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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BRIP1
Full Name:
Fanconi anemia group J protein
Alias:
BACH1; BRCA1 interacting protein C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1-interacting protein 1; FANCJ; FLJ90232; HGNC:20473; OF
Type:
DNA binding protein, helicase
Mass (Da):
140878
Number AA:
1249
UniProt ID:
Q9BX63
International Prot ID:
IPI00012500
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004003
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0000077
GO:0006302
GO:0006357
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
I
Y
F
P
Y
K
A
Y
P
S
Q
L
A
M
M
Site 2
S38
S
I
L
R
G
L
N
S
K
Q
H
C
L
L
E
Site 3
S46
K
Q
H
C
L
L
E
S
P
T
G
S
G
K
S
Site 4
T48
H
C
L
L
E
S
P
T
G
S
G
K
S
L
A
Site 5
S66
S
A
L
A
W
Q
Q
S
L
S
G
K
P
A
D
Site 6
S68
L
A
W
Q
Q
S
L
S
G
K
P
A
D
E
G
Site 7
Y110
G
T
S
R
H
F
N
Y
P
S
T
P
P
S
E
Site 8
S112
S
R
H
F
N
Y
P
S
T
P
P
S
E
R
N
Site 9
T113
R
H
F
N
Y
P
S
T
P
P
S
E
R
N
G
Site 10
S116
N
Y
P
S
T
P
P
S
E
R
N
G
T
S
S
Site 11
T121
P
P
S
E
R
N
G
T
S
S
T
C
Q
D
S
Site 12
S122
P
S
E
R
N
G
T
S
S
T
C
Q
D
S
P
Site 13
S123
S
E
R
N
G
T
S
S
T
C
Q
D
S
P
E
Site 14
T124
E
R
N
G
T
S
S
T
C
Q
D
S
P
E
K
Site 15
S128
T
S
S
T
C
Q
D
S
P
E
K
T
T
L
A
Site 16
T132
C
Q
D
S
P
E
K
T
T
L
A
A
K
L
S
Site 17
S139
T
T
L
A
A
K
L
S
A
K
K
Q
A
S
I
Site 18
S145
L
S
A
K
K
Q
A
S
I
Y
R
D
E
N
D
Site 19
T167
R
I
R
P
L
E
T
T
Q
Q
I
R
K
R
H
Site 20
T178
R
K
R
H
C
F
G
T
E
V
H
N
L
D
A
Site 21
S189
N
L
D
A
K
V
D
S
G
K
T
V
K
L
N
Site 22
T192
A
K
V
D
S
G
K
T
V
K
L
N
S
P
L
Site 23
S197
G
K
T
V
K
L
N
S
P
L
E
K
I
N
S
Site 24
S204
S
P
L
E
K
I
N
S
F
S
P
Q
K
P
P
Site 25
S206
L
E
K
I
N
S
F
S
P
Q
K
P
P
G
H
Site 26
S226
C
S
T
K
Q
G
N
S
Q
E
S
S
N
T
I
Site 27
S229
K
Q
G
N
S
Q
E
S
S
N
T
I
K
K
D
Site 28
S230
Q
G
N
S
Q
E
S
S
N
T
I
K
K
D
H
Site 29
T232
N
S
Q
E
S
S
N
T
I
K
K
D
H
T
G
Site 30
T238
N
T
I
K
K
D
H
T
G
K
S
K
I
P
K
Site 31
S241
K
K
D
H
T
G
K
S
K
I
P
K
I
Y
F
Site 32
Y247
K
S
K
I
P
K
I
Y
F
G
T
R
T
H
K
Site 33
T266
I
T
R
E
L
R
R
T
A
Y
S
G
V
P
M
Site 34
Y268
R
E
L
R
R
T
A
Y
S
G
V
P
M
T
I
Site 35
T274
A
Y
S
G
V
P
M
T
I
L
S
S
R
D
H
Site 36
T282
I
L
S
S
R
D
H
T
C
V
H
P
E
V
V
Site 37
Y311
G
K
N
G
K
S
C
Y
F
Y
H
G
V
H
K
Site 38
Y313
N
G
K
S
C
Y
F
Y
H
G
V
H
K
I
S
Site 39
T324
H
K
I
S
D
Q
H
T
L
Q
T
F
Q
G
M
Site 40
S342
W
D
I
E
E
L
V
S
L
G
K
K
L
K
A
Site 41
Y352
K
K
L
K
A
C
P
Y
Y
T
A
R
E
L
I
Site 42
Y353
K
L
K
A
C
P
Y
Y
T
A
R
E
L
I
Q
Site 43
T354
L
K
A
C
P
Y
Y
T
A
R
E
L
I
Q
D
Site 44
S380
L
D
A
Q
I
R
E
S
M
D
L
N
L
K
E
Site 45
S405
I
E
D
C
A
R
E
S
A
S
Y
S
V
T
E
Site 46
Y408
C
A
R
E
S
A
S
Y
S
V
T
E
V
Q
L
Site 47
S409
A
R
E
S
A
S
Y
S
V
T
E
V
Q
L
R
Site 48
T411
E
S
A
S
Y
S
V
T
E
V
Q
L
R
F
A
Site 49
S424
F
A
R
D
E
L
D
S
M
V
N
N
N
I
R
Site 50
Y461
E
Y
L
V
E
R
D
Y
E
S
A
C
K
I
W
Site 51
S463
L
V
E
R
D
Y
E
S
A
C
K
I
W
S
G
Site 52
S495
P
I
L
Q
G
H
F
S
A
V
L
Q
K
E
E
Site 53
S505
L
Q
K
E
E
K
I
S
P
I
Y
G
K
E
E
Site 54
Y508
E
E
K
I
S
P
I
Y
G
K
E
E
A
R
E
Site 55
Y536
G
L
F
M
V
L
D
Y
L
F
R
Q
N
S
R
Site 56
S542
D
Y
L
F
R
Q
N
S
R
F
A
D
D
Y
K
Site 57
Y548
N
S
R
F
A
D
D
Y
K
I
A
I
Q
Q
T
Site 58
T584
K
K
R
S
R
Q
K
T
A
V
H
V
L
N
F
Site 59
S622
G
T
L
S
P
M
K
S
F
S
S
E
L
G
V
Site 60
S625
S
P
M
K
S
F
S
S
E
L
G
V
T
F
T
Site 61
S653
V
W
V
G
T
I
G
S
G
P
K
G
R
N
L
Site 62
T663
K
G
R
N
L
C
A
T
F
Q
N
T
E
T
F
Site 63
T669
A
T
F
Q
N
T
E
T
F
E
F
Q
D
E
V
Site 64
S710
K
L
K
E
R
W
L
S
T
G
L
W
H
N
L
Site 65
T733
E
P
Q
G
G
E
K
T
N
F
D
E
L
L
Q
Site 66
Y742
F
D
E
L
L
Q
V
Y
Y
D
A
I
K
Y
K
Site 67
Y743
D
E
L
L
Q
V
Y
Y
D
A
I
K
Y
K
G
Site 68
S772
V
S
E
G
L
D
F
S
D
D
N
A
R
A
V
Site 69
Y800
Q
V
E
L
K
R
Q
Y
N
D
H
H
S
K
L
Site 70
S805
R
Q
Y
N
D
H
H
S
K
L
R
G
L
L
P
Site 71
Y817
L
L
P
G
R
Q
W
Y
E
I
Q
A
Y
R
A
Site 72
Y822
Q
W
Y
E
I
Q
A
Y
R
A
L
N
Q
A
L
Site 73
S854
D
R
F
R
N
N
P
S
R
Y
I
S
G
L
S
Site 74
S858
N
N
P
S
R
Y
I
S
G
L
S
K
W
V
R
Site 75
S861
S
R
Y
I
S
G
L
S
K
W
V
R
Q
Q
I
Site 76
T873
Q
Q
I
Q
H
H
S
T
F
E
S
A
L
E
S
Site 77
S876
Q
H
H
S
T
F
E
S
A
L
E
S
L
A
E
Site 78
S880
T
F
E
S
A
L
E
S
L
A
E
F
S
K
K
Site 79
S895
H
Q
K
V
L
N
V
S
I
K
D
R
T
N
I
Site 80
S907
T
N
I
Q
D
N
E
S
T
L
E
V
T
S
L
Site 81
T908
N
I
Q
D
N
E
S
T
L
E
V
T
S
L
K
Site 82
S913
E
S
T
L
E
V
T
S
L
K
Y
S
T
P
P
Site 83
Y916
L
E
V
T
S
L
K
Y
S
T
P
P
Y
L
L
Site 84
S917
E
V
T
S
L
K
Y
S
T
P
P
Y
L
L
E
Site 85
T918
V
T
S
L
K
Y
S
T
P
P
Y
L
L
E
A
Site 86
Y921
L
K
Y
S
T
P
P
Y
L
L
E
A
A
S
H
Site 87
S927
P
Y
L
L
E
A
A
S
H
L
S
P
E
N
F
Site 88
S930
L
E
A
A
S
H
L
S
P
E
N
F
V
E
D
Site 89
S956
P
K
I
I
T
K
N
S
P
L
P
S
S
I
I
Site 90
S960
T
K
N
S
P
L
P
S
S
I
I
S
R
K
E
Site 91
S961
K
N
S
P
L
P
S
S
I
I
S
R
K
E
K
Site 92
S964
P
L
P
S
S
I
I
S
R
K
E
K
N
D
P
Site 93
S986
K
A
E
K
I
V
I
S
R
S
T
S
P
T
F
Site 94
S988
E
K
I
V
I
S
R
S
T
S
P
T
F
N
K
Site 95
T989
K
I
V
I
S
R
S
T
S
P
T
F
N
K
Q
Site 96
S990
I
V
I
S
R
S
T
S
P
T
F
N
K
Q
T
Site 97
T992
I
S
R
S
T
S
P
T
F
N
K
Q
T
K
R
Site 98
T997
S
P
T
F
N
K
Q
T
K
R
V
S
W
S
S
Site 99
S1001
N
K
Q
T
K
R
V
S
W
S
S
F
N
S
L
Site 100
S1003
Q
T
K
R
V
S
W
S
S
F
N
S
L
G
Q
Site 101
S1004
T
K
R
V
S
W
S
S
F
N
S
L
G
Q
Y
Site 102
S1007
V
S
W
S
S
F
N
S
L
G
Q
Y
F
T
G
Site 103
Y1011
S
F
N
S
L
G
Q
Y
F
T
G
K
I
P
K
Site 104
T1013
N
S
L
G
Q
Y
F
T
G
K
I
P
K
A
T
Site 105
T1020
T
G
K
I
P
K
A
T
P
E
L
G
S
S
E
Site 106
S1025
K
A
T
P
E
L
G
S
S
E
N
S
A
S
S
Site 107
S1026
A
T
P
E
L
G
S
S
E
N
S
A
S
S
P
Site 108
S1029
E
L
G
S
S
E
N
S
A
S
S
P
P
R
F
Site 109
S1031
G
S
S
E
N
S
A
S
S
P
P
R
F
K
T
Site 110
S1032
S
S
E
N
S
A
S
S
P
P
R
F
K
T
E
Site 111
T1038
S
S
P
P
R
F
K
T
E
K
M
E
S
K
T
Site 112
S1043
F
K
T
E
K
M
E
S
K
T
V
L
P
F
T
Site 113
T1045
T
E
K
M
E
S
K
T
V
L
P
F
T
D
K
Site 114
T1050
S
K
T
V
L
P
F
T
D
K
C
E
S
S
N
Site 115
T1059
K
C
E
S
S
N
L
T
V
N
T
S
F
G
S
Site 116
T1062
S
S
N
L
T
V
N
T
S
F
G
S
C
P
Q
Site 117
S1063
S
N
L
T
V
N
T
S
F
G
S
C
P
Q
S
Site 118
S1066
T
V
N
T
S
F
G
S
C
P
Q
S
E
T
I
Site 119
S1070
S
F
G
S
C
P
Q
S
E
T
I
I
S
S
L
Site 120
T1072
G
S
C
P
Q
S
E
T
I
I
S
S
L
K
I
Site 121
S1075
P
Q
S
E
T
I
I
S
S
L
K
I
D
A
T
Site 122
T1082
S
S
L
K
I
D
A
T
L
T
R
K
N
H
S
Site 123
T1084
L
K
I
D
A
T
L
T
R
K
N
H
S
E
H
Site 124
S1089
T
L
T
R
K
N
H
S
E
H
P
L
C
S
E
Site 125
S1106
L
D
P
D
I
E
L
S
L
V
S
E
E
D
K
Site 126
S1115
V
S
E
E
D
K
Q
S
T
S
N
R
D
F
E
Site 127
S1117
E
E
D
K
Q
S
T
S
N
R
D
F
E
T
E
Site 128
S1129
E
T
E
A
E
D
E
S
I
Y
F
T
P
E
L
Site 129
Y1131
E
A
E
D
E
S
I
Y
F
T
P
E
L
Y
D
Site 130
T1133
E
D
E
S
I
Y
F
T
P
E
L
Y
D
P
E
Site 131
S1162
G
N
R
L
A
N
N
S
D
C
I
L
A
K
D
Site 132
S1181
R
T
I
K
E
V
D
S
A
R
E
V
K
A
E
Site 133
S1204
G
I
L
H
I
E
E
S
K
I
D
D
I
D
G
Site 134
T1226
N
E
L
E
L
G
K
T
H
E
I
E
I
K
N
Site 135
S1237
E
I
K
N
F
K
P
S
P
S
K
N
K
G
M
Site 136
S1239
K
N
F
K
P
S
P
S
K
N
K
G
M
F
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation