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Updated November 2019
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Protein Info
Short Name:
PRIC285
Full Name:
Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein
Alias:
KIAA1769; P285; PDIP1; Peroxisomal proliferator-activated receptor A interacting complex 285 kDa protein; PPAR-alpha interacting complex protein 285; PPAR-alpha-interacting complex protein 285; PPAR-gamma DBD-interacting protein 1; PPAR-gamma DNA-binding domain-interacting protein 1; PR285
Type:
EC 3.6.1.-; Nuclear receptor co-regulator; Helicase; Transcription, coactivator/corepressor
Mass (Da):
294697
Number AA:
2649
UniProt ID:
Q9BYK8
International Prot ID:
IPI00249304
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
L
Q
R
G
D
L
L
T
P
P
A
P
D
G
D
Site 2
S80
A
L
P
W
E
H
R
S
P
P
P
G
L
S
K
Site 3
S86
R
S
P
P
P
G
L
S
K
F
E
L
C
P
K
Site 4
Y99
P
K
P
D
L
C
E
Y
G
D
A
C
T
K
A
Site 5
T119
L
Q
E
W
V
R
R
T
Q
A
V
E
L
R
G
Site 6
Y137
W
Q
D
G
L
V
P
Y
Q
E
R
L
L
A
E
Site 7
Y145
Q
E
R
L
L
A
E
Y
Q
R
S
S
S
E
V
Site 8
S150
A
E
Y
Q
R
S
S
S
E
V
L
V
L
A
E
Site 9
S182
Q
E
R
K
T
Q
Y
S
W
T
F
A
V
H
S
Site 10
T184
R
K
T
Q
Y
S
W
T
F
A
V
H
S
E
E
Site 11
S208
Q
E
P
G
A
D
F
S
L
V
A
P
G
L
P
Site 12
Y220
G
L
P
P
G
R
L
Y
A
R
G
E
R
F
R
Site 13
S230
G
E
R
F
R
V
P
S
S
T
A
D
F
Q
V
Site 14
S231
E
R
F
R
V
P
S
S
T
A
D
F
Q
V
G
Site 15
T232
R
F
R
V
P
S
S
T
A
D
F
Q
V
G
V
Site 16
S245
G
V
R
V
Q
A
A
S
F
G
T
F
E
Q
W
Site 17
T296
E
E
M
E
R
W
H
T
G
N
R
H
V
V
P
Site 18
S331
A
L
E
F
N
R
S
S
V
A
S
G
P
I
S
Site 19
S334
F
N
R
S
S
V
A
S
G
P
I
S
P
T
N
Site 20
S338
S
V
A
S
G
P
I
S
P
T
N
Y
R
Q
R
Site 21
T340
A
S
G
P
I
S
P
T
N
Y
R
Q
R
M
H
Site 22
Y342
G
P
I
S
P
T
N
Y
R
Q
R
M
H
Q
F
Site 23
Y351
Q
R
M
H
Q
F
L
Y
E
E
E
A
A
Q
Q
Site 24
S400
A
E
V
P
V
P
S
S
L
M
P
D
T
D
Q
Site 25
T405
P
S
S
L
M
P
D
T
D
Q
G
F
L
L
G
Site 26
T429
P
V
P
A
P
D
N
T
V
F
E
V
R
L
E
Site 27
S440
V
R
L
E
R
R
A
S
S
E
Q
A
L
W
L
Site 28
S441
R
L
E
R
R
A
S
S
E
Q
A
L
W
L
L
Site 29
T487
L
W
H
Q
A
V
D
T
L
P
E
E
Q
L
V
Site 30
S508
C
A
L
P
R
P
W
S
V
P
P
L
R
R
G
Site 31
T567
E
V
I
R
R
P
E
T
K
V
L
I
C
T
H
Site 32
T573
E
T
K
V
L
I
C
T
H
T
N
S
A
A
D
Site 33
Y582
T
N
S
A
A
D
I
Y
I
R
E
Y
F
H
S
Site 34
Y586
A
D
I
Y
I
R
E
Y
F
H
S
H
V
S
G
Site 35
T599
S
G
G
H
P
E
A
T
P
L
R
V
M
Y
T
Site 36
Y605
A
T
P
L
R
V
M
Y
T
D
R
P
L
S
Q
Site 37
T606
T
P
L
R
V
M
Y
T
D
R
P
L
S
Q
T
Site 38
S611
M
Y
T
D
R
P
L
S
Q
T
D
P
V
T
L
Site 39
T613
T
D
R
P
L
S
Q
T
D
P
V
T
L
Q
Y
Site 40
Y620
T
D
P
V
T
L
Q
Y
C
C
L
T
D
D
R
Site 41
T634
R
Q
A
F
R
P
P
T
R
A
E
L
A
R
H
Site 42
T647
R
H
R
V
V
V
T
T
T
S
Q
A
R
E
L
Site 43
S649
R
V
V
V
T
T
T
S
Q
A
R
E
L
R
V
Site 44
Y683
E
A
L
T
P
L
A
Y
A
S
H
G
T
R
L
Site 45
T715
R
A
R
A
A
E
H
T
L
L
H
R
L
F
L
Site 46
Y724
L
H
R
L
F
L
C
Y
Q
Q
E
T
H
E
V
Site 47
S735
T
H
E
V
A
R
Q
S
R
L
V
F
H
E
N
Site 48
Y758
S
F
I
S
R
H
F
Y
V
A
K
G
N
P
I
Site 49
S794
G
N
P
D
R
D
M
S
M
A
S
W
L
N
L
Site 50
S840
V
S
H
G
A
Q
V
S
A
L
R
Q
E
L
R
Site 51
S855
R
R
D
L
G
Q
V
S
V
G
S
F
E
I
L
Site 52
S883
H
T
C
Q
S
L
L
S
P
G
A
L
A
P
E
Site 53
T900
T
D
A
R
V
L
N
T
V
L
T
R
A
Q
S
Site 54
S940
R
E
C
V
E
R
H
S
V
C
P
E
G
L
S
Site 55
S947
S
V
C
P
E
G
L
S
M
E
Q
V
E
Q
G
Site 56
T966
R
R
W
P
P
R
G
T
Q
A
G
A
A
G
N
Site 57
S1006
E
P
G
D
E
A
L
S
P
A
S
R
D
I
T
Site 58
T1013
S
P
A
S
R
D
I
T
A
T
T
A
Q
T
E
Site 59
T1015
A
S
R
D
I
T
A
T
T
A
Q
T
E
A
A
Site 60
T1097
G
E
D
G
L
L
D
T
V
A
R
P
E
S
L
Site 61
S1103
D
T
V
A
R
P
E
S
L
Q
Q
A
R
L
Y
Site 62
Y1110
S
L
Q
Q
A
R
L
Y
E
N
L
P
P
A
A
Site 63
Y1129
L
R
A
E
P
E
R
Y
R
H
C
S
F
V
P
Site 64
S1133
P
E
R
Y
R
H
C
S
F
V
P
E
T
F
E
Site 65
T1138
H
C
S
F
V
P
E
T
F
E
R
A
S
A
I
Site 66
S1143
P
E
T
F
E
R
A
S
A
I
P
L
D
D
A
Site 67
S1151
A
I
P
L
D
D
A
S
S
G
P
I
Q
V
R
Site 68
S1152
I
P
L
D
D
A
S
S
G
P
I
Q
V
R
G
Site 69
S1178
E
V
L
V
Q
L
L
S
G
D
K
A
P
E
G
Site 70
T1210
A
F
V
C
R
M
D
T
W
D
P
R
I
M
V
Site 71
S1235
V
A
E
L
K
D
P
S
Q
V
P
I
Y
S
L
Site 72
Y1240
D
P
S
Q
V
P
I
Y
S
L
R
K
G
R
L
Site 73
S1241
P
S
Q
V
P
I
Y
S
L
R
K
G
R
L
Q
Site 74
T1256
R
V
G
L
E
R
L
T
A
E
A
R
H
S
R
Site 75
S1262
L
T
A
E
A
R
H
S
R
L
F
W
V
Q
I
Site 76
Y1278
L
W
R
Q
G
F
Y
Y
P
L
G
I
V
R
E
Site 77
Y1304
L
R
I
L
G
L
E
Y
S
L
R
V
P
P
S
Site 78
S1305
R
I
L
G
L
E
Y
S
L
R
V
P
P
S
D
Site 79
S1311
Y
S
L
R
V
P
P
S
D
Q
A
T
I
T
K
Site 80
T1315
V
P
P
S
D
Q
A
T
I
T
K
V
L
Q
K
Site 81
Y1323
I
T
K
V
L
Q
K
Y
H
T
E
L
G
R
V
Site 82
T1342
E
D
C
R
A
F
L
T
F
T
V
D
P
Q
G
Site 83
S1358
C
N
L
D
D
A
L
S
V
R
D
L
G
P
R
Site 84
S1417
S
L
C
Q
D
V
L
S
L
L
P
G
R
D
R
Site 85
S1428
G
R
D
R
L
A
I
S
L
F
L
T
M
E
K
Site 86
S1442
K
A
S
G
Q
L
K
S
L
R
F
A
P
S
V
Site 87
S1448
K
S
L
R
F
A
P
S
V
V
Q
S
D
R
Q
Site 88
S1452
F
A
P
S
V
V
Q
S
D
R
Q
L
S
Y
E
Site 89
S1457
V
Q
S
D
R
Q
L
S
Y
E
E
A
E
E
V
Site 90
S1503
L
R
R
H
R
L
R
S
D
C
F
Y
E
Q
P
Site 91
Y1507
R
L
R
S
D
C
F
Y
E
Q
P
D
E
D
G
Site 92
T1515
E
Q
P
D
E
D
G
T
L
G
F
R
A
A
H
Site 93
T1548
V
G
S
E
C
T
R
T
V
T
P
L
R
W
Q
Site 94
T1550
S
E
C
T
R
T
V
T
P
L
R
W
Q
P
A
Site 95
S1560
R
W
Q
P
A
P
R
S
Q
Q
L
K
A
L
C
Site 96
S1577
H
G
D
R
V
P
L
S
L
H
L
G
H
H
L
Site 97
S1590
H
L
H
G
G
G
G
S
P
P
D
T
R
L
H
Site 98
T1594
G
G
G
S
P
P
D
T
R
L
H
L
L
A
S
Site 99
Y1615
F
A
A
R
T
Q
D
Y
E
Q
M
V
D
L
V
Site 100
Y1661
H
Q
Q
Q
G
G
H
Y
S
L
Q
V
D
W
Y
Site 101
Y1668
Y
S
L
Q
V
D
W
Y
T
W
A
T
S
P
I
Site 102
Y1678
A
T
S
P
I
R
R
Y
L
D
V
V
L
Q
R
Site 103
Y1698
L
G
H
G
G
S
A
Y
S
A
R
D
I
D
G
Site 104
S1699
G
H
G
G
S
A
Y
S
A
R
D
I
D
G
L
Site 105
S1719
L
Q
H
A
L
A
Q
S
Y
Q
R
R
A
R
S
Site 106
Y1720
Q
H
A
L
A
Q
S
Y
Q
R
R
A
R
S
L
Site 107
S1726
S
Y
Q
R
R
A
R
S
L
H
L
A
V
Q
L
Site 108
S1760
C
F
R
L
L
F
P
S
N
R
E
T
L
P
D
Site 109
T1764
L
F
P
S
N
R
E
T
L
P
D
P
C
P
V
Site 110
Y1773
P
D
P
C
P
V
P
Y
G
S
L
Q
L
A
E
Site 111
S1775
P
C
P
V
P
Y
G
S
L
Q
L
A
E
H
P
Site 112
Y1800
L
L
W
R
R
R
V
Y
S
A
Q
G
S
S
P
Site 113
S1801
L
W
R
R
R
V
Y
S
A
Q
G
S
S
P
P
Site 114
S1805
R
V
Y
S
A
Q
G
S
S
P
P
L
P
L
P
Site 115
S1806
V
Y
S
A
Q
G
S
S
P
P
L
P
L
P
G
Site 116
T1814
P
P
L
P
L
P
G
T
V
P
D
P
H
T
L
Site 117
S1854
I
Q
E
K
G
E
A
S
Q
R
R
E
L
V
Q
Site 118
T1882
R
E
L
G
S
G
D
T
L
Q
V
Q
L
G
T
Site 119
S1924
E
R
P
G
D
C
F
S
G
R
V
Y
R
A
P
Site 120
Y1928
D
C
F
S
G
R
V
Y
R
A
P
R
D
R
Y
Site 121
Y1935
Y
R
A
P
R
D
R
Y
R
D
V
D
E
Y
A
Site 122
Y1941
R
Y
R
D
V
D
E
Y
A
C
V
W
E
P
F
Site 123
S1963
G
A
V
A
E
N
D
S
V
T
L
Q
H
L
S
Site 124
T1965
V
A
E
N
D
S
V
T
L
Q
H
L
S
V
S
Site 125
S1970
S
V
T
L
Q
H
L
S
V
S
W
E
A
S
R
Site 126
S1972
T
L
Q
H
L
S
V
S
W
E
A
S
R
T
P
Site 127
S1976
L
S
V
S
W
E
A
S
R
T
P
Q
G
Q
L
Site 128
T1978
V
S
W
E
A
S
R
T
P
Q
G
Q
L
Q
G
Site 129
T2019
L
E
G
L
P
A
P
T
A
S
P
R
P
G
P
Site 130
S2021
G
L
P
A
P
T
A
S
P
R
P
G
P
S
S
Site 131
S2027
A
S
P
R
P
G
P
S
S
L
G
P
G
L
N
Site 132
S2028
S
P
R
P
G
P
S
S
L
G
P
G
L
N
V
Site 133
T2039
G
L
N
V
D
P
G
T
Y
T
W
V
A
H
G
Site 134
T2143
S
R
F
L
E
R
Q
T
Y
N
I
P
G
G
R
Site 135
Y2144
R
F
L
E
R
Q
T
Y
N
I
P
G
G
R
H
Site 136
S2156
G
R
H
K
L
N
P
S
Q
N
V
A
V
R
E
Site 137
T2170
E
A
L
E
K
P
F
T
V
I
Q
G
P
P
G
Site 138
Y2245
E
L
K
P
L
R
V
Y
S
E
Q
A
E
A
S
Site 139
S2246
L
K
P
L
R
V
Y
S
E
Q
A
E
A
S
E
Site 140
S2252
Y
S
E
Q
A
E
A
S
E
F
P
V
P
R
V
Site 141
S2261
F
P
V
P
R
V
G
S
R
K
L
L
R
K
S
Site 142
S2268
S
R
K
L
L
R
K
S
P
R
E
G
R
P
N
Site 143
S2277
R
E
G
R
P
N
Q
S
L
R
S
I
T
L
H
Site 144
T2282
N
Q
S
L
R
S
I
T
L
H
H
R
I
R
Q
Site 145
S2295
R
Q
A
P
N
P
Y
S
S
E
I
K
A
F
D
Site 146
S2312
L
Q
R
G
E
L
F
S
R
E
D
L
V
W
Y
Site 147
Y2319
S
R
E
D
L
V
W
Y
K
K
V
L
W
E
A
Site 148
S2409
Q
N
L
G
L
D
R
S
L
F
E
R
Y
H
E
Site 149
Y2414
D
R
S
L
F
E
R
Y
H
E
D
A
H
M
L
Site 150
Y2440
A
F
P
S
V
A
F
Y
K
S
K
L
K
T
W
Site 151
S2442
P
S
V
A
F
Y
K
S
K
L
K
T
W
Q
G
Site 152
T2446
F
Y
K
S
K
L
K
T
W
Q
G
L
R
R
P
Site 153
S2455
Q
G
L
R
R
P
P
S
V
L
G
H
A
G
K
Site 154
S2478
H
V
Q
G
H
E
R
S
L
L
V
S
T
D
E
Site 155
S2482
H
E
R
S
L
L
V
S
T
D
E
G
N
E
N
Site 156
T2508
V
R
I
T
K
Q
L
T
L
G
R
T
V
E
P
Site 157
T2512
K
Q
L
T
L
G
R
T
V
E
P
Q
D
I
A
Site 158
T2522
P
Q
D
I
A
V
L
T
P
Y
N
A
Q
A
S
Site 159
S2529
T
P
Y
N
A
Q
A
S
E
I
S
K
A
L
R
Site 160
S2547
I
A
G
V
A
V
S
S
I
T
K
S
Q
G
S
Site 161
S2551
A
V
S
S
I
T
K
S
Q
G
S
E
W
R
Y
Site 162
S2554
S
I
T
K
S
Q
G
S
E
W
R
Y
V
L
V
Site 163
Y2558
S
Q
G
S
E
W
R
Y
V
L
V
S
T
V
R
Site 164
S2570
T
V
R
T
C
A
K
S
D
L
D
Q
R
P
T
Site 165
T2577
S
D
L
D
Q
R
P
T
K
S
W
L
K
K
F
Site 166
S2579
L
D
Q
R
P
T
K
S
W
L
K
K
F
L
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation