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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OSBPL1A
Full Name:
Oxysterol-binding protein-related protein 1
Alias:
ORP1; ORP-1; OSBL1; OSBP8; OSBPL1; OSBPL1B; OSBP-related 1; Oxysterol binding protein-like 1A; Oxysterol-binding protein-related 1
Type:
Mass (Da):
108470
Number AA:
950
UniProt ID:
Q9BXW6
International Prot ID:
IPI00075080
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005543
PhosphoSite+
KinaseNET
Biological Process:
GO:0008203
GO:0006869
GO:0016192
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T27
E
V
R
Q
L
L
E
T
M
A
R
N
E
V
I
Site 2
S45
N
C
K
G
R
S
K
S
N
L
G
W
T
P
L
Site 3
T50
S
K
S
N
L
G
W
T
P
L
H
L
A
C
Y
Site 4
T83
V
L
N
D
M
G
D
T
P
L
H
R
A
A
F
Site 5
T91
P
L
H
R
A
A
F
T
G
R
K
E
L
V
M
Site 6
T107
L
L
E
Y
N
A
D
T
T
I
V
N
G
S
G
Site 7
T108
L
E
Y
N
A
D
T
T
I
V
N
G
S
G
Q
Site 8
S128
T
H
A
E
E
I
R
S
M
L
E
A
V
E
R
Site 9
T155
A
A
R
E
G
K
T
T
E
L
T
A
L
L
N
Site 10
T178
C
S
D
Q
L
G
N
T
P
L
H
C
A
A
Y
Site 11
S198
C
A
L
K
L
L
R
S
G
A
D
P
N
L
K
Site 12
Y238
I
Y
K
A
L
K
R
Y
E
G
P
L
W
K
S
Site 13
S246
E
G
P
L
W
K
S
S
R
F
F
G
W
R
L
Site 14
S264
V
L
E
H
G
V
L
S
W
Y
R
K
Q
P
D
Site 15
Y277
P
D
A
V
H
N
I
Y
R
Q
G
C
K
H
L
Site 16
T285
R
Q
G
C
K
H
L
T
Q
A
V
C
T
V
K
Site 17
S317
G
F
R
V
P
K
N
S
L
Q
Q
S
R
E
D
Site 18
S321
P
K
N
S
L
Q
Q
S
R
E
D
W
L
E
A
Site 19
Y335
A
I
E
E
H
S
A
Y
S
T
H
Y
C
S
Q
Site 20
T337
E
E
H
S
A
Y
S
T
H
Y
C
S
Q
D
Q
Site 21
S341
A
Y
S
T
H
Y
C
S
Q
D
Q
L
T
D
E
Site 22
T346
Y
C
S
Q
D
Q
L
T
D
E
E
E
E
D
T
Site 23
T353
T
D
E
E
E
E
D
T
V
S
A
A
D
L
K
Site 24
S355
E
E
E
E
D
T
V
S
A
A
D
L
K
K
S
Site 25
S362
S
A
A
D
L
K
K
S
L
E
K
A
Q
S
C
Site 26
S368
K
S
L
E
K
A
Q
S
C
Q
Q
R
L
D
R
Site 27
S378
Q
R
L
D
R
E
I
S
N
F
L
K
M
I
K
Site 28
S396
M
A
K
E
M
L
P
S
F
L
Q
K
V
E
V
Site 29
S444
Q
E
K
N
K
I
L
S
E
A
L
E
T
L
A
Site 30
T449
I
L
S
E
A
L
E
T
L
A
T
E
H
H
E
Site 31
T452
E
A
L
E
T
L
A
T
E
H
H
E
L
E
Q
Site 32
S460
E
H
H
E
L
E
Q
S
L
V
K
G
S
P
P
Site 33
S465
E
Q
S
L
V
K
G
S
P
P
A
S
I
L
S
Site 34
S469
V
K
G
S
P
P
A
S
I
L
S
E
D
E
F
Site 35
S472
S
P
P
A
S
I
L
S
E
D
E
F
Y
D
A
Site 36
Y477
I
L
S
E
D
E
F
Y
D
A
L
S
D
S
E
Site 37
S481
D
E
F
Y
D
A
L
S
D
S
E
S
E
R
S
Site 38
S483
F
Y
D
A
L
S
D
S
E
S
E
R
S
L
S
Site 39
S485
D
A
L
S
D
S
E
S
E
R
S
L
S
R
L
Site 40
S488
S
D
S
E
S
E
R
S
L
S
R
L
E
A
V
Site 41
S490
S
E
S
E
R
S
L
S
R
L
E
A
V
T
A
Site 42
T496
L
S
R
L
E
A
V
T
A
R
S
F
E
E
E
Site 43
S499
L
E
A
V
T
A
R
S
F
E
E
E
G
E
H
Site 44
S509
E
E
G
E
H
L
G
S
R
K
H
R
M
S
E
Site 45
S515
G
S
R
K
H
R
M
S
E
E
K
D
C
G
G
Site 46
S527
C
G
G
G
D
A
L
S
N
G
I
K
K
H
R
Site 47
T535
N
G
I
K
K
H
R
T
S
L
P
S
P
M
F
Site 48
S536
G
I
K
K
H
R
T
S
L
P
S
P
M
F
S
Site 49
S539
K
H
R
T
S
L
P
S
P
M
F
S
R
N
D
Site 50
S543
S
L
P
S
P
M
F
S
R
N
D
F
S
I
W
Site 51
T581
L
S
F
L
Q
R
L
T
E
Y
M
E
H
T
Y
Site 52
Y583
F
L
Q
R
L
T
E
Y
M
E
H
T
Y
L
I
Site 53
Y588
T
E
Y
M
E
H
T
Y
L
I
H
K
A
S
S
Site 54
S594
T
Y
L
I
H
K
A
S
S
L
S
D
P
V
E
Site 55
S595
Y
L
I
H
K
A
S
S
L
S
D
P
V
E
R
Site 56
S597
I
H
K
A
S
S
L
S
D
P
V
E
R
M
Q
Site 57
S616
F
A
V
S
A
V
A
S
Q
W
E
R
T
G
K
Site 58
Y633
N
P
L
L
G
E
T
Y
E
L
V
R
D
D
L
Site 59
S646
D
L
G
F
R
L
I
S
E
Q
V
S
H
H
P
Site 60
S650
R
L
I
S
E
Q
V
S
H
H
P
P
I
S
A
Site 61
S656
V
S
H
H
P
P
I
S
A
F
H
A
E
G
L
Site 62
Y674
F
I
F
H
G
S
I
Y
P
K
L
K
F
W
G
Site 63
S683
K
L
K
F
W
G
K
S
V
E
A
E
P
K
G
Site 64
T693
A
E
P
K
G
T
I
T
L
E
L
L
E
H
N
Site 65
Y725
G
K
L
W
I
E
Q
Y
G
N
V
E
I
I
N
Site 66
Y759
E
L
H
K
V
E
G
Y
I
Q
D
K
S
K
K
Site 67
S764
E
G
Y
I
Q
D
K
S
K
K
K
L
C
A
L
Site 68
Y772
K
K
K
L
C
A
L
Y
G
K
W
T
E
C
L
Site 69
Y780
G
K
W
T
E
C
L
Y
S
V
D
P
A
T
F
Site 70
T786
L
Y
S
V
D
P
A
T
F
D
A
Y
K
K
N
Site 71
Y790
D
P
A
T
F
D
A
Y
K
K
N
D
K
K
N
Site 72
S804
N
T
E
E
K
K
N
S
K
Q
M
S
T
S
E
Site 73
S808
K
K
N
S
K
Q
M
S
T
S
E
E
L
D
E
Site 74
S821
D
E
M
P
V
P
D
S
E
S
V
F
I
I
P
Site 75
Y847
P
P
N
S
A
Q
M
Y
N
F
T
S
F
A
M
Site 76
S865
E
V
D
K
D
M
E
S
V
I
P
K
T
D
C
Site 77
T870
M
E
S
V
I
P
K
T
D
C
R
L
R
P
D
Site 78
S890
N
G
E
I
D
Q
A
S
E
E
K
K
R
L
E
Site 79
S908
R
A
A
R
K
N
R
S
K
S
E
E
D
W
K
Site 80
S910
A
R
K
N
R
S
K
S
E
E
D
W
K
T
R
Site 81
Y934
N
G
A
Q
D
W
I
Y
S
G
S
Y
W
D
R
Site 82
Y943
G
S
Y
W
D
R
N
Y
F
N
L
P
D
I
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation