PhosphoNET

           
Protein Info 
   
Short Name:  SETD2
Full Name:  Histone-lysine N-methyltransferase SETD2
Alias:  FLJ23184; HIF-1; Huntingtin interacting protein 1; HYPB; KIAA1732; KMT3A; SET domain containing 2
Type:  Methyltransferase; Amino Acid Metabolism - lysine degradation; EC 2.1.1.43
Mass (Da):  287550
Number AA:  2564
UniProt ID:  Q9BYW2
International Prot ID:  IPI00307733
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634     Uniprot OncoNet
Molecular Function:  GO:0003677  GO:0018024  GO:0016491 PhosphoSite+ KinaseNET
Biological Process:  GO:0055114  GO:0045449  GO:0006350 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1Y16PPKMGDFYDPEHPTP
Site 2T22FYDPEHPTPEEEENE
Site 3T38KIENVQKTGFIKGPM
Site 4S51PMFKGVASSRFLPKG
Site 5S52MFKGVASSRFLPKGT
Site 6S74EQGRQKVSFSFSLTK
Site 7S76GRQKVSFSFSLTKKT
Site 8S78QKVSFSFSLTKKTLQ
Site 9T80VSFSFSLTKKTLQNR
Site 10T90TLQNRFLTALGNEKQ
Site 11T100GNEKQSDTPNPPAVP
Site 12T113VPLQVDSTPKMKMEI
Site 13T123MKMEIGDTLSTAEES
Site 14S125MEIGDTLSTAEESSP
Site 15T126EIGDTLSTAEESSPP
Site 16S130TLSTAEESSPPKSRV
Site 17S131LSTAEESSPPKSRVE
Site 18S135EESSPPKSRVELGKI
Site 19T152KKHLLHVTSRPLLAT
Site 20T181PAVIAESTTVDSPPS
Site 21T182AVIAESTTVDSPPSS
Site 22S185AESTTVDSPPSSPPP
Site 23S188TTVDSPPSSPPPPPP
Site 24S189TVDSPPSSPPPPPPP
Site 25T200PPPPAQATTLSSPAP
Site 26T201PPPAQATTLSSPAPV
Site 27S203PAQATTLSSPAPVTE
Site 28S204AQATTLSSPAPVTEP
Site 29S249PIIIVPESLEADTKQ
Site 30T258EADTKQDTISNSLEE
Site 31S260DTKQDTISNSLEEHV
Site 32S262KQDTISNSLEEHVTQ
Site 33T268NSLEEHVTQILNEQA
Site 34S284ISSKKEDSHIGKDEE
Site 35S295KDEEIPDSSKISLSC
Site 36S296DEEIPDSSKISLSCK
Site 37S299IPDSSKISLSCKKTG
Site 38S301DSSKISLSCKKTGSK
Site 39T305ISLSCKKTGSKKKSS
Site 40S307LSCKKTGSKKKSSQS
Site 41S311KTGSKKKSSQSEGIF
Site 42S312TGSKKKSSQSEGIFL
Site 43S314SKKKSSQSEGIFLGS
Site 44S321SEGIFLGSESDEDSV
Site 45S323GIFLGSESDEDSVRT
Site 46S327GSESDEDSVRTSSSQ
Site 47S331DEDSVRTSSSQRSHD
Site 48S332EDSVRTSSSQRSHDL
Site 49S333DSVRTSSSQRSHDLK
Site 50S336RTSSSQRSHDLKFSA
Site 51S344HDLKFSASIEKERDF
Site 52S354KERDFKKSSAPLKSE
Site 53S355ERDFKKSSAPLKSED
Site 54S360KSSAPLKSEDLGKPS
Site 55S367SEDLGKPSRSKTDRD
Site 56T371GKPSRSKTDRDDKYF
Site 57Y377KTDRDDKYFSYSKLE
Site 58S381DDKYFSYSKLERDTR
Site 59T387YSKLERDTRYVSSRC
Site 60Y389KLERDTRYVSSRCRS
Site 61S391ERDTRYVSSRCRSER
Site 62S392RDTRYVSSRCRSERE
Site 63S396YVSSRCRSERERRRS
Site 64S403SERERRRSRSHSRSE
Site 65S405RERRRSRSHSRSERG
Site 66S407RRRSRSHSRSERGSR
Site 67S409RSRSHSRSERGSRTN
Site 68S413HSRSERGSRTNLSYS
Site 69T415RSERGSRTNLSYSRS
Site 70S418RGSRTNLSYSRSERS
Site 71Y419GSRTNLSYSRSERSH
Site 72S420SRTNLSYSRSERSHY
Site 73S422TNLSYSRSERSHYYD
Site 74S425SYSRSERSHYYDSDR
Site 75Y427SRSERSHYYDSDRRY
Site 76Y428RSERSHYYDSDRRYH
Site 77S430ERSHYYDSDRRYHRS
Site 78Y434YYDSDRRYHRSSPYR
Site 79S437SDRRYHRSSPYRERT
Site 80S438DRRYHRSSPYRERTR
Site 81T444SSPYRERTRYSRPYT
Site 82Y446PYRERTRYSRPYTDN
Site 83S447YRERTRYSRPYTDNR
Site 84Y450RTRYSRPYTDNRARE
Site 85T451TRYSRPYTDNRARES
Site 86S458TDNRARESSDSEEEY
Site 87S459DNRARESSDSEEEYK
Site 88S461RARESSDSEEEYKKT
Site 89Y465SSDSEEEYKKTYSRR
Site 90T468SEEEYKKTYSRRTSS
Site 91Y469EEEYKKTYSRRTSSH
Site 92S470EEYKKTYSRRTSSHS
Site 93T473KKTYSRRTSSHSSSY
Site 94S474KTYSRRTSSHSSSYR
Site 95S475TYSRRTSSHSSSYRD
Site 96S477SRRTSSHSSSYRDLR
Site 97S478RRTSSHSSSYRDLRT
Site 98S479RTSSHSSSYRDLRTS
Site 99T485SSYRDLRTSSYSKSD
Site 100S486SYRDLRTSSYSKSDR
Site 101S487YRDLRTSSYSKSDRD
Site 102S489DLRTSSYSKSDRDCK
Site 103S491RTSSYSKSDRDCKTE
Site 104T497KSDRDCKTETSYLEM
Site 105S500RDCKTETSYLEMERR
Site 106Y501DCKTETSYLEMERRG
Site 107Y510EMERRGKYSSKLERE
Site 108S511MERRGKYSSKLERES
Site 109S512ERRGKYSSKLERESK
Site 110S518SSKLERESKRTSENE
Site 111T521LERESKRTSENEAIK
Site 112S522ERESKRTSENEAIKR
Site 113S532EAIKRCCSPPNELGF
Site 114S543ELGFRRGSSYSKHDS
Site 115S544LGFRRGSSYSKHDSS
Site 116Y545GFRRGSSYSKHDSSA
Site 117S546FRRGSSYSKHDSSAS
Site 118S550SSYSKHDSSASRYKS
Site 119S551SYSKHDSSASRYKST
Site 120S553SKHDSSASRYKSTLS
Site 121Y555HDSSASRYKSTLSKP
Site 122S557SSASRYKSTLSKPIP
Site 123T558SASRYKSTLSKPIPK
Site 124S560SRYKSTLSKPIPKSD
Site 125S566LSKPIPKSDKFKNSF
Site 126S585LNEEIKQSHSFSLQT
Site 127S587EEIKQSHSFSLQTPC
Site 128S589IKQSHSFSLQTPCSK
Site 129T592SHSFSLQTPCSKGSE
Site 130S595FSLQTPCSKGSELRM
Site 131S614PEREKAGSPAPSNRL
Site 132S618KAGSPAPSNRLNDSP
Site 133S624PSNRLNDSPTLKKLD
Site 134T626NRLNDSPTLKKLDEL
Site 135S638DELPIFKSEFITHDS
Site 136T642IFKSEFITHDSHDSI
Site 137S645SEFITHDSHDSIKEL
Site 138S648ITHDSHDSIKELDSL
Site 139S654DSIKELDSLSKVKND
Site 140S656IKELDSLSKVKNDQL
Site 141S665VKNDQLRSFCPIELN
Site 142S676IELNINGSPGAESDL
Site 143T685GAESDLATFCTSKTD
Site 144S698TDAVLMTSDDSVTGS
Site 145S701VLMTSDDSVTGSELS
Site 146T703MTSDDSVTGSELSPL
Site 147S705SDDSVTGSELSPLVK
Site 148S708SVTGSELSPLVKACM
Site 149S725SNGFQNISRCKEKDL
Site 150T735KEKDLDDTCMLHKKS
Site 151S742TCMLHKKSESPFRET
Site 152S744MLHKKSESPFRETEP
Site 153T749SESPFRETEPLVSPH
Site 154S754RETEPLVSPHQDKLM
Site 155Y770MPVMTVDYSKTVVKE
Site 156T773MTVDYSKTVVKEPVD
Site 157T781VVKEPVDTRVSCCKT
Site 158S784EPVDTRVSCCKTKDS
Site 159T788TRVSCCKTKDSDIYC
Site 160Y794KTKDSDIYCTLNDSN
Site 161T796KDSDIYCTLNDSNPS
Site 162S803TLNDSNPSLCNSEAE
Site 163S807SNPSLCNSEAENIEP
Site 164S815EAENIEPSVMKISSN
Site 165S820EPSVMKISSNSFMNV
Site 166S821PSVMKISSNSFMNVH
Site 167S838SKPVICDSRNLTDHS
Site 168T842ICDSRNLTDHSKFAC
Site 169S845SRNLTDHSKFACEEY
Site 170Y852SKFACEEYKQSIGST
Site 171S855ACEEYKQSIGSTSSA
Site 172S858EYKQSIGSTSSASVN
Site 173T859YKQSIGSTSSASVNH
Site 174S860KQSIGSTSSASVNHF
Site 175S861QSIGSTSSASVNHFD
Site 176S863IGSTSSASVNHFDDL
Site 177Y871VNHFDDLYQPIGSSG
Site 178S882GSSGIASSLQSLPPG
Site 179S917AVLKSKKSSEFLKHA
Site 180S918VLKSKKSSEFLKHAG
Site 181S934ETIVEVGSDLPDSGK
Site 182S939VGSDLPDSGKGFASR
Site 183S955NRRNNGLSGKCLQEA
Site 184S980RRGRPEISLDERGEG
Site 185S993EGGHVHTSDDSEVVF
Site 186S996HVHTSDDSEVVFSSC
Site 187S1001DDSEVVFSSCDLNLT
Site 188T1008SSCDLNLTMEDSDGV
Site 189T1016MEDSDGVTYALKCDS
Site 190S1024YALKCDSSGHAPEIV
Site 191S1032GHAPEIVSTVHEDYS
Site 192T1033HAPEIVSTVHEDYSG
Site 193Y1038VSTVHEDYSGSSESS
Site 194S1039STVHEDYSGSSESSN
Site 195S1044DYSGSSESSNDESDS
Site 196S1045YSGSSESSNDESDSE
Site 197S1049SESSNDESDSEDTDS
Site 198S1051SSNDESDSEDTDSDD
Site 199T1054DESDSEDTDSDDSSI
Site 200S1056SDSEDTDSDDSSIPR
Site 201S1059EDTDSDDSSIPRNRL
Site 202S1060DTDSDDSSIPRNRLQ
Site 203S1068IPRNRLQSVVVVPKN
Site 204T1083STLPMEETSPCSSRS
Site 205S1084TLPMEETSPCSSRSS
Site 206S1087MEETSPCSSRSSQSY
Site 207S1088EETSPCSSRSSQSYR
Site 208S1090TSPCSSRSSQSYRHY
Site 209S1091SPCSSRSSQSYRHYS
Site 210S1093CSSRSSQSYRHYSDH
Site 211Y1094SSRSSQSYRHYSDHW
Site 212Y1097SSQSYRHYSDHWEDE
Site 213S1098SQSYRHYSDHWEDER
Site 214S1108WEDERLESRRHLYEE
Site 215Y1113LESRRHLYEEKFESI
Site 216S1119LYEEKFESIASKACP
Site 217T1128ASKACPQTDKFFLHK
Site 218S1144TEKNPEISFTQSSRK
Site 219T1146KNPEISFTQSSRKQI
Site 220S1148PEISFTQSSRKQIDN
Site 221S1161DNRLPELSHPQSDGV
Site 222S1165PELSHPQSDGVDSTS
Site 223S1170PQSDGVDSTSHTDVK
Site 224S1172SDGVDSTSHTDVKSD
Site 225T1174GVDSTSHTDVKSDPL
Site 226S1178TSHTDVKSDPLGHPN
Site 227S1186DPLGHPNSEETVKAK
Site 228T1189GHPNSEETVKAKIPS
Site 229S1196TVKAKIPSRQQEELP
Site 230Y1205QQEELPIYSSDFEDV
Site 231S1207EELPIYSSDFEDVPN
Site 232T1221NKSWQQTTFQNRPDS
Site 233S1228TFQNRPDSRLGKTEL
Site 234T1233PDSRLGKTELSFSSS
Site 235S1236RLGKTELSFSSSCEI
Site 236S1238GKTELSFSSSCEIPH
Site 237S1239KTELSFSSSCEIPHV
Site 238S1240TELSFSSSCEIPHVD
Site 239S1251PHVDGLHSSEELRNL
Site 240S1252HVDGLHSSEELRNLG
Site 241S1263RNLGWDFSQEKPSAT
Site 242Y1271QEKPSATYQQPDSSY
Site 243S1276ATYQQPDSSYGACGG
Site 244S1277TYQQPDSSYGACGGH
Site 245Y1278YQQPDSSYGACGGHK
Site 246Y1286GACGGHKYQQNAEQY
Site 247Y1305DYWQGNGYWDPRSGR
Site 248S1310NGYWDPRSGRPPGTG
Site 249T1316RSGRPPGTGVVYDRT
Site 250Y1320PPGTGVVYDRTQGQV
Site 251T1323TGVVYDRTQGQVPDS
Site 252S1330TQGQVPDSLTDDREE
Site 253T1332GQVPDSLTDDREEEE
Site 254S1353GSHFSDQSDKFLLSL
Site 255S1359QSDKFLLSLQKDKGS
Site 256S1366SLQKDKGSVQAPEIS
Site 257S1376APEISSNSIKDTLAV
Site 258T1380SSNSIKDTLAVNEKK
Site 259S1413KRRQEIESDSESDGE
Site 260S1415RQEIESDSESDGELQ
Site 261S1417EIESDSESDGELQDR
Site 262T1436VEVEQGETSVPPGSA
Site 263S1437EVEQGETSVPPGSAL
Site 264Y1472KQGKMPCYFDLIEEN
Site 265Y1481DLIEENVYLTERKKN
Site 266T1483IEENVYLTERKKNKS
Site 267S1490TERKKNKSHRDIKRM
Site 268T1502KRMQCECTPLSKDER
Site 269S1505QCECTPLSKDERAQG
Site 270S1530RLLMIECSSRCPNGD
Site 271Y1538SRCPNGDYCSNRRFQ
Site 272S1572RAAKDLPSNTFVLEY
Site 273T1574AKDLPSNTFVLEYCG
Site 274Y1596FKARVKEYARNKNIH
Site 275Y1604ARNKNIHYYFMALKN
Site 276Y1605RNKNIHYYFMALKND
Site 277T1618NDEIIDATQKGNCSR
Site 278S1660TKLVPSGSELTFDYQ
Site 279T1663VPSGSELTFDYQFQR
Site 280Y1666GSELTFDYQFQRYGK
Site 281Y1688GSANCRGYLGGENRV
Site 282S1696LGGENRVSIRAAGGK
Site 283S1709GKMKKERSRKKDSVD
Site 284S1714ERSRKKDSVDGELEA
Site 285S1737SDKNQVPSLSRLMVR
Site 286T1747RLMVRIETLEQKLTC
Site 287T1753ETLEQKLTCLELIQN
Site 288S1763ELIQNTHSQSCLKSF
Site 289S1769HSQSCLKSFLERHGL
Site 290S1792ELGDGRESNQKLQEE
Site 291T1803LQEEIIKTLEHLPIP
Site 292S1828LPIIQRWSQTKTAVP
Site 293T1832QRWSQTKTAVPPLSE
Site 294S1838KTAVPPLSEGDGYSS
Site 295Y1843PLSEGDGYSSENTSR
Site 296S1844LSEGDGYSSENTSRA
Site 297S1845SEGDGYSSENTSRAH
Site 298T1848DGYSSENTSRAHTPL
Site 299S1849GYSSENTSRAHTPLN
Site 300T1853ENTSRAHTPLNTPDP
Site 301T1857RAHTPLNTPDPSTKL
Site 302S1861PLNTPDPSTKLSTEA
Site 303T1862LNTPDPSTKLSTEAD
Site 304S1865PDPSTKLSTEADTDT
Site 305T1870KLSTEADTDTPKKLM
Site 306T1872STEADTDTPKKLMFR
Site 307S1885FRRLKIISENSMDSA
Site 308S1888LKIISENSMDSAISD
Site 309S1891ISENSMDSAISDATS
Site 310S1894NSMDSAISDATSELE
Site 311S1898SAISDATSELEGKDG
Site 312S1925EEEEELQSQQLLPQQ
Site 313S1940LPECKVDSETNIEAS
Site 314T1942ECKVDSETNIEASKL
Site 315T1951IEASKLPTSEPEADA
Site 316S1952EASKLPTSEPEADAE
Site 317S1965AEIEPKESNGTKLEE
Site 318T1968EPKESNGTKLEEPIN
Site 319T1978EEPINEETPSQDEEE
Site 320S1980PINEETPSQDEEEGV
Site 321S1988QDEEEGVSDVESERS
Site 322S1992EGVSDVESERSQEQP
Site 323S1995SDVESERSQEQPDKT
Site 324T2002SQEQPDKTVDISDLA
Site 325S2006PDKTVDISDLATKLL
Site 326T2010VDISDLATKLLDSWK
Site 327S2015LATKLLDSWKDLKEV
Site 328Y2023WKDLKEVYRIPKKSQ
Site 329S2029VYRIPKKSQTEKENT
Site 330T2036SQTEKENTTTERGRD
Site 331T2038TEKENTTTERGRDAV
Site 332T2051AVGFRDQTPAPKTPN
Site 333T2056DQTPAPKTPNRSRER
Site 334S2060APKTPNRSRERDPDK
Site 335T2069ERDPDKQTQNKEKRK
Site 336S2079KEKRKRRSSLSPPSS
Site 337S2080EKRKRRSSLSPPSSA
Site 338S2082RKRRSSLSPPSSAYE
Site 339S2085RSSLSPPSSAYERGT
Site 340S2086SSLSPPSSAYERGTK
Site 341Y2088LSPPSSAYERGTKRP
Site 342T2092SSAYERGTKRPDDRY
Site 343Y2099TKRPDDRYDTPTSKK
Site 344T2101RPDDRYDTPTSKKKV
Site 345T2103DDRYDTPTSKKKVRI
Site 346S2104DRYDTPTSKKKVRIK
Site 347S2117IKDRNKLSTEERRKL
Site 348T2118KDRNKLSTEERRKLF
Site 349S2148MQNLGMTSPLPYDSL
Site 350Y2152GMTSPLPYDSLGYNA
Site 351S2154TSPLPYDSLGYNAPH
Site 352Y2157LPYDSLGYNAPHHPF
Site 353Y2167PHHPFAGYPPGYPMQ
Site 354Y2171FAGYPPGYPMQAYVD
Site 355Y2176PGYPMQAYVDPSNPN
Site 356S2199PSMDPVCSPAPYDHA
Site 357Y2203PVCSPAPYDHAQPLV
Site 358S2213AQPLVGHSTEPLSAP
Site 359T2214QPLVGHSTEPLSAPP
Site 360S2218GHSTEPLSAPPPVPV
Site 361S2238APVEVSSSQYVAQSD
Site 362Y2240VEVSSSQYVAQSDGV
Site 363Y2270GPVQGQNYSVWDSNQ
Site 364S2275QNYSVWDSNQQSVSV
Site 365S2281DSNQQSVSVQQQYSP
Site 366S2287VSVQQQYSPAQSQAT
Site 367S2291QQYSPAQSQATIYYQ
Site 368Y2296AQSQATIYYQGQTCP
Site 369T2304YQGQTCPTVYGVTSP
Site 370Y2306GQTCPTVYGVTSPYS
Site 371S2310PTVYGVTSPYSQTTP
Site 372S2313YGVTSPYSQTTPPIV
Site 373T2315VTSPYSQTTPPIVQS
Site 374T2316TSPYSQTTPPIVQSY
Site 375S2322TTPPIVQSYAQPSLQ
Site 376Y2323TPPIVQSYAQPSLQY
Site 377S2327VQSYAQPSLQYIQGQ
Site 378T2372QPSEMVVTNNLLDLP
Site 379S2382LLDLPPPSPPKPKTI
Site 380T2388PSPPKPKTIVLPPNW
Site 381T2397VLPPNWKTARDPEGK
Site 382Y2406RDPEGKIYYYHVITR
Site 383Y2407DPEGKIYYYHVITRQ
Site 384Y2408PEGKIYYYHVITRQT
Site 385T2421QTQWDPPTWESPGDD
Site 386S2424WDPPTWESPGDDASL
Site 387S2430ESPGDDASLEHEAEM
Site 388T2441EAEMDLGTPTYDENP
Site 389T2443EMDLGTPTYDENPMK
Site 390Y2444MDLGTPTYDENPMKA
Site 391T2457KASKKPKTAEADTSS
Site 392S2463KTAEADTSSELAKKS
Site 393S2464TAEADTSSELAKKSK
Site 394S2470SSELAKKSKEVFRKE
Site 395Y2489IVQCLNPYRKPDCKV
Site 396T2500DCKVGRITTTEDFKH
Site 397T2501CKVGRITTTEDFKHL
Site 398T2513KHLARKLTHGVMNKE
Site 399Y2547TKEYIKKYMQKFGAV
Site 400T2561VYKPKEDTELE____
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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