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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBC1D2
Full Name:
TBC1 domain family member 2A
Alias:
PARIS1; PARIS-1; Prostate antigen recognized and identified by SEREX; Prostate antigen recognized and indentified by SEREX; TBC1 domain family member 2; TBC1 domain family, member 2; TBC1D2A; TBC2; TBCD2; TBD2A
Type:
GTPase activating protein, Rab
Mass (Da):
104105
Number AA:
917
UniProt ID:
Q9BYX2
International Prot ID:
IPI00097495
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
A
G
E
N
A
P
E
S
S
S
S
A
P
G
S
Site 2
S13
E
N
A
P
E
S
S
S
S
A
P
G
S
E
E
Site 3
S14
N
A
P
E
S
S
S
S
A
P
G
S
E
E
S
Site 4
S18
S
S
S
S
A
P
G
S
E
E
S
A
R
D
P
Site 5
S21
S
A
P
G
S
E
E
S
A
R
D
P
Q
V
P
Site 6
S40
E
S
G
D
C
A
R
S
L
E
A
V
P
K
K
Site 7
Y51
V
P
K
K
L
C
G
Y
L
S
K
F
G
G
K
Site 8
S53
K
K
L
C
G
Y
L
S
K
F
G
G
K
G
P
Site 9
Y79
D
E
R
K
C
Q
L
Y
Y
S
R
T
A
Q
D
Site 10
Y80
E
R
K
C
Q
L
Y
Y
S
R
T
A
Q
D
A
Site 11
S81
R
K
C
Q
L
Y
Y
S
R
T
A
Q
D
A
N
Site 12
S92
Q
D
A
N
P
L
D
S
I
D
L
S
S
A
V
Site 13
T115
E
G
I
F
E
I
K
T
P
S
R
V
I
T
L
Site 14
T121
K
T
P
S
R
V
I
T
L
K
A
A
T
K
Q
Site 15
Y132
A
T
K
Q
A
M
L
Y
W
L
Q
Q
L
Q
M
Site 16
S147
K
R
W
E
F
H
N
S
P
P
A
P
P
A
T
Site 17
T154
S
P
P
A
P
P
A
T
P
D
A
A
L
A
G
Site 18
T186
E
F
L
C
P
V
K
T
P
P
G
L
V
G
V
Site 19
S240
H
E
P
P
G
E
D
S
P
Q
S
G
E
P
Q
Site 20
S243
P
G
E
D
S
P
Q
S
G
E
P
Q
R
E
E
Site 21
S255
R
E
E
Q
P
L
A
S
D
A
S
T
P
G
R
Site 22
T259
P
L
A
S
D
A
S
T
P
G
R
E
P
E
D
Site 23
S267
P
G
R
E
P
E
D
S
P
K
P
A
P
K
P
Site 24
S275
P
K
P
A
P
K
P
S
L
T
I
S
F
A
Q
Site 25
T277
P
A
P
K
P
S
L
T
I
S
F
A
Q
K
A
Site 26
S279
P
K
P
S
L
T
I
S
F
A
Q
K
A
K
R
Site 27
T290
K
A
K
R
Q
N
N
T
F
P
F
F
S
E
G
Site 28
S295
N
N
T
F
P
F
F
S
E
G
I
T
R
N
R
Site 29
T303
E
G
I
T
R
N
R
T
A
Q
E
K
V
A
A
Site 30
T319
E
Q
Q
V
L
M
L
T
K
E
L
K
S
Q
K
Site 31
S324
M
L
T
K
E
L
K
S
Q
K
E
L
V
K
I
Site 32
S346
A
Q
Q
E
K
R
A
S
S
A
Y
L
A
A
A
Site 33
S347
Q
Q
E
K
R
A
S
S
A
Y
L
A
A
A
E
Site 34
Y349
E
K
R
A
S
S
A
Y
L
A
A
A
E
D
K
Site 35
S385
A
L
E
Q
E
R
E
S
L
A
H
T
A
S
L
Site 36
T389
E
R
E
S
L
A
H
T
A
S
L
R
E
Q
Q
Site 37
S391
E
S
L
A
H
T
A
S
L
R
E
Q
Q
V
Q
Site 38
T426
C
K
L
S
E
K
V
T
Q
D
F
T
H
P
P
Site 39
T430
E
K
V
T
Q
D
F
T
H
P
P
D
Q
S
P
Site 40
S436
F
T
H
P
P
D
Q
S
P
L
R
P
D
A
A
Site 41
S449
A
A
N
R
D
F
L
S
Q
Q
G
K
I
E
H
Site 42
T494
E
K
E
K
A
L
L
T
K
C
A
Y
L
Q
A
Site 43
Y510
N
C
Q
V
E
S
K
Y
L
A
G
L
R
R
L
Site 44
S526
E
A
L
G
D
E
A
S
E
C
S
E
L
L
R
Site 45
S549
W
E
A
G
E
A
S
S
D
S
I
E
L
S
P
Site 46
S551
A
G
E
A
S
S
D
S
I
E
L
S
P
I
S
Site 47
S555
S
S
D
S
I
E
L
S
P
I
S
K
Y
D
E
Site 48
S558
S
I
E
L
S
P
I
S
K
Y
D
E
Y
G
F
Site 49
Y560
E
L
S
P
I
S
K
Y
D
E
Y
G
F
L
T
Site 50
Y563
P
I
S
K
Y
D
E
Y
G
F
L
T
V
P
D
Site 51
T567
Y
D
E
Y
G
F
L
T
V
P
D
Y
E
V
E
Site 52
Y571
G
F
L
T
V
P
D
Y
E
V
E
D
L
K
L
Site 53
S587
A
K
I
Q
A
L
E
S
R
S
H
H
L
L
G
Site 54
T648
L
R
V
Q
H
L
H
T
P
G
C
Y
Q
E
L
Site 55
T677
I
E
L
D
L
N
R
T
F
P
N
N
K
H
F
Site 56
S689
K
H
F
T
C
P
T
S
S
F
P
D
K
L
R
Site 57
S690
H
F
T
C
P
T
S
S
F
P
D
K
L
R
R
Site 58
Y748
E
T
I
M
P
A
D
Y
Y
C
N
T
L
T
A
Site 59
T752
P
A
D
Y
Y
C
N
T
L
T
A
S
Q
V
D
Site 60
T754
D
Y
Y
C
N
T
L
T
A
S
Q
V
D
Q
R
Site 61
S756
Y
C
N
T
L
T
A
S
Q
V
D
Q
R
V
L
Site 62
S768
R
V
L
Q
D
L
L
S
E
K
L
P
R
L
M
Site 63
Y815
R
V
W
D
A
F
L
Y
E
G
T
K
Y
N
E
Site 64
Y820
F
L
Y
E
G
T
K
Y
N
E
K
E
I
L
R
Site 65
Y835
L
Q
N
G
L
E
I
Y
Q
Y
L
R
F
F
T
Site 66
Y837
N
G
L
E
I
Y
Q
Y
L
R
F
F
T
K
T
Site 67
T842
Y
Q
Y
L
R
F
F
T
K
T
I
S
N
S
R
Site 68
T844
Y
L
R
F
F
T
K
T
I
S
N
S
R
K
L
Site 69
S846
R
F
F
T
K
T
I
S
N
S
R
K
L
M
N
Site 70
Y892
L
E
Q
L
K
A
E
Y
L
E
R
R
A
S
R
Site 71
S898
E
Y
L
E
R
R
A
S
R
R
R
A
V
S
E
Site 72
S904
A
S
R
R
R
A
V
S
E
G
C
A
S
E
D
Site 73
S909
A
V
S
E
G
C
A
S
E
D
E
V
E
G
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation