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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NLN
Full Name:
Neurolysin, mitochondrial
Alias:
AGTBP; Angiotensin binding protein; EC 3.4.24.16; KIAA1226; MEP; Metallopeptidase M3 family; Microsomal endopeptidase; Mitochondrial oligopeptidase M; NEUL; Neurolysin; Neurotensin endopeptidase
Type:
Protease; EC 3.4.24.16
Mass (Da):
80652
Number AA:
704
UniProt ID:
Q9BYT8
International Prot ID:
IPI00010346
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005758
GO:0005739
GO:0005758
Uniprot
OncoNet
Molecular Function:
GO:0004222
GO:0008270
GO:0004222
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
GO:0008152
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
S
L
R
R
V
G
G
S
R
I
L
L
R
M
T
Site 2
S32
T
L
G
R
E
V
M
S
P
L
Q
A
M
S
S
Site 3
S39
S
P
L
Q
A
M
S
S
Y
T
V
A
G
R
N
Site 4
Y40
P
L
Q
A
M
S
S
Y
T
V
A
G
R
N
V
Site 5
S53
N
V
L
R
W
D
L
S
P
E
Q
I
K
T
R
Site 6
T59
L
S
P
E
Q
I
K
T
R
T
E
E
L
I
V
Site 7
S114
D
F
P
Q
H
V
S
S
D
K
E
V
R
A
A
Site 8
S122
D
K
E
V
R
A
A
S
T
E
A
D
K
R
L
Site 9
S130
T
E
A
D
K
R
L
S
R
F
D
I
E
M
S
Site 10
S137
S
R
F
D
I
E
M
S
M
R
G
D
I
F
E
Site 11
Y165
I
K
P
E
A
R
R
Y
L
E
K
S
I
K
M
Site 12
S169
A
R
R
Y
L
E
K
S
I
K
M
G
K
R
N
Site 13
S190
Q
V
Q
N
E
I
K
S
M
K
K
R
M
S
E
Site 14
S196
K
S
M
K
K
R
M
S
E
L
C
I
D
F
N
Site 15
T211
K
N
L
N
E
D
D
T
F
L
V
F
S
K
A
Site 16
S230
L
P
D
D
F
I
D
S
L
E
K
T
D
D
D
Site 17
T234
F
I
D
S
L
E
K
T
D
D
D
K
Y
K
I
Site 18
Y239
E
K
T
D
D
D
K
Y
K
I
T
L
K
Y
P
Site 19
Y245
K
Y
K
I
T
L
K
Y
P
H
Y
F
P
V
M
Site 20
Y248
I
T
L
K
Y
P
H
Y
F
P
V
M
K
K
C
Site 21
S311
L
E
M
N
T
A
K
S
T
S
R
V
T
A
F
Site 22
T316
A
K
S
T
S
R
V
T
A
F
L
D
D
L
S
Site 23
S323
T
A
F
L
D
D
L
S
Q
K
L
K
P
L
G
Site 24
Y352
C
K
D
R
G
F
E
Y
D
G
K
I
N
A
W
Site 25
Y362
K
I
N
A
W
D
L
Y
Y
Y
M
T
Q
T
E
Site 26
Y363
I
N
A
W
D
L
Y
Y
Y
M
T
Q
T
E
E
Site 27
Y364
N
A
W
D
L
Y
Y
Y
M
T
Q
T
E
E
L
Site 28
Y373
T
Q
T
E
E
L
K
Y
S
I
D
Q
E
F
L
Site 29
S374
Q
T
E
E
L
K
Y
S
I
D
Q
E
F
L
K
Site 30
Y383
D
Q
E
F
L
K
E
Y
F
P
I
E
V
V
T
Site 31
Y397
T
E
G
L
L
N
T
Y
Q
E
L
L
G
L
S
Site 32
S404
Y
Q
E
L
L
G
L
S
F
E
Q
M
T
D
A
Site 33
Y421
W
N
K
S
V
T
L
Y
T
V
K
D
K
A
T
Site 34
T422
N
K
S
V
T
L
Y
T
V
K
D
K
A
T
G
Site 35
T428
Y
T
V
K
D
K
A
T
G
E
V
L
G
Q
F
Site 36
Y436
G
E
V
L
G
Q
F
Y
L
D
L
Y
P
R
E
Site 37
Y440
G
Q
F
Y
L
D
L
Y
P
R
E
G
K
Y
N
Site 38
Y446
L
Y
P
R
E
G
K
Y
N
H
A
A
C
F
G
Site 39
S485
Q
P
V
A
G
R
P
S
L
L
R
H
D
E
V
Site 40
Y495
R
H
D
E
V
R
T
Y
F
H
E
F
G
H
V
Site 41
S516
Q
T
D
F
A
R
F
S
G
T
N
V
E
T
D
Site 42
S546
V
D
S
L
R
R
L
S
K
H
Y
K
D
G
S
Site 43
Y549
L
R
R
L
S
K
H
Y
K
D
G
S
P
I
A
Site 44
S553
S
K
H
Y
K
D
G
S
P
I
A
D
D
L
L
Site 45
T571
V
A
S
R
L
V
N
T
G
L
L
T
L
R
Q
Site 46
T575
L
V
N
T
G
L
L
T
L
R
Q
I
V
L
S
Site 47
S582
T
L
R
Q
I
V
L
S
K
V
D
Q
S
L
H
Site 48
S587
V
L
S
K
V
D
Q
S
L
H
T
N
T
S
L
Site 49
S593
Q
S
L
H
T
N
T
S
L
D
A
A
S
E
Y
Site 50
S598
N
T
S
L
D
A
A
S
E
Y
A
K
Y
C
S
Site 51
Y600
S
L
D
A
A
S
E
Y
A
K
Y
C
S
E
I
Site 52
T621
P
G
T
N
M
P
A
T
F
G
H
L
A
G
G
Site 53
Y629
F
G
H
L
A
G
G
Y
D
G
Q
Y
Y
G
Y
Site 54
Y633
A
G
G
Y
D
G
Q
Y
Y
G
Y
L
W
S
E
Site 55
Y634
G
G
Y
D
G
Q
Y
Y
G
Y
L
W
S
E
V
Site 56
Y636
Y
D
G
Q
Y
Y
G
Y
L
W
S
E
V
F
S
Site 57
Y648
V
F
S
M
D
M
F
Y
S
C
F
K
K
E
G
Site 58
Y665
N
P
E
V
G
M
K
Y
R
N
L
I
L
K
P
Site 59
S675
L
I
L
K
P
G
G
S
L
D
G
M
D
M
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation