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Updated November 2019
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Protein Info
Short Name:
SYCP2
Full Name:
Synaptonemal complex protein 2
Alias:
SCP2; SCP-2; Synaptonemal complex lateral element protein
Type:
Unknown function
Mass (Da):
175639
Number AA:
1530
UniProt ID:
Q9BX26
International Prot ID:
IPI00306718
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007128
GO:0007130
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S113
K
S
K
D
I
I
Q
S
Q
G
N
S
K
D
E
Site 2
S117
I
I
Q
S
Q
G
N
S
K
D
E
A
V
L
N
Site 3
S140
L
L
V
I
H
D
V
S
D
E
G
K
K
Q
V
Site 4
S150
G
K
K
Q
V
V
E
S
F
V
P
R
I
C
S
Site 5
T227
V
E
A
L
C
R
M
T
T
E
K
Q
R
Q
E
Site 6
T228
E
A
L
C
R
M
T
T
E
K
Q
R
Q
E
L
Site 7
S255
A
F
K
R
I
K
D
S
E
F
E
T
D
C
R
Site 8
T259
I
K
D
S
E
F
E
T
D
C
R
I
F
L
N
Site 9
T280
G
D
K
R
R
V
F
T
F
P
C
L
S
A
F
Site 10
Y291
L
S
A
F
L
D
K
Y
E
L
Q
I
P
S
D
Site 11
S297
K
Y
E
L
Q
I
P
S
D
E
K
L
E
E
F
Site 12
S316
N
L
G
S
Q
T
L
S
F
Y
I
A
G
D
N
Site 13
Y318
G
S
Q
T
L
S
F
Y
I
A
G
D
N
D
D
Site 14
T359
L
T
I
I
L
K
N
T
V
K
I
S
K
R
E
Site 15
S363
L
K
N
T
V
K
I
S
K
R
E
G
K
E
L
Site 16
S396
G
A
T
K
H
R
E
S
I
R
K
Q
G
I
S
Site 17
S403
S
I
R
K
Q
G
I
S
V
A
K
T
S
L
H
Site 18
S425
S
Q
I
L
V
P
E
S
Q
I
S
P
V
G
E
Site 19
S436
P
V
G
E
E
L
V
S
L
K
E
K
S
K
S
Site 20
S441
L
V
S
L
K
E
K
S
K
S
P
K
E
F
A
Site 21
S443
S
L
K
E
K
S
K
S
P
K
E
F
A
K
P
Site 22
S451
P
K
E
F
A
K
P
S
K
Y
I
K
N
S
D
Site 23
Y453
E
F
A
K
P
S
K
Y
I
K
N
S
D
K
G
Site 24
S465
D
K
G
N
R
N
N
S
Q
L
E
K
T
T
P
Site 25
T471
N
S
Q
L
E
K
T
T
P
S
K
R
K
M
S
Site 26
S473
Q
L
E
K
T
T
P
S
K
R
K
M
S
E
A
Site 27
S478
T
P
S
K
R
K
M
S
E
A
S
M
I
V
S
Site 28
S481
K
R
K
M
S
E
A
S
M
I
V
S
G
A
D
Site 29
S485
S
E
A
S
M
I
V
S
G
A
D
R
Y
T
M
Site 30
Y490
I
V
S
G
A
D
R
Y
T
M
R
S
P
V
L
Site 31
T491
V
S
G
A
D
R
Y
T
M
R
S
P
V
L
F
Site 32
S494
A
D
R
Y
T
M
R
S
P
V
L
F
S
N
T
Site 33
S499
M
R
S
P
V
L
F
S
N
T
S
I
P
P
R
Site 34
T501
S
P
V
L
F
S
N
T
S
I
P
P
R
R
R
Site 35
S502
P
V
L
F
S
N
T
S
I
P
P
R
R
R
R
Site 36
S518
K
P
P
L
Q
M
T
S
S
A
E
K
P
S
V
Site 37
S519
P
P
L
Q
M
T
S
S
A
E
K
P
S
V
S
Site 38
S524
T
S
S
A
E
K
P
S
V
S
Q
T
S
E
N
Site 39
S526
S
A
E
K
P
S
V
S
Q
T
S
E
N
R
V
Site 40
T528
E
K
P
S
V
S
Q
T
S
E
N
R
V
D
N
Site 41
S538
N
R
V
D
N
A
A
S
L
K
S
R
S
S
E
Site 42
S541
D
N
A
A
S
L
K
S
R
S
S
E
G
R
H
Site 43
S543
A
A
S
L
K
S
R
S
S
E
G
R
H
R
R
Site 44
S544
A
S
L
K
S
R
S
S
E
G
R
H
R
R
D
Site 45
S588
L
Q
D
V
I
P
D
S
Q
A
A
E
K
R
D
Site 46
T597
A
A
E
K
R
D
H
T
I
L
P
G
V
L
D
Site 47
T619
H
S
K
W
A
C
W
T
P
V
T
N
I
E
L
Site 48
S633
L
C
N
N
Q
R
A
S
T
S
S
G
D
T
L
Site 49
T634
C
N
N
Q
R
A
S
T
S
S
G
D
T
L
N
Site 50
S635
N
N
Q
R
A
S
T
S
S
G
D
T
L
N
Q
Site 51
S636
N
Q
R
A
S
T
S
S
G
D
T
L
N
Q
D
Site 52
T639
A
S
T
S
S
G
D
T
L
N
Q
D
I
V
I
Site 53
T651
I
V
I
N
K
K
L
T
K
Q
K
S
S
S
S
Site 54
S655
K
K
L
T
K
Q
K
S
S
S
S
I
S
D
H
Site 55
S656
K
L
T
K
Q
K
S
S
S
S
I
S
D
H
N
Site 56
S657
L
T
K
Q
K
S
S
S
S
I
S
D
H
N
S
Site 57
S658
T
K
Q
K
S
S
S
S
I
S
D
H
N
S
E
Site 58
S660
Q
K
S
S
S
S
I
S
D
H
N
S
E
G
T
Site 59
S664
S
S
I
S
D
H
N
S
E
G
T
G
K
V
K
Site 60
Y672
E
G
T
G
K
V
K
Y
K
K
E
Q
T
D
H
Site 61
Y702
Q
Q
Q
N
H
P
K
Y
S
G
Q
K
N
T
E
Site 62
S714
N
T
E
N
A
K
Q
S
D
W
P
V
E
S
E
Site 63
S720
Q
S
D
W
P
V
E
S
E
T
T
F
K
S
V
Site 64
T723
W
P
V
E
S
E
T
T
F
K
S
V
L
L
N
Site 65
S726
E
S
E
T
T
F
K
S
V
L
L
N
K
T
I
Site 66
Y739
T
I
E
E
S
L
I
Y
R
K
K
Y
I
L
S
Site 67
Y743
S
L
I
Y
R
K
K
Y
I
L
S
K
D
V
N
Site 68
S746
Y
R
K
K
Y
I
L
S
K
D
V
N
T
A
T
Site 69
T753
S
K
D
V
N
T
A
T
C
D
K
N
P
S
A
Site 70
S759
A
T
C
D
K
N
P
S
A
S
K
N
V
Q
S
Site 71
S761
C
D
K
N
P
S
A
S
K
N
V
Q
S
H
R
Site 72
S766
S
A
S
K
N
V
Q
S
H
R
K
A
E
K
E
Site 73
T775
R
K
A
E
K
E
L
T
S
E
L
N
S
W
D
Site 74
S776
K
A
E
K
E
L
T
S
E
L
N
S
W
D
S
Site 75
S780
E
L
T
S
E
L
N
S
W
D
S
K
Q
K
K
Site 76
S783
S
E
L
N
S
W
D
S
K
Q
K
K
M
R
E
Site 77
S792
Q
K
K
M
R
E
K
S
K
G
K
E
F
T
N
Site 78
S803
E
F
T
N
V
A
E
S
L
I
S
Q
I
N
K
Site 79
S806
N
V
A
E
S
L
I
S
Q
I
N
K
R
Y
K
Site 80
T814
Q
I
N
K
R
Y
K
T
K
D
D
I
K
S
T
Site 81
S820
K
T
K
D
D
I
K
S
T
R
K
L
K
E
S
Site 82
S827
S
T
R
K
L
K
E
S
L
I
N
S
G
F
S
Site 83
S831
L
K
E
S
L
I
N
S
G
F
S
N
K
P
V
Site 84
S850
K
E
K
V
Q
K
K
S
Y
R
K
L
K
T
T
Site 85
T856
K
S
Y
R
K
L
K
T
T
F
V
N
V
T
S
Site 86
T857
S
Y
R
K
L
K
T
T
F
V
N
V
T
S
E
Site 87
Y871
E
C
P
V
N
D
V
Y
N
F
N
L
N
G
A
Site 88
T893
G
I
Q
E
F
Q
A
T
A
K
E
A
C
A
D
Site 89
S902
K
E
A
C
A
D
R
S
I
R
L
V
G
P
R
Site 90
S916
R
N
H
D
E
L
K
S
S
V
K
T
K
D
K
Site 91
S917
N
H
D
E
L
K
S
S
V
K
T
K
D
K
K
Site 92
T920
E
L
K
S
S
V
K
T
K
D
K
K
I
I
T
Site 93
S936
H
Q
K
K
N
L
F
S
D
T
E
T
E
Y
R
Site 94
T938
K
K
N
L
F
S
D
T
E
T
E
Y
R
C
D
Site 95
T940
N
L
F
S
D
T
E
T
E
Y
R
C
D
D
S
Site 96
Y942
F
S
D
T
E
T
E
Y
R
C
D
D
S
K
T
Site 97
T949
Y
R
C
D
D
S
K
T
D
I
S
W
L
R
E
Site 98
S952
D
D
S
K
T
D
I
S
W
L
R
E
P
K
S
Site 99
S959
S
W
L
R
E
P
K
S
K
P
Q
L
I
D
Y
Site 100
Y966
S
K
P
Q
L
I
D
Y
S
R
N
K
N
V
K
Site 101
S977
K
N
V
K
N
H
K
S
G
K
S
R
S
S
L
Site 102
S980
K
N
H
K
S
G
K
S
R
S
S
L
E
K
G
Site 103
S982
H
K
S
G
K
S
R
S
S
L
E
K
G
Q
P
Site 104
S983
K
S
G
K
S
R
S
S
L
E
K
G
Q
P
S
Site 105
S990
S
L
E
K
G
Q
P
S
S
K
M
T
P
S
K
Site 106
S991
L
E
K
G
Q
P
S
S
K
M
T
P
S
K
N
Site 107
T994
G
Q
P
S
S
K
M
T
P
S
K
N
I
T
K
Site 108
S996
P
S
S
K
M
T
P
S
K
N
I
T
K
K
M
Site 109
T1006
I
T
K
K
M
D
K
T
I
P
E
G
R
I
R
Site 110
T1019
I
R
L
P
R
K
A
T
K
T
K
K
N
Y
K
Site 111
T1021
L
P
R
K
A
T
K
T
K
K
N
Y
K
D
L
Site 112
S1029
K
K
N
Y
K
D
L
S
N
S
E
S
E
C
E
Site 113
S1031
N
Y
K
D
L
S
N
S
E
S
E
C
E
Q
E
Site 114
S1033
K
D
L
S
N
S
E
S
E
C
E
Q
E
F
S
Site 115
S1040
S
E
C
E
Q
E
F
S
H
S
F
K
E
N
I
Site 116
S1042
C
E
Q
E
F
S
H
S
F
K
E
N
I
P
V
Site 117
S1056
V
K
E
E
N
I
H
S
R
M
K
T
V
K
L
Site 118
T1060
N
I
H
S
R
M
K
T
V
K
L
P
K
K
Q
Site 119
S1080
A
E
T
E
K
E
L
S
K
Q
W
K
N
S
S
Site 120
S1087
S
K
Q
W
K
N
S
S
L
L
K
D
A
I
R
Site 121
S1101
R
D
N
C
L
D
L
S
P
R
S
L
S
G
S
Site 122
S1104
C
L
D
L
S
P
R
S
L
S
G
S
P
S
S
Site 123
S1106
D
L
S
P
R
S
L
S
G
S
P
S
S
I
E
Site 124
S1108
S
P
R
S
L
S
G
S
P
S
S
I
E
V
T
Site 125
S1110
R
S
L
S
G
S
P
S
S
I
E
V
T
R
C
Site 126
T1115
S
P
S
S
I
E
V
T
R
C
I
E
K
I
T
Site 127
T1127
K
I
T
E
K
D
F
T
Q
D
Y
D
C
I
T
Site 128
Y1130
E
K
D
F
T
Q
D
Y
D
C
I
T
K
S
I
Site 129
T1134
T
Q
D
Y
D
C
I
T
K
S
I
S
P
Y
P
Site 130
S1136
D
Y
D
C
I
T
K
S
I
S
P
Y
P
K
T
Site 131
S1138
D
C
I
T
K
S
I
S
P
Y
P
K
T
S
S
Site 132
Y1140
I
T
K
S
I
S
P
Y
P
K
T
S
S
L
E
Site 133
T1143
S
I
S
P
Y
P
K
T
S
S
L
E
S
L
N
Site 134
S1144
I
S
P
Y
P
K
T
S
S
L
E
S
L
N
S
Site 135
S1145
S
P
Y
P
K
T
S
S
L
E
S
L
N
S
N
Site 136
S1148
P
K
T
S
S
L
E
S
L
N
S
N
S
G
V
Site 137
S1151
S
S
L
E
S
L
N
S
N
S
G
V
G
G
T
Site 138
S1153
L
E
S
L
N
S
N
S
G
V
G
G
T
I
K
Site 139
S1161
G
V
G
G
T
I
K
S
P
K
N
N
E
K
N
Site 140
S1173
E
K
N
F
L
C
A
S
E
S
C
S
P
I
P
Site 141
S1175
N
F
L
C
A
S
E
S
C
S
P
I
P
R
P
Site 142
S1177
L
C
A
S
E
S
C
S
P
I
P
R
P
L
F
Site 143
T1189
P
L
F
L
P
R
H
T
P
T
K
S
N
T
I
Site 144
T1191
F
L
P
R
H
T
P
T
K
S
N
T
I
V
N
Site 145
S1193
P
R
H
T
P
T
K
S
N
T
I
V
N
R
K
Site 146
T1195
H
T
P
T
K
S
N
T
I
V
N
R
K
K
I
Site 147
S1204
V
N
R
K
K
I
S
S
L
V
L
T
Q
E
T
Site 148
T1208
K
I
S
S
L
V
L
T
Q
E
T
Q
N
S
N
Site 149
T1211
S
L
V
L
T
Q
E
T
Q
N
S
N
S
Y
S
Site 150
S1214
L
T
Q
E
T
Q
N
S
N
S
Y
S
D
V
S
Site 151
S1216
Q
E
T
Q
N
S
N
S
Y
S
D
V
S
S
Y
Site 152
Y1217
E
T
Q
N
S
N
S
Y
S
D
V
S
S
Y
S
Site 153
S1218
T
Q
N
S
N
S
Y
S
D
V
S
S
Y
S
S
Site 154
S1221
S
N
S
Y
S
D
V
S
S
Y
S
S
E
E
R
Site 155
S1222
N
S
Y
S
D
V
S
S
Y
S
S
E
E
R
F
Site 156
S1225
S
D
V
S
S
Y
S
S
E
E
R
F
M
E
I
Site 157
S1244
I
N
E
N
Y
I
Q
S
K
R
E
E
S
H
L
Site 158
S1249
I
Q
S
K
R
E
E
S
H
L
A
S
S
L
S
Site 159
S1253
R
E
E
S
H
L
A
S
S
L
S
K
S
S
E
Site 160
S1254
E
E
S
H
L
A
S
S
L
S
K
S
S
E
G
Site 161
S1256
S
H
L
A
S
S
L
S
K
S
S
E
G
R
E
Site 162
S1258
L
A
S
S
L
S
K
S
S
E
G
R
E
K
T
Site 163
S1259
A
S
S
L
S
K
S
S
E
G
R
E
K
T
W
Site 164
T1265
S
S
E
G
R
E
K
T
W
F
D
M
P
C
D
Site 165
T1274
F
D
M
P
C
D
A
T
H
V
S
G
P
T
Q
Site 166
S1277
P
C
D
A
T
H
V
S
G
P
T
Q
H
L
S
Site 167
T1280
A
T
H
V
S
G
P
T
Q
H
L
S
R
K
R
Site 168
S1284
S
G
P
T
Q
H
L
S
R
K
R
I
Y
I
E
Site 169
Y1289
H
L
S
R
K
R
I
Y
I
E
D
N
L
S
N
Site 170
S1295
I
Y
I
E
D
N
L
S
N
S
N
E
V
E
M
Site 171
S1297
I
E
D
N
L
S
N
S
N
E
V
E
M
E
E
Site 172
S1331
D
H
H
I
H
K
M
S
E
S
V
S
S
L
S
Site 173
S1333
H
I
H
K
M
S
E
S
V
S
S
L
S
T
N
Site 174
S1335
H
K
M
S
E
S
V
S
S
L
S
T
N
D
F
Site 175
S1336
K
M
S
E
S
V
S
S
L
S
T
N
D
F
S
Site 176
S1338
S
E
S
V
S
S
L
S
T
N
D
F
S
I
P
Site 177
T1339
E
S
V
S
S
L
S
T
N
D
F
S
I
P
W
Site 178
Y1363
I
E
M
T
Y
E
T
Y
E
R
L
N
S
E
F
Site 179
S1368
E
T
Y
E
R
L
N
S
E
F
K
R
R
N
N
Site 180
Y1383
I
R
H
K
M
L
S
Y
F
T
T
Q
S
W
K
Site 181
T1386
K
M
L
S
Y
F
T
T
Q
S
W
K
T
A
Q
Site 182
S1403
L
R
T
M
N
H
Q
S
Q
D
S
R
I
K
K
Site 183
S1429
L
E
N
F
E
K
D
S
Q
S
L
K
D
L
E
Site 184
S1431
N
F
E
K
D
S
Q
S
L
K
D
L
E
K
E
Site 185
S1451
E
K
I
F
Q
K
F
S
A
Y
Q
K
S
E
Q
Site 186
Y1453
I
F
Q
K
F
S
A
Y
Q
K
S
E
Q
Q
R
Site 187
S1456
K
F
S
A
Y
Q
K
S
E
Q
Q
R
L
H
L
Site 188
S1471
L
K
T
S
L
A
K
S
V
F
C
N
T
D
S
Site 189
S1478
S
V
F
C
N
T
D
S
E
E
T
V
F
T
S
Site 190
T1481
C
N
T
D
S
E
E
T
V
F
T
S
E
M
C
Site 191
T1484
D
S
E
E
T
V
F
T
S
E
M
C
L
M
K
Site 192
S1519
N
V
R
R
E
L
M
S
V
F
M
S
H
E
R
Site 193
S1523
E
L
M
S
V
F
M
S
H
E
R
N
A
N
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation