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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CARD14
Full Name:
Caspase recruitment domain-containing protein 14
Alias:
BIMP2; CAR14; CARMA2; caspase recruitment domain family, member 14
Type:
Adaptor/scaffold
Mass (Da):
113300
Number AA:
UniProt ID:
Q9BXL6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0050700
PhosphoSite+
KinaseNET
Biological Process:
GO:0007250
GO:0001934
GO:0042981
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
G
E
L
C
R
R
D
S
A
L
T
A
L
D
E
Site 2
T12
C
R
R
D
S
A
L
T
A
L
D
E
E
T
L
Site 3
T40
C
I
C
P
S
R
L
T
P
Y
L
R
Q
A
K
Site 4
Y42
C
P
S
R
L
T
P
Y
L
R
Q
A
K
V
L
Site 5
S60
D
E
E
E
V
L
H
S
P
R
L
T
N
S
A
Site 6
T64
V
L
H
S
P
R
L
T
N
S
A
M
R
A
G
Site 7
S66
H
S
P
R
L
T
N
S
A
M
R
A
G
H
L
Site 8
Y100
K
F
H
N
P
D
V
Y
T
L
V
T
G
L
Q
Site 9
T101
F
H
N
P
D
V
Y
T
L
V
T
G
L
Q
P
Site 10
S113
L
Q
P
D
V
D
F
S
N
F
S
G
L
M
E
Site 11
T165
E
H
L
G
L
A
E
T
R
A
E
G
L
H
Q
Site 12
S178
H
Q
L
E
A
D
H
S
R
M
K
R
E
V
S
Site 13
S185
S
R
M
K
R
E
V
S
A
H
F
H
E
V
L
Site 14
S200
R
L
K
D
E
M
L
S
L
S
L
H
Y
S
N
Site 15
S202
K
D
E
M
L
S
L
S
L
H
Y
S
N
A
L
Site 16
S206
L
S
L
S
L
H
Y
S
N
A
L
Q
E
K
E
Site 17
S217
Q
E
K
E
L
A
A
S
R
C
R
S
L
Q
E
Site 18
S221
L
A
A
S
R
C
R
S
L
Q
E
E
L
Y
L
Site 19
Y227
R
S
L
Q
E
E
L
Y
L
L
K
Q
E
L
Q
Site 20
S240
L
Q
R
A
N
M
V
S
S
C
E
L
E
L
Q
Site 21
S250
E
L
E
L
Q
E
Q
S
L
R
T
A
S
D
Q
Site 22
S255
E
Q
S
L
R
T
A
S
D
Q
E
S
G
D
E
Site 23
S259
R
T
A
S
D
Q
E
S
G
D
E
E
L
N
R
Site 24
S276
E
E
N
E
K
L
R
S
L
T
F
S
L
A
E
Site 25
T278
N
E
K
L
R
S
L
T
F
S
L
A
E
K
D
Site 26
S290
E
K
D
I
L
E
Q
S
L
D
E
A
R
G
S
Site 27
S297
S
L
D
E
A
R
G
S
R
Q
E
L
V
E
R
Site 28
S307
E
L
V
E
R
I
H
S
L
R
E
R
A
V
A
Site 29
Y322
A
E
R
Q
R
E
Q
Y
W
E
E
K
E
Q
T
Site 30
T329
Y
W
E
E
K
E
Q
T
L
L
Q
F
Q
K
S
Site 31
Y343
S
K
M
A
C
Q
L
Y
R
E
K
V
N
A
L
Site 32
Y365
Q
K
E
R
D
Q
A
Y
S
A
R
D
S
A
Q
Site 33
S366
K
E
R
D
Q
A
Y
S
A
R
D
S
A
Q
R
Site 34
S370
Q
A
Y
S
A
R
D
S
A
Q
R
E
I
S
Q
Site 35
S376
D
S
A
Q
R
E
I
S
Q
S
L
V
E
K
D
Site 36
S378
A
Q
R
E
I
S
Q
S
L
V
E
K
D
S
L
Site 37
S384
Q
S
L
V
E
K
D
S
L
R
R
Q
V
F
E
Site 38
T393
R
R
Q
V
F
E
L
T
D
Q
V
C
E
L
R
Site 39
S443
A
I
C
P
R
D
D
S
D
C
S
L
V
S
S
Site 40
S446
P
R
D
D
S
D
C
S
L
V
S
S
T
E
S
Site 41
S449
D
S
D
C
S
L
V
S
S
T
E
S
Q
L
L
Site 42
S450
S
D
C
S
L
V
S
S
T
E
S
Q
L
L
S
Site 43
T451
D
C
S
L
V
S
S
T
E
S
Q
L
L
S
D
Site 44
S453
S
L
V
S
S
T
E
S
Q
L
L
S
D
L
S
Site 45
S457
S
T
E
S
Q
L
L
S
D
L
S
A
T
S
S
Site 46
S460
S
Q
L
L
S
D
L
S
A
T
S
S
R
E
L
Site 47
S463
L
S
D
L
S
A
T
S
S
R
E
L
V
D
S
Site 48
S464
S
D
L
S
A
T
S
S
R
E
L
V
D
S
F
Site 49
S470
S
S
R
E
L
V
D
S
F
R
S
S
S
P
A
Site 50
S473
E
L
V
D
S
F
R
S
S
S
P
A
P
P
S
Site 51
S474
L
V
D
S
F
R
S
S
S
P
A
P
P
S
Q
Site 52
S475
V
D
S
F
R
S
S
S
P
A
P
P
S
Q
Q
Site 53
S480
S
S
S
P
A
P
P
S
Q
Q
S
L
Y
K
R
Site 54
S483
P
A
P
P
S
Q
Q
S
L
Y
K
R
V
A
E
Site 55
Y485
P
P
S
Q
Q
S
L
Y
K
R
V
A
E
D
F
Site 56
S498
D
F
G
E
E
P
W
S
F
S
S
C
L
E
I
Site 57
S500
G
E
E
P
W
S
F
S
S
C
L
E
I
P
E
Site 58
S501
E
E
P
W
S
F
S
S
C
L
E
I
P
E
G
Site 59
Y525
A
G
D
P
H
L
D
Y
E
L
L
D
T
A
D
Site 60
T530
L
D
Y
E
L
L
D
T
A
D
L
P
Q
L
E
Site 61
S538
A
D
L
P
Q
L
E
S
S
L
Q
P
V
S
P
Site 62
S539
D
L
P
Q
L
E
S
S
L
Q
P
V
S
P
G
Site 63
S544
E
S
S
L
Q
P
V
S
P
G
R
L
D
V
S
Site 64
S551
S
P
G
R
L
D
V
S
E
S
G
V
L
M
R
Site 65
S553
G
R
L
D
V
S
E
S
G
V
L
M
R
R
R
Site 66
T599
G
I
F
I
H
R
V
T
P
G
S
A
A
D
Q
Site 67
T635
K
A
V
L
E
D
T
T
L
E
E
A
V
G
L
Site 68
Y661
V
K
V
N
T
D
G
Y
K
R
L
L
Q
D
L
Site 69
S678
K
V
A
T
S
G
D
S
F
Y
I
R
V
N
L
Site 70
T725
A
H
R
V
N
S
Y
T
M
K
D
T
A
A
H
Site 71
T729
N
S
Y
T
M
K
D
T
A
A
H
G
T
I
P
Site 72
Y738
A
H
G
T
I
P
N
Y
S
R
A
Q
Q
Q
L
Site 73
T757
Q
D
M
T
Q
Q
C
T
V
T
R
K
P
S
S
Site 74
T759
M
T
Q
Q
C
T
V
T
R
K
P
S
S
G
G
Site 75
S763
C
T
V
T
R
K
P
S
S
G
G
P
Q
K
L
Site 76
S764
T
V
T
R
K
P
S
S
G
G
P
Q
K
L
V
Site 77
S775
Q
K
L
V
R
I
V
S
M
D
K
A
K
A
S
Site 78
S782
S
M
D
K
A
K
A
S
P
L
R
L
S
F
D
Site 79
S787
K
A
S
P
L
R
L
S
F
D
R
G
Q
L
D
Site 80
S796
D
R
G
Q
L
D
P
S
R
M
E
G
S
S
T
Site 81
S801
D
P
S
R
M
E
G
S
S
T
C
F
W
A
E
Site 82
S802
P
S
R
M
E
G
S
S
T
C
F
W
A
E
S
Site 83
T803
S
R
M
E
G
S
S
T
C
F
W
A
E
S
C
Site 84
Y858
F
K
K
C
L
A
E
Y
L
S
Q
E
E
Y
E
Site 85
S860
K
C
L
A
E
Y
L
S
Q
E
E
Y
E
A
W
Site 86
Y864
E
Y
L
S
Q
E
E
Y
E
A
W
S
Q
R
G
Site 87
S893
V
T
R
H
A
V
E
S
L
M
E
K
N
T
H
Site 88
T944
K
G
L
Q
R
L
G
T
S
E
E
Q
L
L
E
Site 89
Y967
L
D
R
A
P
C
L
Y
S
S
L
A
P
D
G
Site 90
S969
R
A
P
C
L
Y
S
S
L
A
P
D
G
W
S
Site 91
S976
S
L
A
P
D
G
W
S
D
L
D
G
L
L
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation