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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CARD10
Full Name:
Caspase recruitment domain-containing protein 10
Alias:
BIMP1; CAR10; CARD-containing MAGUK protein 3; Carma 3; CARMA3; Caspase recruitment domain family, member 10
Type:
Intracellular, Cytoplasm, CBM complex protein
Mass (Da):
115931
Number AA:
1032
UniProt ID:
Q9BWT7
International Prot ID:
IPI00002313
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032449
Uniprot
OncoNet
Molecular Function:
GO:0030159
PhosphoSite+
KinaseNET
Biological Process:
GO:0007250
GO:0006461
GO:0042981
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
E
A
G
A
G
S
G
S
E
A
E
E
D
A
L
Site 2
T48
A
L
N
P
A
K
L
T
P
Y
L
R
Q
C
R
Site 3
Y50
N
P
A
K
L
T
P
Y
L
R
Q
C
R
V
I
Site 4
S67
Q
D
E
E
E
V
L
S
T
Y
R
F
P
C
R
Site 5
T68
D
E
E
E
V
L
S
T
Y
R
F
P
C
R
V
Site 6
Y69
E
E
E
V
L
S
T
Y
R
F
P
C
R
V
N
Site 7
Y93
R
C
R
G
K
R
G
Y
E
A
F
L
E
A
L
Site 8
S121
Q
E
P
A
Q
R
C
S
M
I
L
D
E
E
G
Site 9
T138
G
L
T
Q
F
L
M
T
E
V
R
R
L
R
E
Site 10
S149
R
L
R
E
A
R
K
S
Q
L
Q
R
E
Q
Q
Site 11
Y207
L
R
L
K
D
E
N
Y
M
I
A
M
R
L
A
Site 12
S217
A
M
R
L
A
Q
L
S
E
E
K
N
S
A
V
Site 13
S222
Q
L
S
E
E
K
N
S
A
V
L
R
S
R
D
Site 14
S242
D
Q
L
K
L
K
V
S
R
L
E
E
E
C
A
Site 15
S281
P
D
N
V
D
L
V
S
E
L
R
A
E
N
Q
Site 16
T291
R
A
E
N
Q
R
L
T
A
S
L
R
E
L
Q
Site 17
S293
E
N
Q
R
L
T
A
S
L
R
E
L
Q
E
G
Site 18
S306
E
G
L
Q
Q
E
A
S
R
P
G
A
P
G
S
Site 19
S313
S
R
P
G
A
P
G
S
E
R
I
L
L
D
I
Site 20
S331
D
W
R
E
A
Q
D
S
R
Q
E
L
C
Q
K
Site 21
Y356
A
E
E
L
R
D
Q
Y
L
Q
E
M
E
D
L
Site 22
T369
D
L
R
L
K
H
R
T
L
Q
K
D
C
D
L
Site 23
Y377
L
Q
K
D
C
D
L
Y
K
H
R
M
A
T
V
Site 24
T383
L
Y
K
H
R
M
A
T
V
L
A
Q
L
E
E
Site 25
Y409
R
D
R
I
Q
L
Q
Y
S
Q
S
L
I
E
K
Site 26
S410
D
R
I
Q
L
Q
Y
S
Q
S
L
I
E
K
D
Site 27
S412
I
Q
L
Q
Y
S
Q
S
L
I
E
K
D
Q
Y
Site 28
Y419
S
L
I
E
K
D
Q
Y
R
K
Q
V
R
G
L
Site 29
T435
A
E
R
D
E
L
L
T
T
L
T
S
L
E
G
Site 30
T436
E
R
D
E
L
L
T
T
L
T
S
L
E
G
T
Site 31
S468
K
A
C
A
S
S
H
S
L
C
S
N
L
S
S
Site 32
S471
A
S
S
H
S
L
C
S
N
L
S
S
T
W
S
Site 33
S474
H
S
L
C
S
N
L
S
S
T
W
S
L
S
E
Site 34
S475
S
L
C
S
N
L
S
S
T
W
S
L
S
E
F
Site 35
T476
L
C
S
N
L
S
S
T
W
S
L
S
E
F
P
Site 36
S478
S
N
L
S
S
T
W
S
L
S
E
F
P
S
P
Site 37
S480
L
S
S
T
W
S
L
S
E
F
P
S
P
L
G
Site 38
S484
W
S
L
S
E
F
P
S
P
L
G
G
P
E
A
Site 39
S506
G
G
P
E
P
H
N
S
E
E
A
T
D
S
E
Site 40
T510
P
H
N
S
E
E
A
T
D
S
E
K
E
I
N
Site 41
S512
N
S
E
E
A
T
D
S
E
K
E
I
N
R
L
Site 42
S520
E
K
E
I
N
R
L
S
I
L
P
F
P
P
S
Site 43
S530
P
F
P
P
S
A
G
S
I
L
R
R
Q
R
E
Site 44
S546
D
P
A
P
P
K
R
S
F
S
S
M
S
D
I
Site 45
S548
A
P
P
K
R
S
F
S
S
M
S
D
I
T
G
Site 46
S549
P
P
K
R
S
F
S
S
M
S
D
I
T
G
S
Site 47
S551
K
R
S
F
S
S
M
S
D
I
T
G
S
V
T
Site 48
T554
F
S
S
M
S
D
I
T
G
S
V
T
L
K
P
Site 49
S556
S
M
S
D
I
T
G
S
V
T
L
K
P
W
S
Site 50
T558
S
D
I
T
G
S
V
T
L
K
P
W
S
P
G
Site 51
S563
S
V
T
L
K
P
W
S
P
G
L
S
S
S
S
Site 52
S567
K
P
W
S
P
G
L
S
S
S
S
S
S
D
S
Site 53
S568
P
W
S
P
G
L
S
S
S
S
S
S
D
S
V
Site 54
S569
W
S
P
G
L
S
S
S
S
S
S
D
S
V
W
Site 55
S570
S
P
G
L
S
S
S
S
S
S
D
S
V
W
P
Site 56
S571
P
G
L
S
S
S
S
S
S
D
S
V
W
P
L
Site 57
S572
G
L
S
S
S
S
S
S
D
S
V
W
P
L
G
Site 58
S574
S
S
S
S
S
S
D
S
V
W
P
L
G
K
P
Site 59
S603
R
S
L
A
I
R
V
S
G
R
S
P
P
G
G
Site 60
S606
A
I
R
V
S
G
R
S
P
P
G
G
P
E
P
Site 61
S622
D
K
G
P
D
G
L
S
F
Y
G
D
R
W
S
Site 62
Y624
G
P
D
G
L
S
F
Y
G
D
R
W
S
G
A
Site 63
S629
S
F
Y
G
D
R
W
S
G
A
V
V
R
R
V
Site 64
S642
R
V
L
S
G
P
G
S
A
R
M
E
P
R
E
Site 65
S677
T
L
L
W
N
Q
G
S
T
L
P
S
L
M
D
Site 66
S681
N
Q
G
S
T
L
P
S
L
M
D
S
K
A
C
Site 67
S685
T
L
P
S
L
M
D
S
K
A
C
Q
S
F
H
Site 68
S690
M
D
S
K
A
C
Q
S
F
H
E
A
L
E
A
Site 69
S737
E
I
L
R
L
V
D
S
A
Y
K
R
R
Q
E
Site 70
Y739
L
R
L
V
D
S
A
Y
K
R
R
Q
E
W
F
Site 71
T748
R
R
Q
E
W
F
C
T
R
V
D
P
L
T
L
Site 72
T754
C
T
R
V
D
P
L
T
L
R
D
L
D
R
G
Site 73
T762
L
R
D
L
D
R
G
T
V
P
N
Y
Q
R
A
Site 74
Y766
D
R
G
T
V
P
N
Y
Q
R
A
Q
Q
L
L
Site 75
S782
V
Q
E
K
C
L
P
S
S
R
H
R
G
P
R
Site 76
S783
Q
E
K
C
L
P
S
S
R
H
R
G
P
R
S
Site 77
S790
S
R
H
R
G
P
R
S
N
L
K
K
R
A
L
Site 78
S815
V
G
A
P
A
G
D
S
P
D
Q
L
L
L
E
Site 79
S830
P
C
A
E
P
E
R
S
L
R
P
Y
S
L
V
Site 80
Y834
P
E
R
S
L
R
P
Y
S
L
V
R
P
L
L
Site 81
S835
E
R
S
L
R
P
Y
S
L
V
R
P
L
L
V
Site 82
S868
R
N
L
L
D
L
P
S
S
R
L
D
F
Q
V
Site 83
S882
V
C
P
A
E
S
L
S
G
E
E
L
C
P
S
Site 84
S889
S
G
E
E
L
C
P
S
S
A
P
G
A
P
K
Site 85
S890
G
E
E
L
C
P
S
S
A
P
G
A
P
K
A
Site 86
T901
A
P
K
A
Q
P
A
T
P
G
L
G
S
R
I
Site 87
S914
R
I
R
A
I
Q
E
S
V
G
K
K
H
C
L
Site 88
S966
G
R
P
G
W
R
D
S
E
L
L
R
Q
C
R
Site 89
S975
L
L
R
Q
C
R
G
S
E
Q
V
L
W
G
L
Site 90
S1022
L
V
W
V
E
C
G
S
S
R
G
C
P
S
S
Site 91
S1023
V
W
V
E
C
G
S
S
R
G
C
P
S
S
S
Site 92
S1028
G
S
S
R
G
C
P
S
S
S
E
A
_
_
_
Site 93
S1029
S
S
R
G
C
P
S
S
S
E
A
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation