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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DRCTNNB1A
Full Name:
Hyccin
Alias:
Down-regulated by CTNNB1 A; HYCCI
Type:
Membrane, Cytoplasm protein
Mass (Da):
57625
Number AA:
521
UniProt ID:
Q9BYI3
International Prot ID:
IPI00102291
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
G
V
V
E
E
W
L
S
E
F
K
T
L
P
E
Site 2
T18
E
W
L
S
E
F
K
T
L
P
E
T
S
L
P
Site 3
T22
E
F
K
T
L
P
E
T
S
L
P
N
Y
A
T
Site 4
S23
F
K
T
L
P
E
T
S
L
P
N
Y
A
T
N
Site 5
Y27
P
E
T
S
L
P
N
Y
A
T
N
L
K
D
K
Site 6
T29
T
S
L
P
N
Y
A
T
N
L
K
D
K
S
S
Site 7
S35
A
T
N
L
K
D
K
S
S
L
V
S
S
L
Y
Site 8
S36
T
N
L
K
D
K
S
S
L
V
S
S
L
Y
K
Site 9
S39
K
D
K
S
S
L
V
S
S
L
Y
K
V
I
Q
Site 10
S40
D
K
S
S
L
V
S
S
L
Y
K
V
I
Q
E
Site 11
Y42
S
S
L
V
S
S
L
Y
K
V
I
Q
E
P
Q
Site 12
S50
K
V
I
Q
E
P
Q
S
E
L
L
E
P
V
C
Site 13
S66
Q
L
F
E
F
Y
R
S
G
E
E
Q
L
L
Q
Site 14
S92
C
Y
L
A
V
S
A
S
R
N
V
H
S
S
G
Site 15
S124
Q
G
H
T
K
V
L
S
F
T
I
P
S
L
S
Site 16
S131
S
F
T
I
P
S
L
S
K
P
S
V
Y
H
E
Site 17
S134
I
P
S
L
S
K
P
S
V
Y
H
E
P
S
S
Site 18
Y136
S
L
S
K
P
S
V
Y
H
E
P
S
S
I
G
Site 19
S140
P
S
V
Y
H
E
P
S
S
I
G
S
M
A
L
Site 20
S141
S
V
Y
H
E
P
S
S
I
G
S
M
A
L
T
Site 21
S144
H
E
P
S
S
I
G
S
M
A
L
T
E
S
A
Site 22
T148
S
I
G
S
M
A
L
T
E
S
A
L
S
Q
H
Site 23
S150
G
S
M
A
L
T
E
S
A
L
S
Q
H
G
L
Site 24
S153
A
L
T
E
S
A
L
S
Q
H
G
L
S
K
V
Site 25
S158
A
L
S
Q
H
G
L
S
K
V
V
Y
S
G
P
Site 26
Y162
H
G
L
S
K
V
V
Y
S
G
P
H
P
Q
R
Site 27
Y188
L
T
F
L
L
L
C
Y
N
A
A
L
T
Y
M
Site 28
T193
L
C
Y
N
A
A
L
T
Y
M
P
S
V
S
L
Site 29
S208
Q
S
L
C
Q
I
C
S
R
I
C
V
C
G
Y
Site 30
Y215
S
R
I
C
V
C
G
Y
P
R
Q
H
V
R
K
Site 31
Y223
P
R
Q
H
V
R
K
Y
K
G
I
S
S
R
I
Site 32
S227
V
R
K
Y
K
G
I
S
S
R
I
P
V
S
S
Site 33
S228
R
K
Y
K
G
I
S
S
R
I
P
V
S
S
G
Site 34
Y265
K
A
L
D
D
I
I
Y
R
A
Q
L
E
L
Y
Site 35
S293
L
P
H
G
P
M
K
S
N
K
E
G
T
R
C
Site 36
T306
R
C
I
Q
V
E
I
T
P
T
S
S
R
I
S
Site 37
T308
I
Q
V
E
I
T
P
T
S
S
R
I
S
R
N
Site 38
S309
Q
V
E
I
T
P
T
S
S
R
I
S
R
N
A
Site 39
S313
T
P
T
S
S
R
I
S
R
N
A
V
T
S
M
Site 40
S319
I
S
R
N
A
V
T
S
M
S
I
R
G
H
R
Site 41
S321
R
N
A
V
T
S
M
S
I
R
G
H
R
W
K
Site 42
S345
Q
E
E
L
M
E
I
S
E
V
D
E
G
F
Y
Site 43
Y352
S
E
V
D
E
G
F
Y
S
R
A
A
S
S
T
Site 44
S353
E
V
D
E
G
F
Y
S
R
A
A
S
S
T
S
Site 45
S357
G
F
Y
S
R
A
A
S
S
T
S
Q
S
G
L
Site 46
S358
F
Y
S
R
A
A
S
S
T
S
Q
S
G
L
S
Site 47
T359
Y
S
R
A
A
S
S
T
S
Q
S
G
L
S
N
Site 48
S360
S
R
A
A
S
S
T
S
Q
S
G
L
S
N
S
Site 49
S362
A
A
S
S
T
S
Q
S
G
L
S
N
S
S
H
Site 50
S365
S
T
S
Q
S
G
L
S
N
S
S
H
N
C
S
Site 51
S367
S
Q
S
G
L
S
N
S
S
H
N
C
S
N
K
Site 52
S368
Q
S
G
L
S
N
S
S
H
N
C
S
N
K
P
Site 53
S372
S
N
S
S
H
N
C
S
N
K
P
S
I
G
K
Site 54
S376
H
N
C
S
N
K
P
S
I
G
K
N
H
R
R
Site 55
S384
I
G
K
N
H
R
R
S
G
G
S
K
T
G
G
Site 56
S387
N
H
R
R
S
G
G
S
K
T
G
G
K
E
K
Site 57
T397
G
G
K
E
K
E
T
T
G
E
S
C
K
D
H
Site 58
T410
D
H
F
A
R
K
Q
T
Q
R
A
Q
S
E
N
Site 59
S415
K
Q
T
Q
R
A
Q
S
E
N
L
E
L
L
S
Site 60
S422
S
E
N
L
E
L
L
S
L
K
R
L
T
L
T
Site 61
T429
S
L
K
R
L
T
L
T
T
S
Q
S
L
P
K
Site 62
T430
L
K
R
L
T
L
T
T
S
Q
S
L
P
K
P
Site 63
S431
K
R
L
T
L
T
T
S
Q
S
L
P
K
P
S
Site 64
S433
L
T
L
T
T
S
Q
S
L
P
K
P
S
S
H
Site 65
S439
Q
S
L
P
K
P
S
S
H
G
L
A
K
T
A
Site 66
T445
S
S
H
G
L
A
K
T
A
A
T
V
F
S
K
Site 67
S453
A
A
T
V
F
S
K
S
F
E
Q
V
S
G
V
Site 68
S458
S
K
S
F
E
Q
V
S
G
V
T
V
P
H
N
Site 69
T461
F
E
Q
V
S
G
V
T
V
P
H
N
P
S
S
Site 70
S468
T
V
P
H
N
P
S
S
A
V
G
C
G
A
G
Site 71
S482
G
T
D
A
N
R
F
S
A
C
S
L
Q
E
E
Site 72
S485
A
N
R
F
S
A
C
S
L
Q
E
E
K
L
I
Site 73
Y493
L
Q
E
E
K
L
I
Y
V
S
E
R
T
E
L
Site 74
S495
E
E
K
L
I
Y
V
S
E
R
T
E
L
P
M
Site 75
S506
E
L
P
M
K
H
Q
S
G
Q
Q
R
P
P
S
Site 76
S513
S
G
Q
Q
R
P
P
S
I
S
I
T
L
S
T
Site 77
S515
Q
Q
R
P
P
S
I
S
I
T
L
S
T
D
_
Site 78
T517
R
P
P
S
I
S
I
T
L
S
T
D
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation