KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SHANK3
Full Name:
SH3 and multiple ankyrin repeat domains protein 3
Alias:
KIAA1650; Proline rich synapse associated protein 2; Proline-rich synapse-associated protein 2; ProSAP2; PROSAP2; PSAP2; SH3 and multiple ankyrin repeat domains 3; SHAN3; Shank postsynaptic density protein; Shank3; SPANK-2
Type:
Adapter/scaffold protein
Mass (Da):
186295
Number AA:
1741
UniProt ID:
Q9BYB0
International Prot ID:
IPI00738457
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005737
GO:0014069
Uniprot
OncoNet
Molecular Function:
GO:0017124
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
SH3 and multiple ankyrin repeat domains protein 3 pan-specific antibody AB-NN319-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN319-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y53
S
L
Q
D
A
L
N
Y
G
L
F
Q
P
P
S
Site 2
S60
Y
G
L
F
Q
P
P
S
R
G
R
A
G
K
F
Site 3
Y77
E
E
R
L
L
Q
E
Y
P
P
N
L
D
T
P
Site 4
T83
E
Y
P
P
N
L
D
T
P
L
P
Y
L
E
F
Site 5
Y87
N
L
D
T
P
L
P
Y
L
E
F
R
Y
K
R
Site 6
Y92
L
P
Y
L
E
F
R
Y
K
R
R
V
Y
A
Q
Site 7
Y97
F
R
Y
K
R
R
V
Y
A
Q
N
L
I
D
D
Site 8
Y122
N
L
K
K
F
M
D
Y
V
Q
L
H
S
T
D
Site 9
S148
P
N
F
H
D
P
D
S
G
E
C
P
L
S
L
Site 10
S154
D
S
G
E
C
P
L
S
L
A
A
Q
L
D
N
Site 11
S208
T
L
L
D
L
G
A
S
P
D
Y
K
D
S
R
Site 12
Y211
D
L
G
A
S
P
D
Y
K
D
S
R
G
L
T
Site 13
S214
A
S
P
D
Y
K
D
S
R
G
L
T
P
L
Y
Site 14
T218
Y
K
D
S
R
G
L
T
P
L
Y
H
S
A
L
Site 15
Y221
S
R
G
L
T
P
L
Y
H
S
A
L
G
G
G
Site 16
Y314
A
N
R
D
V
R
N
Y
N
S
Q
T
A
F
Q
Site 17
S316
R
D
V
R
N
Y
N
S
Q
T
A
F
Q
V
A
Site 18
T337
E
L
A
E
V
I
K
T
H
K
D
S
D
V
V
Site 19
S341
V
I
K
T
H
K
D
S
D
V
V
P
F
R
E
Site 20
T349
D
V
V
P
F
R
E
T
P
S
Y
A
K
R
R
Site 21
Y352
P
F
R
E
T
P
S
Y
A
K
R
R
R
L
A
Site 22
S362
R
R
R
L
A
G
P
S
G
L
A
S
P
R
P
Site 23
S366
A
G
P
S
G
L
A
S
P
R
P
L
Q
R
S
Site 24
S373
S
P
R
P
L
Q
R
S
A
S
D
I
N
L
K
Site 25
S375
R
P
L
Q
R
S
A
S
D
I
N
L
K
G
E
Site 26
S388
G
E
A
Q
P
A
A
S
P
G
P
S
L
R
S
Site 27
S392
P
A
A
S
P
G
P
S
L
R
S
L
P
H
Q
Site 28
S395
S
P
G
P
S
L
R
S
L
P
H
Q
L
L
L
Site 29
S419
D
R
D
A
D
Q
E
S
N
I
S
G
P
L
A
Site 30
S435
R
A
G
Q
S
K
I
S
E
P
G
A
P
R
S
Site 31
S442
S
E
P
G
A
P
R
S
C
I
R
I
R
A
R
Site 32
Y469
R
G
P
K
R
K
L
Y
S
A
V
P
G
R
K
Site 33
S484
F
I
A
V
K
A
H
S
P
Q
G
E
G
E
I
Site 34
T513
E
G
G
F
W
E
G
T
V
K
G
R
T
G
W
Site 35
T540
Q
H
D
T
R
P
E
T
R
E
D
R
T
K
R
Site 36
T545
P
E
T
R
E
D
R
T
K
R
L
F
R
H
Y
Site 37
Y552
T
K
R
L
F
R
H
Y
T
V
G
S
Y
D
S
Site 38
T553
K
R
L
F
R
H
Y
T
V
G
S
Y
D
S
L
Site 39
S556
F
R
H
Y
T
V
G
S
Y
D
S
L
T
S
H
Site 40
Y557
R
H
Y
T
V
G
S
Y
D
S
L
T
S
H
S
Site 41
S559
Y
T
V
G
S
Y
D
S
L
T
S
H
S
D
Y
Site 42
T561
V
G
S
Y
D
S
L
T
S
H
S
D
Y
V
I
Site 43
S562
G
S
Y
D
S
L
T
S
H
S
D
Y
V
I
D
Site 44
S564
Y
D
S
L
T
S
H
S
D
Y
V
I
D
D
K
Site 45
Y566
S
L
T
S
H
S
D
Y
V
I
D
D
K
V
A
Site 46
T594
L
R
G
A
K
A
E
T
P
I
E
E
F
T
P
Site 47
T600
E
T
P
I
E
E
F
T
P
T
P
A
F
P
A
Site 48
T602
P
I
E
E
F
T
P
T
P
A
F
P
A
L
Q
Site 49
S664
R
L
V
M
K
V
V
S
V
T
R
K
P
E
E
Site 50
S687
P
P
P
K
R
A
P
S
T
T
L
T
L
R
S
Site 51
T688
P
P
K
R
A
P
S
T
T
L
T
L
R
S
K
Site 52
T689
P
K
R
A
P
S
T
T
L
T
L
R
S
K
S
Site 53
T691
R
A
P
S
T
T
L
T
L
R
S
K
S
M
T
Site 54
S694
S
T
T
L
T
L
R
S
K
S
M
T
A
E
L
Site 55
S696
T
L
T
L
R
S
K
S
M
T
A
E
L
E
E
Site 56
T698
T
L
R
S
K
S
M
T
A
E
L
E
E
L
A
Site 57
S706
A
E
L
E
E
L
A
S
I
R
R
R
K
G
E
Site 58
S736
P
D
I
A
D
A
D
S
R
A
A
T
V
K
Q
Site 59
T740
D
A
D
S
R
A
A
T
V
K
Q
R
P
T
S
Site 60
T746
A
T
V
K
Q
R
P
T
S
R
R
I
T
P
A
Site 61
S747
T
V
K
Q
R
P
T
S
R
R
I
T
P
A
E
Site 62
T751
R
P
T
S
R
R
I
T
P
A
E
I
S
S
L
Site 63
S757
I
T
P
A
E
I
S
S
L
F
E
R
Q
G
L
Site 64
S773
G
P
E
K
L
P
G
S
L
R
K
G
I
P
R
Site 65
S783
K
G
I
P
R
T
K
S
V
G
E
D
E
K
L
Site 66
S792
G
E
D
E
K
L
A
S
L
L
E
G
R
F
P
Site 67
S801
L
E
G
R
F
P
R
S
T
S
M
Q
D
P
V
Site 68
T802
E
G
R
F
P
R
S
T
S
M
Q
D
P
V
R
Site 69
S803
G
R
F
P
R
S
T
S
M
Q
D
P
V
R
E
Site 70
T820
G
I
P
P
P
P
Q
T
A
P
P
P
P
P
A
Site 71
Y829
P
P
P
P
P
A
P
Y
Y
F
D
S
G
P
P
Site 72
Y830
P
P
P
P
A
P
Y
Y
F
D
S
G
P
P
P
Site 73
S833
P
A
P
Y
Y
F
D
S
G
P
P
P
A
F
S
Site 74
S840
S
G
P
P
P
A
F
S
P
P
P
P
P
G
R
Site 75
Y849
P
P
P
P
G
R
A
Y
D
T
V
R
S
S
F
Site 76
T851
P
P
G
R
A
Y
D
T
V
R
S
S
F
K
P
Site 77
S855
A
Y
D
T
V
R
S
S
F
K
P
G
L
E
A
Site 78
Y872
G
A
G
A
A
G
L
Y
E
P
G
A
A
L
G
Site 79
Y883
A
A
L
G
P
L
P
Y
P
E
R
Q
K
R
A
Site 80
S892
E
R
Q
K
R
A
R
S
M
I
I
L
Q
D
S
Site 81
S899
S
M
I
I
L
Q
D
S
A
P
E
S
G
D
A
Site 82
S903
L
Q
D
S
A
P
E
S
G
D
A
P
R
P
P
Site 83
T914
P
R
P
P
P
A
A
T
P
P
E
R
P
K
R
Site 84
S930
P
R
P
P
G
P
D
S
P
Y
A
N
L
G
A
Site 85
Y932
P
P
G
P
D
S
P
Y
A
N
L
G
A
F
S
Site 86
S946
S
A
S
L
F
A
P
S
K
P
Q
R
R
K
S
Site 87
S953
S
K
P
Q
R
R
K
S
P
L
V
K
Q
L
Q
Site 88
S974
R
A
A
L
A
V
G
S
P
G
P
G
G
G
S
Site 89
S981
S
P
G
P
G
G
G
S
F
A
R
E
P
S
P
Site 90
S987
G
S
F
A
R
E
P
S
P
T
H
R
G
P
R
Site 91
T989
F
A
R
E
P
S
P
T
H
R
G
P
R
P
G
Site 92
Y1000
P
R
P
G
G
L
D
Y
G
A
G
D
G
P
G
Site 93
S1027
R
L
E
E
R
R
R
S
T
V
F
L
S
V
G
Site 94
T1028
L
E
E
R
R
R
S
T
V
F
L
S
V
G
A
Site 95
S1032
R
R
S
T
V
F
L
S
V
G
A
I
E
G
S
Site 96
S1047
A
P
G
A
D
L
P
S
L
Q
P
S
R
S
I
Site 97
S1051
D
L
P
S
L
Q
P
S
R
S
I
D
E
R
L
Site 98
S1053
P
S
L
Q
P
S
R
S
I
D
E
R
L
L
G
Site 99
S1086
K
P
L
V
S
G
P
S
L
G
P
S
G
S
T
Site 100
S1090
S
G
P
S
L
G
P
S
G
S
T
F
I
H
P
Site 101
S1092
P
S
L
G
P
S
G
S
T
F
I
H
P
L
T
Site 102
T1099
S
T
F
I
H
P
L
T
G
K
P
L
D
P
S
Site 103
S1122
A
R
E
R
A
L
A
S
Q
A
P
S
R
S
P
Site 104
S1126
A
L
A
S
Q
A
P
S
R
S
P
T
P
V
H
Site 105
S1128
A
S
Q
A
P
S
R
S
P
T
P
V
H
S
P
Site 106
T1130
Q
A
P
S
R
S
P
T
P
V
H
S
P
D
A
Site 107
S1134
R
S
P
T
P
V
H
S
P
D
A
D
R
P
G
Site 108
S1156
A
R
D
P
E
R
G
S
L
A
S
P
A
F
S
Site 109
S1159
P
E
R
G
S
L
A
S
P
A
F
S
P
R
S
Site 110
S1163
S
L
A
S
P
A
F
S
P
R
S
P
A
W
I
Site 111
S1166
S
P
A
F
S
P
R
S
P
A
W
I
P
V
P
Site 112
S1188
V
P
R
E
E
R
K
S
P
E
D
K
K
S
M
Site 113
S1194
K
S
P
E
D
K
K
S
M
I
L
S
V
L
D
Site 114
S1198
D
K
K
S
M
I
L
S
V
L
D
T
S
L
Q
Site 115
S1217
L
I
V
V
H
A
T
S
N
G
Q
E
P
S
R
Site 116
T1235
A
E
E
E
R
P
G
T
P
E
L
A
P
A
P
Site 117
S1254
A
V
A
E
P
L
P
S
P
R
A
Q
P
P
G
Site 118
T1263
R
A
Q
P
P
G
G
T
P
A
D
A
G
P
G
Site 119
S1273
D
A
G
P
G
Q
G
S
S
E
E
E
P
E
L
Site 120
S1274
A
G
P
G
Q
G
S
S
E
E
E
P
E
L
V
Site 121
S1292
N
L
P
P
A
Q
L
S
S
S
D
E
E
T
R
Site 122
S1294
P
P
A
Q
L
S
S
S
D
E
E
T
R
E
E
Site 123
T1298
L
S
S
S
D
E
E
T
R
E
E
L
A
R
I
Site 124
S1330
P
L
A
G
P
G
P
S
P
T
T
V
P
S
P
Site 125
T1332
A
G
P
G
P
S
P
T
T
V
P
S
P
A
S
Site 126
T1333
G
P
G
P
S
P
T
T
V
P
S
P
A
S
G
Site 127
S1336
P
S
P
T
T
V
P
S
P
A
S
G
K
P
S
Site 128
S1339
T
T
V
P
S
P
A
S
G
K
P
S
S
E
P
Site 129
S1343
S
P
A
S
G
K
P
S
S
E
P
P
P
A
P
Site 130
S1344
P
A
S
G
K
P
S
S
E
P
P
P
A
P
E
Site 131
S1352
E
P
P
P
A
P
E
S
A
A
D
S
G
V
E
Site 132
S1356
A
P
E
S
A
A
D
S
G
V
E
E
A
D
T
Site 133
T1363
S
G
V
E
E
A
D
T
R
S
S
S
D
P
H
Site 134
S1365
V
E
E
A
D
T
R
S
S
S
D
P
H
L
E
Site 135
S1366
E
E
A
D
T
R
S
S
S
D
P
H
L
E
T
Site 136
S1367
E
A
D
T
R
S
S
S
D
P
H
L
E
T
T
Site 137
T1373
S
S
D
P
H
L
E
T
T
S
T
I
S
T
V
Site 138
T1374
S
D
P
H
L
E
T
T
S
T
I
S
T
V
S
Site 139
S1375
D
P
H
L
E
T
T
S
T
I
S
T
V
S
S
Site 140
T1376
P
H
L
E
T
T
S
T
I
S
T
V
S
S
M
Site 141
S1378
L
E
T
T
S
T
I
S
T
V
S
S
M
S
T
Site 142
T1379
E
T
T
S
T
I
S
T
V
S
S
M
S
T
L
Site 143
S1381
T
S
T
I
S
T
V
S
S
M
S
T
L
S
S
Site 144
S1382
S
T
I
S
T
V
S
S
M
S
T
L
S
S
E
Site 145
S1384
I
S
T
V
S
S
M
S
T
L
S
S
E
S
G
Site 146
T1385
S
T
V
S
S
M
S
T
L
S
S
E
S
G
E
Site 147
S1387
V
S
S
M
S
T
L
S
S
E
S
G
E
L
T
Site 148
S1388
S
S
M
S
T
L
S
S
E
S
G
E
L
T
D
Site 149
T1394
S
S
E
S
G
E
L
T
D
T
H
T
S
F
A
Site 150
T1396
E
S
G
E
L
T
D
T
H
T
S
F
A
D
G
Site 151
T1398
G
E
L
T
D
T
H
T
S
F
A
D
G
H
T
Site 152
S1399
E
L
T
D
T
H
T
S
F
A
D
G
H
T
F
Site 153
T1405
T
S
F
A
D
G
H
T
F
L
L
E
K
P
P
Site 154
S1421
P
P
K
P
K
L
K
S
P
L
G
K
G
P
V
Site 155
T1429
P
L
G
K
G
P
V
T
F
R
D
P
L
L
K
Site 156
S1439
D
P
L
L
K
Q
S
S
D
S
E
L
M
A
Q
Site 157
S1441
L
L
K
Q
S
S
D
S
E
L
M
A
Q
Q
H
Site 158
Y1466
A
G
P
A
R
P
R
Y
L
F
Q
R
R
S
K
Site 159
S1472
R
Y
L
F
Q
R
R
S
K
L
W
G
D
P
V
Site 160
T1493
G
P
E
D
D
K
P
T
V
I
S
E
L
S
S
Site 161
S1496
D
D
K
P
T
V
I
S
E
L
S
S
R
L
Q
Site 162
S1499
P
T
V
I
S
E
L
S
S
R
L
Q
Q
L
N
Site 163
S1500
T
V
I
S
E
L
S
S
R
L
Q
Q
L
N
K
Site 164
S1511
Q
L
N
K
D
T
R
S
L
G
E
E
P
V
G
Site 165
S1522
E
P
V
G
G
L
G
S
L
L
D
P
A
K
K
Site 166
S1530
L
L
D
P
A
K
K
S
P
I
A
A
A
R
C
Site 167
S1539
I
A
A
A
R
C
R
S
P
M
V
G
L
R
L
Site 168
S1548
M
V
G
L
R
L
F
S
S
L
G
E
L
S
S
Site 169
S1549
V
G
L
R
L
F
S
S
L
G
E
L
S
S
I
Site 170
S1554
F
S
S
L
G
E
L
S
S
I
S
A
Q
R
S
Site 171
S1555
S
S
L
G
E
L
S
S
I
S
A
Q
R
S
P
Site 172
S1557
L
G
E
L
S
S
I
S
A
Q
R
S
P
G
G
Site 173
S1561
S
S
I
S
A
Q
R
S
P
G
G
P
G
G
G
Site 174
S1570
G
G
P
G
G
G
A
S
Y
S
V
R
P
S
G
Site 175
Y1571
G
P
G
G
G
A
S
Y
S
V
R
P
S
G
R
Site 176
S1572
P
G
G
G
A
S
Y
S
V
R
P
S
G
R
Y
Site 177
S1576
A
S
Y
S
V
R
P
S
G
R
Y
P
V
A
R
Site 178
Y1579
S
V
R
P
S
G
R
Y
P
V
A
R
R
A
P
Site 179
S1587
P
V
A
R
R
A
P
S
P
V
K
P
A
S
L
Site 180
S1593
P
S
P
V
K
P
A
S
L
E
R
V
E
G
L
Site 181
T1614
A
G
R
P
F
G
L
T
P
P
T
I
L
K
S
Site 182
S1621
T
P
P
T
I
L
K
S
S
S
L
S
I
P
H
Site 183
S1623
P
T
I
L
K
S
S
S
L
S
I
P
H
E
P
Site 184
S1625
I
L
K
S
S
S
L
S
I
P
H
E
P
K
E
Site 185
S1639
E
V
R
F
V
V
R
S
V
S
A
R
S
R
S
Site 186
S1641
R
F
V
V
R
S
V
S
A
R
S
R
S
P
S
Site 187
S1644
V
R
S
V
S
A
R
S
R
S
P
S
P
S
P
Site 188
S1646
S
V
S
A
R
S
R
S
P
S
P
S
P
L
P
Site 189
S1648
S
A
R
S
R
S
P
S
P
S
P
L
P
S
P
Site 190
S1650
R
S
R
S
P
S
P
S
P
L
P
S
P
A
S
Site 191
S1654
P
S
P
S
P
L
P
S
P
A
S
G
P
G
P
Site 192
S1657
S
P
L
P
S
P
A
S
G
P
G
P
G
A
P
Site 193
T1723
D
F
V
E
L
G
V
T
R
V
G
H
R
M
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation