVAY
Site 35T253KSIRKYLTSNVAYGS
Site 36S254SIRKYLTSNVAYGST
Site 37Y258YLTSNVAYGSTGIRD
Site 38T274HLELKDLTLCGRKGN
Site 39S306GRDKNFSSLHTVFCA
Site 40S351KGILYIDSVGFNGRS
Site 41Y362NGRSQCYYFENPADS
Site 42Y400GVSILAVYSKDNYKR
Site 43Y405AVYSKDNYKRVTGTS
Site 44T409KDNYKRVTGTSLGGG
Site 45S412YKRVTGTSLGGGTFF
Site 46S439EEALEMASRGDSTKV
Site 47S443EMASRGDSTKVDKLV
Site 48T444MASRGDSTKVDKLVR
Site 49Y454DKLVRDIYGGDYERF
Site 50Y458RDIYGGDYERFGLPG
Site 51S471PGWAVASSFGNMMSK
Site 52S477SSFGNMMSKEKREAV
Site 53T493KEDLARATLITITNN
Site 54Y540LLAYALDYWSKGQLK
Site 55S542AYALDYWSKGQLKAL
Site 56S551GQLKALFSEHEGYFG
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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