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Updated November 2019
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Protein Info
Short Name:
SORBS1
Full Name:
Sorbin and SH3 domain-containing protein 1
Alias:
CAP; C-Cbl-associated protein; FLJ12406; KIAA1296; Ponsin; SH3 domain protein 5; SH3D5; SH3P12; Sorbin and SH3 domain containing 1; Sorbin and SH3 domain-containing protein 1; SRBS1
Type:
Adhesion; Cytoskeletal protein
Mass (Da):
142497
Number AA:
1292
UniProt ID:
Q9BX66
International Prot ID:
IPI00002491
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005924
GO:0005829
GO:0045121
Uniprot
OncoNet
Molecular Function:
GO:0005070
GO:0003779
GO:0005158
PhosphoSite+
KinaseNET
Biological Process:
GO:0048041
GO:0015758
GO:0008286
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
S
E
C
D
G
G
S
K
A
V
M
N
G
L
Site 2
T27
S
N
G
Q
D
K
A
T
A
D
P
L
R
A
R
Site 3
T62
L
P
T
D
M
D
P
T
K
I
C
T
G
K
G
Site 4
T72
C
T
G
K
G
A
V
T
L
R
A
S
S
S
Y
Site 5
S76
G
A
V
T
L
R
A
S
S
S
Y
R
E
T
P
Site 6
S77
A
V
T
L
R
A
S
S
S
Y
R
E
T
P
S
Site 7
S78
V
T
L
R
A
S
S
S
Y
R
E
T
P
S
S
Site 8
Y79
T
L
R
A
S
S
S
Y
R
E
T
P
S
S
S
Site 9
T82
A
S
S
S
Y
R
E
T
P
S
S
S
P
A
S
Site 10
S84
S
S
Y
R
E
T
P
S
S
S
P
A
S
P
Q
Site 11
S85
S
Y
R
E
T
P
S
S
S
P
A
S
P
Q
E
Site 12
S86
Y
R
E
T
P
S
S
S
P
A
S
P
Q
E
T
Site 13
S89
T
P
S
S
S
P
A
S
P
Q
E
T
R
Q
H
Site 14
T93
S
P
A
S
P
Q
E
T
R
Q
H
E
S
K
P
Site 15
S107
P
G
L
E
P
E
P
S
S
A
D
E
W
R
L
Site 16
S108
G
L
E
P
E
P
S
S
A
D
E
W
R
L
S
Site 17
S115
S
A
D
E
W
R
L
S
S
S
A
D
A
N
G
Site 18
S116
A
D
E
W
R
L
S
S
S
A
D
A
N
G
N
Site 19
S127
A
N
G
N
A
Q
P
S
S
L
A
A
K
G
Y
Site 20
S128
N
G
N
A
Q
P
S
S
L
A
A
K
G
Y
R
Site 21
Y134
S
S
L
A
A
K
G
Y
R
S
V
H
P
N
L
Site 22
S136
L
A
A
K
G
Y
R
S
V
H
P
N
L
P
S
Site 23
S146
P
N
L
P
S
D
K
S
Q
D
A
T
S
S
S
Site 24
T150
S
D
K
S
Q
D
A
T
S
S
S
A
A
Q
P
Site 25
S151
D
K
S
Q
D
A
T
S
S
S
A
A
Q
P
E
Site 26
S152
K
S
Q
D
A
T
S
S
S
A
A
Q
P
E
V
Site 27
T169
V
P
L
Y
L
V
N
T
D
R
G
Q
E
G
T
Site 28
T176
T
D
R
G
Q
E
G
T
A
R
P
P
T
P
L
Site 29
T181
E
G
T
A
R
P
P
T
P
L
G
P
L
G
C
Site 30
S222
L
Q
R
W
P
H
H
S
Q
P
A
R
A
S
G
Site 31
S228
H
S
Q
P
A
R
A
S
G
S
F
A
P
I
S
Site 32
S230
Q
P
A
R
A
S
G
S
F
A
P
I
S
Q
T
Site 33
S235
S
G
S
F
A
P
I
S
Q
T
P
P
S
F
S
Site 34
T237
S
F
A
P
I
S
Q
T
P
P
S
F
S
P
P
Site 35
S240
P
I
S
Q
T
P
P
S
F
S
P
P
P
P
L
Site 36
S242
S
Q
T
P
P
S
F
S
P
P
P
P
L
V
P
Site 37
S259
P
E
D
L
R
R
V
S
E
P
D
L
T
G
A
Site 38
T264
R
V
S
E
P
D
L
T
G
A
V
S
S
T
D
Site 39
S268
P
D
L
T
G
A
V
S
S
T
D
S
S
P
L
Site 40
S272
G
A
V
S
S
T
D
S
S
P
L
L
N
E
V
Site 41
S273
A
V
S
S
T
D
S
S
P
L
L
N
E
V
S
Site 42
S280
S
P
L
L
N
E
V
S
S
S
L
I
G
T
D
Site 43
S281
P
L
L
N
E
V
S
S
S
L
I
G
T
D
S
Site 44
S282
L
L
N
E
V
S
S
S
L
I
G
T
D
S
Q
Site 45
T286
V
S
S
S
L
I
G
T
D
S
Q
A
F
P
S
Site 46
S288
S
S
L
I
G
T
D
S
Q
A
F
P
S
V
S
Site 47
S293
T
D
S
Q
A
F
P
S
V
S
K
P
S
S
A
Site 48
S295
S
Q
A
F
P
S
V
S
K
P
S
S
A
Y
P
Site 49
S299
P
S
V
S
K
P
S
S
A
Y
P
S
T
T
I
Site 50
Y301
V
S
K
P
S
S
A
Y
P
S
T
T
I
V
N
Site 51
S303
K
P
S
S
A
Y
P
S
T
T
I
V
N
P
T
Site 52
T304
P
S
S
A
Y
P
S
T
T
I
V
N
P
T
I
Site 53
S325
R
E
Q
Q
K
R
L
S
S
L
S
D
P
V
S
Site 54
S326
E
Q
Q
K
R
L
S
S
L
S
D
P
V
S
E
Site 55
S328
Q
K
R
L
S
S
L
S
D
P
V
S
E
R
R
Site 56
S332
S
S
L
S
D
P
V
S
E
R
R
V
G
E
Q
Site 57
S341
R
R
V
G
E
Q
D
S
A
P
T
Q
E
K
P
Site 58
T344
G
E
Q
D
S
A
P
T
Q
E
K
P
T
S
P
Site 59
T349
A
P
T
Q
E
K
P
T
S
P
G
K
A
I
E
Site 60
S350
P
T
Q
E
K
P
T
S
P
G
K
A
I
E
K
Site 61
S363
E
K
R
A
K
D
D
S
R
R
V
V
K
S
T
Site 62
S369
D
S
R
R
V
V
K
S
T
Q
D
L
S
D
V
Site 63
T370
S
R
R
V
V
K
S
T
Q
D
L
S
D
V
S
Site 64
S374
V
K
S
T
Q
D
L
S
D
V
S
M
D
E
V
Site 65
S377
T
Q
D
L
S
D
V
S
M
D
E
V
G
I
P
Site 66
T388
V
G
I
P
L
R
N
T
E
R
S
K
D
W
Y
Site 67
Y395
T
E
R
S
K
D
W
Y
K
T
M
F
K
Q
I
Site 68
T409
I
H
K
L
N
R
D
T
P
E
E
N
P
Y
F
Site 69
Y415
D
T
P
E
E
N
P
Y
F
P
T
Y
K
F
P
Site 70
Y419
E
N
P
Y
F
P
T
Y
K
F
P
E
L
P
E
Site 71
T430
E
L
P
E
I
Q
Q
T
S
E
E
D
N
P
Y
Site 72
Y437
T
S
E
E
D
N
P
Y
T
P
T
Y
Q
F
P
Site 73
T438
S
E
E
D
N
P
Y
T
P
T
Y
Q
F
P
A
Site 74
Y441
D
N
P
Y
T
P
T
Y
Q
F
P
A
S
T
P
Site 75
S446
P
T
Y
Q
F
P
A
S
T
P
S
P
K
S
E
Site 76
T447
T
Y
Q
F
P
A
S
T
P
S
P
K
S
E
D
Site 77
S449
Q
F
P
A
S
T
P
S
P
K
S
E
D
D
D
Site 78
S452
A
S
T
P
S
P
K
S
E
D
D
D
S
D
L
Site 79
S457
P
K
S
E
D
D
D
S
D
L
Y
S
P
R
Y
Site 80
Y460
E
D
D
D
S
D
L
Y
S
P
R
Y
S
F
S
Site 81
S461
D
D
D
S
D
L
Y
S
P
R
Y
S
F
S
E
Site 82
Y464
S
D
L
Y
S
P
R
Y
S
F
S
E
D
T
K
Site 83
S465
D
L
Y
S
P
R
Y
S
F
S
E
D
T
K
S
Site 84
S467
Y
S
P
R
Y
S
F
S
E
D
T
K
S
P
L
Site 85
T470
R
Y
S
F
S
E
D
T
K
S
P
L
S
V
P
Site 86
S472
S
F
S
E
D
T
K
S
P
L
S
V
P
R
S
Site 87
S475
E
D
T
K
S
P
L
S
V
P
R
S
K
S
E
Site 88
S479
S
P
L
S
V
P
R
S
K
S
E
M
S
Y
I
Site 89
S481
L
S
V
P
R
S
K
S
E
M
S
Y
I
D
G
Site 90
Y485
R
S
K
S
E
M
S
Y
I
D
G
E
K
V
V
Site 91
T497
K
V
V
K
R
S
A
T
L
P
L
P
A
R
S
Site 92
S504
T
L
P
L
P
A
R
S
S
S
L
K
S
S
S
Site 93
S505
L
P
L
P
A
R
S
S
S
L
K
S
S
S
E
Site 94
S506
P
L
P
A
R
S
S
S
L
K
S
S
S
E
R
Site 95
S509
A
R
S
S
S
L
K
S
S
S
E
R
N
D
W
Site 96
S510
R
S
S
S
L
K
S
S
S
E
R
N
D
W
E
Site 97
S511
S
S
S
L
K
S
S
S
E
R
N
D
W
E
P
Site 98
Y528
K
K
V
D
T
R
K
Y
R
A
E
P
K
S
I
Site 99
S534
K
Y
R
A
E
P
K
S
I
Y
E
Y
Q
P
G
Site 100
Y536
R
A
E
P
K
S
I
Y
E
Y
Q
P
G
K
S
Site 101
Y538
E
P
K
S
I
Y
E
Y
Q
P
G
K
S
S
V
Site 102
T547
P
G
K
S
S
V
L
T
N
E
K
M
S
R
D
Site 103
S556
E
K
M
S
R
D
I
S
P
E
E
I
D
L
K
Site 104
Y568
D
L
K
N
E
P
W
Y
K
F
F
S
E
L
E
Site 105
Y587
P
P
K
K
I
W
D
Y
T
P
G
D
C
S
I
Site 106
T588
P
K
K
I
W
D
Y
T
P
G
D
C
S
I
L
Site 107
S593
D
Y
T
P
G
D
C
S
I
L
P
R
E
D
R
Site 108
T602
L
P
R
E
D
R
K
T
N
L
D
K
D
L
S
Site 109
S609
T
N
L
D
K
D
L
S
L
C
Q
T
E
L
E
Site 110
T613
K
D
L
S
L
C
Q
T
E
L
E
A
D
L
E
Site 111
T624
A
D
L
E
K
M
E
T
L
N
K
A
P
S
A
Site 112
S630
E
T
L
N
K
A
P
S
A
N
V
P
Q
S
S
Site 113
S636
P
S
A
N
V
P
Q
S
S
A
I
S
P
T
P
Site 114
S637
S
A
N
V
P
Q
S
S
A
I
S
P
T
P
E
Site 115
S640
V
P
Q
S
S
A
I
S
P
T
P
E
I
S
S
Site 116
T642
Q
S
S
A
I
S
P
T
P
E
I
S
S
E
T
Site 117
S646
I
S
P
T
P
E
I
S
S
E
T
P
G
Y
I
Site 118
S647
S
P
T
P
E
I
S
S
E
T
P
G
Y
I
Y
Site 119
T649
T
P
E
I
S
S
E
T
P
G
Y
I
Y
S
S
Site 120
Y652
I
S
S
E
T
P
G
Y
I
Y
S
S
N
F
H
Site 121
Y654
S
E
T
P
G
Y
I
Y
S
S
N
F
H
A
V
Site 122
S655
E
T
P
G
Y
I
Y
S
S
N
F
H
A
V
K
Site 123
S665
F
H
A
V
K
R
E
S
D
G
A
P
G
D
L
Site 124
T673
D
G
A
P
G
D
L
T
S
L
E
N
E
R
Q
Site 125
S674
G
A
P
G
D
L
T
S
L
E
N
E
R
Q
I
Site 126
Y682
L
E
N
E
R
Q
I
Y
K
S
V
L
E
G
G
Site 127
S684
N
E
R
Q
I
Y
K
S
V
L
E
G
G
D
I
Site 128
S697
D
I
P
L
Q
G
L
S
G
L
K
R
P
S
S
Site 129
S703
L
S
G
L
K
R
P
S
S
S
A
S
T
K
D
Site 130
S704
S
G
L
K
R
P
S
S
S
A
S
T
K
D
S
Site 131
S705
G
L
K
R
P
S
S
S
A
S
T
K
D
S
E
Site 132
S707
K
R
P
S
S
S
A
S
T
K
D
S
E
S
P
Site 133
T708
R
P
S
S
S
A
S
T
K
D
S
E
S
P
R
Site 134
S711
S
S
A
S
T
K
D
S
E
S
P
R
H
F
I
Site 135
S713
A
S
T
K
D
S
E
S
P
R
H
F
I
P
A
Site 136
Y722
R
H
F
I
P
A
D
Y
L
E
S
T
E
E
F
Site 137
S725
I
P
A
D
Y
L
E
S
T
E
E
F
I
R
R
Site 138
T762
D
I
A
A
R
R
H
T
G
V
I
P
T
H
H
Site 139
T773
P
T
H
H
Q
F
I
T
N
E
R
F
G
D
L
Site 140
T786
D
L
L
N
I
D
D
T
A
K
R
K
S
G
S
Site 141
S791
D
D
T
A
K
R
K
S
G
S
E
M
R
P
A
Site 142
S793
T
A
K
R
K
S
G
S
E
M
R
P
A
R
A
Site 143
T808
K
F
D
F
K
A
Q
T
L
K
E
L
P
L
Q
Site 144
Y821
L
Q
K
G
D
I
V
Y
I
Y
K
Q
I
D
Q
Site 145
Y823
K
G
D
I
V
Y
I
Y
K
Q
I
D
Q
N
W
Site 146
Y831
K
Q
I
D
Q
N
W
Y
E
G
E
H
H
G
R
Site 147
T862
K
A
Q
P
K
K
L
T
P
V
Q
V
L
E
Y
Site 148
S887
G
D
T
Q
V
E
M
S
F
R
K
G
E
R
I
Site 149
T895
F
R
K
G
E
R
I
T
L
L
R
Q
V
D
E
Site 150
Y905
R
Q
V
D
E
N
W
Y
E
G
R
I
P
G
T
Site 151
T912
Y
E
G
R
I
P
G
T
S
R
Q
G
I
F
P
Site 152
S913
E
G
R
I
P
G
T
S
R
Q
G
I
F
P
I
Site 153
T921
R
Q
G
I
F
P
I
T
Y
V
D
V
I
K
R
Site 154
Y937
L
V
K
N
P
V
D
Y
M
D
L
P
F
S
S
Site 155
S943
D
Y
M
D
L
P
F
S
S
S
P
S
R
S
A
Site 156
S944
Y
M
D
L
P
F
S
S
S
P
S
R
S
A
T
Site 157
S945
M
D
L
P
F
S
S
S
P
S
R
S
A
T
A
Site 158
S947
L
P
F
S
S
S
P
S
R
S
A
T
A
S
P
Site 159
S949
F
S
S
S
P
S
R
S
A
T
A
S
P
Q
F
Site 160
T951
S
S
P
S
R
S
A
T
A
S
P
Q
F
S
S
Site 161
S953
P
S
R
S
A
T
A
S
P
Q
F
S
S
H
S
Site 162
S957
A
T
A
S
P
Q
F
S
S
H
S
K
L
I
T
Site 163
S958
T
A
S
P
Q
F
S
S
H
S
K
L
I
T
P
Site 164
T964
S
S
H
S
K
L
I
T
P
A
P
S
S
L
P
Site 165
S968
K
L
I
T
P
A
P
S
S
L
P
H
S
R
R
Site 166
S969
L
I
T
P
A
P
S
S
L
P
H
S
R
R
A
Site 167
S973
A
P
S
S
L
P
H
S
R
R
A
L
S
P
E
Site 168
S978
P
H
S
R
R
A
L
S
P
E
M
H
A
V
T
Site 169
T992
T
S
E
W
I
S
L
T
V
G
V
P
G
R
R
Site 170
T1004
G
R
R
S
L
A
L
T
P
P
L
P
P
L
P
Site 171
Y1016
P
L
P
E
A
S
I
Y
N
T
D
H
L
A
L
Site 172
T1018
P
E
A
S
I
Y
N
T
D
H
L
A
L
S
P
Site 173
S1024
N
T
D
H
L
A
L
S
P
R
A
S
P
S
L
Site 174
S1030
L
S
P
R
A
S
P
S
L
S
L
S
L
P
H
Site 175
S1032
P
R
A
S
P
S
L
S
L
S
L
P
H
L
S
Site 176
S1034
A
S
P
S
L
S
L
S
L
P
H
L
S
W
S
Site 177
S1039
S
L
S
L
P
H
L
S
W
S
D
R
P
T
P
Site 178
S1041
S
L
P
H
L
S
W
S
D
R
P
T
P
R
S
Site 179
T1045
L
S
W
S
D
R
P
T
P
R
S
V
A
S
P
Site 180
S1048
S
D
R
P
T
P
R
S
V
A
S
P
L
A
L
Site 181
S1051
P
T
P
R
S
V
A
S
P
L
A
L
P
S
P
Site 182
S1057
A
S
P
L
A
L
P
S
P
H
K
T
Y
S
L
Site 183
T1061
A
L
P
S
P
H
K
T
Y
S
L
A
P
T
S
Site 184
S1063
P
S
P
H
K
T
Y
S
L
A
P
T
S
Q
A
Site 185
T1067
K
T
Y
S
L
A
P
T
S
Q
A
S
L
H
M
Site 186
S1068
T
Y
S
L
A
P
T
S
Q
A
S
L
H
M
N
Site 187
S1071
L
A
P
T
S
Q
A
S
L
H
M
N
G
D
G
Site 188
T1082
N
G
D
G
G
V
H
T
P
S
S
G
I
H
Q
Site 189
S1084
D
G
G
V
H
T
P
S
S
G
I
H
Q
D
S
Site 190
S1085
G
G
V
H
T
P
S
S
G
I
H
Q
D
S
F
Site 191
S1091
S
S
G
I
H
Q
D
S
F
L
Q
L
P
L
G
Site 192
S1102
L
P
L
G
S
S
D
S
V
I
S
Q
L
S
D
Site 193
S1105
G
S
S
D
S
V
I
S
Q
L
S
D
A
F
S
Site 194
S1108
D
S
V
I
S
Q
L
S
D
A
F
S
S
Q
S
Site 195
S1112
S
Q
L
S
D
A
F
S
S
Q
S
K
R
Q
P
Site 196
S1113
Q
L
S
D
A
F
S
S
Q
S
K
R
Q
P
W
Site 197
S1115
S
D
A
F
S
S
Q
S
K
R
Q
P
W
R
E
Site 198
S1124
R
Q
P
W
R
E
E
S
G
Q
Y
E
R
K
A
Site 199
Y1127
W
R
E
E
S
G
Q
Y
E
R
K
A
E
R
G
Site 200
S1146
G
P
G
G
P
K
I
S
K
K
S
C
L
K
P
Site 201
S1149
G
P
K
I
S
K
K
S
C
L
K
P
S
D
V
Site 202
S1154
K
K
S
C
L
K
P
S
D
V
V
R
C
L
S
Site 203
S1161
S
D
V
V
R
C
L
S
T
E
Q
R
L
S
D
Site 204
S1167
L
S
T
E
Q
R
L
S
D
L
N
T
P
E
E
Site 205
T1171
Q
R
L
S
D
L
N
T
P
E
E
S
R
P
G
Site 206
S1175
D
L
N
T
P
E
E
S
R
P
G
K
P
L
G
Site 207
S1183
R
P
G
K
P
L
G
S
A
F
P
G
S
E
A
Site 208
S1188
L
G
S
A
F
P
G
S
E
A
E
Q
T
E
R
Site 209
T1193
P
G
S
E
A
E
Q
T
E
R
H
R
G
G
E
Site 210
S1212
K
A
A
R
R
G
G
S
Q
Q
P
Q
A
Q
Q
Site 211
T1223
Q
A
Q
Q
R
R
V
T
P
D
R
S
Q
T
S
Site 212
S1227
R
R
V
T
P
D
R
S
Q
T
S
Q
D
L
F
Site 213
T1229
V
T
P
D
R
S
Q
T
S
Q
D
L
F
S
Y
Site 214
S1230
T
P
D
R
S
Q
T
S
Q
D
L
F
S
Y
Q
Site 215
S1235
Q
T
S
Q
D
L
F
S
Y
Q
A
L
Y
S
Y
Site 216
Y1236
T
S
Q
D
L
F
S
Y
Q
A
L
Y
S
Y
I
Site 217
Y1240
L
F
S
Y
Q
A
L
Y
S
Y
I
P
Q
N
D
Site 218
T1272
D
D
G
W
F
V
G
T
S
R
R
T
K
Q
F
Site 219
T1276
F
V
G
T
S
R
R
T
K
Q
F
G
T
F
P
Site 220
T1281
R
R
T
K
Q
F
G
T
F
P
G
N
Y
V
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation