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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP26
Full Name:
Ubiquitin carboxyl-terminal hydrolase 26
Alias:
Deubiquitinating enzyme 26; Ubiquitin specific peptidase 26; Ubiquitin thiolesterase 26; Ubiquitin-specific processing protease 26; UBP26
Type:
EC 3.1.2.15; Ubiquitin conjugating system; Protease
Mass (Da):
104047
Number AA:
913
UniProt ID:
Q9BXU7
International Prot ID:
IPI00011092
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
V
Q
I
G
N
C
K
T
G
I
S
K
S
K
E
Site 2
S20
G
N
C
K
T
G
I
S
K
S
K
E
A
F
I
Site 3
S22
C
K
T
G
I
S
K
S
K
E
A
F
I
E
A
Site 4
Y41
K
K
D
R
L
V
L
Y
F
K
S
G
K
Y
S
Site 5
S44
R
L
V
L
Y
F
K
S
G
K
Y
S
T
F
R
Site 6
Y47
L
Y
F
K
S
G
K
Y
S
T
F
R
L
S
D
Site 7
S48
Y
F
K
S
G
K
Y
S
T
F
R
L
S
D
N
Site 8
T49
F
K
S
G
K
Y
S
T
F
R
L
S
D
N
I
Site 9
S53
K
Y
S
T
F
R
L
S
D
N
I
Q
N
V
V
Site 10
S88
L
F
I
E
G
L
S
S
T
D
A
E
Q
L
K
Site 11
S117
V
R
P
G
K
G
G
S
V
F
S
S
T
T
Q
Site 12
S121
K
G
G
S
V
F
S
S
T
T
Q
K
E
I
N
Site 13
T122
G
G
S
V
F
S
S
T
T
Q
K
E
I
N
K
Site 14
S131
Q
K
E
I
N
K
T
S
F
H
K
V
D
E
K
Site 15
S139
F
H
K
V
D
E
K
S
S
S
K
S
F
E
I
Site 16
S141
K
V
D
E
K
S
S
S
K
S
F
E
I
A
K
Site 17
S143
D
E
K
S
S
S
K
S
F
E
I
A
K
G
S
Site 18
S150
S
F
E
I
A
K
G
S
G
T
G
V
L
Q
R
Site 19
T168
L
T
S
K
L
T
L
T
C
G
E
L
S
E
N
Site 20
S185
K
K
R
K
R
M
L
S
S
S
S
E
M
N
E
Site 21
S187
R
K
R
M
L
S
S
S
S
E
M
N
E
E
F
Site 22
S188
K
R
M
L
S
S
S
S
E
M
N
E
E
F
L
Site 23
S200
E
F
L
K
E
N
N
S
V
E
Y
K
K
S
K
Site 24
Y203
K
E
N
N
S
V
E
Y
K
K
S
K
A
D
C
Site 25
S206
N
S
V
E
Y
K
K
S
K
A
D
C
S
R
C
Site 26
S211
K
K
S
K
A
D
C
S
R
C
V
S
Y
N
R
Site 27
S215
A
D
C
S
R
C
V
S
Y
N
R
E
K
Q
L
Site 28
Y216
D
C
S
R
C
V
S
Y
N
R
E
K
Q
L
K
Site 29
S238
K
K
L
E
C
E
S
S
C
I
M
N
A
T
G
Site 30
Y276
Q
Q
G
Y
S
D
G
Y
T
K
W
D
K
L
K
Site 31
T277
Q
G
Y
S
D
G
Y
T
K
W
D
K
L
K
L
Site 32
Y305
P
N
L
G
N
T
C
Y
M
N
A
V
L
Q
S
Site 33
S327
A
D
D
L
L
N
Q
S
F
P
W
G
K
I
P
Site 34
T351
R
L
L
F
F
K
D
T
Y
N
I
E
I
K
E
Site 35
Y352
L
L
F
F
K
D
T
Y
N
I
E
I
K
E
M
Site 36
T403
D
N
M
E
K
L
N
T
I
W
K
P
K
S
E
Site 37
T427
V
F
A
D
D
P
D
T
S
G
F
S
C
P
V
Site 38
S431
D
P
D
T
S
G
F
S
C
P
V
I
T
N
F
Site 39
Y463
L
K
T
E
L
N
N
Y
L
S
I
N
L
P
Q
Site 40
S465
T
E
L
N
N
Y
L
S
I
N
L
P
Q
R
I
Site 41
S477
Q
R
I
K
A
H
P
S
S
I
Q
S
T
F
D
Site 42
S478
R
I
K
A
H
P
S
S
I
Q
S
T
F
D
L
Site 43
Y494
F
G
A
E
E
L
E
Y
K
C
A
K
C
E
H
Site 44
S504
A
K
C
E
H
K
T
S
V
G
V
H
S
F
S
Site 45
S509
K
T
S
V
G
V
H
S
F
S
R
L
P
R
I
Site 46
S542
N
D
Q
E
V
I
I
S
K
Y
L
K
V
S
S
Site 47
Y544
Q
E
V
I
I
S
K
Y
L
K
V
S
S
H
C
Site 48
S549
S
K
Y
L
K
V
S
S
H
C
N
E
G
T
R
Site 49
T555
S
S
H
C
N
E
G
T
R
P
P
L
P
L
S
Site 50
S562
T
R
P
P
L
P
L
S
E
D
G
E
I
T
D
Site 51
S581
K
V
I
R
K
M
T
S
G
N
I
S
V
S
W
Site 52
S585
K
M
T
S
G
N
I
S
V
S
W
P
A
T
K
Site 53
S587
T
S
G
N
I
S
V
S
W
P
A
T
K
E
S
Site 54
T591
I
S
V
S
W
P
A
T
K
E
S
K
D
I
L
Site 55
S604
I
L
A
P
H
I
G
S
D
K
E
S
E
Q
K
Site 56
S608
H
I
G
S
D
K
E
S
E
Q
K
K
G
Q
T
Site 57
T615
S
E
Q
K
K
G
Q
T
V
F
K
G
A
S
R
Site 58
S621
Q
T
V
F
K
G
A
S
R
R
Q
Q
Q
K
Y
Site 59
Y628
S
R
R
Q
Q
Q
K
Y
L
G
K
N
S
K
P
Site 60
S633
Q
K
Y
L
G
K
N
S
K
P
N
E
L
E
S
Site 61
S640
S
K
P
N
E
L
E
S
V
Y
S
G
D
R
A
Site 62
S643
N
E
L
E
S
V
Y
S
G
D
R
A
F
I
E
Site 63
S678
K
A
G
G
K
P
A
S
S
P
G
T
P
L
S
Site 64
S679
A
G
G
K
P
A
S
S
P
G
T
P
L
S
K
Site 65
T682
K
P
A
S
S
P
G
T
P
L
S
K
V
D
F
Site 66
S685
S
S
P
G
T
P
L
S
K
V
D
F
Q
T
V
Site 67
T691
L
S
K
V
D
F
Q
T
V
P
E
N
P
K
R
Site 68
Y701
E
N
P
K
R
K
K
Y
V
K
T
S
K
F
V
Site 69
Y721
I
N
P
T
K
D
L
Y
E
D
K
N
I
R
I
Site 70
S736
P
E
R
F
Q
K
V
S
E
Q
T
Q
Q
C
D
Site 71
S759
P
Q
Q
A
L
P
Q
S
F
P
K
P
G
T
Q
Site 72
T776
T
K
N
L
L
R
P
T
K
L
N
L
Q
K
S
Site 73
S783
T
K
L
N
L
Q
K
S
N
R
N
S
L
L
A
Site 74
S787
L
Q
K
S
N
R
N
S
L
L
A
L
G
S
N
Site 75
S793
N
S
L
L
A
L
G
S
N
K
N
P
R
N
K
Site 76
S808
D
I
L
D
K
I
K
S
K
A
K
E
T
K
R
Site 77
T823
N
D
D
K
G
D
H
T
Y
R
L
I
S
V
V
Site 78
Y824
D
D
K
G
D
H
T
Y
R
L
I
S
V
V
S
Site 79
S828
D
H
T
Y
R
L
I
S
V
V
S
H
L
G
K
Site 80
T836
V
V
S
H
L
G
K
T
L
K
S
G
H
Y
I
Site 81
Y842
K
T
L
K
S
G
H
Y
I
C
D
A
Y
D
F
Site 82
Y857
E
K
Q
I
W
F
T
Y
D
D
M
R
V
L
G
Site 83
T909
N
S
K
E
V
E
E
T
L
Q
K
E
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation